메뉴 건너뛰기




Volumn 344, Issue 3, 2013, Pages 561-567

Cannabinoid discrimination and antagonism by CB1 neutral and inverse agonist antagonists

Author keywords

[No Author keywords available]

Indexed keywords

AM 4054; AM 4113; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 1 RECEPTOR ANTAGONIST; DRONABINOL; RIMONABANT; UNCLASSIFIED DRUG;

EID: 84874441447     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.201962     Document Type: Article
Times cited : (41)

References (48)
  • 4
    • 0023878607 scopus 로고
    • Behavioral effects of histamine H1 antagonists: Comparison with other drugs and modification by haloperidol
    • Bergman J and Spealman RD (1988) Behavioral effects of histamine H1 antagonists: Comparison with other drugs and modification by haloperidol. J Pharmacol Exp Ther 245:471-478.
    • (1988) J Pharmacol Exp Ther , vol.245 , pp. 471-478
    • Bergman, J.1    Spealman, R.D.2
  • 5
    • 0033808151 scopus 로고    scopus 로고
    • Cannabinoid agonist signal transduction in rat brain: Comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition
    • Breivogel CS and Childers SR (2000) Cannabinoid agonist signal transduction in rat brain: Comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition. J Pharmacol Exp Ther 295:328-336.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 328-336
    • Breivogel, C.S.1    Childers, S.R.2
  • 6
    • 0030901709 scopus 로고    scopus 로고
    • Delta 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain
    • Burkey TH, Quock RM, Consroe P, Roeske WR, and Yamamura HI (1997) delta 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain. Eur J Pharmacol 323:R3-R4.
    • (1997) Eur J Pharmacol , vol.323
    • Burkey, T.H.1    Quock, R.M.2    Consroe, P.3    Roeske, W.R.4    Yamamura, H.I.5
  • 10
    • 0030423694 scopus 로고    scopus 로고
    • In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): Inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity
    • Compton DR, Aceto MD, Lowe J, and Martin BR (1996) In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): Inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity. J Pharmacol Exp Ther 277:586-594.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 586-594
    • Compton, D.R.1    Aceto, M.D.2    Lowe, J.3    Martin, B.R.4
  • 11
    • 84874412956 scopus 로고    scopus 로고
    • Behavioral effects of cannabinoid and non-cannabinoid drugs during chronic CB1 agonist treatment
    • DOI:10.1124/jpet.112.198374 [published ahead of print]
    • Desai RI, Thakur GA, Vemuri VK, Bajaj S, Makriyannis A, and Bergman J (2012) Behavioral effects of cannabinoid and non-cannabinoid drugs during chronic CB1 agonist treatment. J Pharmacol Exp Ther DOI:10.1124/jpet.112.198374 [published ahead of print].
    • J Pharmacol Exp Ther , vol.2012
    • Desai, R.I.1    Thakur, G.A.2    Vemuri, V.K.3    Bajaj, S.4    Makriyannis, A.5    Bergman, J.6
  • 12
    • 27844463517 scopus 로고    scopus 로고
    • Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • Rimonabant in Obesity-Lipids Study Group
    • Després JP, Golay A, and Sjöström L; Rimonabant in Obesity-Lipids Study Group (2005) Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 353:2121-2134.
    • (2005) N Engl J Med , vol.353 , pp. 2121-2134
    • Després, J.P.1    Golay, A.2    Sjöström, L.3
  • 13
    • 0023731706 scopus 로고
    • Discriminative and analgesic effects of mu and kappa opioids: In vivo pA2 analysis
    • (Colpaert FC and Balster RL eds), Springer-Verlag, Berlin
    • Dykstra LA, Bertalmio AJ, and Woods JH (1988) Discriminative and analgesic effects of mu and kappa opioids: In vivo pA2 analysis, in Transduction Mechanisms of Drug Stimuli (Colpaert FC and Balster RL eds) pp 107-121, Springer-Verlag, Berlin.
    • (1988) Transduction Mechanisms of Drug Stimuli , pp. 107-121
    • Dykstra, L.A.1    Bertalmio, A.J.2    Woods, J.H.3
  • 15
    • 0014545381 scopus 로고
    • Arterial hypertension in the squirrel monkey during behavioral experiments
    • Herd JA, Morse WH, Kelleher RT, and Jones LG (1969) Arterial hypertension in the squirrel monkey during behavioral experiments. Am J Physiol 217:24-29.
    • (1969) Am J Physiol , vol.217 , pp. 24-29
    • Herd, J.A.1    Morse, W.H.2    Kelleher, R.T.3    Jones, L.G.4
  • 16
    • 84858450136 scopus 로고    scopus 로고
    • AM2389, a high-affinity, in vivo potent CB1-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice
    • Järbe TUC, Tai S, LeMay BJ, Nikas SP, Shukla VG, Zvonok A, and Makriyannis A (2012) AM2389, a high-affinity, in vivo potent CB1-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice. Psychopharmacology (Berl) 220:417-426.
    • (2012) Psychopharmacology (Berl , vol.220 , pp. 417-426
    • Järbe, T.U.C.1    Tai, S.2    LeMay, B.J.3    Nikas, S.P.4    Shukla, V.G.5    Zvonok, A.6    Makriyannis, A.7
  • 17
    • 0034939394 scopus 로고    scopus 로고
    • (R)-Methanandamide and Delta 9-THC as discriminative stimuli in rats: Tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide
    • Järbe TUC, Lamb RJ, Lin S, and Makriyannis A (2001) (R)-methanandamide and Delta 9-THC as discriminative stimuli in rats: Tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide. Psychopharmacology (Berl) 156:369-380.
    • (2001) Psychopharmacology (Berl , vol.156 , pp. 369-380
    • Järbe, T.U.C.1    Lamb, R.J.2    Lin, S.3    Makriyannis, A.4
  • 18
    • 84864871340 scopus 로고    scopus 로고
    • Pro-depressantlike effects of CB1 receptor inverse agonists/antagonists in male Sprague-Dawley rats (Abstract
    • Jutkiewicz EM, Makriyannis A, Vemuri K, and Bergman J (2010) Pro-depressantlike effects of CB1 receptor inverse agonists/antagonists in male Sprague-Dawley rats (Abstract). FASEB J 24 (Suppl):581.7.
    • (2010) FASEB J , vol.24 , Issue.SUPPL. , pp. 5817
    • Jutkiewicz, E.M.1    Makriyannis, A.2    Vemuri, K.3    Bergman, J.4
  • 19
    • 84858984433 scopus 로고    scopus 로고
    • CB1 receptor antagonists: New discoveries leading to new perspectives
    • Kirilly E, Gonda X, and Bagdy G (2012) CB1 receptor antagonists: New discoveries leading to new perspectives. Acta Physiol (Oxf) 205:41-60.
    • (2012) Acta Physiol (Oxf , vol.205 , pp. 41-60
    • Kirilly, E.1    Gonda, X.2    Bagdy, G.3
  • 20
    • 0343239120 scopus 로고    scopus 로고
    • Effects of D 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily D 9-tetrahydrocannabinol dosing
    • Lamb RJ, Järbe TUC, Makriyannis A, Lin S, and Goutopoulos A (2000) Effects of D 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily D 9-tetrahydrocannabinol dosing. Eur J Pharmacol 398: 251-258.
    • (2000) Eur J Pharmacol , vol.398 , pp. 251-258
    • Lamb, R.J.1    Järbe, T.U.C.2    Makriyannis, A.3    Lin, S.4    Goutopoulos, A.5
  • 21
    • 43749103982 scopus 로고    scopus 로고
    • Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: Insights from pre-clinical and clinical studies
    • Le Foll B, Forget B, Aubin HJ, and Goldberg SR (2008) Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: Insights from pre-clinical and clinical studies. Addict Biol 13:239-252.
    • (2008) Addict Biol , vol.13 , pp. 239-252
    • Le Foll, B.1    Forget, B.2    Aubin, H.J.3    Goldberg, S.R.4
  • 22
    • 84864869951 scopus 로고    scopus 로고
    • Reports of the death of CB1 antagonists have been greatly exaggerated: Recent preclinical findings predict improved safety in the treatment of obesity
    • McLaughlin PJ (2012) Reports of the death of CB1 antagonists have been greatly exaggerated: Recent preclinical findings predict improved safety in the treatment of obesity. Behav Pharmacol 23:537-550.
    • (2012) Behav Pharmacol , vol.23 , pp. 537-550
    • McLaughlin, P.J.1
  • 23
    • 33751182888 scopus 로고    scopus 로고
    • Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating D9-tetrahydrocannabinol
    • McMahon LR (2006a) Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating D9-tetrahydrocannabinol. J Pharmacol Exp Ther 319:1211-1218.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 1211-1218
    • McMahon, L.R.1
  • 24
    • 33748663275 scopus 로고    scopus 로고
    • Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with D9-tetrahydrocannabinol
    • McMahon LR (2006b) Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with D9- tetrahydrocannabinol. Psychopharmacology (Berl) 188:306-314.
    • (2006) Psychopharmacology (Berl , vol.188 , pp. 306-314
    • McMahon, L.R.1
  • 25
    • 26044474696 scopus 로고    scopus 로고
    • SR 141716A differentially attenuates the behavioral effects of delta9-THC in rhesus monkeys
    • McMahon LR, Amin MR, and France CP (2005) SR 141716A differentially attenuates the behavioral effects of delta9-THC in rhesus monkeys. Behav Pharmacol 16:363-372.
    • (2005) Behav Pharmacol , vol.16 , pp. 363-372
    • McMahon, L.R.1    Amin, M.R.2    France, C.P.3
  • 26
    • 84888290970 scopus 로고    scopus 로고
    • Neutral antagonism at the cannabinoid 1 receptor: A safer treatment for obesity
    • DOI: 10.1038/mp.2012.145 [published ahead of print]
    • Meye FJ, Trezza V, Vanderschuren LJ, Ramakers GM, and Adan RA (2012) Neutral antagonism at the cannabinoid 1 receptor: A safer treatment for obesity. Mol Psychiatry DOI: 10.1038/mp.2012.145 [published ahead of print].
    • (2012) Mol Psychiatry
    • Meye, F.J.1    Trezza, V.2    Vanderschuren, L.J.3    Ramakers, G.M.4    Adan, R.A.5
  • 29
    • 0345490945 scopus 로고    scopus 로고
    • International union of pharmacology committee on receptor nomenclature and drug classification
    • International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology
    • Neubig RR, Spedding M, Kenakin T, and Christopoulos A; International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification (2003) International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacol Rev 55:597-606.
    • (2003) Pharmacol Rev , vol.55 , pp. 597-606
    • Neubig, R.R.1    Spedding, M.2    Kenakin, T.3    Christopoulos, A.4
  • 30
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • Pacher P, Bátkai S, and Kunos G (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58:389-462.
    • (2006) Pharmacol Rev , vol.58 , pp. 389-462
    • Pacher, P.1    Bátkai, S.2    Kunos, G.3
  • 31
    • 33845874637 scopus 로고    scopus 로고
    • Drug treatments for obesity: Orlistat, sibutramine, and rimonabant
    • Padwal RS and Majumdar SR (2007) Drug treatments for obesity: Orlistat, sibutramine, and rimonabant. Lancet 369:71-77.
    • (2007) Lancet , vol.369 , pp. 71-77
    • Padwal, R.S.1    Majumdar, S.R.2
  • 32
    • 0032588314 scopus 로고    scopus 로고
    • Apparent pA2 values of benzodiazepine antagonists and partial agonists in monkeys
    • Paronis CA and Bergman J (1999) Apparent pA2 values of benzodiazepine antagonists and partial agonists in monkeys. J Pharmacol Exp Ther 290:1222-1229.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 1222-1229
    • Paronis, C.A.1    Bergman, J.2
  • 33
    • 12744258029 scopus 로고    scopus 로고
    • Inverse agonism and neutral antagonism at cannabinoid CB1 receptors
    • Pertwee RG (2005) Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sci 76:1307-1324.
    • (2005) Life Sci , vol.76 , pp. 1307-1324
    • Pertwee, R.G.1
  • 34
    • 0032577340 scopus 로고    scopus 로고
    • Complex pharmacology of natural cannabinoids: Evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors
    • Petitet F, Jeantaud B, Reibaud M, Imperato A, and Dubroeucq MC (1998) Complex pharmacology of natural cannabinoids: Evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life Sci 63:PL1-PL6.
    • (1998) Life Sci , vol.63
    • Petitet, F.1    Jeantaud, B.2    Reibaud, M.3    Imperato, A.4    Dubroeucq, M.C.5
  • 36
    • 58349105218 scopus 로고    scopus 로고
    • A randomized controlled trial of adding the nicotine patch to rimonabant for smoking cessation: Efficacy, safety and weight gain
    • CIRRUS Study Group
    • Rigotti NA, Gonzales D, Dale LC, Lawrence D, and Chang Y; CIRRUS Study Group (2009) A randomized controlled trial of adding the nicotine patch to rimonabant for smoking cessation: Efficacy, safety and weight gain. Addiction 104:266-276.
    • (2009) Addiction , vol.104 , pp. 266-276
    • Rigotti, N.A.1    Gonzales, D.2    Dale, L.C.3    Lawrence, D.4    Chang, Y.5
  • 37
    • 34347336422 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor inverse agonists and neutral antagonists: Effects on food intake, food-reinforced behavior and food aversions
    • Salamone JD, McLaughlin PJ, Sink K, Makriyannis A, and Parker LA (2007) Cannabinoid CB1 receptor inverse agonists and neutral antagonists: Effects on food intake, food-reinforced behavior and food aversions. Physiol Behav 91:383-388.
    • (2007) Physiol Behav , vol.91 , pp. 383-388
    • Salamone, J.D.1    McLaughlin, P.J.2    Sink, K.3    Makriyannis, A.4    Parker, L.A.5
  • 38
    • 0032589801 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol acts as a partial agonist to modulate glutamatergic synaptic transmission between rat hippocampal neurons in culture
    • Shen M and Thayer SA (1999) Delta9-tetrahydrocannabinol acts as a partial agonist to modulate glutamatergic synaptic transmission between rat hippocampal neurons in culture. Mol Pharmacol 55:8-13.
    • (1999) Mol Pharmacol , vol.55 , pp. 8-13
    • Shen, M.1    Thayer, S.A.2
  • 39
    • 0029829841 scopus 로고    scopus 로고
    • Effects of chronic treatment with delta9-tetrahydrocannabinol on cannabinoid-stimulated [35S] GTPgammaS autoradiography in rat brain
    • Sim LJ, Hampson RE, Deadwyler SA, and Childers SR (1996) Effects of chronic treatment with delta9-tetrahydrocannabinol on cannabinoid-stimulated [35S] GTPgammaS autoradiography in rat brain. J Neurosci 16:8057-8066.
    • (1996) J Neurosci , vol.16 , pp. 8057-8066
    • Sim, L.J.1    Hampson, R.E.2    Deadwyler, S.A.3    Childers, S.R.4
  • 42
    • 0022180819 scopus 로고
    • Discriminative-stimulus effects of midazolam in squirrel monkeys: Comparison with other drugs and antagonism by Ro 15-1788
    • Spealman RD (1985) Discriminative-stimulus effects of midazolam in squirrel monkeys: Comparison with other drugs and antagonism by Ro 15-1788. J Pharmacol Exp Ther 235:456-462.
    • (1985) J Pharmacol Exp Ther , vol.235 , pp. 456-462
    • Spealman, R.D.1
  • 43
    • 34447574994 scopus 로고    scopus 로고
    • Panel advises against rimonabant approval
    • Traynor K (2007) Panel advises against rimonabant approval. Am J Health Syst Pharm 64:1460-1461.
    • (2007) Am J Health Syst Pharm , vol.64 , pp. 1460-1461
    • Traynor, K.1
  • 44
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
    • RIO-Europe Study Group
    • Van Gaal LF, Rissanen AM, Scheen AJ, Ziegler O, and Rössner S; RIO-Europe Study Group (2005) Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 365:1389-1397.
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.M.2    Scheen, A.J.3    Ziegler, O.4    Rössner, S.5
  • 45
    • 79959653392 scopus 로고    scopus 로고
    • Rimonabant redux and strategies to improve the future outlook of CB1 receptor neutral-antagonist/inverse-agonist therapies
    • Ward SJ and Raffa RB (2011) Rimonabant redux and strategies to improve the future outlook of CB1 receptor neutral-antagonist/inverse-agonist therapies. Obesity (Silver Spring) 19:1325-1334.
    • (2011) Obesity (Silver Spring , vol.19 , pp. 1325-1334
    • Ward, S.J.1    Raffa, R.B.2
  • 46
    • 0027456885 scopus 로고
    • Discriminative stimulus effects of delta 9-tetrahydrocannabinol and delta 9-11-tetrahydrocannabinol in rats and rhesus monkeys
    • Wiley JL, Barrett RL, Britt DT, Balster RL, and Martin BR (1993) Discriminative stimulus effects of delta 9-tetrahydrocannabinol and delta 9-11-tetrahydrocannabinol in rats and rhesus monkeys. Neuropharmacology 32:359-365.
    • (1993) Neuropharmacology , vol.32 , pp. 359-365
    • Wiley, J.L.1    Barrett, R.L.2    Britt, D.T.3    Balster, R.L.4    Martin, B.R.5
  • 47
    • 0028867110 scopus 로고
    • Antagonism of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rats and rhesus monkeys
    • Wiley JL, Lowe JA, Balster RL, and Martin BR (1995) Antagonism of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rats and rhesus monkeys. J Pharmacol Exp Ther 275:1-6.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 1-6
    • Wiley, J.L.1    Lowe, J.A.2    Balster, R.L.3    Martin, B.R.4
  • 48
    • 0026612135 scopus 로고
    • Use of in vivo apparent pA2 analysis in assessment of opioid abuse liability
    • Woods JH, Winger G, and France CP (1992) Use of in vivo apparent pA2 analysis in assessment of opioid abuse liability. Trends Pharmacol Sci 13:282-286.
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 282-286
    • Woods, J.H.1    Winger, G.2    France, C.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.