Local autoantigen expression as essential gatekeeper of memory t-cell recruitment to islet grafts in diabetic hosts

Diabetes

Volumn 62, Issue 3, 2013, Pages 905-911

  Alkemade, Gonnie M ^a   Clemente Casares, Xavier ^a,b,c   Yu, Zhenguo ^a   Xu, Bao You ^a   Wang, Jinguo ^a   Tsai, Sue ^a   Wright, James R ^a   Roep, Bart O ^a,b   Santamaria, Pere ^a,d  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; GLUCOSE 6 PHOSPHATASE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CATALYSIS; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DIABETES MELLITUS; FLOW CYTOMETRY; IMMUNE RESPONSE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RECURRENT DISEASE; SYNGENEIC EXTRAPANCREATIC ISLET GRAFT; T LYMPHOCYTE; WILD TYPE;

ANIMALS; AUTOANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; EPITOPES; GLUCOSE-6-PHOSPHATASE; GRAFT SURVIVAL; IMMUNOLOGIC MEMORY; ISLETS OF LANGERHANS TRANSPLANTATION; KIDNEY; LYMPH NODES; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; PANCREAS; PEPTIDE FRAGMENTS; PROTEINS; SPLEEN; TRANSPLANTATION, HETEROTOPIC; TRANSPLANTATION, ISOGENEIC;

EID: 84874411828     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0600     Document Type: Article

References (24)

1. Babad J, Geliebter A, DiLorenzo TP. T-cell autoantigens in the non-obese diabetic mouse model of autoimmune diabetes. Immunology 2010;131:459-465
2. Anderson B, Park BJ, Verdaguer J, Amrani A, Santamaria P. Prevalent CD8 (+) T cell response against one peptide/MHC complex in autoimmune diabetes. Proc Natl Acad Sci USA 1999;96:9311-9316
3. DiLorenzo T, Graser T, Ono T, et al. Major histocompatibility complex class I-restricted T cells are required for all but end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement. Proc Natl Acad Sci USA 1998;95:12538-12543
4. Verdaguer J, Yoon JW, Anderson B, et al. Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-alpha chains. J Immunol 1996;157:4726-4735
5. Verdaguer J, Schmidt D, Amrani A, Anderson B, Averill N, Santamaria P. Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. J Exp Med 1997;186:1663-1676
6. Lieberman SM, Evans AM, Han B, et al. Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci USA 2003;100:8384-8388
7. Trudeau J, Kelly-Smith C, Verchere B, Finegood D, Santamaria P, Tan R. Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood. J Clin Invest 2003;111: 217-223
8. Amrani A, Verdaguer J, Serra P, Tafuro S, Tan R, Santamaria P. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature 2000;406:739-742
9. Stephens R, Randolph DA, Huang G, Holtzman MJ, Chaplin DD. Antigennonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma. J Immunol 2002;169:5458-5467
10. Ostler T, Pircher H, Ehl S. "Bystander" recruitment of systemic memory T cells delays the immune response to respiratory virus infection. Eur J Immunol 2003;33:1839-1848
11. Chen AM, Khanna N, Stohlman SA, Bergmann CC. Virus-specific and bystander CD8 T cells recruited during virus-induced encephalomyelitis. J Virol 2005;79:4700-4708
12. Wang J, Tsai S, Shameli A, Yamanouchi J, Alkemade G, Santamaria P. In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammation. Proc Natl Acad Sci USA 2010;107:9317-9322
13. Lukinius A, Jansson L, Korsgren O. Ultrastructural evidence for blood microvessels devoid of an endothelial cell lining in transplanted pancreatic islets. Am J Pathol 1995;146:429-435
14. Vajkoczy P, Menger MD, Simpson E, Messmer K. Angiogenesis and vascularization of murine pancreatic islet isografts. Transplantation 1995;60: 123-127
15. Morini S, Brown ML, Cicalese L, et al. Revascularization and remodelling of pancreatic islets grafted under the kidney capsule. J Anat 2007;210:565-577
16. Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC. Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes 1996;45:1161-1167
17. Tsai S, Shameli A, Yamanouchi J, et al. Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 2010;32:568-580
18. Serreze DV, Chapman HD, Varnum DS, Gerling I, Leiter EH, Shultz LD. Initiation of autoimmune diabetes in NOD/Lt mice is MHC class Idependent. J Immunol 1997;158:3978-3986
19. Coppieters KT, Dotta F, Amirian N, et al. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med 2012;209:51-60
20. Tailor P, Tsai S, Shameli A, et al. The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling. J Immunol 2008;181:243-255
21. Roep BO, Stobbe I, Duinkerken G, et al. Auto-and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients. Diabetes 1999;48:484-490
22. Huurman VA, Hilbrands R, Pinkse GG, et al. Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation. PLoS ONE 2008;3:e2435
23. Hilbrands R, Huurman VA, Gillard P, et al. Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients. Diabetes 2009; 58:2267-2276
24. Pinkse GG, Tysma OH, Bergen CA, et al. Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci USA 2005;102:18425-18430