Medications as a potential source of exposure to phthalates among women of childbearing age

Reproductive Toxicology

Volumn 37, Issue , 2013, Pages 1-5

  Hernández Díaz, Sonia ^a   Su, Yung Cheng ^a,b   Mitchell, Allen A ^c   Kelley, Katherine E ^c   Calafat, Antonia M ^d   Hauser, Russ ^a,e  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c BOSTON UNIVERSITY   (United States)

^d NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Male reproductive system; Medications; Mesalamine; Phthalate; Toxicology

Indexed keywords

CYCLOBENZAPRINE; MESALAZINE; OMEPRAZOLE; PHTHALIC ACID BUTYL ESTER; PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DIBUTYL ESTER; PHTHALIC ACID DIETHYL ESTER; PHTHALIC ACID ETHYL ESTER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONCEPTION; CONTROLLED STUDY; DRUG USE; FEMALE; HUMAN; LONG TERM EXPOSURE; METABOLITE; OUTCOME ASSESSMENT; PREGNANCY OUTCOME; PREGNANT WOMAN; URINALYSIS; URINE LEVEL; WOMEN'S HEALTH;

ADOLESCENT; ADULT; AMITRIPTYLINE; DRUG UTILIZATION; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; MESALAMINE; MIDDLE AGED; OMEPRAZOLE; PHTHALIC ACIDS; PREGNANCY; YOUNG ADULT;

EID: 84874443532     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2013.01.001     Document Type: Article

References (19)

1. Hauser R., Calafat A.M. Phthalates and human health. Occupational and Environmental Medicine 2005, 62:806-818.
2. CDC. Fourth National Report on Human Exposure to Environmental Chemicals. Updated Tables JA, GA: Centers for Disease Control and Prevention; National Center for Environmental Health; Division of Laboratory Sciences. 2010. http://www.cdc.gov/exposurereport/.
3. Saillenfait A.M., Payan J.P., Fabry J.P., Beydon D., Langonne I., Gallissot F., et al. Assessment of the developmental toxicity, metabolism, and placental transfer of Di-n-butyl phthalate administered to pregnant rats. Toxicological Sciences 1998, 45:212-224.
4. Vo T.T., Jung E.M., Dang V.H., Yoo Y.M., Choi K.C., Yu F.H., et al. Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats. Reproductive Biology and Endocrinology 2009, 7:104.
5. Gray L.E., Ostby J., Furr J., Price M., Veeramachaneni D.N., Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicological Sciences 2000, 58:350-365.
6. Parks L.G., Ostby J.S., Lambright C.R., Abbott B.D., Klinefelter G.R., Barlow N.J., et al. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicological Sciences 2000, 58:339-349.
7. Swan S.H., Main K.M., Liu F., Stewart S.L., Kruse R.L., Calafat A.M., et al. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environmental Health Perspectives 2005, 113:1056-1061.
8. Hotchkiss A.K., Parks-Saldutti L.G., Ostby J.S., Lambright C., Furr J., Vandenbergh J.G., et al. A mixture of the " antiandrogens" linuron and butyl benzyl phthalate alters sexual differentiation of the male rat in a cumulative fashion. Biology of Reproduction 2004, 71:1852-1861.
9. Hauser R., Duty S., Godfrey-Bailey L., Calafat A.M. Medications as a source of human exposure to phthalates. Environmental Health Perspectives 2004, 112:751-753.
10. Hernandez-Diaz S., Mitchell A.A., Kelley K.E., Calafat A.M., Hauser R. Medications as a potential source of exposure to phthalates in the U.S. population. Environmental Health Perspectives 2009, 117:185-189.
11. Koch H., Drexler M.J., Angerer H.J. Dibutylphthalate (DBP) in medications: are pregnant women and infants at risk?. Umweltmed Forsch Prax 2005, 10:144-146.
12. Seckin E., Fromme H., Volkel W. Determination of total and free mono-n-butyl phthalate in human urine samples after medication of a di-n-butyl phthalate containing capsule. Toxicology Letters 2009, 188:33-37.
13. Silva M.J., Samandar E., Preau J.L., Reidy J.A., Needham L.L., Calafat A.M. Quantification of 22 phthalate metabolites in human urine. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2007, 860:106-112.
14. Kato K., Silva M.J., Needham L.L., Calafat A.M. Determination of 16 phthalate metabolites in urine using automated sample preparation and on-line preconcentration/high-performance liquid chromatography/tandem mass spectrometry. Analytical Chemistry 2005, 77:2985-2991.
15. Caudill S.P., Schleicher R.L., Pirkle J.L. Multi-rule quality control for the age-related eye disease study. Statistics in Medicine 2008, 27:4094-4106.
16. Barr D.B., Silva M.J., Kato K., Reidy J.A., Malek N.A., Hurtz D., et al. Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers. Environmental Health Perspectives 2003, 111:1148-1151.
17. Calafat A.M., Silva M.J., Reidy J.A., Earl Gray L., Samandar E., Preau J.L., et al. Mono-(3-carboxypropyl) phthalate, a metabolite of di-n-octyl phthalate. Journal of Toxicology and Environmental Health. Part A 2006, 69:215-227.
18. Silva M.J., Samandar E., Reidy J.A., Hauser R., Needham L.L., Calafat A.M. Metabolite profiles of di-n-butyl phthalate in humans and rats. Environmental Science and Technology 2007, 41:7576-7580.
19. Marsee K., Woodruff T.J., Axelrad D.A., Calafat A.M., Swan S.H. Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance. Environmental Health Perspectives 2006, 114:805-809.