Stages of pathological tau-protein processing in Alzheimer's disease: From soluble aggregations to polymerization into insoluble tau-PHFs

Current Hypotheses and Research Milestones in Alzheimer's Disease

Volumn , Issue , 2009, Pages 79-91

  Mena, Raúl ^a   Luna Muñoz, José ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84874457654     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-87995-6_7     Document Type: Chapter

References (40)

1. Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42: 631-639
2. Kidd M (1963) Paired helical filaments in electron microscopy of Alzheimer's disease. Nature 197: 192-193
3. Kondo J, Honda T, Mori H,. et al. (1988) The carboxyl third of tau is tightly bound to paired helical filaments. Neuron 1: 827-834
4. Braak E, Braak H, Mandelkow EM (1994) A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol 87: 554-567
5. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239-259
6. Mena R, Edwards PC, Harrington CR,. et al. (1996) Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's disease. Acta Neuropathol 91: 633-641
7. Goedert M, Jakes R, Crowther RA,. et al. (1993) The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. Proc Natl Acad Sci USA 90: 5066-5070
8. Novak M, Kabat J, Wischik CM (1993) Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament. EMBO J 12: 365-370
9. Trojanowski JQ, Schmidt ML, Shin RW,. et al. (1993) Altered tau and neurofilament proteins in neuro-degenerative diseases: Diagnostic implications for Alzheimer's disease and Lewy body dementias. Brain Pathol 3: 45-54
10. Wischik CM, Novak M, Edwards PC,. et al. (1988) Structural characterization of the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci USA 85: 4884-4888
11. Jicha GA, Berenfeld B, Davies P (1999) Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease. J Neurosci Res 55: 713-723
12. Jicha GA, Bowser R, Kazam IG,. et al. (1997) Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau. J Neurosci Res 48: 128-132
13. Jicha GA, Lane E, Vincent I,. et al. (1997) A conformation-And phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease. J Neurochem 69: 2087-2095
14. Luna-Muñoz J, García-Sierra F, Falcón V,. et al. (2005) Regional conformational change involving phosphorylation of tau protein at the Thr231, precedes the structural change detected by Alz-50 antibody in Alzheimer's disease. J Alzheimers Dis 8: 29-41
15. Skrabana R, Kontsek P, Mederlyova A,. et al. (2004) Folding of Alzheimer's core PHF subunit revealed by monoclonal antibody 423. FEBS Lett 568: 178-182
16. Mena R, Wischik CM, Novak M,. et al. (1991) A progressive deposition of paired helical filaments (PHF) in the brain characterizes the evolution of dementia in Alzheimer's disease. An immunocytochemical study with a monoclonal antibody against the PHF core. J Neuropathol Exp Neurol 50: 474-490
17. Fasulo L, Ugolini G, Visintin M,. et al. (2000) The neuronal microtubule-Associated protein tau is a substrate for caspase-3 and an effector of apoptosis. J Neurochem 75: 624-633
18. Gamblin TC, Berry RW, Binder LI (2003) Modeling tau polymerization in vitro: A review and synthesis. Biochemistry 42: 15009-15017
19. Gamblin TC, Chen F, Zambrano A,. et al. (2003) Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci USA 100: 10032-10037
20. Guillozet-Bongaarts AL, Cahill ME, Cryns VL,. et al. (2006) Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: In vitro evidence and implications for tangle formation in vivo. J Neurochem 97: 1005-1014
21. Guillozet-Bongaarts AL, Garcia-Sierra F, Reynolds MR,. et al. (2005) Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease. Neurobiol Aging 26: 1015-1022
22. García-Sierra F, Ghoshal N, Quinn B,. et al. (2003) Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease. J Alzheimers Dis 5: 65-77
23. Bancher C, Brunner C, Lassmann H,. et al. (1989) Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease. Brain Res 477: 90-99
24. Augustinack JC, Schneider A, Mandelkow EM,. et al. (2002) Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol 103: 26-35
25. Luna-Muñoz J, Chávez-Macías L, García-Sierra F,. et al. (2007) Earliest stages of tau conformational changes are related to the appearance of a sequence of specific phospho-dependent tau epitopes in Alzheimer's disease. J Alzheimers Dis 12: 365-375
26. Berry RW, Abraha A, Lagalwar S,. et al. (2003) Inhibition of tau polymerization by its carboxyterminal caspase cleavage fragment. Biochemistry 42: 8325-8331
27. Gamblin TC, Berry RW, Binder LI (2003) Tau polymerization: Role of the amino terminus. Biochemistry 42: 2252-2257
28. Wischik CM, Edwards PC, Lai RY,. et al. (1995) Quantitative analysis of tau protein in paired helical filament preparations: Implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer's disease. Neurobiol Aging 16: 409-417
29. Mena R, Edwards P, Pérez-Olvera O,. et al. (1995) Monitoring pathological assembly of tau and beta-Amyloid proteins in Alzheimer's disease. Acta Neuropathol 89: 50-56
30. Mondragón-Rodríguez S, Basurto-Islas G, Santa-Maria I,. et al. (2008) Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease. Int J Exp Pathol 89: 81-90
31. Carmel G, Mager EM, Binder LI,. et al. (1996) The structural basis of monoclonal antibody Alz50s selectivity for Alzheimer's disease pathology. J Biol Chem 271: 32789-32795
32. Uchihara T, Nakamura A, Yamazaki M,. et al. (2001) Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence. Acta Neuropathol 101: 535-539
33. García-Sierra F, Wischik CM, Harrington CR,. et al. (2001) Accumulation of C-Terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease. J Chem Neuroanat 22: 65-77
34. Novak M (1994) Truncated tau protein as a new marker for Alzheimer's disease. Acta Virol 38: 173-189
35. Vincent I, Zheng JH, Dickson DW,. et al. (1998) Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease. Neurobiol Aging 19: 287-296
36. Zheng-Fischhöfer Q, Biernat J, Mandelkow EM,. et al. (1998) Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation. Eur J Biochem 252: 542-552
37. Weaver CL, Espinoza M, Kress Y,. et al. (2000) Conformational change as one of the earliest alterations of tau in Alzheimer's disease. Neurobiol Aging 21: 719-727
38. Novak M, Wischik CM, Edwards P,. et al. (1989) Characterisation of the first monoclonal antibody against the pronase resistant core of the Alzheimer PHF. Prog Clin Biol Res 317: 755-761
39. Abraha A, Ghoshal N, Gamblin TC,. et al. (2000) C-Terminal inhibition of tau assembly in vitro and in Alzheimer's disease. J Cell Sci 113 Pt. 21: 3737-3745
40. Galván M, David JP, Delacourte A,. et al. (2001) Sequence of neurofibrillary changes in aging and Alzheimer's disease: A confocal study with phospho-Tau antibody, AD2. J Alzheimers Dis 3: 417-425