Silencing of the WFS1 gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage

Physiological Genomics

Volumn 45, Issue 5, 2013, Pages 182-190

  Kõks, Sulev ^a   Overall, Rupert W ^b   Ivask, Marilin ^a   Soomets, Ursel ^a   Guha, Mithu ^a   Vasar, Eero ^a   Fernandes, Cathy ^c   Schalkwyk, Leo C ^c  

^a UNIVERSITY OF TARTU   (Estonia)

^b CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

ER stress; Gene expression profiling; Gene silencing; HEK cells; Mitochondrial dysfunction; WFs1 gene; Wolfram syndrome

Indexed keywords

PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WFS1 PROTEIN;

APOPTOSIS; ARTICLE; CELL DAMAGE; GENE EXPRESSION PROFILING; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KIDNEY CELL; MITOCHONDRION; NERVE DEGENERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; GENE EXPRESSION PROFILING; GENE SILENCING; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MODELS, THEORETICAL; NEURODEGENERATIVE DISEASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WOLFRAM SYNDROME;

EID: 84874640463     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00122.2012     Document Type: Article

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