Curcumin induces apoptotic cell death of activated human CD4 + T cells via increasing endoplasmic reticulum stress and mitochondrial dysfunction

International Immunopharmacology

Volumn 15, Issue 3, 2013, Pages 517-523

  Zheng, Min ^a   Zhang, Qinggao ^b   Joe, Yeonsoo ^a   Lee, Bong Hee ^c   Ryu, Do Gon ^c   Kwon, Kang Beom ^c   Ryter, Stefan W ^d   Chung, Hun Taeg ^a  

^a University of Ulsan   (South Korea)

^b YANBIAN UNIVERSITY   (China)

^c Wonkwang University   (South Korea)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

C EBP homologous protein (CHOP); CD4 + T cells; Curcumin; Endoplasmic reticulum (ER) stress; Unfolded protein response (UPR)

Indexed keywords

4 PHENYLBUTYRIC ACID; ANTIINFLAMMATORY AGENT; CURCUMIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INTERLEUKIN 2; MESSENGER RNA; PROTEIN BCL 2; SMALL INTERFERING RNA; X BOX BINDING PROTEIN 1;

APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL DEATH; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; UNFOLDED PROTEIN RESPONSE;

APOPTOSIS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; CURCUMIN; DNA-BINDING PROTEINS; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MITOCHONDRIA; PHENYLBUTYRATES; PHYTOHEMAGGLUTININS; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84874621649     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.02.002     Document Type: Article

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