Cell stress, hypoxic response and apoptosis in murine adriamycin-induced nephropathy

Journal of Pharmacology and Toxicology

Volumn 7, Issue 8, 2012, Pages 344-358

  Stoyanoff, Tania R ^a   Todaro, Juan S ^a   Aguirre, Maria V ^a   Brandan, Nora C ^a  

^a UNIVERSIDAD NACIONAL DEL NORDESTE   (Argentina)

Author keywords

Adriamycin induced nephropathy; Apoptosis; HIF l ; Hsp60; Inducible nitric oxide synthase; Renal hypoxia

Indexed keywords

CASPASE 3; CHAPERONIN 60; CREATININE; DOXORUBICIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; NITROGEN; PROTEIN BAX; PROTEIN BCL XL; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL STRESS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; HISTOPATHOLOGY; HYPOALBUMINEMIA; IN VIVO STUDY; INTERSTITIAL NEPHRITIS; KIDNEY CORTEX; KIDNEY ISCHEMIA; MALE; MOUSE; NEPHROTIC SYNDROME; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; PROTEINURIA; UREA NITROGEN BLOOD LEVEL;

EID: 84874405190     PISSN: 1816496X     EISSN: 2152100X     Source Type: Journal    
DOI: 10.3923/jpt.2012.344.358     Document Type: Article

References (41)

1. Aispuru, G.R., M.V. Aguirre, J.A. Aquino-Esperanza, C.N. Lettieri, J.A. Juaristi and N.C. Brandan, 2008. Erythroid expansion and survival in response to acute anemia stress: The role of EPO receptor, GATA-1, Bcl-xL and caspase-3. Cell Biol. Int., 32: 966-978.
2. Aquino-Esperanza, J.A., M.V. Aguirre, G.R. Aispuru, C.N. Lettieri, J.A. Juaristi, M.A. Alvarez and N.C. Brandan, 2008. In vivo 5-flourouracil-induced apoptosis on murine thymocytes: Involvement of FAS, Bax and Caspase3. Cell Biol. Toxicol., 24: 411-422.
3. Barbey, M.M., L.M. Fels, M. Soose, K. Poelstra, W. Gwinner, W. Bakker and H. Stolte, 1989. Adriamycin affects glomerular renal function: Evidence for the involvement of oxygen radicals. Free Radic. Res. Commun., 7: 195-203.
4. Beck, F., W. Neuhofer and E. Muller, 2000. Molecular chaperones in the kidney: Distribution, putative roles and regulation. Am. J. Renal. Physiol., 279: F203-F215.
5. Bertani, T., A. Poggi, R. Pozzoni, F. Delaini and G. Sacchi et al., 1982. Adriamycin-induced nephrotic syndrome in rats: Sequence of pathologic events. Lab. Invest., 46: 16-23.
6. Brenner, D. and T.W. Mak, 2009. Mitochondrial cell death effectors. Curr. Opin. Cell Biol., 21: 871-877.
7. Brune, B. and J. Zhou, 2003. The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1 α (HIF-1 α). Curr. Med. Chem., 10: 845-855.
8. Bukau, B. and A.L. Horwich, 1998. The Hsp70 and Hsp60 chaperone machines. Cell, 92: 351-366.
9. Chandra, D., G. Choy and D.G. Tang, 2007. Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release. J. Biol. Chem., 282: 31289-31301.
10. Chen, C.H., H. Lin, Y.H. Hsu, Y.M. Sue, T.H. Cheng, P. Chan and T.H. Chen, 2006. The protective effect of prostacyclin on adriamycin-induced apoptosis in rat renal tubular cells. Eur. J. Pharmacol., 529: 8-15.
11. Chien, C.T., S.K. Shyue and M.K. Lai, 2007. Bcl-xL augmentation potentially reduces ischemia/reperfusion induced proximal and distal tubular apoptosis and autophagy. Transplantation, 84: 1183-1190.
12. Dalkara, T. and A. Moskowitz, 1996. Programmed Cell Death and Nitric Oxide Toxicity: What is the Evidence? In: Pharmacology of Cerebral Ischemia, Krieglstin, J. and H. Oberpichler-Schwen (Eds.). Medpharm, Stuttgart, Germany, pp: 1-7.
13. Gupta, S. and A.A. Knowlton, 2002. Cytosolic heat shock protein 60, hypoxia and apoptosis. Circulation, 106: 2727-2733.
14. Hierholzer, C., B.G. Harbrecht, T.R. Billiar and D.J. Tweardy, 2001. Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock. Arch. Orthop. Trauma Surg., 121: 219-222.
15. Jeansson, M., K. Bjorck, O. Tenstad and B. Haraldson, 2009. Adriamycin alters glomerular endothelium to induce proteinuria. J. Am. Soc. Nephrol., 20: 114-122.
16. Kairaitis, L.K., Y. Wang, M. Gassmann, Y.C. Tay and D.C. Harris, 2005. HIF-1alpha expression follows microvascular loss in advanced murine adriamycin nephrosis. Am. J. Physiol. Renal. Physiol., 288: 198-206.
17. Khan, S., R.P. Cleveland, C.J. Koch and J.R. Schelling, 1999. Hypoxia induces renal tubular epithelial cell apoptosis in chronic renal disease. Lab. Invest., 79: 1089-1099.
18. Klemm, K., C. Eipel, D. Cantre, K. Abshagen, M.D. Menger and B. Vollmar, 2008. Multiple doses of erythropoietin impair liver regeneration by increasing TNF-α, the Bax to Bcl-xL ratio and apoptotic cell death. PLoS One, Vol. 3.
19. Lang, A., D. Benke, F. Eitner, D. Engel and S. Ehrlich et al., 2005. Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: In vivo evidence for an immunologic danger signal. J. Am. Soc. Nephrol., 16: 383-391.
20. Lee, V.W.S. and D.C.H. Harris, 2011. Adriamycin nephropathy: A model of focal segmental glomerulosclerosis. Nephrology, 16: 30-38.
21. Liu, L.H., Q.X. Li, L. Xia, J. Li and L. Shao, 2007. Differential effects of dihydropyridine calcium antagonists on doxorubicin-induced nephrotoxicity in rats. Toxicology, 231: 81-90.
22. Muller, I., D. Niethammer and G. Bruchelt, 1998. Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity. Int. J. Mol. Med., 1: 491-494.
23. Nangaku, M. and K.U. Eckardt, 2007. Hypoxia and the HIF system in kidney disease. J. Mol. Med., 85: 1325-1330.
24. Nangaku, M., 2004. Hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure. Nephron. Exp. Nephrol., 98: e8-e12.
25. Oktem, G., A. Uysal, O. Oral, E.D. Sezer and M. Olukman et al., 2010. Resveratrol attenuates doxorubicin-induced cellular damage by modulating nitric oxide and apoptosis. Exp. Toxicol. Pathol., 64: 471-479.
26. Okuda, S., Y. Oh, H. Tsuruda, K. Onoyama, S. Fujimi and M. Fujishima, 1986. Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease. Kidney Int., 29: 502-510.
27. Ortiz, A., P. Justo, M.P. Catalan, A.B. Sanz, C. Lorz and J. Egido, 2002. Apoptotic cell death in renal injury: The rationale for intervention. Curr. Drug Targets Immune. Endocr. Metabol. Disord., 2: 181-192.
28. Ozen, S., Y. Usta, I. Sahin-Erdemli, D. Orhan and B. Gumusel et al., 2001. Association of nitric oxide production and apoptosis in a model of experimental nephropathy. Nephrol. Dial. Transplant, 16: 32-38.
29. Sandau, K.B., J. Zhou, T. Kietzmann and B. Brune, 2001. Regulation of the hypoxia-inducible factor 1α by the inflammatory mediators nitric oxide and tumor necrosis factor-α in contrast to desferroxamine and phenylarsine oxide. J. Biol. Chem., 276: 39805-39811.
30. Schelling, J.R., N. Nkemere, J.B. Kopp and R.P. Cleveland, 1998. Fas dependent fratricidal apoptosis is a mechanism of tubular epithelial cell deletion in chronic renal failure. Lab. Invest., 78: 813-824.
31. Strauss, M. and N. Porras, 2007. Differential expression of HSP70 and ultraestructure of heart and liver tissues of rats treated with adriamycin: Protective role of L-carnitine. Invest. Clin., 48: 33-43.
32. Tanaka, T. and M. Nangaku, 2009. Drug discovery for overcoming Chronic Kidney Disease (CKD): Prolyl-hydroxylase inhibitors to activate Hypoxia-Inducible Factor (HIF) as a novel therapeutic approach in CKD. J. Pharmacol. Sci., 109: 24-31.
33. Turnberg, D., M. Lewis, J. Moss, Y. Xu, M. Botto and H.T. Cook, 2006. Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice. J. Immunol., 177: 4094-4102.
34. Wang, J.S., H.H. Tseng, D.F. Shih, H.S. Jou and L.P. Ger, 1997. Expression of oxide nitric synthase and apoptosis in human lupus nephritis. Nephron, 77: 404-411.
35. Wang, Y., Y.P. Wang, Y.C. Tay and D.C.H. Harris, 2000. Progressive adriamycin nephropathy in mice: Sequence of histologic and immunohistochemical events. Kidney Int., 58: 1797-1804.
36. Wei, M.C., W.X. Zong, E.H. Cheng, T. Lindsten and V. Panoutsakopoulou et al., 2001. Pro-apoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science, 292: 727-730.
37. Yang, B., T.S. Johnson, G.L. Thomas, P.F. Watson, B. Wagner, P.N. Furness and A.M. El Nahas, 2002. A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glomerulonephritis. Kidney Int., 62: 1301-1313.
38. Youle, R.J. and A. Strasser, 2008. The BCL-2 protein family: Opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol., 9: 47-59.
39. Zhang, J., J.R. Clark, E.H. Herman and V.J. Ferrans, 1996. Doxorubicin-induced apoptosis in spontaneously hypertensive rats: Differential effects in heart, kidney and intestine and inhibition by ICRF-187. J. Mol. Cell Cardiol., 28: 1931-1943.
40. Zheng, L., M. He, M. Long, R. Blomgran and O. Stendahl, 2004. Pathogen-induced apoptotic neutrophils express heat shock proteins and elicit activation of human macrophages. J. Immunol., 173: 6319-6326.
41. Zhou, Y., X. Kong, P. Zhao, H. Yang and L. Chen et al., 2011. Peroxisome proliferator-activated receptor-α is renoprotective in doxorubicin-induced glomerular injury. Kidney Int., 79: 1302-1311.