The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat

Pharmacology Biochemistry and Behavior

Volumn 97, Issue 3, 2011, Pages 537-543

  Cluny, Nina L ^a   Chambers, Adam P ^a,d   Vemuri, V Kiran ^b   Wood, Jodianne T ^b   Eller, Lindsay K ^c   Freni, Carmelina ^b   Reimer, Raylene A ^c   Makriyannis, Alexandros ^b   Sharkey, Keith A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b NORTHEASTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

2 AG; Cannabinoid; Food intake; Metabolism; Neutral cannabinoid antagonist; Pair feeding; Weight loss

Indexed keywords

2 ARACHIDONOYLGLYCEROL; AM 4113; CANNABINOID 1 RECEPTOR ANTAGONIST; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY FAT; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; FEEDING BEHAVIOR; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEROL BLOOD LEVEL; HYPOPHAGIA; HYPOTHALAMUS; LEAN BODY WEIGHT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT CONTROL; WEIGHT GAIN; WILD TYPE;

ABSORPTIOMETRY, PHOTON; ANIMALS; BODY WEIGHT; ENERGY METABOLISM; MALE; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1;

ANIMALIA; MUS; RATTUS;

EID: 78549281113     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.10.013     Document Type: Article

References (47)

1. M. Bensaid, M. Gary-Bobo, A. Esclangon, J.P. Maffrand, G. Le Fur, and F. Oury-Donat The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells Mol Pharmacol 63 2003 908 914 (Pubitemid 36368998)
2. M. Bluher, S. Engeli, N. Kloting, J. Berndt, M. Fasshauer, and S. Batkai Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity Diabetes 55 2006 3053 3060 (Pubitemid 44923642)
3. G. Burdyga, S. Lal, A. Varro, R. Dimaline, D.G. Thompson, and G.J. Dockray Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin J Neurosci 24 2004 2708 2715 (Pubitemid 38380947)
4. G. Burdyga, A. Varro, R. Dimaline, D.G. Thompson, and G.J. Dockray Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance Am J Physiol Gastrointest Liver Physiol 290 2006 G1289 G1297
5. A.P. Chambers, H.S. Koopmans, Q.J. Pittman, and K.A. Sharkey AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion Br J Pharmacol 147 2006 109 116 (Pubitemid 43069102)
6. A.P. Chambers, V.K. Vemuri, Y. Peng, J.T. Wood, T. Olszewska, and Q.J. Pittman A neutral CB1 receptor antagonist reduces weight gain in rat Am J Physiol Regul Integr Comp Physiol 293 2007 R2185 R2193
7. N.L. Cluny, V.K. Vemuri, A.P. Chambers, C.L. Limebeer, H. Bedard, J.T. Wood, B. Lutz, A. Zimmer, L.A. Parker, A. Makriyannis, and K.A. Sharkey A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents Br J Pharmacol 161 2010 629 642
8. G. Colombo, R. Agabio, G. Diaz, C. Lobina, R. Reali, and G.L. Gessa Appetite suppression and weight loss after the cannabinoid antagonist SR 141716 Life Sci 63 1998 L113 L117
9. D. Cota CB1 receptors: emerging evidence for central and peripheral mechanisms that regulate energy balance, metabolism, and cardiovascular health Diab Metab Res Rev 23 2007 507 517 (Pubitemid 350018024)
10. D. Cota, G. Marsicano, M. Tschop, Y. Grubler, C. Flachskamm, and M. Schubert The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis J Clin Invest 112 2003 423 431 (Pubitemid 38063771)
11. D. Cota, D.A. Sandoval, M. Olivieri, E. Prodi, D.A. D'Alessio, and S.C. Woods Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism Obesity (Silver Spring) 17 2009 1641 1645
12. M. Cote, I. Matias, I. Lemieux, S. Petrosino, N. Almeras, and J.P. Despres Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men Int J Obes (Lond) 31 2007 692 699 (Pubitemid 46482358)
13. J.P. Despres, A. Golay, and L. Sjostrom Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia N Engl J Med 353 2005 2121 2134 (Pubitemid 41653104)
14. C. Doyon, R.G. Denis, E.D. Baraboi, P. Samson, J. Lalonde, and Y. Deshaies Effects of rimonabant (SR141716) on fasting-induced hypothalamic-pituitary-adrenal axis and neuronal activation in lean and obese Zucker rats Diabetes 55 2006 3403 3410 (Pubitemid 44923599)
15. M. Duncan, J.S. Davison, and K.A. Sharkey Review article: endocannabinoids and their receptors in the enteric nervous system Aliment Pharmacol Ther 22 2005 667 683 (Pubitemid 41475329)
16. J. Folch, M. Lees, and G.H. Sloane Stanley A simple method for the isolation and purification of total lipides from animal tissues J Biol Chem 226 1957 497 509
17. R. Gómez, M. Navarro, B. Ferrer, J.M. Trigo, A. Bilbao, and I. Del Arco A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding J Neurosci 22 2002 9612 9617 (Pubitemid 35356203)
18. A.W. Herling, M. Gossel, G. Haschke, S. Stengelin, J. Kuhlmann, and G. Muller CB1 receptor antagonist AVE1625 affects primarily metabolic parameters independently of reduced food intake in Wistar rats Am J Physiol Endocrinol Metab 293 2007 E826 E832
19. A.W. Herling, S. Kilp, R. Elvert, G. Haschke, and W. Kramer Increased energy expenditure contributes more to the body weight-reducing effect of rimonabant than reduced food intake in candy-fed wistar rats Endocrinology 149 2008 2557 2566 (Pubitemid 351574492)
20. A.L. Hildebrandt, D.M. Kelly-Sullivan, and S.C. Black Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice Eur J Pharmacol 462 2003 125 132 (Pubitemid 36183743)
21. T.L. Horvath The unfolding cannabinoid story on energy homeostasis: central or peripheral site of action? Int J Obes (Lond) 30 Suppl 1 2006 S30 S32
22. N. Irwin, K. Hunter, N. Frizzell, and P.R. Flatt Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice Eur J Pharmacol 581 2008 226 233
23. P. Janiak, B. Poirier, J.P. Bidouard, C. Cadrouvele, F. Pierre, and L. Gouraud Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats Kidney Int 72 2007 1345 1357 (Pubitemid 350126778)
24. O. Jbilo, C. Ravinet-Trillou, M. Arnone, I. Buisson, E. Bribes, and A. Peleraux The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance FASEB J 19 2005 1567 1569 (Pubitemid 41279033)
25. T.C. Kirkham, and C.M. Williams Endogenous cannabinoids and appetite Nutr Res Rev 14 2001 65 86 (Pubitemid 32574404)
26. T.C. Kirkham, C.M. Williams, F. Fezza, and V. Di Marzo Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol Br J Pharmacol 136 2002 550 557 (Pubitemid 34717699)
27. A.H. Koolman, V.W. Bloks, M.H. Oosterveer, I. Jonas, F. Kuipers, and P.J. Sauer Metabolic responses to long-term pharmacological inhibition of CB1-receptor activity in mice in relation to dietary fat composition Int J Obes (Lond) 34 2010 374 384
28. I. Kunz, M.K. Meier, A. Bourson, M. Fisseha, and W. Schilling Effects of rimonabant, a cannabinoid CB1 receptor ligand, on energy expenditure in lean rats Int J Obes (Lond) 32 2008 863 870 (Pubitemid 351670628)
29. Y.L. Liu, I.P. Connoley, C.A. Wilson, and M.J. Stock Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice Int J Obes (Lond) 29 2005 183 187 (Pubitemid 40188413)
30. G. Marsicano, C.T. Wotjak, S.C. Azad, T. Bisogno, G. Rammes, and M.G. Cascio The endogenous cannabinoid system controls extinction of aversive memories Nature 418 2002 530 534 (Pubitemid 34851398)
31. E. Martin-Garcia, A. Burokas, M. Martin, F. Berrendero, B. Rubi, and C. Kiesselbach Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant J Neurochem 112 2010 1338 13351
32. I. Matias, and V. Di Marzo Endocannabinoid synthesis and degradation, and their regulation in the framework of energy balance J Endocrinol Investig 29 2006 15 26
33. R. Nogueiras, C. Veyrat-Durebex, P.M. Suchanek, M. Klein, J. Tschop, and C. Caldwell Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats Diabetes 57 2008 2977 2991
34. R. Nogueiras, A. Diaz-Arteaga, S.H. Lockie, D.A. Velasquez, J. Tschop, and M. Lopez The endocannabinoid system: role in glucose and energy metabolism Pharmacol Res 60 2009 93 98
35. D. Osei-Hyiaman, M. Depetrillo, P. Pacher, J. Liu, S. Radaeva, and S. Batkai Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity J Clin Invest 115 2005 1298 1305 (Pubitemid 40629049)
36. D. Osei-Hyiaman, J. Harvey-White, S. Batkai, and G. Kunos The role of the endocannabinoid system in the control of energy homeostasis Int J Obes (Lond) 30 Suppl 1 2006 S33 S38
37. F.X. Pi-Sunyer, L.J. Aronne, H.M. Heshmati, J. Devin, and J. Rosenstock Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial JAMA 295 2006 761 775 (Pubitemid 43244304)
38. P.A. Randall, V.K. Vemuri, K.N. Segovia, E.F. Torres, S. Hosmer, and E.J. Nunes The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior Pharmacol Biochem Behav 2010
39. C. Ravinet Trillou, M. Arnone, C. Delgorge, N. Gonalons, P. Keane, and J.P. Maffrand Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice Am J Physiol Regul Integr Comp Physiol 284 2003 R345 R353
40. K.S. Sink, P.J. McLaughlin, J.A. Wood, C. Brown, P. Fan, and V.K. Vemuri The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats Neuropsychopharmacology 33 2008 946 955 (Pubitemid 351252707)
41. K.M. Starowicz, L. Cristino, I. Matias, R. Capasso, A. Racioppi, and A.A. Izzo Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet Obesity (Silver Spring) 16 2008 553 565 (Pubitemid 351328005)
42. T. Sugiura, Y. Kobayashi, S. Oka, and K. Waku Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance Prostaglandins Leukot Essent Fatty Acids 66 2002 173 192 (Pubitemid 34743593)
43. Z.D. Thornton-Jones, G.A. Kennett, K.R. Benwell, D.F. Revell, A. Misra, and D.M. Sellwood The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake Pharmacol Biochem Behav 84 2006 353 359 (Pubitemid 44137303)
44. L.F. Van Gaal, A.M. Rissanen, A.J. Scheen, O. Ziegler, and S. Rossner Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study Lancet 365 2005 1389 1397 (Pubitemid 40523733)
45. S.P. Vickers, L.J. Webster, A. Wyatt, C.T. Dourish, and G.A. Kennett Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats Psychopharmacology (Berl) 167 2003 103 111 (Pubitemid 36535298)
46. J. Williams, J. Wood, L. Pandarinathan, D.A. Karanian, B.A. Bahr, and P. Vouros Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS Anal Chem 79 2007 5582 5593 (Pubitemid 47229803)
47. J.T. Wood, J.S. Williams, L. Pandarinathan, D.R. Janero, C.J. Lammi-Keefe, and A. Makriyannis Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma J Lipid Res 51 2010 1416 1423