Mucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment

American Journal of Gastroenterology

Volumn 106, Issue 4, 2011, Pages 748-761

  Arijs, Ingrid ^a,b   De Hertogh, Gert ^a   MacHiels, Kathleen ^a   Van Steen, Kristel ^c   Lemaire, Katleen ^b   Schraenen, Anica ^b   Van Lommel, Leentje ^b   Quintens, Roel ^b   Van Assche, Gert ^a   Vermeire, Séverine ^a   Schuit, Frans ^b   Rutgeerts, Paul ^a,d  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d LEUVEN FOOD SCIENCE AND NUTRITION RESEARCH CENTRE LFORCE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; C REACTIVE PROTEIN; CD31 ANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE; CHEMOKINE RECEPTOR; CORTICOSTEROID; CXCL1 CHEMOKINE; CXCL11 CHEMOKINE; CXCL2 CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GRANULOCYTE CHEMOTACTIC PROTEIN 2; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; UVOMORULIN;

ARTICLE; COLON BIOPSY; COLON CROHN DISEASE; COLON MUCOSA; COLON ULCER; CONTROLLED STUDY; CROHN DISEASE; DOWN REGULATION; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; ILEUM; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LAMINA PROPRIA; LEUKOCYTE; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TREATMENT RESPONSE; ULCERATIVE COLITIS; UPREGULATION; WESTERN BLOTTING;

ADULT; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CELL ADHESION MOLECULES; CHEMOKINES; COLITIS; COLITIS, ULCERATIVE; COLON; CROHN DISEASE; DOWN-REGULATION; FEMALE; GENE EXPRESSION; HUMANS; ILEITIS; ILEUM; IMMUNOHISTOCHEMISTRY; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; RECEPTORS, CHEMOKINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION; YOUNG ADULT;

EID: 79953800521     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2011.27     Document Type: Article

References (28)

1. Teksteen B, Liaskou E, Adams DH. Lymphocyte homing and its role in the pathogenesis of IBD. Infamm Bowel Dis 2008;14:1298-312.
2. Rutgeerts P, Vermeire S, Van Assche G. Biological therapies for Infamma-torybowel diseases. Gastroenterology 2009;136:1182-97.
3. Geboes K, Riddell R, Ost A et al A reproducible grading scale for histological assessment of Infammation in ulcerative colitis. Gut 2000;47:404-9.
4. D'Haens GR Geboes K, Peeters M et al Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology 1998;114:262-7. (Pubitemid 28093532)
5. Rutgeerts P, Sandborn WJ, Feagan BG et al Inf iximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005;353:2462-76. (Pubitemid 41770166)
6. Arijs I, Li K, Toedter G et al Mucosal gene signatures to predict response to inf iximab in patients with ulcerative colitis. Gut 2009; 58: 1612-9.
7. Gentleman RC, Carey VJ, Bates DM et al Bioconductor: open sof ware development for computational biology and bioinformatics. Genome Biol 2004;5:R80.
8. Irizarry RA, Hobbs B, Collin F et al Exploration, normalization, and sum-maries of high density oligonucleotide array probe level data. Biostatistics 2003;4:249-64.
9. Smyth GK. Linear models and empirical Bayes methods for assessing Differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004;3:Article 3.
10. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B 1995; 85: 289-300.
11. Pfaf MW. A newmathematical model for relative quantif cation in real-time RT-PCR Nucleic Acids Res 2001;29:e45.
12. Rivera-Nieves J, Gorfu G, Ley K. Leukocyte adhesion molecules in animal models of Infammatory bowel disease. Infamm Bowel Dis 2008;14: 1715-35.
13. Sans M, Salas A, Soriano A et al. Differential role of selectins in experimen-tal colitis. Gastroenterology 2001;120:1162-72. (Pubitemid 32246670)
14. Yacyshyn B, Chey WY, Wedel MK et al. A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercel-lular adhesion molecule 1, for the treatment of subjects with active Crohn's disease. Clin Gastroenterol Hepatol 2007; 5: 215-20. (Pubitemid 46216935)
15. Soriano A,SalasA,SalasAet al. VCAM-1,butnotICAM-1 orMAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice. Lab Invest 2000;80:1541-51.
16. Feagan BG, Greenberg GR, Wild G et al Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. N Engl J Med 2005;352:2499-507. (Pubitemid 41007865)
17. FeaganBG, Greenberg GR,Wild Get al. Treatment ofactive Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin. Clin Gastroenterol Hepatol 2008; 6: 1370-7.
18. Rijcken E, Mennigen RB, Schaefer SD et al. PECAM-1 (CD 31) mediates transendothelial leukocyte migration in experimental colitis. Am J Physiol Gastrointest Liver Physiol 2007; 293: G446-52. (Pubitemid 47263189)
19. Yoshie O, Imai T, Nomiyama H. Chemokines in immunity. Adv Immunol 2001;78:57-110. (Pubitemid 32566018)
20. Puleston J, Cooper M, Murch S et al A distinct subset of chemokines domi-nates the mucosal chemokine response in Infammatory bowel disease. Aliment Pharmacol Ter 2005;21:109-20. (Pubitemid 40222964)
21. Kaser A, Ludwiczek O, Holzmann S et al Increased expression ofCCL20 in human Infammatory bowel disease. J Clin Immunol 2004; 24: 74-85. (Pubitemid 38375798)
22. Banks C, Bateman A, Payne R et al Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease. J Pathol 2003;199:28-35. (Pubitemid 36054726)
23. Kwon JH, Keates S, Bassani L et al. Colonic epithelial cells are a major site of macrophage Infammatory protein 3alpha (MIP-3alpha) production in normal colon and Infammatory bowel disease. Gut 2002; 51: 818-26. (Pubitemid 35408603)
24. Nishimura M, Kuboi Y Muramoto K et al Chemokines as novel therapeutic targets for Infammatory bowel disease. Ann NY Acad Sci 2009;1173:350-6.
25. Nob le CL, Abbas AR, Cornelius J et al Regional variation in gene expres-sion in the healthy colon is dysregulated in ulcerative colitis. Gut 2008;57:1398-405.
26. Papadakis KA, Prehn J, Moreno STet al CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease. Gastroenterology 2001;121:246-54. (Pubitemid 32729371)
27. Izutani R Loh EY, Reinecker H-C et al Increased expression of interleukin-8 mRNA in ulcerative colitis and Crohn's disease mucosa and epithelial cells. Infamm Bowel Dis 2006;1:37-47.
28. Daig R Rogler G, Aschenbrenner E et al Human intestinal epithelial cells secrete interleukin-1 receptor antagonist and interleukin-8 but not inter-leukin-1 or interleukin-6. Gut 2000; 46: 350-8. (Pubitemid 30313386)