Lead enhances CD4+ T cell proliferation indirectly by targeting antigen presenting cells and modulating antigen-specific interactions

Toxicology and Applied Pharmacology

Volumn 207, Issue 2, 2005, Pages 125-137

  Farrer, David G ^a   Hueber, Sara M ^a   McCabe Jr , Michael J ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Alloantigen; Antigen presenting cells; Immunotoxicity; Interleukin 2; Lead; Pb allo enhancement; Transgenic mice

Indexed keywords

ALLOANTIGEN; CONCANAVALIN A; LEAD; PARAFORMALDEHYDE;

ALLOIMMUNITY; ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; FEMALE; IMMUNOTOXICITY; MACROPHAGE; MIXED LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; T LYMPHOCYTE;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD11C; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; FEMALE; INTERLEUKIN-2; ISOANTIGENS; LEAD; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C;

ANIMALIA; MUS MUSCULUS;

EID: 23644446319     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.12.017     Document Type: Article

References (41)

1. H. Auchincloss Jr., R. Lee, S. Shea, J.S. Markowitz, M.J. Grusby, and L.H. Glimcher The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice Proc. Natl. Acad. Sci. U.S.A. 90 1993 3373 3377
2. N. Basaran, and U. Undeger Effects of lead on immune parameters in occupationally exposed workers Am. J. Ind. Med. 38 2000 349 354
3. P. Bedford, K. Garner, and S.C. Knight MHC class II molecules transferred between allogeneic dendritic cells stimulate primary mixed leukocyte reactions Int. Immunol. 11 1999 1739 1744
4. B. Bishayi, and M. Sengupta Intracellular survival of Staphylococcus aureus due to alteration of cellular activity in arsenic and lead intoxicated mature Swiss albino mice Toxicology 184 2003 31 39
5. P. Boscolo, M. Di Gioacchino, E. Sabbioni, F. Benvenuti, P. Conti, M. Reale, P. Bavazzano, and G. Giuliano Expression of lymphocyte subpopulations, cytokine serum levels, and blood and urinary trace elements in asymptomatic atopic men exposed to an urban environment Int. Arch. Occup. Environ. Health 72 1999 26 32
6. R.L. Canfield, C.R. Henderson Jr., D.A. Cory-Slechta, C. Cox, T.A. Jusko, and B.P. Lanphear Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter N. Engl. J. Med. 348 2003 1517 1526
7. Centers for Disease Control and Prevention Childhood Lead Poisoning 2003 http://www.cdc.gov/exposurereport/2nd/lead_factsheet.htm
8. A. Fischbein, P. Tsang, J.C. Luo, J.P. Roboz, J.D. Jiang, and J.G. Bekesi Phenotypic aberrations of CD3+ and CD4+ cells and functional impairments of lymphocytes at low-level occupational exposure to lead Clin. Immunol. Immunopathol. 66 1993 163 168
9. B.L. Gulson, and I.C. Calder Lead mobilisation during pregnancy Med. J. Aust. 163 1995 447
10. B.L. Gulson, C.W. Jameson, K.R. Mahaffey, K.J. Mizon, M.J. Korsch, and G. Vimpani Pregnancy increases mobilization of lead from maternal skeleton J. Lab. Clin. Med. 130 1997 51 62
11. B.L. Gulson, K.R. Mahaffey, C.W. Jameson, K.J. Mizon, M.J. Korsch, M.A. Cameron, and J.A. Eisman Mobilization of lead from the skeleton during the postnatal period is larger than during pregnancy J. Lab. Clin. Med. 131 1998 324 329
12. B.L. Gulson, K.J. Mizon, M.J. Korsch, J.M. Palmer, and J.B. Donnelly Mobilization of lead from human bone tissue during pregnancy and lactation-a summary of long-term research Sci. Total Environ. 303 2003 79 104
13. L.A. Harshyne, S.C. Watkins, A. Gambotto, and S.M. Barratt-Boyes Dendritic cells acquire antigens from live cells for cross-presentation to CTL J. Immunol. 166 2001 3717 3723
14. K. Haskins, R. Kubo, J. White, M. Pigeon, J. Kappler, and P. Marrack The major histocompatibility complex-restricted antigen receptor on T cells: I. Isolation with a monoclonal antibody J. Exp. Med. 157 1983 1149 1169
15. Y. Heo, W.T. Lee, and D.A. Lawrence In vivo the environmental pollutants lead and mercury induce oligoclonal T cell responses skewed toward type-2 reactivities Cell Immunol. 179 1997 185 195
16. O.B. Herrera, D. Golshayan, R. Tibbott, F.S. Ochoa, M.J. James, F.M. Marelli-Berg, and R.I. Lechler A novel pathway of alloantigen presentation by dendritic cells J. Immunol. 173 2004 4828 4837
17. Z. Krocova, A. Macela, M. Kroca, and L. Hernychova The immunomodulatory effect(s) of lead and cadmium on the cells of immune system in vitro Toxicol. In Vitro 14 2000 33 40
18. D.A. Lawrence In vivo and in vitro effects of lead on humoral and cell-mediated immunity Infect. Immun. 31 1981 136 143
19. R.I. Lechler, and J.R. Batchelor Immunogenicity of retransplanted rat kidney allografts. Effect of inducing chimerism in the first recipient and quantitative studies on immunosuppression of the second recipient J. Exp. Med. 156 1982 1835 1841
20. J.E. Lee, S. Chen, K.A. Golemboski, P.J. Parsons, and R.R. Dietert Developmental windows of differential lead-induced immunotoxicity in chickens Toxicology 156 2001 161 170
21. P.M. Lutz, T.J. Wilson, J. Ireland, A.L. Jones, J.S. Gorman, N.L. Gale, J.C. Johnson, and J.E. Hewett Elevated immunoglobulin E (IgE) levels in children with exposure to environmental lead Toxicology 134 1999 63 78
22. M.J. McCabe Jr., and D.A. Lawrence The heavy metal lead exhibits B cell-stimulatory factor activity by enhancing B cell Ia expression and differentiation J. Immunol. 145 1990 671 677
23. M.J. McCabe Jr., K.P. Singh, and J.J. Reiners Jr. Low level lead exposure in vitro stimulates the proliferation and expansion of alloantigen-reactive CD4(high) T cells Toxicol. Appl. Pharmacol. 177 2001 219 231
24. S. Razani-Boroujerdi, B. Edwards, and M.L. Sopori Lead stimulates lymphocyte proliferation through enhanced T cell-B cell interaction J. Pharmacol. Exp. Ther. 288 1999 714 719
25. J.M. Robertson, P.E. Jensen, and B.D. Evavold DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope J. Immunol. 164 2000 4706 4712
26. N.W. Roehm, P. Marrack, and J.W. Kappler Antigen-specific, H-2-restricted helper T cell hybridomas J. Exp. Med. 156 1982 191 204
27. V. Russo, D. Zhou, C. Sartirana, P. Rovere, A. Villa, S. Rossini, C. Traversari, and C. Bordignon Acquisition of intact allogeneic human leukocyte antigen molecules by human dendritic cells Blood 95 2000 3473 3477
28. M. Sengupta, and B. Bishayi Effect of lead and arsenic on murine macrophage response Drug Chem. Toxicol. 25 2002 459 472
29. A. Sette, S. Buus, S. Colon, J.A. Smith, C. Miles, and H.M. Grey Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells Nature 328 1987 395 399
30. X. Shen, K. Lee, and R. Konig Effects of heavy metal ions on resting and antigen-activated CD4(+) T cells Toxicology 169 2001 67 80
31. D.A. Shoskes, and K.J. Wood Indirect presentation of MHC antigens in transplantation Immunol. Today 15 1994 32 38
32. E.K. Silbergeld, J. Schwartz, and K. Mahaffey Lead and osteoporosis: mobilization of lead from bone in postmenopausal women Environ. Res. 47 1988 79 94
33. E.K. Silbergeld, J. Sauk, M. Somerman, A. Todd, F. McNeill, B. Fowler, A. Fontaine, and J. van Buren Lead in bone: storage site, exposure source, and target organ Neurotoxicology 14 1993 225 236
34. K.L. Smith, and D.A. Lawrence Immunomodulation of in vitro antigen presentation by cations Toxicol. Appl. Pharmacol. 96 1988 476 484
35. J.S. Song, S.Y. Sim, D.P. Hong, S. Dal Rhee, C.W. Song, S.S. Han, and S.D. Yang Lead treatment in vitro at early developmental stage of bone marrow-derived macrophages enhances NO production through IL-1beta and IL-6 but not TNF-alpha Toxicology 162 2001 61 68
36. E.J. Suchin, P.B. Langmuir, E. Palmer, M.H. Sayegh, A.D. Wells, and L.A. Turka Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question J. Immunol. 166 2001 973 981
37. L. Tian, and D.A. Lawrence Lead inhibits nitric oxide production in vitro by murine splenic macrophages Toxicol. Appl. Pharmacol. 132 1995 156 163
38. L. Tian, and D.A. Lawrence Metal-induced modulation of nitric oxide production in vitro by murine macrophages: lead, nickel, and cobalt utilize different mechanisms Toxicol. Appl. Pharmacol. 141 1996 540 547
39. R. Villanueva, R. Albaladejo, P. Ortega, P. Astasio, M.E. Calle, A. Gil, B. Granados, and V. Dominguez-Rojas Adherence of mouse peritoneal macrophages following exposure to lead Ind. Health 35 1997 291 293
40. R. Villanueva, R. Albaladejo, P. Ortega, P. Astasio, A. Gil, M.E. Calle, and V. Dominguez-Rojas Chemotaxis of mouse peritoneal macrophages following exposure to lead Bull. Environ. Contam. Toxicol. 59 1997 159 163
41. J. White, K.M. Haskins, P. Marrack, and J. Kappler Use of I region-restricted, antigen-specific T cell hybridomas to produce idiotypically specific anti-receptor antibodies J. Immunol. 130 1983 1033 1037