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Volumn 10, Issue , 2011, Pages

Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation

Author keywords

Coactivation; Hsp90; Ovarian cancer; Tyrosine kinases

Indexed keywords

AUY 922; BETA ACTIN; CASPASE 8; CYCLINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 4; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN AXL; PROTEIN KINASE B; PROTEIN P53; PROTEIN TYROSINE KINASE; RAF PROTEIN; SCATTER FACTOR RECEPTOR; TANESPIMYCIN; UNCLASSIFIED DRUG; 17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN; ANTINEOPLASTIC AGENT; AXL RECEPTOR TYROSINE KINASE; BENZOQUINONE DERIVATIVE; ERBB2 PROTEIN, HUMAN; MACROCYCLIC LACTAM; MET PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN KINASE INHIBITOR; RECEPTOR TYROSINE PROTEIN KINASE ERBB 4; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4;

EID: 80053364033     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-10-125     Document Type: Article
Times cited : (42)

References (54)
  • 2
    • 77954832763 scopus 로고    scopus 로고
    • A current review of targeted therapeutics for ovarian cancer
    • 2804109, 20069122
    • Campos SM, Ghosh S. A current review of targeted therapeutics for ovarian cancer. J Oncol 2010, 2010:149362. 2804109, 20069122.
    • (2010) J Oncol , vol.2010 , pp. 149362
    • Campos, S.M.1    Ghosh, S.2
  • 3
    • 77955649600 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor in epithelial ovarian cancer: current knowledge and future challenges
    • 2796463, 20037743
    • Siwak DR, Carey M, Hennessy BT, Nguyen CT, Gahren Murray MJ, Nolden L, Mills GB. Targeting the epidermal growth factor receptor in epithelial ovarian cancer: current knowledge and future challenges. J Oncol 2010, 2010:568938. 2796463, 20037743.
    • (2010) J Oncol , vol.2010 , pp. 568938
    • Siwak, D.R.1    Carey, M.2    Hennessy, B.T.3    Nguyen, C.T.4    Gahren Murray, M.J.5    Nolden, L.6    Mills, G.B.7
  • 4
    • 0035123775 scopus 로고    scopus 로고
    • Precursor lesions of ovarian epithelial malignancy
    • 10.1046/j.1365-2559.2001.01042.x, 11207821
    • Feeley KM, Wells M. Precursor lesions of ovarian epithelial malignancy. Histopathology 2001, 38:87-95. 10.1046/j.1365-2559.2001.01042.x, 11207821.
    • (2001) Histopathology , vol.38 , pp. 87-95
    • Feeley, K.M.1    Wells, M.2
  • 5
    • 69949160097 scopus 로고    scopus 로고
    • Stage IIIC epithelial ovarian cancer classified solely by lymph node metastasis has a more favorable prognosis than other types of stage IIIC epithelial ovarian cancer
    • 10.3802/jgo.2008.19.4.223, 2676474, 19471577
    • Baek SJ, Park JY, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH. Stage IIIC epithelial ovarian cancer classified solely by lymph node metastasis has a more favorable prognosis than other types of stage IIIC epithelial ovarian cancer. J Gynecol Oncol 2008, 19:223-228. 10.3802/jgo.2008.19.4.223, 2676474, 19471577.
    • (2008) J Gynecol Oncol , vol.19 , pp. 223-228
    • Baek, S.J.1    Park, J.Y.2    Kim, D.Y.3    Kim, J.H.4    Kim, Y.M.5    Kim, Y.T.6    Nam, J.H.7
  • 6
    • 33746742412 scopus 로고    scopus 로고
    • Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma
    • 10.1007/s00109-006-0054-4, 16607561
    • Lassus H, Sihto H, Leminen A, Joensuu H, Isola J, Nupponen NN, Butzow R. Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma. J Mol Med 2006, 84:671-681. 10.1007/s00109-006-0054-4, 16607561.
    • (2006) J Mol Med , vol.84 , pp. 671-681
    • Lassus, H.1    Sihto, H.2    Leminen, A.3    Joensuu, H.4    Isola, J.5    Nupponen, N.N.6    Butzow, R.7
  • 8
    • 40749101689 scopus 로고    scopus 로고
    • Genomic activation of the EGFR and HER2-neu genes in a significant proportion of invasive epithelial ovarian cancers
    • 10.1186/1471-2407-8-3, 2266762, 18182111
    • Vermeij J, Teugels E, Bourgain C, Xiangming J, in 't Veld P, Ghislain V, Neyns B, Greve JD. Genomic activation of the EGFR and HER2-neu genes in a significant proportion of invasive epithelial ovarian cancers. BMC Cancer 2008, 8:3. 10.1186/1471-2407-8-3, 2266762, 18182111.
    • (2008) BMC Cancer , vol.8 , pp. 3
    • Vermeij, J.1    Teugels, E.2    Bourgain, C.3    Xiangming, J.4    in 't Veld, P.5    Ghislain, V.6    Neyns, B.7    Greve, J.D.8
  • 14
    • 73949092289 scopus 로고    scopus 로고
    • An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis
    • 2805878, 20072648
    • Zillhardt M, Christensen JG, Lengyel E. An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis. Neoplasia 2010, 12:1-10. 2805878, 20072648.
    • (2010) Neoplasia , vol.12 , pp. 1-10
    • Zillhardt, M.1    Christensen, J.G.2    Lengyel, E.3
  • 17
    • 1842582507 scopus 로고    scopus 로고
    • Expression of platelet-derived growth factor and activated receptor in clinical specimens of epithelial ovarian cancer and ovarian carcinoma cell lines
    • 10.1016/j.ygyno.2003.12.041, 15047217
    • Apte SM, Bucana CD, Killion JJ, Gershenson DM, Fidler IJ. Expression of platelet-derived growth factor and activated receptor in clinical specimens of epithelial ovarian cancer and ovarian carcinoma cell lines. Gynecol Oncol 2004, 93:78-86. 10.1016/j.ygyno.2003.12.041, 15047217.
    • (2004) Gynecol Oncol , vol.93 , pp. 78-86
    • Apte, S.M.1    Bucana, C.D.2    Killion, J.J.3    Gershenson, D.M.4    Fidler, I.J.5
  • 18
    • 12344312294 scopus 로고    scopus 로고
    • Genetic alterations and protein expression of KIT and PDGFRA in serous ovarian carcinoma
    • 10.1038/sj.bjc.6602252, 2409787, 15583695
    • Lassus H, Sihto H, Leminen A, Nordling S, Joensuu H, Nupponen NN, Butzow R. Genetic alterations and protein expression of KIT and PDGFRA in serous ovarian carcinoma. Br J Cancer 2004, 91:2048-2055. 10.1038/sj.bjc.6602252, 2409787, 15583695.
    • (2004) Br J Cancer , vol.91 , pp. 2048-2055
    • Lassus, H.1    Sihto, H.2    Leminen, A.3    Nordling, S.4    Joensuu, H.5    Nupponen, N.N.6    Butzow, R.7
  • 19
    • 33645506349 scopus 로고    scopus 로고
    • Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer
    • 10.1038/sj.onc.1209232, 16331269
    • Matei D, Emerson RE, Lai YC, Baldridge LA, Rao J, Yiannoutsos C, Donner DD. Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer. Oncogene 2006, 25:2060-2069. 10.1038/sj.onc.1209232, 16331269.
    • (2006) Oncogene , vol.25 , pp. 2060-2069
    • Matei, D.1    Emerson, R.E.2    Lai, Y.C.3    Baldridge, L.A.4    Rao, J.5    Yiannoutsos, C.6    Donner, D.D.7
  • 21
    • 0034046917 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor expression in human ovarian carcinoma
    • 2363477, 10901370
    • Shen GH, Ghazizadeh M, Kawanami O, Shimizu H, Jin E, Araki T, Sugisaki Y. Prognostic significance of vascular endothelial growth factor expression in human ovarian carcinoma. Br J Cancer 2000, 83:196-203. 2363477, 10901370.
    • (2000) Br J Cancer , vol.83 , pp. 196-203
    • Shen, G.H.1    Ghazizadeh, M.2    Kawanami, O.3    Shimizu, H.4    Jin, E.5    Araki, T.6    Sugisaki, Y.7
  • 22
    • 5644239572 scopus 로고    scopus 로고
    • Coexpression of Gas6/Axl in human ovarian cancers
    • 10.1159/000079499, 15452374
    • Sun W, Fujimoto J, Tamaya T. Coexpression of Gas6/Axl in human ovarian cancers. Oncology 2004, 66:450-457. 10.1159/000079499, 15452374.
    • (2004) Oncology , vol.66 , pp. 450-457
    • Sun, W.1    Fujimoto, J.2    Tamaya, T.3
  • 23
    • 69349088990 scopus 로고    scopus 로고
    • Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems
    • Review, 10.1097/PAP.0b013e3181b4fffa, 2745605, 19700937
    • Vang R, Shih I, Kurman RJ. Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. Adv Anat Pathol 2009, 16:267-82. Review, 10.1097/PAP.0b013e3181b4fffa, 2745605, 19700937.
    • (2009) Adv Anat Pathol , vol.16 , pp. 267-282
    • Vang, R.1    Shih, I.2    Kurman, R.J.3
  • 25
    • 0031903646 scopus 로고    scopus 로고
    • Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
    • Pegram MD, Lipton A, Hayes DF, Weber BL, Baselga JM, Tripathy D, Baly D, Baughman SA, Twaddell T, Glaspy JA, Slamon DJ. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 1998, 16:2659-2671.
    • (1998) J Clin Oncol , vol.16 , pp. 2659-2671
    • Pegram, M.D.1    Lipton, A.2    Hayes, D.F.3    Weber, B.L.4    Baselga, J.M.5    Tripathy, D.6    Baly, D.7    Baughman, S.A.8    Twaddell, T.9    Glaspy, J.A.10    Slamon, D.J.11
  • 31
    • 1542298267 scopus 로고    scopus 로고
    • Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone
    • 10.1016/j.canlet.2003.08.032, 15013520
    • Workman P. Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone. Cancer Lett 2004, 206:149-157. 10.1016/j.canlet.2003.08.032, 15013520.
    • (2004) Cancer Lett , vol.206 , pp. 149-157
    • Workman, P.1
  • 32
    • 42349084306 scopus 로고    scopus 로고
    • NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and matastasis
    • 10.1158/0008-5472.CAN-07-5256, 18413753
    • Eccles SA, Massey A, Raynaud FI, Sharp SY, Box G, Valenti M, et al. NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and matastasis. Cancer Res 2008, 68:2850-2860. 10.1158/0008-5472.CAN-07-5256, 18413753.
    • (2008) Cancer Res , vol.68 , pp. 2850-2860
    • Eccles, S.A.1    Massey, A.2    Raynaud, F.I.3    Sharp, S.Y.4    Box, G.5    Valenti, M.6
  • 33
    • 74549205168 scopus 로고    scopus 로고
    • Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2
    • 10.1158/1078-0432.CCR-09-2308, 2943831, 20068097
    • Annunziata CM, Walker AJ, Minasian L, Yu M, Kotz H, Wood BJ, Calvo K, Choyke P, Kimm D, Steinberg SM, Kohn EC. Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2. Clin Cancer Res 2010, 16:664-672. 10.1158/1078-0432.CCR-09-2308, 2943831, 20068097.
    • (2010) Clin Cancer Res , vol.16 , pp. 664-672
    • Annunziata, C.M.1    Walker, A.J.2    Minasian, L.3    Yu, M.4    Kotz, H.5    Wood, B.J.6    Calvo, K.7    Choyke, P.8    Kimm, D.9    Steinberg, S.M.10    Kohn, E.C.11
  • 34
    • 49149108140 scopus 로고    scopus 로고
    • Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group Study
    • 10.1200/JCO.2007.14.3420, 18612157
    • Schilder RJ, Sill MW, Lee RB, Shaw TJ, Senterman MK, Klein-Szanto AJ, Miner Z, Vanderhyden BC. Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol 2008, 26:3418-3425. 10.1200/JCO.2007.14.3420, 18612157.
    • (2008) J Clin Oncol , vol.26 , pp. 3418-3425
    • Schilder, R.J.1    Sill, M.W.2    Lee, R.B.3    Shaw, T.J.4    Senterman, M.K.5    Klein-Szanto, A.J.6    Miner, Z.7    Vanderhyden, B.C.8
  • 35
    • 77952800807 scopus 로고    scopus 로고
    • Receptor tyrosine kinase coactivation networks in cancer
    • 10.1158/0008-5472.CAN-10-0163, 2875162, 20406984
    • Xu AM, Huang PH. Receptor tyrosine kinase coactivation networks in cancer. Cancer Res 2010, 70:3857-3860. 10.1158/0008-5472.CAN-10-0163, 2875162, 20406984.
    • (2010) Cancer Res , vol.70 , pp. 3857-3860
    • Xu, A.M.1    Huang, P.H.2
  • 36
    • 0030827155 scopus 로고    scopus 로고
    • Hepatocyte growth factor stimulates motility, chemotaxis and mitogenesis in ovarian carcinoma cells expressing high levels of c-met
    • Corps AN, Sowter HM, Smith SK. Hepatocyte growth factor stimulates motility, chemotaxis and mitogenesis in ovarian carcinoma cells expressing high levels of c-met. Int J Cancer 2001, 73:151-155.
    • (2001) Int J Cancer , vol.73 , pp. 151-155
    • Corps, A.N.1    Sowter, H.M.2    Smith, S.K.3
  • 37
    • 0035868390 scopus 로고    scopus 로고
    • Coexpression of hepatocyte growth factor-Met: an early step in ovarian carcinogenesis?
    • 10.1038/sj.onc.1204253, 11313876
    • Wong AS, Pelech SL, Woo MM, Yim G, Rosen B, Ehlen T. Coexpression of hepatocyte growth factor-Met: an early step in ovarian carcinogenesis?. Oncogene 2001, 20:1318-1328. 10.1038/sj.onc.1204253, 11313876.
    • (2001) Oncogene , vol.20 , pp. 1318-1328
    • Wong, A.S.1    Pelech, S.L.2    Woo, M.M.3    Yim, G.4    Rosen, B.5    Ehlen, T.6
  • 38
    • 4043054354 scopus 로고    scopus 로고
    • Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation
    • 10.1016/j.yexcr.2004.06.002, 15302591
    • Wong AS, Roskelley CD, Pelech S, Miller D, Leung PC, Auersperg N. Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation. Exp Cell Res 2004, 299:248-256. 10.1016/j.yexcr.2004.06.002, 15302591.
    • (2004) Exp Cell Res , vol.299 , pp. 248-256
    • Wong, A.S.1    Roskelley, C.D.2    Pelech, S.3    Miller, D.4    Leung, P.C.5    Auersperg, N.6
  • 41
    • 26444482073 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models
    • 10.1158/1078-0432.CCR-05-0518, 16203796
    • Banerji U, Walton M, Raynaud F, Grimshaw R, Kelland L, Valenti M, Judson I, Workman P. Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models. Clin Cancer Res 2005, 11:7023-7032. 10.1158/1078-0432.CCR-05-0518, 16203796.
    • (2005) Clin Cancer Res , vol.11 , pp. 7023-7032
    • Banerji, U.1    Walton, M.2    Raynaud, F.3    Grimshaw, R.4    Kelland, L.5    Valenti, M.6    Judson, I.7    Workman, P.8
  • 42
    • 33745071182 scopus 로고    scopus 로고
    • Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT
    • 10.1158/1535-7163.MCT-05-0445, 16731752
    • Sain N, Krishnan B, Ormerod MG, De RA, Liu WM, Kaye SB, Workman P, Jackman AL. Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT. Mol Cancer Ther 2006, 5:1197-1208. 10.1158/1535-7163.MCT-05-0445, 16731752.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1197-1208
    • Sain, N.1    Krishnan, B.2    Ormerod, M.G.3    De, R.A.4    Liu, W.M.5    Kaye, S.B.6    Workman, P.7    Jackman, A.L.8
  • 44
    • 67650744588 scopus 로고    scopus 로고
    • Degradation of activated protein kinases by ubiquitination
    • 10.1146/annurev.biochem.013008.092711, 2776765, 19489726
    • Lu Z, Hunter T. Degradation of activated protein kinases by ubiquitination. Annu Rev Biochem 2009, 78:435-475. 10.1146/annurev.biochem.013008.092711, 2776765, 19489726.
    • (2009) Annu Rev Biochem , vol.78 , pp. 435-475
    • Lu, Z.1    Hunter, T.2
  • 45
    • 12144266330 scopus 로고    scopus 로고
    • Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation
    • 10.1038/sj.embor.7400300, 1299195, 15568014
    • Citri A, Gan J, Mosesson Y, Vereb G, Szollosi J, Yarden Y. Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation. EMBO Rep 2004, 5:1165-1170. 10.1038/sj.embor.7400300, 1299195, 15568014.
    • (2004) EMBO Rep , vol.5 , pp. 1165-1170
    • Citri, A.1    Gan, J.2    Mosesson, Y.3    Vereb, G.4    Szollosi, J.5    Yarden, Y.6
  • 46
    • 33749461709 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor
    • 10.1158/0008-5472.CAN-06-0165, 16982758
    • Bauer S, Yu LK, Demetri GD, Fletcher JA. Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor. Cancer Res 2006, 66:9153-9161. 10.1158/0008-5472.CAN-06-0165, 16982758.
    • (2006) Cancer Res , vol.66 , pp. 9153-9161
    • Bauer, S.1    Yu, L.K.2    Demetri, G.D.3    Fletcher, J.A.4
  • 47
    • 67650930911 scopus 로고    scopus 로고
    • Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer
    • Moser C, Lang SA, Stoeltzing O. Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer. Anticancer Res 2009, 29:2031-2042.
    • (2009) Anticancer Res , vol.29 , pp. 2031-2042
    • Moser, C.1    Lang, S.A.2    Stoeltzing, O.3
  • 48
    • 77954945333 scopus 로고    scopus 로고
    • Targeting the dynamic HSP90 complex in cancer
    • 10.1038/nrc2887, 20651736
    • Trepel J, Mollapour M, Giaccone G, Neckers L. Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer 2010, 10:537-549. 10.1038/nrc2887, 20651736.
    • (2010) Nat Rev Cancer , vol.10 , pp. 537-549
    • Trepel, J.1    Mollapour, M.2    Giaccone, G.3    Neckers, L.4
  • 50
    • 27144503120 scopus 로고    scopus 로고
    • 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
    • 10.1038/nm1298, 16155577
    • Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, Inukai A, Doyu M, Sobue G. 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Nat Med 2005, 11:1088-1095. 10.1038/nm1298, 16155577.
    • (2005) Nat Med , vol.11 , pp. 1088-1095
    • Waza, M.1    Adachi, H.2    Katsuno, M.3    Minamiyama, M.4    Sang, C.5    Tanaka, F.6    Inukai, A.7    Doyu, M.8    Sobue, G.9
  • 51
    • 0031873752 scopus 로고    scopus 로고
    • The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review
    • 10.1016/S0163-7258(98)00013-8, 9749880
    • Csermely P, Schnaider T, Soti C, Prohaszka Z, Nardai G. The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review. Pharmacol Ther 1998, 79:129-168. 10.1016/S0163-7258(98)00013-8, 9749880.
    • (1998) Pharmacol Ther , vol.79 , pp. 129-168
    • Csermely, P.1    Schnaider, T.2    Soti, C.3    Prohaszka, Z.4    Nardai, G.5
  • 52
    • 24044551995 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR pathway as a target for cancer therapy
    • 10.1097/01.cad.0000173476.67239.3b, 16096426
    • Morgensztern D, McLeod HL. PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer Drugs 2005, 16:797-803. 10.1097/01.cad.0000173476.67239.3b, 16096426.
    • (2005) Anticancer Drugs , vol.16 , pp. 797-803
    • Morgensztern, D.1    McLeod, H.L.2
  • 53
    • 32444436962 scopus 로고    scopus 로고
    • Cell signaling. A sophisticated scaffold wields a new trick
    • 10.1126/science.1124620, 16469909
    • Breitkreutz A, Tyers M. Cell signaling. A sophisticated scaffold wields a new trick. Science 2006, 311:789-790. 10.1126/science.1124620, 16469909.
    • (2006) Science , vol.311 , pp. 789-790
    • Breitkreutz, A.1    Tyers, M.2
  • 54
    • 27544500981 scopus 로고    scopus 로고
    • Growing roles for the mTOR pathway
    • 10.1016/j.ceb.2005.09.009, 16226444
    • Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol 2005, 17:596-603. 10.1016/j.ceb.2005.09.009, 16226444.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 596-603
    • Sarbassov, D.D.1    Ali, S.M.2    Sabatini, D.M.3


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