Identification of structural motifs critical for Epstein-Barr virus- induced molecule 2 function and homology modeling of the ligand docking site

Molecular Pharmacology

Volumn 82, Issue 6, 2012, Pages 1094-1103

  Zhang, Li ^a   Shih, Amy Y ^a   Yang, Xia V ^a,b   Kuei, Chester ^a   Wu, Jiejun ^a   Deng, Xiaohu ^a   Mani, Neelakandha S ^a   Mirzadegan, Taraneh ^a   Sun, Siquan ^a   Lovenberg, Timothy W ^a   Liu, Changlu ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b REGULUS THERAPEUTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7ALPHA, 25 DIHYDROXYCHOLESTEROL; 7ALPHA, 27 DIHYDROXYCHOLESTEROL; ALPHA CHEMOKINE; ARGININE; ASPARAGINE; BETA 2 ADRENERGIC RECEPTOR; CHOLESTEROL DERIVATIVE; EPSTEIN BARR VIRUS INDUCED MOLECULE 2 PROTEIN; GLUTAMINE; HYDROXYL GROUP; OXYSTEROL; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; BIOCHEMISTRY; CHEMICAL COMPOSITION; CONTROLLED STUDY; ENZYME ACTIVATION; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; LIGAND BINDING; LIGAND DOCKING SITE; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; RAT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; CHEMOKINES, CXC; COS CELLS; CYSTEINE; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84869809791     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.080275     Document Type: Article

References (24)

1. Angel TE, Chance MR, and Palczewski K (2009) Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proc Natl Acad Sci USA 106:8555-8560.
2. Benned-Jensen T and Rosenkilde MM (2008) Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist. Mol Pharmacol 74:1008-1021.
3. Benned-Jensen T, Smethurst C, Holst PJ, Page KR, Sauls H, Sivertsen B, Schwartz TW, Blanchard A, Jepras R, and Rosenkilde MM (2011) Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J Biol Chem 286:29292-29302.
4. Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, and Kieff E (1993) Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J Virol 67:2209-2220. (Pubitemid 23088397)
5. 2-adrenergic G protein-coupled receptor. Science 318:1258-1265.
6. Gatto D, Paus D, Basten A, Mackay CR, and Brink R (2009) Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 31:259-269.
7. Gatto D, Wood K, and Brink R (2011) EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center. J Immunol 187:4621-4628.
8. Gether U (2000) Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr Rev 21:90-113.
9. Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, et al. (2011) Oxysterols direct immune cell migration via EBI2. Nature 475:524-527.
10. Karnik SS, Gogonea C, Patil S, Saad Y, and Takezako T (2003) Activation of G-protein-coupled receptors: a common molecular mechanism. Trends Endocrinol Metab 14:431-437. (Pubitemid 37392216)
11. Kelly LM, Pereira JP, Yi T, Xu Y, and Cyster JG (2011) EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. J Immunol 187:3026-3032.
12. Klco JM, Wiegand CB, Narzinski K, and Baranski TJ (2005) Essential role for the second extracellular loop in C5a receptor activation. Nat Struct Mol Biol 12:320-326. (Pubitemid 43093086)
13. Liu C, Eriste E, Sutton S, Chen J, Roland B, Kuei C, Farmer N, Jörnvall H, Sillard R, and Lovenberg TW (2003) Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. J Biol Chem 278: 50754-50764. (Pubitemid 37548924)
14. Liu C, Wilson SJ, Kuei C, and Lovenberg TW (2001) Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther 299:121-130. (Pubitemid 32905126)
15. Liu C, Yang XV, Wu J, Kuei C, Mani NS, Zhang L, Yu J, Sutton SW, Qin N, Banie H, et al. (2011) Oxysterols direct B-cell migration through EBI2. Nature 475:519-523.
16. Mirzadegan T, Benkö G, Filipek S, and Palczewski K (2003) Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry 42:2759-2767. (Pubitemid 36331518)
17. Pereira JP, Kelly LM, and Cyster JG (2010) Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int Immunol 22:413-419.
18. Pereira JP, Kelly LM, Xu Y, and Cyster JG (2009) EBI2 mediates B cell segregation between the outer and centre follicle. Nature 460:1122-1126.
19. Rose KA, Stapleton G, Dott K, Kieny MP, Best R, Schwarz M, Russell DW, Björkhem I, Seckl J, and Lathe R (1997) Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7α-hydroxy dehydroepiandrosterone and 7α-hydroxy pregnenolone. Proc Natl Acad Sci USA 94:4925-4930. (Pubitemid 27214712)
20. Rosenkilde MM, Benned-Jensen T, Andersen H, Holst PJ, Kledal TN, Lüttichau HR, Larsen JK, Christensen JP, and Schwartz TW (2006) Molecular pharmacological phenotyping of EBI2: an orphan seven-transmembrane receptor with constitutive activity. J Biol Chem 281:13199-13208. (Pubitemid 43855231)
21. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, et al. (2003) The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci USA 100:4903-4908. (Pubitemid 36457826)
22. Worth CL, Kleinau G, and Krause G (2009) Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PLoS One 4:e7011.
23. Worth CL, Kreuchwig A, Kleinau G, and Krause G (2011) GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models. BMC Bioinformatics 12:185.
24. Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, et al. (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science 330:1066-1071.