Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma

Radiotherapy and Oncology

Volumn 106, Issue 1, 2013, Pages 147-154

  Mansour, Wael Y ^a,b,c   Bogdanova, Natalia V ^d   Kasten Pisula, Ulla ^b   Rieckmann, Thorsten ^b   Köcher, Sabrina ^a,b   Borgmann, Kerstin ^b   Baumann, Michael ^e   Krause, Mechtild ^e   Petersen, Cordula ^b   Hu, Hailiang ^f   Gatti, Richard A ^f   Dikomey, Ekkehard ^b   Dörk, Thilo ^d   Dahm Daphi, Jochen ^a,b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c CAIRO UNIVERSITY   (Egypt)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATM; miR421; Radiosensitivity

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ATM PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 421; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; AGED; ARTICLE; CASE REPORT; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; EXON; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; MICRORNAS; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; TUMOR SUPPRESSOR PROTEINS;

EID: 84874654073     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2012.10.020     Document Type: Article

References (41)

1. P.L. Olive Retention of gammaH2AX foci as an indication of lethal DNA damage Radiother Oncol 101 2011 18 23
2. U. Kasten-Pisula, H. Tastan, and E. Dikomey Huge differences in cellular radiosensitivity due to only very small variations in double-strand break repair capacity Int J Radiat Biol 81 2005 409 419 (Pubitemid 41657557)
3. K.K. Khanna ATM, a central controller of cellular responses to DNA damage Cell Death Differ 8 2001 1052 1065 (Pubitemid 33061823)
4. B.J. Moeller DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy Clin Cancer Res 17 2011 2035 2043
5. L. Ai Ataxia-telangiectasia-mutated (ATM) gene in head and neck squamous cell carcinoma: promoter hypermethylation with clinical correlation in 100 cases Cancer Epidemiol Biomarkers Prev 13 2004 150 156 (Pubitemid 38116634)
6. A.M. Lim Correlation of ataxia-telangiectasia-mutated (ATM) gene loss with outcome in head and neck squamous cell carcinoma Oral Oncol 48 2012 698 702
7. F. Roossink The role of ATM and 53BP1 as predictive markers in cervical cancer Int J Cancer 131 9 2012 2056 2066
8. R.C. Friedman Most mammalian mRNAs are conserved targets of microRNAs Genome Res 19 2009 92 105
9. L. He, and G.J. Hannon MicroRNAs: small RNAs with a big role in gene regulation Nat Rev Genet 5 2004 522 531 (Pubitemid 38868508)
10. C. Sevignani Mammalian microRNAs: a small world for fine-tuning gene expression Mamm Genome 17 2006 189 202 (Pubitemid 43327650)
11. C. Cai MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5 PLoS ONE 7 2012 e29750
12. T. Greither Expression of microRNA 210 associates with poor survival and age of tumor onset of soft-tissue sarcoma patients Int J Cancer 130 2012 1230 1235
13. H. Hidaka Tumor suppressive microRNA-1285 regulates novel molecular targets: aberrant expression and functional significance in renal cell carcinoma Oncotarget 3 2012 44 57
14. J. Jiang Tumor microRNA-335 expression is associated with poor prognosis in human glioma Med Oncol 2012 http://dx.doi.org/10.1007/s12032-012-0259-z
15. B. Kumar Dysregulation of MicroRNA-34a expression in head and neck squamous cell carcinoma promotes tumor growth and tumor angiogenesis PLoS ONE 7 2012 e37601
16. M.W. Audeh Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial Lancet 376 2009 245 251
17. P.C. Fong Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers N Engl J Med 361 2009 123 134
18. A. Tutt Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial Lancet 376 2009 235 244
19. U. Kasten-Pisula The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair Radiother Oncol 90 2009 257 264
20. A. Menegakis Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining Int J Radiat Biol 85 2009 1032 1041
21. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
22. S. Kocher Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase Nucleic Acids Res 40 17 2012 8336 8347
23. N.J. Finnie DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair Proc Nat Acad Sci U S A 92 1995 320 324
24. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408 (Pubitemid 34164012)
25. M. Kuhne A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity Cancer Res 64 2004 500 508 (Pubitemid 38120888)
26. H. Hu ATM is down-regulated by N-Myc-regulated microRNA-421 Proc Natl Acad Sci U S A 107 2010 1506 1511
27. M.F. Lavin Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer Nat Rev Mol Cell Biol 9 2008 759 769
28. W. Eicheler Splicing mutations in TP53 in human squamous cell carcinoma lines influence immunohistochemical detection J Histochem Cytochem 50 2002 197 204 (Pubitemid 34106758)
29. J. Bartkova ATM activation in normal human tissues and testicular cancer Cell Cycle 4 2005 838 845 (Pubitemid 41353838)
30. J. Bartkova DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis Nature 434 2005 864 870 (Pubitemid 40558993)
31. J. Bartkova Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints Nature 444 2006 633 637 (Pubitemid 44864442)
32. R. Di Micco Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication Nature 444 2006 638 642 (Pubitemid 44864443)
33. V.G. Gorgoulis Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions Nature 434 2005 907 913 (Pubitemid 40559004)
34. S. Bose The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma J Pathol 217 2009 345 352
35. M.J. Pillaire A 'DNA replication' signature of progression and negative outcome in colorectal cancer Oncogene 29 2009 876 887
36. B. Friedenson The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers BMC cancer 7 2007 152
37. W.L. Ng Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J DNA Repair 9 2010 1170 1175
38. D. Yan Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation PLoS ONE 5 2010 e11397
39. K. Basso Identification of the human mature B cell miRNome Immunity 30 2009 744 752
40. U. Klein, and R. Dalla-Favera Germinal centres: role in B-cell physiology and malignancy Nat Rev Immunol 8 2008 22 33
41. P. Sethupathy, and F.S. Collins MicroRNA target site polymorphisms and human disease Trends Genet 24 2008 489 497