Metabolic profiling to identify potential serum biomarkers for gastric ulceration induced by nonsteroid anti-inflammatory drugs

Journal of Proteome Research

Volumn 12, Issue 3, 2013, Pages 1399-1407

  Takeuchi, Kenichiro ^a   Ohishi, Maki ^b   Ota, Sana ^b   Suzumura, Kenichi ^a   Naraoka, Hitoshi ^a   Ohata, Takeji ^a   Seki, Jiro ^a   Miyamae, Youichi ^a   Honma, Masashi ^c   Soga, Tomoyoshi ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

capillary electrophoresis mass spectrometry; diagnostic marker candidate; gastric injury; metabolomics; nonsteroid anti inflammatory drugs

Indexed keywords

3 HYDROXY BUTANOIC ACID; ACETYLSALICYLIC ACID; ACONITIC ACID; BIOLOGICAL MARKER; CITRIC ACID; COLLAGENASE; HYDROXYPROLINE; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; O ACETYL CARNITINE; PROLINE; SUCCINIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; ENZYME ACTIVATION; MALE; MASS SPECTROMETRY; METABOLITE; METABOLOMICS; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; SERUM; SINGLE DRUG DOSE; STOMACH ULCER;

EID: 84874634612     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr3010452     Document Type: Article

References (28)

1. Steinmeyer, J. Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs Arthritis Res. 2000, 2 (5) 379-85
2. Gabriel, S. E.; Fehring, R. A. Trends in the utilization of non-steroidal anti-inflammatory drugs in the United States, 1986-1990 J. Clin. Epidemiol. 1992, 45 (9) 1041-4
3. Gabriel, S. E.; Jaakkimainen, L.; Bombardier, C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. A meta-analysis Ann. Intern. Med. 1991, 115 (10) 787-96
4. Ishihara, T.; Tanaka, K.; Tashiro, S.; Yoshida, K.; Mizushima, T. Protective effect of rebamipide against celecoxib-induced gastric mucosal cell apoptosis Biochem. Pharmacol. 2010, 79 (11) 1622-33
5. Hawkey, C. J. Nonsteroidal anti-inflammatory drug gastropathy Gastroenterology 2000, 119 (2) 521-35
6. Sutherland, L. R.; Verhoef, M.; Wallace, J. L.; Van Rosendaal, G.; Crutcher, R.; Meddings, J. B. A simple, non-invasive marker of gastric damage: sucrose permeability Lancet 1994, 343 (8904) 998-1000
7. Szewczyk, A.; Wojtczak, L. Mitochondria as a pharmacological target Pharmacol. Rev. 2002, 54 (1) 101-27
8. Richardson, P.; Hawkey, C. J.; Stack, W. A. Proton pump inhibitors. Pharmacology and rationale for use in gastrointestinal disorders Drugs 1998, 56 (3) 307-35
9. Takeda, M.; Takagi, T.; Yashima, Y.; Maeno, H. Effect of a new potent H2-blocker, 3-[[[2-(diaminomethylene)amino]-4-thiazolyl]methyl]thio]-N2- sulfamoyl propionamidine (YM-11170), on gastric secretion, ulcer formation and weight of male accessory sex organs in rats Arzneimittelforschung 1982, 32 (7) 734-7
10. Fiehn, O.; Kopka, J.; Dormann, P.; Altmann, T.; Trethewey, R. N.; Willmitzer, L. Metabolite profiling for plant functional genomics Nat. Biotechnol. 2000, 18 (11) 1157-61
11. Schauer, N.; Semel, Y.; Roessner, U.; Gur, A.; Balbo, I.; Carrari, F.; Pleban, T.; Perez-Melis, A.; Bruedigam, C.; Kopka, J.; Willmitzer, L.; Zamir, D.; Fernie, A. R. Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement Nat. Biotechnol. 2006, 24 (4) 447-54
12. Plumb, R.; Granger, J.; Stumpf, C.; Wilson, I. D.; Evans, J. A.; Lenz, E. M. Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences Analyst 2003, 128 (7) 819-23
13. Monton, M. R.; Soga, T. Metabolome analysis by capillary electrophoresis-mass spectrometry J. Chromatogr. A 2007, 1168 (1-2) 237-46 discussion 236
14. Nicholson, J. K.; Connelly, J.; Lindon, J. C.; Holmes, E. Metabonomics: a platform for studying drug toxicity and gene function Nat. Rev. Drug Discovery 2002, 1 (2) 153-61
15. Soga, T.; Ohashi, Y.; Ueno, Y.; Naraoka, H.; Tomita, M.; Nishioka, T. Quantitative metabolome analysis using capillary electrophoresis mass spectrometry J. Proteome Res. 2003, 2 (5) 488-94
16. Soga, T.; Baran, R.; Suematsu, M.; Ueno, Y.; Ikeda, S.; Sakurakawa, T.; Kakazu, Y.; Ishikawa, T.; Robert, M.; Nishioka, T.; Tomita, M. Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption J. Biol. Chem. 2006, 281 (24) 16768-76
17. Shintani, T.; Iwabuchi, T.; Soga, T.; Kato, Y.; Yamamoto, T.; Takano, N.; Hishiki, T.; Ueno, Y.; Ikeda, S.; Sakuragawa, T.; Ishikawa, K.; Goda, N.; Kitagawa, Y.; Kajimura, M.; Matsumoto, K.; Suematsu, M. Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion Hepatology 2009, 49 (1) 141-50
18. Soga, T.; Heiger, D. N. Amino acid analysis by capillary electrophoresis electrospray ionization mass spectrometry Anal. Chem. 2000, 72 (6) 1236-41
19. Katayama, H.; Ishihama, Y.; Asakawa, N. Stable cationic capillary coating with successive multiple ionic polymer layers for capillary electrophoresis Anal. Chem. 1998, 70 (24) 5272-7
20. Soga, T.; Igarashi, K.; Ito, C.; Mizobuchi, K.; Zimmermann, H. P.; Tomita, M. Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry Anal. Chem. 2009, 81 (15) 6165-74
21. Petrescu, I.; Tarba, C. Uncoupling effects of diclofenac and aspirin in the perfused liver and isolated hepatic mitochondria of rat Biochim. Biophys. Acta 1997, 1318 (3) 385-94
22. Moreno-Sanchez, R.; Bravo, C.; Vasquez, C.; Ayala, G.; Silveira, L. H.; Martinez-Lavin, M. Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart Biochem. Pharmacol. 1999, 57 (7) 743-52
23. Mingatto, F. E.; Santos, A. C.; Uyemura, S. A.; Jordani, M. C.; Curti, C. In vitro interaction of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation of rat kidney mitochondria: respiration and ATP synthesis Arch. Biochem. Biophys. 1996, 334 (2) 303-8
24. Masubuchi, Y.; Yamada, S.; Horie, T. Diphenylamine as an important structure of nonsteroidal anti-inflammatory drugs to uncouple mitochondrial oxidative phosphorylation Biochem. Pharmacol. 1999, 58 (5) 861-5
25. Mahmud, T.; Rafi, S. S.; Scott, D. L.; Wrigglesworth, J. M.; Bjarnason, I. Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation Arthritis Rheum. 1996, 39 (12) 1998-2003
26. Tomoda, T.; Kurashige, T.; Hayashi, Y.; Enzan, H. Primary changes in liver damage by aspirin in rats Acta Paediatr. Jpn. 1998, 40 (6) 593-6
27. Somasundaram, S.; Rafi, S.; Hayllar, J.; Sigthorsson, G.; Jacob, M.; Price, A. B.; Macpherson, A.; Mahmod, T.; Scott, D.; Wrigglesworth, J. M.; Bjarnason, I. Mitochondrial damage: a possible mechanism of the ″topical″ phase of NSAID induced injury to the rat intestine Gut 1997, 41 (3) 344-53
28. Hasebe, T.; Harasawa, S.; Miwa, T.; Shibata, T.; Inayama, S. Collagen and collagenase in ulcer tissue - 1. The healing process of acetic acid ulcers in rats Tokai J. Exp. Clin. Med. 1987, 12 (3) 147-58