Lead at 2.5 and 5.0μM induced aberrant MH-II surface expression through increased MII exocytosis and increased autophagosome formation in Raw 267.4 cells

Toxicology in Vitro

Volumn 27, Issue 3, 2013, Pages 1018-1024

  Kerr, R P ^a   Krunkosky, T M ^a   Hurley, D J ^a   Cummings, B S ^a   Holladay, S D ^a   Gogal, R M ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Antigen presenting cell; Autophagy; Endosomal trafficking; MHC II; MIIC exocytosis

Indexed keywords

ANTIBODY; B7 ANTIGEN; BETA N ACETYLHEXOSAMINIDASE; CD40 ANTIGEN; CD86 ANTIGEN; LC3B ANTIBODY; LEAD; LIPID; LIPOPOLYSACCHARIDE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; AUTOPHAGOSOME; CELL ACTIVITY; CELL MATURATION; CELL METABOLISM; CELL STRAIN; CELL STRAIN RAW 267.4; CELL SURFACE; CELL ULTRASTRUCTURE; CELL VACUOLE; CELL VIABILITY; CONFOCAL MICROSCOPY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; EX VIVO STUDY; EXOCYTOSIS; MACROAUTOPHAGY; METABOLIC REGULATION; MOUSE; MYELINATION; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN TRANSPORT; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; AUTOPHAGY; BETA-N-ACETYLHEXOSAMINIDASES; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; ENVIRONMENTAL POLLUTANTS; EXOCYTOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS II; LEAD; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MICE;

EID: 84874561506     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.01.018     Document Type: Article

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