Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism Implications for breast cancer prevention

Cell Cycle

Volumn 12, Issue 2, 2013, Pages 289-301

  Sanchez Alvarez, Rosa ^a   Martinez Outschoorn, Ubaldo E ^a   Lin, Zhao ^a   Lamb, Rebecca ^b   Hulit, James ^b   Howell, Anthony ^b   Sotgia, Federica ^a,b   Rubin, Emanuel ^c   Lisanti, Michael P ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Alcohol consumption; Breast cancer prevention; Cancer metabolism; Caveolin 1; Ethanol; Ketone bodies; MCT4; Mitochondrial biogenesis; Myofibroblast; Oxidative phosphorylation (OXPHOS); Oxidative stress; Reactive oxygen species (ROS)

Indexed keywords

ACETALDEHYDE; ACETYL COENZYME A; ACETYLCYSTEINE; ALCOHOL; CATHEPSIN B; CAVEOLIN 1; CYTOCHROME P450 2E1; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; KETONE BODY; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MONOCARBOXYLATE TRANSPORTER 4; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; CANCER GROWTH; CANCER PATIENT; CANCER PREVENTION; CANCER PROGNOSIS; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; DNA DAMAGE; DOWN REGULATION; EPITHELIUM CELL; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; FIBROBLAST; GLYCOLYSIS; HIGH RISK PATIENT; HUMAN; IMMUNE RESPONSE; LOW RISK POPULATION; MITOCHONDRIAL RESPIRATION; MITOPHAGY; OXIDATIVE STRESS; PHENOTYPE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; TUMOR RECURRENCE; UPREGULATION;

EID: 84873659762     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.23109     Document Type: Article

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