Structural-functional studies of Burkholderia cenocepacia d-glycero-β-d-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties

Journal of Medicinal Chemistry

Volumn 56, Issue 4, 2013, Pages 1405-1417

  Lee, Ting Wai ^a   Verhey, Theodore B ^a   Antiperovitch, Pavel A ^a   Atamanyuk, Dmytro ^b   Desroy, Nicolas ^b,f   Oliveira, Chrystelle ^b   Denis, Alexis ^b,g   Gerusz, Vincent ^b   Drocourt, Elodie ^b   Loutet, Slade A ^c,h   Hamad, Mohamad A ^c   Stanetty, Christian ^d   Andres, Sara N ^a   Sugiman Marangos, Seiji ^a   Kosma, Paul ^d   Valvano, Miguel A ^c,e   Moreau, Francois ^b   Junop, Murray S ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b Biodim Mutabilis   (France)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^e QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^f Galapagos SASU   (France)

^g GLAXOSMITHKLINE   (France)

^h UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; DEXTRO GLYCERO BETA DEXTRO MANNO HAPTOSE 7 PHOSPHATE KINASE; DEXTRO GLYCERO BETA DEXTRO MANNO HAPTOSE 7 PHOSPHATE KINASE INHIBITOR; MAGNESIUM ION; PHOSPHOTRANSFERASE INHIBITOR; PICEATANNOL; QUERCETIN; TYRPHOSTIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; BURKHOLDERIA CENOCEPACIA; CATALYSIS; CELL VIABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN CELL; HYDROGEN BOND; NONHUMAN; NUCLEOTIDE BINDING SITE; PHOSPHORYLATION;

EID: 84874593935     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301483h     Document Type: Article

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