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Volumn 2013, Issue , 2013, Pages

Clinical use and mechanisms of infliximab treatment on inflammatory bowel disease: A recent update

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GELATINASE A; GELATINASE B; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLIXIMAB; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 4; INTERSTITIAL COLLAGENASE; MESSENGER RNA; NITRIC OXIDE; PLACEBO; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE 1; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; TUMOR NECROSIS FACTOR ALPHA;

EID: 84874619851     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/581631     Document Type: Review
Times cited : (54)

References (92)
  • 1
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • DOI 10.1038/nature06005, PII NATURE06005
    • Xavier R. J., Podolsky D. K., Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007 448 7152 427 434 2-s2.0-34547176642 10.1038/nature06005 (Pubitemid 47123518)
    • (2007) Nature , vol.448 , Issue.7152 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 2
    • 27744437941 scopus 로고    scopus 로고
    • Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria
    • Kamada N., Hisamatsu T., Okamoto S., Sato T., Matsuoka K., Arai K., Nakai T., Hasegawa A., Inoue N., Watanabe N., Akagawa K. S., Hibi T., Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria. Journal of Immunology 2005 175 10 6900 6908 2-s2.0-27744437941 (Pubitemid 41598935)
    • (2005) Journal of Immunology , vol.175 , Issue.10 , pp. 6900-6908
    • Kamada, N.1    Hisamatsu, T.2    Okamoto, S.3    Sato, T.4    Matsuoka, K.5    Arai, K.6    Nakai, T.7    Hasegawa, A.8    Inoue, N.9    Watanabe, N.10    Akagawa, K.S.11    Hibi, T.12
  • 3
    • 33745413808 scopus 로고    scopus 로고
    • Probiotics and inflammatory bowel diseases
    • DOI 10.1136/pgmj.2005.040899
    • Bai A. P., Ouyang Q., Probiotics and inflammatory bowel diseases. Postgraduate Medical Journal 2006 82 968 376 382 2-s2.0-33745413808 10.1136/pgmj.2005.040899 (Pubitemid 43945473)
    • (2006) Postgraduate Medical Journal , vol.82 , Issue.968 , pp. 376-382
    • Bai, A.-P.1    Ouyang, Q.2
  • 4
    • 0034005581 scopus 로고    scopus 로고
    • Role of cytokines in the pathogenesis of inflammatory bowel disease
    • DOI 10.1146/annurev.med.51.1.289
    • Papadakis K. A., Targan S. R., Role of cytokines in the pathogenesis of inflammatory bowel disease. Annual Review of Medicine 2000 51 289 298 2-s2.0-0034005581 10.1146/annurev.med.51.1.289 (Pubitemid 30216038)
    • (2000) Annual Review of Medicine , vol.51 , pp. 289-298
    • Papadakis, K.A.1    Targan, S.R.2
  • 5
    • 79951501790 scopus 로고    scopus 로고
    • Cellular mechanisms of TNF function in models of inflammation and autoimmunity
    • 2-s2.0-77949442340 10.1159/000289195
    • Apostolaki M., Armaka M., Victoratos P., Kollias G., Cellular mechanisms of TNF function in models of inflammation and autoimmunity. Current Directions in Autoimmunity 2010 11 1 26 2-s2.0-77949442340 10.1159/000289195
    • (2010) Current Directions in Autoimmunity , vol.11 , pp. 1-26
    • Apostolaki, M.1    Armaka, M.2    Victoratos, P.3    Kollias, G.4
  • 6
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • 2-s2.0-79959216005 10.1038/nature10209
    • Khor B., Gardet A., Xavier R. J., Genetics and pathogenesis of inflammatory bowel disease. Nature 2011 474 7351 307 317 2-s2.0-79959216005 10.1038/nature10209
    • (2011) Nature , vol.474 , Issue.7351 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 7
  • 9
    • 16244410786 scopus 로고    scopus 로고
    • Tumor necrosis factor family members and inflammatory bowel disease
    • DOI 10.1111/j.0105-2896.2005.00218.x
    • Wang J., Fu Y. X., Tumor necrosis factor family members and inflammatory bowel disease. Immunological Reviews 2005 204 144 155 2-s2.0-16244410786 10.1111/j.0105-2896.2005.00218.x (Pubitemid 40460499)
    • (2005) Immunological Reviews , vol.204 , pp. 144-155
    • Wang, J.1    Fu, Y.-X.2
  • 10
    • 0034727474 scopus 로고    scopus 로고
    • Mechanisms in failure of infliximab for Crohn's disease
    • 2-s2.0-0034727474
    • Nikolaus S., Raedler A., Kühbacher T., Sfikas N., Fölsch U. R., Schreiber S., Mechanisms in failure of infliximab for Crohn's disease. Lancet 2000 356 9240 1475 1479 2-s2.0-0034727474
    • (2000) Lancet , vol.356 , Issue.9240 , pp. 1475-1479
    • Nikolaus, S.1    Raedler, A.2    Kühbacher, T.3    Sfikas, N.4    Fölsch, U.R.5    Schreiber, S.6
  • 11
    • 2442560241 scopus 로고    scopus 로고
    • Optimizing Anti-TNF treatment in inflammatory bowel disease
    • DOI 10.1053/j.gastro.2004.02.070
    • Rutgeerts P., Van Assche G., Vermeire S., Optimizing anti-TNF treatment in inflammatory bowel disease. Gastroenterology 2004 126 6 1593 1610 2-s2.0-2442560241 10.1053/j.gastro.2004.02.070 (Pubitemid 38649876)
    • (2004) Gastroenterology , vol.126 , Issue.6 , pp. 1593-1610
    • Rutgeerts, P.1    Van Assche, G.2    Vermeire, S.3
  • 12
    • 55249091834 scopus 로고    scopus 로고
    • Current directions in IBD therapy: What goals are feasible with biological modifiers?
    • 2-s2.0-55249091834 10.1053/j.gastro.2008.09.053
    • Sandborn W. J., Current directions in IBD therapy: what goals are feasible with biological modifiers? Gastroenterology 2008 135 5 1442 1447 2-s2.0-55249091834 10.1053/j.gastro.2008.09.053
    • (2008) Gastroenterology , vol.135 , Issue.5 , pp. 1442-1447
    • Sandborn, W.J.1
  • 13
    • 33845896308 scopus 로고    scopus 로고
    • Advances in biologic therapy for ulcerative colitis and Crohn's disease
    • DOI 10.1007/s11894-006-0041-5
    • D'Haens G., Daperno M., Advances in biologic therapy for ulcerative colitis and Crohn's disease. Current Gastroenterology Reports 2006 8 6 506 512 2-s2.0-33845896308 10.1007/s11894-006-0041-5 (Pubitemid 46017163)
    • (2006) Current Gastroenterology Reports , vol.8 , Issue.6 , pp. 506-512
    • D'Haens, G.1    Daperno, M.2
  • 14
    • 62949219864 scopus 로고    scopus 로고
    • Biological therapies for inflammatory bowel diseases
    • 2-s2.0-62949219864 10.1053/j.gastro.2009.02.001
    • Rutgeerts P., Vermeire S., Van Assche G., Biological therapies for inflammatory bowel diseases. Gastroenterology 2009 136 4 1182 1197 2-s2.0-62949219864 10.1053/j.gastro.2009.02.001
    • (2009) Gastroenterology , vol.136 , Issue.4 , pp. 1182-1197
    • Rutgeerts, P.1    Vermeire, S.2    Van Assche, G.3
  • 15
    • 34248582436 scopus 로고    scopus 로고
    • Innovative therapeutics for inflammatory bowel disease
    • Yamamoto-Furusho J. K., Innovative therapeutics for inflammatory bowel disease. World Journal of Gastroenterology 2007 13 13 1893 1896 2-s2.0-34248582436 (Pubitemid 46746374)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.13 , pp. 1893-1896
    • Yamamoto-Furusho, J.K.1
  • 16
    • 45849083467 scopus 로고    scopus 로고
    • Mechanisms of action of infliximab in inflammatory bowel disease: An anti-inflammatory multitasker
    • DOI 10.1016/S1590-8658(08)60530-7, PII S1590865808605307
    • Danese S., Mechanisms of action of infliximab in inflammatory bowel disease: an anti-inflammatory multitasker. Digestive and Liver Disease 2008 40 supplement 2 S225 S228 2-s2.0-45849083467 10.1016/S1590-8658(08)60530-7 (Pubitemid 351878064)
    • (2008) Digestive and Liver Disease , vol.40 , Issue.SUPPL. 2
    • Danese, S.1
  • 19
    • 9644252669 scopus 로고    scopus 로고
    • New cytokine therapeutics for inflammatory bowel disease
    • DOI 10.1016/j.cyto.2004.07.012, PII S1043466604002285, First International Conference on Cytokine Medicine
    • Stokkers P. C. F., Hommes D. W., New cytokine therapeutics for inflammatory bowel disease. Cytokine 2004 28 4-5 167 173 2-s2.0-9644252669 10.1016/j.cyto.2004.07.012 (Pubitemid 39573504)
    • (2004) Cytokine , vol.28 , Issue.4-5 , pp. 167-173
    • Stokkers, P.C.F.1    Hommes, D.W.2
  • 20
    • 34047159242 scopus 로고    scopus 로고
    • Early changes in rectal nitric oxide and mucosal inflammatory mediators in Crohn's colitis in response to infliximab treatment
    • DOI 10.1111/j.1365-2036.2007.03284.x
    • Ljung T., Axelsson L. G., Herulf M., Lundberg J. O., Hellström P. M., Early changes in rectal nitric oxide and mucosal inflammatory mediators in Crohn's colitis in response to infliximab treatment. Alimentary Pharmacology and Therapeutics 2007 25 8 925 932 2-s2.0-34047159242 10.1111/j.1365-2036.2007. 03284.x (Pubitemid 46525348)
    • (2007) Alimentary Pharmacology and Therapeutics , vol.25 , Issue.8 , pp. 925-932
    • Ljung, T.1    Axelsson, L.-G.2    Herulf, M.3    Lundberg, J.O.4    Hellstrom, P.M.5
  • 21
    • 3142588819 scopus 로고    scopus 로고
    • Increased production of granulocyte-macrophage colony-stimulating factor in Crohn's disease - A possible target for infliximab treatment
    • DOI 10.1097/01.meg.0000108344.41221.8b
    • Agnholt J., Kelsen J., Brandsborg B., Jakobsen N. O., Dahlerup J. F., Increased production of granulocyte-macrophage colony-stimulating factor in Crohn's disease-a possible target for infliximab treatment. European Journal of Gastroenterology and Hepatology 2004 16 7 649 655 2-s2.0-3142588819 10.1097/01.meg.0000108344.41221.8b (Pubitemid 38901632)
    • (2004) European Journal of Gastroenterology and Hepatology , vol.16 , Issue.7 , pp. 649-655
    • Agnholt, J.1    Kelsen, J.2    Brandsborg, B.3    Jakobsen, N.O.4    Dahlerup, J.F.5
  • 23
    • 0346461662 scopus 로고    scopus 로고
    • Defective mucosal T cell death is sustainably reverted by infliximab in a caspase dependent pathway in Crohn's disease
    • DOI 10.1136/gut.53.1.70
    • Di Sabatino A., Ciccocioppo R., Cinque B., Millimaggi D., Morera R., Ricevuti L., Cifone M. G., Corazza G. R., Defective mucosal T cell death is sustainably reverted by infliximab in a caspase dependent pathway in Crohn's disease. Gut 2004 53 1 70 77 2-s2.0-0346461662 10.1136/gut.53.1.70 (Pubitemid 38083013)
    • (2004) Gut , vol.53 , Issue.1 , pp. 70-77
    • Di Sabatino, A.1    Ciccocioppo, R.2    Cinque, B.3    Millimaggi, D.4    Morera, R.5    Ricevuti, L.6    Cifone, M.G.7    Corazza, G.R.8
  • 24
    • 0036151047 scopus 로고    scopus 로고
    • Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease
    • DOI 10.1136/gut.0500206..
    • ten Hove T., Van Montfrans C., Peppelenbosch M. P., Van Deventer S. J. H., Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut 2002 50 2 206 211 2-s2.0-0036151047 10.1136/gut.0500206. (Pubitemid 34087933)
    • (2002) Gut , vol.50 , Issue.2 , pp. 206-211
    • Ten Hove, T.1    Van Montfrans, C.2    Peppelenbosch, M.P.3    Van Deventer, S.J.H.4
  • 28
    • 0035928895 scopus 로고    scopus 로고
    • Infliximab downregulates interferon-γ production in activated gut T-lymphocytes from patients with Crohn's disease
    • DOI 10.1006/cyto.2001.0919
    • Agnholt J., Kaltoft K., Infliximab downregulates interferon- γ production in activated gut T-lymphocytes from patients with Crohn's disease. Cytokine 2001 15 4 212 222 2-s2.0-0035928895 10.1006/cyto.2001.0919 (Pubitemid 34587646)
    • (2001) Cytokine , vol.15 , Issue.4 , pp. 212-222
    • Agnholt, J.1    Kaltoft, K.2
  • 29
    • 80052573212 scopus 로고    scopus 로고
    • Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFalpha treatment
    • 10.1136/gut.2010.217117
    • Veltkamp C., Anstaett M., Wahl K., Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFalpha treatment. Gut 2011 60 1345 1353 10.1136/gut.2010.217117
    • (2011) Gut , vol.60 , pp. 1345-1353
    • Veltkamp, C.1    Anstaett, M.2    Wahl, K.3
  • 30
    • 51249084103 scopus 로고    scopus 로고
    • + regulatory T cells in children affected by Crohn's disease
    • 2-s2.0-51249084103 10.1111/j.1365-2567.2008.02839.x
    • + regulatory T cells in children affected by Crohn's disease. Immunology 2008 125 2 178 183 2-s2.0-51249084103 10.1111/j.1365-2567.2008.02839.x
    • (2008) Immunology , vol.125 , Issue.2 , pp. 178-183
    • Ricciardelli, I.1    Lindley, K.J.2    Londei, M.3    Quaratino, S.4
  • 31
    • 80052180187 scopus 로고    scopus 로고
    • Regulatory macrophages: Setting the threshold for therapy
    • 10.1002/eji.201141717
    • Fleming B. D., Mosser D. M., Regulatory macrophages: setting the threshold for therapy. European Journal of Immunology 2011 41 9 2498 2502 10.1002/eji.201141717
    • (2011) European Journal of Immunology , vol.41 , Issue.9 , pp. 2498-2502
    • Fleming, B.D.1    Mosser, D.M.2
  • 33
    • 4344700784 scopus 로고    scopus 로고
    • Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor α antibody treatment
    • DOI 10.1136/gut.2003.036632
    • Zeissig S., Bojarski C., Buergel N., Mankertz J., Zeitz M., Fromm M., Schulzke J. D., Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor α antibody treatment. Gut 2004 53 9 1295 1302 2-s2.0-4344700784 10.1136/gut.2003.036632 (Pubitemid 39120115)
    • (2004) Gut , vol.53 , Issue.9 , pp. 1295-1302
    • Zeissig, S.1    Bojarski, C.2    Buergel, N.3    Mankertz, J.4    Zeitz, M.5    Fromm, M.6    Schulzke, J.D.7
  • 35
    • 37549028415 scopus 로고    scopus 로고
    • Tumor necrosis factor- α antagonism improves endothelial dysfunction in patients with Crohn's disease
    • 2-s2.0-37549028415 10.1038/sj.clpt.6100229
    • Schinzari F., Armuzzi A., De Pascalis B., Mores N., Tesauro M., Melina D., Cardillo C., Tumor necrosis factor- α antagonism improves endothelial dysfunction in patients with Crohn's disease. Clinical Pharmacology and Therapeutics 2008 83 1 70 76 2-s2.0-37549028415 10.1038/sj.clpt.6100229
    • (2008) Clinical Pharmacology and Therapeutics , vol.83 , Issue.1 , pp. 70-76
    • Schinzari, F.1    Armuzzi, A.2    De Pascalis, B.3    Mores, N.4    Tesauro, M.5    Melina, D.6    Cardillo, C.7
  • 37
    • 34249341647 scopus 로고    scopus 로고
    • Effect of the anti-tumor necrosis factor-α antibody infliximab on the ex vivo mucosal matrix metalloproteinase-proteolytic phenotype in inflammatory bowel disease
    • DOI 10.1002/ibd.20051
    • Meijer M. J., Mieremet-Ooms M. A. C., van Duijn W., Van Der Zon A. M., Hanemaaijer R., Verheijen J. H., Van Hogezand R. A., Lamers C. B. H. W., Verspaget H. W., Effect of the anti-tumor necrosis factor- α antibody infliximab on the ex vivo mucosal matrix metalloproteinase-proteolytic phenotype in inflammatory bowel disease. Inflammatory Bowel Diseases 2007 13 2 200 210 2-s2.0-34249341647 10.1002/ibd.20051 (Pubitemid 46806229)
    • (2007) Inflammatory Bowel Diseases , vol.13 , Issue.2 , pp. 200-210
    • Meijer, M.J.1    Mieremet-Ooms, M.A.C.2    Van Duijn, W.3    Van Der Zon, A.M.4    Hanemaaijer, R.5    Verheijen, J.H.6    Van Hogezand, R.A.7    Lamers, C.B.H.W.8    Verspaget, H.W.9
  • 39
    • 84859435862 scopus 로고    scopus 로고
    • The impact of infliximab induction therapy on mucosal healing and clinical remission in Polish pediatric patients with moderate-to-severe Crohn's disease
    • 10.1097/MEG.0b013e32835159f2
    • Kierkus J., Dadalski M., Szymanska E., The impact of infliximab induction therapy on mucosal healing and clinical remission in Polish pediatric patients with moderate-to-severe Crohn's disease. European Journal of Gastroenterology & Hepatology 2012 24 5 495 500 10.1097/MEG.0b013e32835159f2
    • (2012) European Journal of Gastroenterology & Hepatology , vol.24 , Issue.5 , pp. 495-500
    • Kierkus, J.1    Dadalski, M.2    Szymanska, E.3
  • 41
    • 0037093877 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase is activated and linked to TNF-α signaling in inflammatory bowel disease
    • Waetzig G. H., Seegert D., Rosenstiel P., Nikolaus S., Schreiber S., p38 mitogen-activated protein kinase is activated and linked to TNF- α signaling in inflammatory bowel disease. Journal of Immunology 2002 168 10 5342 5351 2-s2.0-0037093877 (Pubitemid 34496003)
    • (2002) Journal of Immunology , vol.168 , Issue.10 , pp. 5342-5351
    • Waetzig, G.H.1    Seegert, D.2    Rosenstiel, P.3    Nikolaus, S.4    Schreiber, S.5
  • 42
    • 79958095982 scopus 로고    scopus 로고
    • Severe infusion reactions to infliximab: Aetiology, immunogenicity and risk factors in patients with inflammatory bowel disease
    • 2-s2.0-79958095982 10.1111/j.1365-2036.2011.04682.x
    • Steenholdt C., Svenson M., Bendtzen K., Thomsen O. A., Brynskov J., Ainsworth M. A., Severe infusion reactions to infliximab: aetiology, immunogenicity and risk factors in patients with inflammatory bowel disease. Alimentary Pharmacology and Therapeutics 2011 34 1 51 58 2-s2.0-79958095982 10.1111/j.1365-2036.2011.04682.x
    • (2011) Alimentary Pharmacology and Therapeutics , vol.34 , Issue.1 , pp. 51-58
    • Steenholdt, C.1    Svenson, M.2    Bendtzen, K.3    Thomsen, O.A.4    Brynskov, J.5    Ainsworth, M.A.6
  • 43
    • 78651327288 scopus 로고    scopus 로고
    • Severe neutropenia following infliximab treatment in a child with ulcerative colitis
    • 2-s2.0-78651327288 10.1002/ibd.21466
    • Sherlock M., Bandsma R., Ota K., Kirby-Allen M., Griffiths A., Severe neutropenia following infliximab treatment in a child with ulcerative colitis. Inflammatory Bowel Diseases 2011 17 2 E17 E18 2-s2.0-78651327288 10.1002/ibd.21466
    • (2011) Inflammatory Bowel Diseases , vol.17 , Issue.2
    • Sherlock, M.1    Bandsma, R.2    Ota, K.3    Kirby-Allen, M.4    Griffiths, A.5
  • 44
    • 84861333218 scopus 로고    scopus 로고
    • Risk of infection and prevention in pediatric patients with IBD: ESPGHAN IBD Porto Group commentary
    • 10.1097/MPG.0b013e31824d1438
    • Veereman-Wauters G., de Ridder L., Veres G., Risk of infection and prevention in pediatric patients with IBD: ESPGHAN IBD Porto Group commentary. Journal of Pediatric Gastroenterology & Nutrition 2012 54 6 830 837 10.1097/MPG.0b013e31824d1438
    • (2012) Journal of Pediatric Gastroenterology & Nutrition , vol.54 , Issue.6 , pp. 830-837
    • Veereman-Wauters, G.1    De Ridder, L.2    Veres, G.3
  • 45
    • 67650430007 scopus 로고    scopus 로고
    • Infliximab and other immunomodulating drugs in patients with inflammatory bowel disease and the risk of serious bacterial infections
    • 2-s2.0-67650430007 10.1111/j.1365-2036.2009.04037.x
    • Schneeweiss S., Korzenik J., Solomon D. H., Canning C., Lee J., Bressler B., Infliximab and other immunomodulating drugs in patients with inflammatory bowel disease and the risk of serious bacterial infections. Alimentary Pharmacology and Therapeutics 2009 30 3 253 264 2-s2.0-67650430007 10.1111/j.1365-2036.2009.04037.x
    • (2009) Alimentary Pharmacology and Therapeutics , vol.30 , Issue.3 , pp. 253-264
    • Schneeweiss, S.1    Korzenik, J.2    Solomon, D.H.3    Canning, C.4    Lee, J.5    Bressler, B.6
  • 46
    • 3543106683 scopus 로고    scopus 로고
    • Human antichimeric antibody in children and young adults with inflammatory bowel disease receiving infliximab
    • 2-s2.0-3543106683
    • Miele E., Markowitz J. E., Mamula P., Baldassano R. N., Human antichimeric antibody in children and young adults with inflammatory bowel disease receiving infliximab. Journal of Pediatric Gastroenterology and Nutrition 2004 38 5 502 508 2-s2.0-3543106683
    • (2004) Journal of Pediatric Gastroenterology and Nutrition , vol.38 , Issue.5 , pp. 502-508
    • Miele, E.1    Markowitz, J.E.2    Mamula, P.3    Baldassano, R.N.4
  • 48
    • 79953329803 scopus 로고    scopus 로고
    • Infliximab induces clonal expansion of γ δ -T cells in Crohn's disease: A predictor of lymphoma risk?
    • 2-s2.0-79953329803 10.1371/journal.pone.0017890, ARTICLE E17890
    • Kelsen J., Dige A., Schwindt H., D'Amore F., Pedersen F. S., Agnholt J., Christensen L. A., Dahlerup J. F., Hvas C. L., Infliximab induces clonal expansion of γ δ -T cells in Crohn's disease: a predictor of lymphoma risk? PLoS One 2011 6 3, article e17890 2-s2.0-79953329803 10.1371/journal.pone.0017890
    • (2011) PLoS One , vol.6 , Issue.3
    • Kelsen, J.1    Dige, A.2    Schwindt, H.3    D'Amore, F.4    Pedersen, F.S.5    Agnholt, J.6    Christensen, L.A.7    Dahlerup, J.F.8    Hvas, C.L.9
  • 49
    • 79953099459 scopus 로고    scopus 로고
    • Infliximab and adalimumab-induced psoriasis in Crohn's disease: A paradoxical side effect
    • 2-s2.0-79953099459 10.1016/j.crohns.2010.11.001
    • Iborra M., Beltrán B., Bastida G., Aguas M., Nos P., Infliximab and adalimumab-induced psoriasis in Crohn's disease: a paradoxical side effect. Journal of Crohn's and Colitis 2011 5 2 157 161 2-s2.0-79953099459 10.1016/j.crohns.2010.11.001
    • (2011) Journal of Crohn's and Colitis , vol.5 , Issue.2 , pp. 157-161
    • Iborra, M.1    Beltrán, B.2    Bastida, G.3    Aguas, M.4    Nos, P.5
  • 52
    • 46749096760 scopus 로고    scopus 로고
    • Sequential therapies for Crohn's disease: Optimizing conventional and biologic strategies
    • Desilva S., Kaplan G., Panaccione R., Sequential therapies for Crohn's disease: optimizing conventional and biologic strategies. Reviews in Gastroenterological Disorders 2008 8 2 109 116 2-s2.0-46749096760 (Pubitemid 351947610)
    • (2008) Reviews in Gastroenterological Disorders , vol.8 , Issue.2 , pp. 109-116
    • DeSilva, S.1    Kaplan, G.2    Panaccione, R.3
  • 53
    • 39649115628 scopus 로고    scopus 로고
    • Dilation of colonic strictures by intralesional injection of infliximab in patients with Crohn's colitis
    • DOI 10.1002/ibd.20318
    • Swaminath A., Lichtiger S., Dilation of colonic strictures by intralesional injection of infliximab in patients with Crohn's colitis. Inflammatory Bowel Diseases 2008 14 2 213 216 2-s2.0-39649115628 10.1002/ibd.20318 (Pubitemid 351288042)
    • (2008) Inflammatory Bowel Diseases , vol.14 , Issue.2 , pp. 213-216
    • Swaminath, A.1    Lichtiger, S.2
  • 54
    • 70349580667 scopus 로고    scopus 로고
    • Emerging treatments for complex perianal fistula in Crohn's disease
    • 2-s2.0-70349580667 10.3748/wjg.15.4263
    • Taxonera C., Schwartz D. A., García-Olmo D., Emerging treatments for complex perianal fistula in Crohn's disease. World Journal of Gastroenterology 2009 15 34 4263 4272 2-s2.0-70349580667 10.3748/wjg.15.4263
    • (2009) World Journal of Gastroenterology , vol.15 , Issue.34 , pp. 4263-4272
    • Taxonera, C.1    Schwartz, D.A.2    García-Olmo, D.3
  • 58
    • 0036841277 scopus 로고    scopus 로고
    • Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease
    • Bamias G., Marini M., Moskaluk C. A., Odashima M., Ross W. G., Rivera-Nieves J., Cominelli F., Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease. Journal of Immunology 2002 169 9 5308 5314 2-s2.0-0036841277 (Pubitemid 35217204)
    • (2002) Journal of Immunology , vol.169 , Issue.9 , pp. 5308-5314
    • Bamias, G.1    Marini, M.2    Moskaluk, C.A.3    Odashima, M.4    Ross, W.G.5    Rivera-Nieves, J.6    Cominelli, F.7
  • 59
    • 0036677473 scopus 로고    scopus 로고
    • Crohn's disease, TNF- α, and the leaky gut. The chicken or the egg?
    • 2-s2.0-0036677473 10.1016/S0002-9270(02)04252-1
    • Hollander D., Crohn's disease, TNF- α and the leaky gut. The chicken or the egg? American Journal of Gastroenterology 2002 97 8 1867 1868 2-s2.0-0036677473 10.1016/S0002-9270(02)04252-1
    • (2002) American Journal of Gastroenterology , vol.97 , Issue.8 , pp. 1867-1868
    • Hollander, D.1
  • 60
    • 67651146891 scopus 로고    scopus 로고
    • Infliximab therapy decreases the levels of TNF- α and IFN- γ mRNA in colonic mucosa of ulcerative colitis
    • 2-s2.0-67651146891 10.1080/00365520902803507
    • Olsen T., Cui G., Goll R., Husebekk A., Florholmen J., Infliximab therapy decreases the levels of TNF- α and IFN- γ mRNA in colonic mucosa of ulcerative colitis. Scandinavian Journal of Gastroenterology 2009 44 6 727 735 2-s2.0-67651146891 10.1080/00365520902803507
    • (2009) Scandinavian Journal of Gastroenterology , vol.44 , Issue.6 , pp. 727-735
    • Olsen, T.1    Cui, G.2    Goll, R.3    Husebekk, A.4    Florholmen, J.5
  • 61
    • 57049185731 scopus 로고    scopus 로고
    • The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation
    • 2-s2.0-57049185731 10.1038/cr.2008.310
    • Xu Y., Hunt N. H., Bao S., The role of granulocyte macrophage-colony- stimulating factor in acute intestinal inflammation. Cell Research 2008 18 12 1220 1229 2-s2.0-57049185731 10.1038/cr.2008.310
    • (2008) Cell Research , vol.18 , Issue.12 , pp. 1220-1229
    • Xu, Y.1    Hunt, N.H.2    Bao, S.3
  • 62
    • 0034133163 scopus 로고    scopus 로고
    • The key role of macrophages in the immunopathogenesis of inflammatory bowel disease
    • 2-s2.0-0034133163
    • Mahida Y. R., The key role of macrophages in the immunopathogenesis of inflammatory bowel disease. Inflammatory Bowel Diseases 2000 6 1 21 33 2-s2.0-0034133163
    • (2000) Inflammatory Bowel Diseases , vol.6 , Issue.1 , pp. 21-33
    • Mahida, Y.R.1
  • 63
    • 0037268936 scopus 로고    scopus 로고
    • Cytokine and anti-cytokine therapies for inflammatory bowel disease
    • DOI 10.2174/1381612033455035
    • Ogata H., Hibi T., Cytokine and anti-cytokine therapies for inflammatory bowel disease. Current Pharmaceutical Design 2003 9 14 1107 1113 2-s2.0-0037268936 10.2174/1381612033455035 (Pubitemid 36443211)
    • (2003) Current Pharmaceutical Design , vol.9 , Issue.14 , pp. 1107-1113
    • Ogata, H.1    Hibi, T.2
  • 64
    • 0034957289 scopus 로고    scopus 로고
    • Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease
    • DOI 10.1136/gut.49.1.35
    • Itoh J., de la Motte C., Strong S. A., Levine A. D., Fiocchi C., Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease. Gut 2001 49 1 35 41 2-s2.0-0034957289 10.1136/gut.49.1.35 (Pubitemid 32601877)
    • (2001) Gut , vol.49 , Issue.1 , pp. 35-41
    • Itoh, J.1    De La Motte, C.2    Strong, S.A.3    Levine, A.D.4    Fiocchi, C.5
  • 65
    • 29744450121 scopus 로고    scopus 로고
    • Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
    • DOI 10.1097/01.MIB.0000194183.92671.b6
    • Fuss I. J., Becker C., Yang Z., Groden C., Hornung R. L., Heller F., Neurath M. F., Strober W., Mannon P. J., Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflammatory Bowel Diseases 2006 12 1 9 15 2-s2.0-29744450121 10.1097/01.MIB.0000194183.92671.b6 (Pubitemid 43032445)
    • (2006) Inflammatory Bowel Diseases , vol.12 , Issue.1 , pp. 9-15
    • Fuss, I.J.1    Becker, C.2    Yang, Z.3    Groden, C.4    Hornung, R.L.5    Heller, F.6    Neurath, M.F.7    Strober, W.8    Mannon, P.J.9
  • 66
    • 64649084323 scopus 로고    scopus 로고
    • Modulation of inflammatory response via α 2-adrenoceptor blockade in acute murine colitis
    • 2-s2.0-64649084323 10.1111/j.1365-2249.2009.03894.x
    • Bai A., Lu N., Guo Y., Chen J., Liu Z., Modulation of inflammatory response via α 2-adrenoceptor blockade in acute murine colitis. Clinical and Experimental Immunology 2009 156 2 353 362 2-s2.0-64649084323 10.1111/j.1365-2249.2009.03894.x
    • (2009) Clinical and Experimental Immunology , vol.156 , Issue.2 , pp. 353-362
    • Bai, A.1    Lu, N.2    Guo, Y.3    Chen, J.4    Liu, Z.5
  • 68
    • 69449091637 scopus 로고    scopus 로고
    • Modulation of the Th1/Th2 balance by infliximab improves hyperthyroidism associated with a flareup of ulcerative colitis
    • 2-s2.0-69449091637 10.1002/ibd.20760
    • Matsumura K., Nakase H., Yamamoto S., Yoshino T., Takeda Y., Kasahara K., Ueno S., Uza N., Chiba T., Modulation of the Th1/Th2 balance by infliximab improves hyperthyroidism associated with a flareup of ulcerative colitis. Inflammatory Bowel Diseases 2009 15 7 967 968 2-s2.0-69449091637 10.1002/ibd.20760
    • (2009) Inflammatory Bowel Diseases , vol.15 , Issue.7 , pp. 967-968
    • Matsumura, K.1    Nakase, H.2    Yamamoto, S.3    Yoshino, T.4    Takeda, Y.5    Kasahara, K.6    Ueno, S.7    Uza, N.8    Chiba, T.9
  • 69
    • 70449505391 scopus 로고    scopus 로고
    • Therapeutic options to modulate barrier defects in inflammatory bowel disease
    • 2-s2.0-70449505391 10.1159/000233283
    • Hering N. A., Schulzke J. D., Therapeutic options to modulate barrier defects in inflammatory bowel disease. Digestive Diseases 2009 27 4 450 454 2-s2.0-70449505391 10.1159/000233283
    • (2009) Digestive Diseases , vol.27 , Issue.4 , pp. 450-454
    • Hering, N.A.1    Schulzke, J.D.2
  • 70
    • 33749026654 scopus 로고    scopus 로고
    • Disrupted barrier function through epithelial cell apoptosis
    • DOI 10.1196/annals.1326.027, Inflammatory Bowel Disease: Genetics, Barrier Function, Immunologic Mechanisms, and Microbial Pathways
    • Schulzke J. D., Bojarski C., Zeissig S., Heller F., Gitter A. H., Fromm M., Disrupted barrier function through epithelial cell apoptosis. Annals of the New York Academy of Sciences 2006 1072 288 299 2-s2.0-33749026654 10.1196/annals.1326.027 (Pubitemid 44448461)
    • (2006) Annals of the New York Academy of Sciences , vol.1072 , pp. 288-299
    • Schulzke, J.-D.1    Bojarski, C.2    Zeissig, S.3    Heller, F.4    Gitter, A.H.5    Fromm, M.6
  • 72
    • 33747626518 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in intestinal inflammation
    • DOI 10.1124/jpet.106.103465
    • Medina C., Radomski M. W., Role of matrix metalloproteinases in intestinal inflammation. Journal of Pharmacology and Experimental Therapeutics 2006 318 3 933 938 2-s2.0-33747626518 10.1124/jpet.106.103465 (Pubitemid 44268297)
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.318 , Issue.3 , pp. 933-938
    • Medina, C.1    Radomski, M.W.2
  • 73
    • 77049113770 scopus 로고    scopus 로고
    • The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity
    • 2-s2.0-77049113770 10.1016/j.bbamcr.2010.01.003
    • Brew K., Nagase H., The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochimica et Biophysica Acta 2010 1803 1 55 71 2-s2.0-77049113770 10.1016/j.bbamcr.2010.01. 003
    • (2010) Biochimica et Biophysica Acta , vol.1803 , Issue.1 , pp. 55-71
    • Brew, K.1    Nagase, H.2
  • 75
    • 43549085501 scopus 로고    scopus 로고
    • NF-κB in inflammatory bowel disease
    • DOI 10.1111/j.1365-2796.2008.01953.x
    • Atreya I., Atreya R., Neurath M. F., NF- B in inflammatory bowel disease. Journal of Internal Medicine 2008 263 6 591 596 2-s2.0-43549085501 10.1111/j.1365-2796.2008.01953.x (Pubitemid 351678589)
    • (2008) Journal of Internal Medicine , vol.263 , Issue.6 , pp. 591-596
    • Atreya, I.1    Atreya, R.2    Neurath, M.F.3
  • 76
    • 9444228220 scopus 로고    scopus 로고
    • Inhibition of p38 MAP kinase- and RICK/NF-κB-signaling suppresses inflammatory bowel disease
    • DOI 10.1096/fj.04-1642fje
    • Hollenbach E., Neumann M., Vieth M., Roessner A., Malfertheiner P., Naumann M., Inhibition of p38 MAP kinase- and RICK/NF- B-signaling suppresses inflammatory bowel disease. The FASEB Journal 2004 18 13 1550 1552 2-s2.0-9444228220 10.1096/fj.04-1642fje (Pubitemid 39561629)
    • (2004) FASEB Journal , vol.18 , Issue.13 , pp. 1550-1552
    • Hollenbach, E.1    Neumann, M.2    Vieth, M.3    Roessner, A.4    Malfertheiner, P.5    Naumann, M.6
  • 77
    • 0033930261 scopus 로고    scopus 로고
    • Abnormal activation of transcription factor NF-κB involved in steroid resistance in chronic inflammatory bowel disease [11]
    • DOI 10.1016/S0002-9270(00)00935-7
    • Bantel H., Domschke W., Schulze-Osthoff K., Kaskas B., Gregor M., Abnormal activation of transcription factor NF- B involved in steroid resistance in chronic inflammatory bowel disease. American Journal of Gastroenterology 2000 95 7 1845 1846 2-s2.0-0033930261 10.1016/S0002-9270(00)00935-7 (Pubitemid 30485038)
    • (2000) American Journal of Gastroenterology , vol.95 , Issue.7 , pp. 1845-1846
    • Bantel, H.1    Domschke, W.2    Schulze-Osthoff, K.3    Kaskas, B.4    Gregor, M.5
  • 78
    • 70350586944 scopus 로고    scopus 로고
    • Mitogen activated protein kinases: A role in inflammatory bowel disease?
    • 2-s2.0-70350586944 10.1111/j.1365-2249.2009.04033.x
    • Broom O. J., Widjaya B., Troelsen J., Olsen J., Nielsen O. H., Mitogen activated protein kinases: a role in inflammatory bowel disease? Clinical and Experimental Immunology 2009 158 3 272 280 2-s2.0-70350586944 10.1111/j.1365-2249.2009.04033.x
    • (2009) Clinical and Experimental Immunology , vol.158 , Issue.3 , pp. 272-280
    • Broom, O.J.1    Widjaya, B.2    Troelsen, J.3    Olsen, J.4    Nielsen, O.H.5
  • 79
    • 38149113537 scopus 로고    scopus 로고
    • NLR proteins: Integral members of innate immunity and mediators of inflammatory diseases
    • 2-s2.0-38149113537 10.1189/jlb.0607402
    • Wilmanski J. M., Petnicki-Ocwieja T., Kobayashi K. S., NLR proteins: integral members of innate immunity and mediators of inflammatory diseases. Journal of Leukocyte Biology 2008 83 1 13 30 2-s2.0-38149113537 10.1189/jlb.0607402
    • (2008) Journal of Leukocyte Biology , vol.83 , Issue.1 , pp. 13-30
    • Wilmanski, J.M.1    Petnicki-Ocwieja, T.2    Kobayashi, K.S.3
  • 80
    • 0033548249 scopus 로고    scopus 로고
    • Different mitogen-activated protein kinase signaling pathways cooperate to regulate tumor necrosis factor α gene expression in T lymphocytes
    • DOI 10.1074/jbc.274.7.4319
    • Hoffmeyer A., Grosse-Wilde A., Flory E., Neufeld B., Kunz M., Rapp U. R., Ludwig S., Different mitogen-activated protein kinase signaling pathways cooperate to regulate tumor necrosis factor α gene expression in T lymphocytes. Journal of Biological Chemistry 1999 274 7 4319 4327 2-s2.0-0033548249 10.1074/jbc.274.7.4319 (Pubitemid 29090967)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.7 , pp. 4319-4327
    • Hoffmeyer, A.1    Grosse-Wilde, A.2    Flory, E.3    Neufeld, B.4    Kunz, M.5    Rapp, U.R.6    Ludwig, S.7
  • 81
    • 77953440013 scopus 로고    scopus 로고
    • Predicting response to anti-TNF agents for the treatment of Crohn's disease
    • 2-s2.0-77953440013 10.1177/1756283X09336364
    • Siegel C. A., Melmed G. Y., Predicting response to anti-TNF agents for the treatment of Crohn's disease. Therapeutic Advances in Gastroenterology 2009 2 4 245 251 2-s2.0-77953440013 10.1177/1756283X09336364
    • (2009) Therapeutic Advances in Gastroenterology , vol.2 , Issue.4 , pp. 245-251
    • Siegel, C.A.1    Melmed, G.Y.2
  • 83
    • 0036726041 scopus 로고    scopus 로고
    • Predictors of response to infliximab in patients with Crohn's disease
    • DOI 10.1053/gast.2002.35390
    • Parsi M. A., Achkar J., Richardson S., Katz J., Hammel J. P., Lashner B. A., Brzezinski A., Predictors of response to infliximab in patients with Crohn's disease. Gastroenterology 2002 123 3 707 713 2-s2.0-0036726041 10.1053/gast.2002.35390 (Pubitemid 34977076)
    • (2002) Gastroenterology , vol.123 , Issue.3 , pp. 707-713
    • Parsi, M.A.1    Achkar, J.2    Richardson, S.3    Katz, J.4    Hammel, J.P.5    Lashner, B.A.6    Brzezinski, A.7
  • 84
    • 0037560163 scopus 로고    scopus 로고
    • An analysis of factors influencing short-term and sustained response to infliximab treatment for Crohn's disease
    • DOI 10.1046/j.1365-2036.2003.01574.x
    • Arnott I. D. R., McNeill G., Satsangi J., An analysis of factors influencing short-term and sustained response to infliximab treatment for Crohn's disease. Alimentary Pharmacology and Therapeutics 2003 17 12 1451 1457 2-s2.0-0037560163 10.1046/j.1365-2036.2003.01574.x (Pubitemid 36831435)
    • (2003) Alimentary Pharmacology and Therapeutics , vol.17 , Issue.12 , pp. 1451-1457
    • Arnott, I.D.R.1    McNeill, G.2    Satsangi, J.3
  • 85
    • 3543074116 scopus 로고    scopus 로고
    • Smoking and immunomodulators do not influence the response or duration of response to infliximab in Chrohn's disease
    • DOI 10.1097/00054725-200407000-00004
    • Fefferman D. S., Lodhavia P. J., Alsahli M., Falchuk K. R., Peppercorn M. A., Shah S. A., Farrel R. J., Smoking and immunomodulators do not influence the response or duration of response to infliximab in Chrohn's disease. Inflammatory Bowel Diseases 2004 10 4 346 351 2-s2.0-3543074116 10.1097/00054725-200407000-00004 (Pubitemid 39029176)
    • (2004) Inflammatory Bowel Diseases , vol.10 , Issue.4 , pp. 346-351
    • Fefferman, D.S.1    Lodhavia, P.J.2    Alsahli, M.3    Falchuk, K.R.4    Peppercorn, M.A.5    Shah, S.A.6    Farrel, R.J.7
  • 90
    • 77952832453 scopus 로고    scopus 로고
    • Interleukin-15 and its soluble receptor mediate the response to infliximab in patients with Crohn's disease
    • 2-s2.0-77952832453 10.1053/j.gastro.2010.02.044
    • Bouchaud G., Mortier E., Flamant M., Barbieux I., Plet A., Galmiche J. P., Jacques Y., Bourreille A., Interleukin-15 and its soluble receptor mediate the response to infliximab in patients with Crohn's disease. Gastroenterology 2010 138 7 2378 2387 2-s2.0-77952832453 10.1053/j.gastro.2010.02.044
    • (2010) Gastroenterology , vol.138 , Issue.7 , pp. 2378-2387
    • Bouchaud, G.1    Mortier, E.2    Flamant, M.3    Barbieux, I.4    Plet, A.5    Galmiche, J.P.6    Jacques, Y.7    Bourreille, A.8
  • 91
    • 34247165137 scopus 로고    scopus 로고
    • The efficacy and tolerability of newer biologics in rheumatoid arthritis: Best current evidence
    • DOI 10.1097/01.bor.0000265447.48722.04, PII 0000228120070500000015
    • Siddiqui M. A. A., The efficacy and tolerability of newer biologics in rheumatoid arthritis: best current evidence. Current Opinion in Rheumatology 2007 19 3 308 313 2-s2.0-34247165137 10.1097/01.bor.0000265447.48722.04 (Pubitemid 46597472)
    • (2007) Current Opinion in Rheumatology , vol.19 , Issue.3 , pp. 308-313
    • Siddiqui, M.A.A.1
  • 92
    • 36549065772 scopus 로고    scopus 로고
    • Biologics for the treatment of juvenile idiopathic arthritis: A systematic review and critical analysis of the evidence
    • DOI 10.1007/s10067-007-0654-6
    • Gartlehner G., Hansen R. A., Jonas B. L., Thieda P., Lohr K. N., Biologics for the treatment of juvenile idiopathic arthritis: a systematic review and critical analysis of the evidence. Clinical Rheumatology 2008 27 1 67 76 2-s2.0-36549065772 10.1007/s10067-007-0654-6 (Pubitemid 350182680)
    • (2008) Clinical Rheumatology , vol.27 , Issue.1 , pp. 67-76
    • Gartlehner, G.1    Hansen, R.A.2    Jonas, B.L.3    Thieda, P.4    Lohr, K.N.5


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