Multiple doses of erythropoietin impair liver regeneration by increasing TNF-α, the Bax to Bcl-xL ratio and apoptotic cell death

PLoS ONE

Volumn 3, Issue 12, 2008, Pages

  Klemm, Katja ^a   Eipel, Christian ^a   Cantré, Daniel ^a   Abshagen, Kerstin ^a   Menger, Michael D ^b   Vollmar, Brigitte ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN BCL XL; RECOMBINANT ERYTHROPOIETIN; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; AMINOTRANSFERASE; BROXURIDINE; CYCLINE; CYTOKINE; PROTEIN BCL X;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; DRUG MEGADOSE; ERYTHROCYTE COUNT; HEMATOCRIT; IMMUNOHISTOCHEMISTRY; LIVER REGENERATION; LIVER RESECTION; LIVER TRANSPLANTATION; LIVER TUMOR; LOW DRUG DOSE; MALE; MITOGENESIS; NONHUMAN; PLEIOTROPY; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; SURGICAL TECHNIQUE; WESTERN BLOTTING; ANIMAL; BLOOD; BLOOD CELL COUNT; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; ENZYMOLOGY; HISTOLOGY; HUMAN; LIVER; LIVER CELL; METABOLISM; ORGAN SIZE; SECRETION;

RATTUS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BLOOD CELL COUNT; BROMODEOXYURIDINE; CELL PROLIFERATION; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROPOIETIN, RECOMBINANT; HEMATOCRIT; HEPATOCYTES; HUMANS; LIVER; LIVER REGENERATION; MALE; ORGAN SIZE; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, SPRAGUE-DAWLEY; TRANSAMINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 57749206773     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003924     Document Type: Article

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