메뉴 건너뛰기




Volumn 8, Issue 3, 2013, Pages

Geographical Distribution of MTHFR C677T, A1298C and MTRR A66G Gene Polymorphisms in China: Findings from 15357 Adults of Han Nationality

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); GENOMIC DNA; METHIONINE SYNTHASE REDUCTASE; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

EID: 84874597689     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057917     Document Type: Article
Times cited : (115)

References (64)
  • 1
    • 75649103201 scopus 로고    scopus 로고
    • Genetics of homocysteine metabolism and associated disorders
    • Brustolin S, Giugliani R, Felix TM, (2010) Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res 43: 1-7.
    • (2010) Braz J Med Biol Res , vol.43 , pp. 1-7
    • Brustolin, S.1    Giugliani, R.2    Felix, T.M.3
  • 2
    • 84862001854 scopus 로고    scopus 로고
    • Association between MTHFR C677T and A1298C, and MTRR A66G polymorphisms and susceptibility to schizophrenia in a Syrian study cohort
    • Lajin B, Alhaj SA, Michati R, Alachkar A, (2012) Association between MTHFR C677T and A1298C, and MTRR A66G polymorphisms and susceptibility to schizophrenia in a Syrian study cohort. Asian J Psychiatr 5: 144-149.
    • (2012) Asian J Psychiatr , vol.5 , pp. 144-149
    • Lajin, B.1    Alhaj, S.A.2    Michati, R.3    Alachkar, A.4
  • 3
    • 84858764633 scopus 로고    scopus 로고
    • Association of the MTHFR A1298C variant with unexplained severe male infertility
    • Eloualid A, Abidi O, Charif M, El HB, Benrahma H, et al. (2012) Association of the MTHFR A1298C variant with unexplained severe male infertility. PLoS One 7: e34111.
    • (2012) PLoS One , vol.7
    • Eloualid, A.1    Abidi, O.2    Charif, M.3    El, H.B.4    Benrahma, H.5
  • 4
    • 27744603884 scopus 로고    scopus 로고
    • Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials
    • Homocysteine Lowering Trialists' Collaboration
    • Homocysteine Lowering Trialists' Collaboration, (2005) Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 82: 806-812.
    • (2005) Am J Clin Nutr , vol.82 , pp. 806-812
  • 5
    • 0035076561 scopus 로고    scopus 로고
    • Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete
    • McKinley MC, McNulty H, McPartlin J, Strain JJ, Pentieva K, et al. (2001) Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. Am J Clin Nutr 73: 759-764.
    • (2001) Am J Clin Nutr , vol.73 , pp. 759-764
    • McKinley, M.C.1    McNulty, H.2    McPartlin, J.3    Strain, J.J.4    Pentieva, K.5
  • 6
    • 33644863502 scopus 로고    scopus 로고
    • Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C→T polymorphism
    • McNulty H, Dowey LR, Strain JJ, Dunne A, Ward M, et al. (2006) Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C→T polymorphism. Circulation 113: 74-80.
    • (2006) Circulation , vol.113 , pp. 74-80
    • McNulty, H.1    Dowey, L.R.2    Strain, J.J.3    Dunne, A.4    Ward, M.5
  • 7
    • 84858679262 scopus 로고    scopus 로고
    • Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population
    • Yakub M, Moti N, Parveen S, Chaudhry B, Azam I, et al. (2012) Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population. PLoS One 7: e33222.
    • (2012) PLoS One , vol.7
    • Yakub, M.1    Moti, N.2    Parveen, S.3    Chaudhry, B.4    Azam, I.5
  • 8
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, et al. (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10: 111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5
  • 9
    • 0031971515 scopus 로고    scopus 로고
    • A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects
    • van der Put NM, Gabreels F, Stevens EM, Smeitink JA, Trijbels FJ, et al. (1998) A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 62: 1044-1051.
    • (1998) Am J Hum Genet , vol.62 , pp. 1044-1051
    • van der Put, N.M.1    Gabreels, F.2    Stevens, E.M.3    Smeitink, J.A.4    Trijbels, F.J.5
  • 10
    • 0030811925 scopus 로고    scopus 로고
    • Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR)
    • Rozen R, (1997) Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb Haemost 78: 523-526.
    • (1997) Thromb Haemost , vol.78 , pp. 523-526
    • Rozen, R.1
  • 11
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I, Tran P, Christensen B, Sibani S, Rozen R, (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64: 169-172.
    • (1998) Mol Genet Metab , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3    Sibani, S.4    Rozen, R.5
  • 12
    • 0034904708 scopus 로고    scopus 로고
    • The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations
    • Gaughan DJ, Kluijtmans LA, Barbaux S, McMaster D, Young IS, et al. (2001) The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations. Atherosclerosis 157: 451-456.
    • (2001) Atherosclerosis , vol.157 , pp. 451-456
    • Gaughan, D.J.1    Kluijtmans, L.A.2    Barbaux, S.3    McMaster, D.4    Young, I.S.5
  • 13
    • 0037069353 scopus 로고    scopus 로고
    • Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase
    • Olteanu H, Munson T, Banerjee R, (2002) Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry 41: 13378-13385.
    • (2002) Biochemistry , vol.41 , pp. 13378-13385
    • Olteanu, H.1    Munson, T.2    Banerjee, R.3
  • 14
    • 79551621896 scopus 로고    scopus 로고
    • Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis
    • Wald DS, Morris JK, Wald NJ, (2011) Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis. PLoS One 6: e16473.
    • (2011) PLoS One , vol.6
    • Wald, D.S.1    Morris, J.K.2    Wald, N.J.3
  • 15
    • 84874583417 scopus 로고    scopus 로고
    • A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population
    • Zeng W, Liu L, Tong Y, Liu HM, Dai L, et al. (2011) A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population. Genet Mol Res 10: 2597-2605.
    • (2011) Genet Mol Res , vol.10 , pp. 2597-2605
    • Zeng, W.1    Liu, L.2    Tong, Y.3    Liu, H.M.4    Dai, L.5
  • 16
    • 0035987006 scopus 로고    scopus 로고
    • Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population
    • De Marco P, Calevo MG, Moroni A, Arata L, Merello E, et al. (2002) Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population. J Hum Genet 47: 319-324.
    • (2002) J Hum Genet , vol.47 , pp. 319-324
    • De Marco, P.1    Calevo, M.G.2    Moroni, A.3    Arata, L.4    Merello, E.5
  • 18
    • 33750704194 scopus 로고    scopus 로고
    • The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida
    • van der Linden IJ, den Heijer M, Afman LA, Gellekink H, Vermeulen SH, et al. (2006) The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida. J Mol Med (Berl) 84: 1047-1054.
    • (2006) J Mol Med (Berl) , vol.84 , pp. 1047-1054
    • van der Linden, I.J.1    den Heijer, M.2    Afman, L.A.3    Gellekink, H.4    Vermeulen, S.H.5
  • 19
    • 79551668559 scopus 로고    scopus 로고
    • Interactions of 5′-UTR thymidylate synthase polymorphism with 677C→T methylene tetrahydrofolate reductase and 66A→G methyltetrahydrofolate homocysteine methyl-transferase reductase polymorphisms determine susceptibility to coronary artery disease
    • Vijaya LS, Naushad SM, Rupasree Y, Seshagiri RD, Kutala VK, (2011) Interactions of 5′-UTR thymidylate synthase polymorphism with 677C→T methylene tetrahydrofolate reductase and 66A→G methyltetrahydrofolate homocysteine methyl-transferase reductase polymorphisms determine susceptibility to coronary artery disease. J Atheroscler Thromb 18: 56-64.
    • (2011) J Atheroscler Thromb , vol.18 , pp. 56-64
    • Vijaya, L.S.1    Naushad, S.M.2    Rupasree, Y.3    Seshagiri, R.D.4    Kutala, V.K.5
  • 20
    • 84860326556 scopus 로고    scopus 로고
    • Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies
    • Han D, Shen C, Meng X, Bai J, Chen F, et al. (2012) Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies. Mol Biol Rep 39: 805-816.
    • (2012) Mol Biol Rep , vol.39 , pp. 805-816
    • Han, D.1    Shen, C.2    Meng, X.3    Bai, J.4    Chen, F.5
  • 21
    • 77949266729 scopus 로고    scopus 로고
    • Available online, Accessed 26 Apr 2012
    • ALFRED: the ALlele FREquency Databese. Available online: http://alfred.med.yale.edu/alfred/SiteTable1A_working.asp?siteuid=SI001032G. Accessed 26 Apr 2012.
    • ALFRED: The ALlele FREquency Databese
  • 22
    • 77949266729 scopus 로고    scopus 로고
    • Available online. Accessed 26 Apr 2012
    • ALFRED: the ALlele FREquency Databese. Available online: http://alfred.med.yale.edu/alfred/SiteTable1A_working.asp?siteuid=SI003687Y. Accessed 26 Apr 2012.
    • ALFRED: The ALlele FREquency Databese
  • 23
    • 0037079957 scopus 로고    scopus 로고
    • Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas; a report of a novel MTHFR polymorphic site, G1793A
    • Rady PL, Szucs S, Grady J, Hudnall SD, Kellner LH, et al. (2002) Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas; a report of a novel MTHFR polymorphic site, G1793A. Am J Med Genet 107: 162-168.
    • (2002) Am J Med Genet , vol.107 , pp. 162-168
    • Rady, P.L.1    Szucs, S.2    Grady, J.3    Hudnall, S.D.4    Kellner, L.H.5
  • 24
    • 0041326346 scopus 로고    scopus 로고
    • Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide
    • Wilcken B, Bamforth F, Li Z, Zhu H, Ritvanen A, et al. (2003) Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide. J Med Genet 40: 619-625.
    • (2003) J Med Genet , vol.40 , pp. 619-625
    • Wilcken, B.1    Bamforth, F.2    Li, Z.3    Zhu, H.4    Ritvanen, A.5
  • 25
    • 0032231408 scopus 로고    scopus 로고
    • Heterogeneity in world distribution of the thermolabile C677T mutation in 5,10-methylenetetrahydrofolate reductase
    • Pepe G, Camacho VO, Giusti B, Brunelli T, Marcucci R, et al. (1998) Heterogeneity in world distribution of the thermolabile C677T mutation in 5,10-methylenetetrahydrofolate reductase. Am J Hum Genet 63: 917-920.
    • (1998) Am J Hum Genet , vol.63 , pp. 917-920
    • Pepe, G.1    Camacho, V.O.2    Giusti, B.3    Brunelli, T.4    Marcucci, R.5
  • 26
    • 70350459869 scopus 로고    scopus 로고
    • Prevalence of the C677T single-nucleotide polymorphism in the methylenetetrahydrofolate reductase gene among Pakistani ethnic groups
    • Mansoor A, Mazhar K, Ali L, Muazzam AG, Siddiqi S, et al. (2009) Prevalence of the C677T single-nucleotide polymorphism in the methylenetetrahydrofolate reductase gene among Pakistani ethnic groups. Genet Test Mol Biomarkers 13: 521-526.
    • (2009) Genet Test Mol Biomarkers , vol.13 , pp. 521-526
    • Mansoor, A.1    Mazhar, K.2    Ali, L.3    Muazzam, A.G.4    Siddiqi, S.5
  • 27
    • 84863113514 scopus 로고    scopus 로고
    • Spectrum of MTHFR gene SNPs C677T and A1298C: a study among 23 population groups of India
    • Saraswathy KN, Asghar M, Samtani R, Murry B, Mondal PR, et al. (2012) Spectrum of MTHFR gene SNPs C677T and A1298C: a study among 23 population groups of India. Mol Biol Rep 39: 5025-5031.
    • (2012) Mol Biol Rep , vol.39 , pp. 5025-5031
    • Saraswathy, K.N.1    Asghar, M.2    Samtani, R.3    Murry, B.4    Mondal, P.R.5
  • 28
    • 42949134479 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms in 13 Chinese ethnic populations
    • Mao R, Fan Y, Chen F, Sun D, Bai J, et al. (2008) Methylenetetrahydrofolate reductase gene polymorphisms in 13 Chinese ethnic populations. Cell Biochem Funct 26: 352-358.
    • (2008) Cell Biochem Funct , vol.26 , pp. 352-358
    • Mao, R.1    Fan, Y.2    Chen, F.3    Sun, D.4    Bai, J.5
  • 30
    • 1542404526 scopus 로고    scopus 로고
    • Ethnic differences in the linkage disequilibrium and distribution of single-nucleotide polymorphisms in 35 candidate genes for cardiovascular diseases
    • Ng MC, Wang Y, So WY, Cheng S, Visvikis S, et al. (2004) Ethnic differences in the linkage disequilibrium and distribution of single-nucleotide polymorphisms in 35 candidate genes for cardiovascular diseases. Genomics 83: 559-565.
    • (2004) Genomics , vol.83 , pp. 559-565
    • Ng, M.C.1    Wang, Y.2    So, W.Y.3    Cheng, S.4    Visvikis, S.5
  • 31
    • 0034190659 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review
    • Botto LD, Yang Q, (2000) 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 151: 862-877.
    • (2000) Am J Epidemiol , vol.151 , pp. 862-877
    • Botto, L.D.1    Yang, Q.2
  • 32
    • 0036178211 scopus 로고    scopus 로고
    • The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans
    • Rosenberg N, Murata M, Ikeda Y, Opare-Sem O, Zivelin A, et al. (2002) The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans. Am J Hum Genet 70: 758-762.
    • (2002) Am J Hum Genet , vol.70 , pp. 758-762
    • Rosenberg, N.1    Murata, M.2    Ikeda, Y.3    Opare-Sem, O.4    Zivelin, A.5
  • 33
    • 33645652119 scopus 로고    scopus 로고
    • Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations
    • Gueant-Rodriguez RM, Gueant JL, Debard R, Thirion S, Hong LX, et al. (2006) Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am J Clin Nutr 83: 701-707.
    • (2006) Am J Clin Nutr , vol.83 , pp. 701-707
    • Gueant-Rodriguez, R.M.1    Gueant, J.L.2    Debard, R.3    Thirion, S.4    Hong, L.X.5
  • 34
    • 83355172206 scopus 로고    scopus 로고
    • Dietary patterns and hypertension among Chinese adults: a nationally representative cross-sectional study
    • Wang D, He Y, Li Y, Luan D, Yang X, et al. (2011) Dietary patterns and hypertension among Chinese adults: a nationally representative cross-sectional study. BMC Public Health 11: 925.
    • (2011) BMC Public Health , vol.11 , pp. 925
    • Wang, D.1    He, Y.2    Li, Y.3    Luan, D.4    Yang, X.5
  • 35
    • 0242661097 scopus 로고    scopus 로고
    • Geographical, seasonal and gender differences in folate status among Chinese adults
    • Hao L, Ma J, Stampfer MJ, Ren A, Tian Y, et al. (2003) Geographical, seasonal and gender differences in folate status among Chinese adults. J Nutr 133: 3630-3635.
    • (2003) J Nutr , vol.133 , pp. 3630-3635
    • Hao, L.1    Ma, J.2    Stampfer, M.J.3    Ren, A.4    Tian, Y.5
  • 36
    • 33750912762 scopus 로고    scopus 로고
    • Ultraviolet radiation represents an evolutionary selective pressure for the south-to-north gradient of the MTHFR 677TT genotype
    • Cordain L, Hickey MS (2006) Ultraviolet radiation represents an evolutionary selective pressure for the south-to-north gradient of the MTHFR 677TT genotype. Am J Clin Nutr 84: 1243, 1244-1245.
    • (2006) Am J Clin Nutr , vol.84
    • Cordain, L.1    Hickey, M.S.2
  • 37
    • 0033912992 scopus 로고    scopus 로고
    • The evolution of human skin coloration
    • Jablonski NG, Chaplin G, (2000) The evolution of human skin coloration. J Hum Evol 39: 57-106.
    • (2000) J Hum Evol , vol.39 , pp. 57-106
    • Jablonski, N.G.1    Chaplin, G.2
  • 38
    • 0018180775 scopus 로고
    • Skin color and nutrient photolysis: an evolutionary hypothesis
    • Branda RF, Eaton JW, (1978) Skin color and nutrient photolysis: an evolutionary hypothesis. Science 201: 625-626.
    • (1978) Science , vol.201 , pp. 625-626
    • Branda, R.F.1    Eaton, J.W.2
  • 39
    • 19644399071 scopus 로고    scopus 로고
    • Evolutionary biology: geography and skin colour
    • Diamond J, (2005) Evolutionary biology: geography and skin colour. Nature 435: 283-284.
    • (2005) Nature , vol.435 , pp. 283-284
    • Diamond, J.1
  • 40
    • 0033762701 scopus 로고    scopus 로고
    • Y chromosome sequence variation and the history of human populations
    • Underhill PA, Shen P, Lin AA, Jin L, Passarino G, et al. (2000) Y chromosome sequence variation and the history of human populations. Nat Genet 26: 358-361.
    • (2000) Nat Genet , vol.26 , pp. 358-361
    • Underhill, P.A.1    Shen, P.2    Lin, A.A.3    Jin, L.4    Passarino, G.5
  • 41
    • 11244255194 scopus 로고    scopus 로고
    • Genotype and allele frequencies of the polymorphic methylenetetrahydrofolate reductase gene in Turkey
    • Sazci A, Ergul E, Kaya G, Kara I, (2005) Genotype and allele frequencies of the polymorphic methylenetetrahydrofolate reductase gene in Turkey. Cell Biochem Funct 23: 51-54.
    • (2005) Cell Biochem Funct , vol.23 , pp. 51-54
    • Sazci, A.1    Ergul, E.2    Kaya, G.3    Kara, I.4
  • 42
    • 41449106682 scopus 로고    scopus 로고
    • High prevalence of MTHFR gene A1298C polymorphism in Lebanon
    • Sabbagh AS, Mahfoud Z, Taher A, Zaatari G, Daher R, et al. (2008) High prevalence of MTHFR gene A1298C polymorphism in Lebanon. Genet Test 12: 75-80.
    • (2008) Genet Test , vol.12 , pp. 75-80
    • Sabbagh, A.S.1    Mahfoud, Z.2    Taher, A.3    Zaatari, G.4    Daher, R.5
  • 44
    • 84862922222 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and related genetic polymorphisms correlate with ulcerative colitis in Chinese Han population in Central China [corrected]
    • Jiang Y, Xia X, Wang W, Lin L, Xu C, et al. (2012) Hyperhomocysteinemia and related genetic polymorphisms correlate with ulcerative colitis in Chinese Han population in Central China [corrected]. Cell Biochem Biophys 62: 203-210.
    • (2012) Cell Biochem Biophys , vol.62 , pp. 203-210
    • Jiang, Y.1    Xia, X.2    Wang, W.3    Lin, L.4    Xu, C.5
  • 46
    • 84855999935 scopus 로고    scopus 로고
    • Triplex tetra-primer ARMS-PCR method for the simultaneous detection of MTHFR c.677C>T and c.1298A>C, and MTRR c.66A>G polymorphisms of the folate-homocysteine metabolic pathway
    • Lajin B, Alachkar A, Sakur AA, (2012) Triplex tetra-primer ARMS-PCR method for the simultaneous detection of MTHFR c.677C>T and c.1298A>C, and MTRR c.66A>G polymorphisms of the folate-homocysteine metabolic pathway. Mol Cell Probes 26: 16-20.
    • (2012) Mol Cell Probes , vol.26 , pp. 16-20
    • Lajin, B.1    Alachkar, A.2    Sakur, A.A.3
  • 48
    • 0035844029 scopus 로고    scopus 로고
    • African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes
    • Ke Y, Su B, Song X, Lu D, Chen L, et al. (2001) African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes. Science 292: 1151-1153.
    • (2001) Science , vol.292 , pp. 1151-1153
    • Ke, Y.1    Su, B.2    Song, X.3    Lu, D.4    Chen, L.5
  • 49
    • 84855353573 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2012 update: a report from the American Heart Association
    • Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, et al. (2012) Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 125: e2-e220.
    • (2012) Circulation , vol.125
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3    Benjamin, E.J.4    Berry, J.D.5
  • 51
    • 0343503018 scopus 로고    scopus 로고
    • High prevalence of the thermolabile methylenetetrahydrofolate reductase variant in Mexico: a country with a very high prevalence of neural tube defects
    • Mutchinick OM, Lopez MA, Luna L, Waxman J, Babinsky VE, (1999) High prevalence of the thermolabile methylenetetrahydrofolate reductase variant in Mexico: a country with a very high prevalence of neural tube defects. Mol Genet Metab 68: 461-467.
    • (1999) Mol Genet Metab , vol.68 , pp. 461-467
    • Mutchinick, O.M.1    Lopez, M.A.2    Luna, L.3    Waxman, J.4    Babinsky, V.E.5
  • 52
    • 79960053714 scopus 로고    scopus 로고
    • Subclinical atherosclerosis in northern and southern China: the Chinese paradox
    • Huang J, Wu YF, Liu XQ, Ding D, Zhao LC, et al. (2011) Subclinical atherosclerosis in northern and southern China: the Chinese paradox. J Geriatr Cardiol 8: 72-77.
    • (2011) J Geriatr Cardiol , vol.8 , pp. 72-77
    • Huang, J.1    Wu, Y.F.2    Liu, X.Q.3    Ding, D.4    Zhao, L.C.5
  • 53
    • 33646270883 scopus 로고    scopus 로고
    • Extremely high prevalence of neural tube defects in a 4-county area in Shanxi Province, China
    • Li Z, Ren A, Zhang L, Ye R, Li S, et al. (2006) Extremely high prevalence of neural tube defects in a 4-county area in Shanxi Province, China. Birth Defects Res A Clin Mol Teratol 76: 237-240.
    • (2006) Birth Defects Res A Clin Mol Teratol , vol.76 , pp. 237-240
    • Li, Z.1    Ren, A.2    Zhang, L.3    Ye, R.4    Li, S.5
  • 54
    • 34447125612 scopus 로고    scopus 로고
    • Comparison of blood folate levels among pregnant Chinese women in areas with high and low prevalence of neural tube defects
    • Ren A, Zhang L, Hao L, Li Z, Tian Y, et al. (2007) Comparison of blood folate levels among pregnant Chinese women in areas with high and low prevalence of neural tube defects. Public Health Nutr 10: 762-768.
    • (2007) Public Health Nutr , vol.10 , pp. 762-768
    • Ren, A.1    Zhang, L.2    Hao, L.3    Li, Z.4    Tian, Y.5
  • 55
    • 2542419008 scopus 로고    scopus 로고
    • Blood pressure differences between northern and southern Chinese: role of dietary factors: the International Study on Macronutrients and Blood Pressure
    • Zhao L, Stamler J, Yan LL, Zhou B, Wu Y, et al. (2004) Blood pressure differences between northern and southern Chinese: role of dietary factors: the International Study on Macronutrients and Blood Pressure. Hypertension 43: 1332-1337.
    • (2004) Hypertension , vol.43 , pp. 1332-1337
    • Zhao, L.1    Stamler, J.2    Yan, L.L.3    Zhou, B.4    Wu, Y.5
  • 56
    • 84862799541 scopus 로고    scopus 로고
    • Association between MTHFR A1298C polymorphism and neural tube defect susceptibility: a meta-analysis
    • Wang XW, Luo YL, Wang W, Zhang Y, Chen Q, et al. (2012) Association between MTHFR A1298C polymorphism and neural tube defect susceptibility: a meta-analysis. Am J Obstet Gynecol 206: 251.
    • (2012) Am J Obstet Gynecol , vol.206 , pp. 251
    • Wang, X.W.1    Luo, Y.L.2    Wang, W.3    Zhang, Y.4    Chen, Q.5
  • 57
    • 84863018527 scopus 로고    scopus 로고
    • Three genetic polymorphisms of homocysteine-metabolizing enzymes and risk of coronary heart disease: a meta-analysis based on 23 case-control studies
    • Chen L, Liu L, Hong K, Hu J, Cheng X, (2012) Three genetic polymorphisms of homocysteine-metabolizing enzymes and risk of coronary heart disease: a meta-analysis based on 23 case-control studies. DNA Cell Biol 31: 238-249.
    • (2012) DNA Cell Biol , vol.31 , pp. 238-249
    • Chen, L.1    Liu, L.2    Hong, K.3    Hu, J.4    Cheng, X.5
  • 58
    • 0035067094 scopus 로고    scopus 로고
    • Interaction of folate and homocysteine pathway genotypes evaluated in susceptibility to neural tube defects (NTD) in a German population
    • Richter B, Stegmann K, Roper B, Boddeker I, Ngo ET, et al. (2001) Interaction of folate and homocysteine pathway genotypes evaluated in susceptibility to neural tube defects (NTD) in a German population. J Hum Genet 46: 105-109.
    • (2001) J Hum Genet , vol.46 , pp. 105-109
    • Richter, B.1    Stegmann, K.2    Roper, B.3    Boddeker, I.4    Ngo, E.T.5
  • 59
    • 0032856882 scopus 로고    scopus 로고
    • A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida
    • Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, et al. (1999) A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab 67: 317-323.
    • (1999) Mol Genet Metab , vol.67 , pp. 317-323
    • Wilson, A.1    Platt, R.2    Wu, Q.3    Leclerc, D.4    Christensen, B.5
  • 60
    • 0037865225 scopus 로고    scopus 로고
    • Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans
    • Gueant-Rodriguez RM, Rendeli C, Namour B, Venuti L, Romano A, et al. (2003) Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans. Neurosci Lett 344: 189-192.
    • (2003) Neurosci Lett , vol.344 , pp. 189-192
    • Gueant-Rodriguez, R.M.1    Rendeli, C.2    Namour, B.3    Venuti, L.4    Romano, A.5
  • 61
    • 0037341890 scopus 로고    scopus 로고
    • Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects
    • Zhu H, Wicker NJ, Shaw GM, Lammer EJ, Hendricks K, et al. (2003) Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects. Mol Genet Metab 78: 216-221.
    • (2003) Mol Genet Metab , vol.78 , pp. 216-221
    • Zhu, H.1    Wicker, N.J.2    Shaw, G.M.3    Lammer, E.J.4    Hendricks, K.5
  • 62
    • 0033912873 scopus 로고    scopus 로고
    • A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease
    • Brown CA, McKinney KQ, Kaufman JS, Gravel RA, Rozen R, (2000) A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease. J Cardiovasc Risk 7: 197-200.
    • (2000) J Cardiovasc Risk , vol.7 , pp. 197-200
    • Brown, C.A.1    McKinney, K.Q.2    Kaufman, J.S.3    Gravel, R.A.4    Rozen, R.5
  • 63
    • 84555206538 scopus 로고    scopus 로고
    • Associations of polymorphisms of methionine synthase A2756G and methionine synthase reductase G66A with the risks of coronary artery disease: a meta-analysis
    • Li YJ, Li YW, Ding X, Zhao HT, Li Y, (2010) Associations of polymorphisms of methionine synthase A2756G and methionine synthase reductase G66A with the risks of coronary artery disease: a meta-analysis. Zhonghua Yu Fang Yi Xue Za Zhi 44: 820-824 (in Chinese).
    • (2010) Zhonghua Yu Fang Yi Xue Za Zhi , vol.44 , pp. 820-824
    • Li, Y.J.1    Li, Y.W.2    Ding, X.3    Zhao, H.T.4    Li, Y.5
  • 64
    • 0033548679 scopus 로고    scopus 로고
    • Decreased proportion of female newborn infants homozygous for the 677C→T mutation in methylenetetrahydrofolate reductase
    • Rozen R, Fraser FC, Shaw G, (1999) Decreased proportion of female newborn infants homozygous for the 677C→T mutation in methylenetetrahydrofolate reductase. Am J Med Genet 83: 142-143.
    • (1999) Am J Med Genet , vol.83 , pp. 142-143
    • Rozen, R.1    Fraser, F.C.2    Shaw, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.