Selection of an Aptamer Antidote to the Anticoagulant Drug Bivalirudin

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Martin, Jennifer A ^a   Parekh, Parag ^a   Kim, Youngmi ^a   Morey, Timothy E ^b   Sefah, Kwame ^a   Gravenstein, Nikolaus ^b   Dennis, Donn M ^b   Tan, Weihong ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; HIRULOG; THROMBIN;

ARTICLE; BINDING AFFINITY; BLOOD CLOTTING TIME; CHROMATOGRAPHY; CONTROLLED STUDY; DNA SEQUENCE; DRUG DNA BINDING; DRUG RELEASE; DRUG SELECTIVITY; DRUG TARGETING; FLOW CYTOMETRY; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

ANTICOAGULANTS; ANTIDOTES; APTAMERS, NUCLEOTIDE; BLOOD COAGULATION; BUFFERS; FLOW CYTOMETRY; FLUORESCENCE POLARIZATION; HIRUDINS; HUMANS; KINETICS; PEPTIDE FRAGMENTS; REAL-TIME POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; SELEX APTAMER TECHNIQUE; SEQUENCE ANALYSIS, DNA;

EID: 84874641960     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057341     Document Type: Article

References (31)

1. Fanikos J, Cina JL, Baroletti S, Fiumara K, Matta L, et al. (2007) Adverse drug events in hospitalized cardiac patients. American Journal of Cardiology 100: 1465-1469.
2. Oney S, Lam RTS, Bompiani KM, Blake CM, Quick G, et al. (2009) Development of universal antidotes to control aptamer activity. Nature Medicine 15: 1224-1228.
3. Rusconi CP, Roberts JD, Pitoc GA, Nimjee SM, White RR, et al. (2004) Antidote-mediated control of an anticoagulant aptamer in vivo. Nature Biotechnology 22: 1423-1428.
4. Weitz JI, Crowther M, (2002) Direct thrombin inhibitors. Thrombosis Research 106: V275-V284.
5. Kam PCA, Kaur N, Thong CL, (2005) Direct thrombin inhibitors: pharmacology and clinical relevance. Anaesthesia 60: 565-574.
6. Gopinath SCB, (2008) Anti-coagulant aptamers. Thrombosis Research 122: 838-847.
7. Sciulli TM, Mauro VF, (2002) Pharmacology and clinical use of bivalirudin. Annals of Pharmacotherapy 36: 1028-1041.
8. Ellington AD, Szostak JW, (1990) invitro selection of rna molecules that bind specific ligands. Nature 346: 818-822.
9. Gopinath SCB, (2007) Methods developed for selex. Analytical and Bioanalytical Chemistry 387: 171-182.
10. Jayasena SD, (1999) Aptamers: An emerging class of molecules that rival antibodies in diagnostics. Clinical Chemistry 45: 1628-1650.
11. Bock LC, Griffin LC, Latham JA, Vermaas EH, Toole JJ, (1992) selection of single-stranded-dna molecules that bind and inhibit human thrombin. Nature 355: 564-566.
12. Rusconi CP, Scardino E, Layzer J, Pitoc GA, Ortel TL, et al. (2002) RNA aptamers as reversible antagonists of coagulation factor IXa. Nature 419: 90-94.
13. Rusconi CP, Yeh A, Lyerly HK, Lawson JH, Sullenger BA, (2000) Blocking the initiation of coagulation by RNA aptamers to factor VIIa. Thrombosis and Haemostasis 84: 841-848.
14. Buddai SK, Layzer JM, Lu G, Rusconi CP, Sullenger BA, et al. (2010) An Anticoagulant RNA Aptamer That Inhibits Proteinase-Cofactor Interactions within Prothrombinase. Journal of Biological Chemistry 285: 5212-5223.
15. Gal SW, Amontov S, Urvil PT, Vishnuvardhan D, Nishikawa F, et al. (1998) Selection of a RNA aptamer that binds to human activated protein C and inhibits its protease function. European Journal of Biochemistry 252: 553-562.
16. Oney S, Nimjee SM, Layzer J, Que-Gewirth N, Ginsburg D, et al. (2007) Antidote-controlled platelet inhibition targeting von Willebrand factor with aptamers. Oligonucleotides 17: 265-274.
17. Heckel A, Buff MCR, Raddatz MSL, Muller J, Potzsch B, et al. (2006) An anticoagulant with light-triggered antidote activity. Angewandte Chemie-International Edition 45: 6748-6750.
18. Kim Y, Phillips JA, Liu H, Kang H, Tan W, (2009) Using photons to manipulate enzyme inhibition by an azobenzene-modified nucleic acid probe. Proc Natl Acad Sci U S A 106: 6489-6494.
19. Joachimi A, Mayer G, Hartig JS, (2007) A new anticoagulant-antidote pair: Control of thrombin activity by aptamers and porphyrins. Journal of the American Chemical Society 129: 3036-3037.
20. Ishizuka N, Kobayashi H, Minakuchi H, Nakanishi K, Hirao K, et al. (2002) Monolithic silica columns for high-efficiency separations by high-performance liquid chromatography. Journal of Chromatography A 960: 85-96.
21. Roberts MW, Ongkudon CM, Forde GM, Danquah MK, (2009) Versatility of polymethacrylate monoliths for chromatographic purification of biomolecules. J Sep Sci 32: 2485-2494.
22. Giovannini R, Freitag R, Tennikova TB, (1998) High-performance membrane chromatography of supercoiled plasmid DNA. Anal Chem 70: 3348-3354.
23. Glickman JF, Wu X, Mercuri R, Illy C, Bowen BR, et al. (2002) A comparison of ALPHAScreen, TR-FRET, and TRF as assay methods for FXR nuclear receptors. Journal of Biomolecular Screening 7: 3-10.
24. Stoltenburg R, Reinemann C, Strehlitz B, (2007) SELEX-A (r)evolutionary method to generate high-affinity nucleic acid ligands. Biomolecular Engineering 24: 381-403.
25. Tok JBH, Fischer NO (2008) Single microbead SELEX for efficient ssDNA aptamer generation against botulinum neurotoxin. Chemical Communications: 1883-1885.
26. Huizenga DE, Szostak JW, (1995) A DNA APTAMER THAT BINDS ADENOSINE AND ATP. Biochemistry 34: 656-665.
27. Tang ZW, Parekh P, Turner P, Moyer RW, Tan WH, (2009) Generating Aptamers for Recognition of Virus-Infected Cells. Clinical Chemistry 55: 813-822.
28. Bode W, (2006) Structure and interaction modes of thrombin. Blood Cells Molecules and Diseases 36: 122-130.
29. Wicker T, Schlagenhauf E, Graner A, Close TJ, Keller B, et al. (2006) 454 sequencing put to the test using the complex genome of barley. BMC Genomics 7: 275-286.
30. Becker RC, Rusconi C, Sullenger B, (2005) Nucleic acid aptamers in therapeutic anticoagulation- Technology, development and clinical application. Thrombosis and Haemostasis 93: 1014-1020.
31. Petersen M, Wengel J, (2003) LNA: a versatile tool for therapeutics and genomics. Trends in Biotechnology 21: 74-81.