Syndecan 4 supports bone fracture repair, but not fetal skeletal development, in mice

Arthritis and Rheumatism

Volumn 65, Issue 3, 2013, Pages 743-752

  Bertrand, Jessica ^a   Stange, Richard ^b   Hidding, Heriburg ^b   Echtermeyer, Frank ^c   Nalesso, Giovanna ^a   Godmann, Lars ^b   Timmen, Melanie ^b   Bruckner, Peter ^b   Dell'Accio, Francesco ^a   Raschke, Michael J ^b   Pap, Thomas ^b   Dreier, Rita ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; AGGRECANASE; BETA GALACTOSIDASE; CERTULIZUMAB; CYCLINE; SYNDECAN 2; SYNDECAN 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; WNT3A PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE DEVELOPMENT; CALLUS; CARTILAGE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ENCHONDRAL OSSIFICATION; EPIPHYSIS; FEMALE; FEMUR FRACTURE; FETUS; FETUS DEVELOPMENT; FRACTURE HEALING; GENE ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HISTOLOGY; IMMUNOHISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METABOLISM; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WILD TYPE;

ANIMALS; BONE DEVELOPMENT; CELL DIFFERENTIATION; CHONDROCYTES; FEMALE; FEMORAL FRACTURES; FEMUR; FRACTURE HEALING; GROWTH PLATE; INFLAMMATION; LAC OPERON; MALE; MICE; MICE, KNOCKOUT; OSTEOGENESIS; PREGNANCY; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SYNDECAN-2; SYNDECAN-4; TIBIA;

EID: 84874403806     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.37817     Document Type: Article

References (42)

1. Kim CW, Goldberger OA, Gallo RL, Bernfield M,. Members of the syndecan family of heparan sulfate proteoglycans are expressed in distinct cell-, tissue-, and development-specific patterns. Mol Biol Cell 1994; 5: 797-805.
2. Oh ES, Couchman JR,. Syndecans-2 and -4; close cousins, but not identical twins. Mol Cells 2004; 17: 181-7.
3. Molteni A, Modrowski D, Hott M, Marie PJ,. Differential expression of fibroblast growth factor receptor-1, -2, and -3 and syndecan-1, -2, and -4 in neonatal rat mandibular condyle and calvaria during osteogenic differentiation in vitro. Bone 1999; 24: 337-47.
4. Hall BK, Miyake T,. All for one and one for all: condensations and the initiation of skeletal development. Bioessays 2000; 22: 138-47.
5. Koyama E, Leatherman JL, Shimazu A, Nah HD, Pacifici M,. Syndecan-3, tenascin-C, and the development of cartilaginous skeletal elements and joints in chick limbs. Dev Dyn 1995; 203: 152-62.
6. Shimo T, Gentili C, Iwamoto M, Wu C, Koyama E, Pacifici M,. Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis. Dev Dyn 2004; 229: 607-17.
7. Shimazu A, Nah HD, Kirsch T, Koyama E, Leatherman JL, Golden EB, et al. Syndecan-3 and the control of chondrocyte proliferation during endochondral ossification. Exp Cell Res 1996; 229: 126-36.
8. Pacifici M, Shimo T, Gentili C, Kirsch T, Freeman TA, Enomoto-Iwamoto M, et al. Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis. J Bone Miner Metab 2005; 23: 191-9.
9. Wang Z, Telci D, Griffin M,. Importance of syndecan-4 and syndecan -2 in osteoblast cell adhesion and survival mediated by a tissue transglutaminase- fibronectin complex. Exp Cell Res 2011; 317: 367-81.
10. Echtermeyer F, Streit M, Wilcox-Adelman S, Saoncella S, Denhez F, Detmar M, et al. Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4. J Clin Invest 2001; 107: R9-14.
11. Echtermeyer F, Bertrand J, Dreier R, Meinecke I, Neugebauer K, Fuerst M, et al. Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat Med 2009; 15: 1072-6.
12. Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, et al. Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development. Nat Med 2010; 16: 678-86.
13. Ferguson C, Alpern E, Miclau T, Helms JA,. Does adult fracture repair recapitulate embryonic skeletal formation? Mech Dev 1999; 87: 57-66.
14. Vortkamp A, Pathi S, Peretti GM, Caruso EM, Zaleske DJ, Tabin CJ,. Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech Dev 1998; 71: 65-76.
15. Lange J, Sapozhnikova A, Lu C, Hu D, Li X, Miclau T III, et al. Action of IL-1β during fracture healing. J Orthop Res 2010; 28: 778-84.
16. Gerstenfeld LC, Cho TJ, Kon T, Aizawa T, Tsay A, Fitch J, et al. Impaired fracture healing in the absence of TNF-α signaling: the role of TNF-α in endochondral cartilage resorption. J Bone Miner Res 2003; 18: 1584-92.
17. Kim JE, Nakashima K, de Crombrugghe B,. Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth. Am J Pathol 2004; 165: 1875-82.
18. Holstein JH, Menger MD, Culemann U, Meier C, Pohlemann T,. Development of a locking femur nail for mice. J Biomech 2007; 40: 215-9.
19. Schmidmaier G, Wildemann B, Bail H, Lucke M, Fuchs T, Stemberger A, et al. Local application of growth factors (insulin-like growth factor-1 and transforming growth factor-β1) from a biodegradable poly(D, L -lactide) coating of osteosynthetic implants accelerates fracture healing in rats. Bone 2001; 28: 341-50.
20. Gosset M, Berenbaum F, Thirion S, Jacques C,. Primary culture and phenotyping of murine chondrocytes. Nat Protoc 2008; 3: 1253-60.
21. Goldring MB, Tsuchimochi K, Ijiri K,. The control of chondrogenesis. J Cell Biochem 2006; 97: 33-44.
22. Wang J, Markova D, Anderson DG, Zheng Z, Shapiro IM, Risbud MV,. TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J Biol Chem 2011; 286: 39738-49.
23. Little CB, Meeker CT, Golub SB, Lawlor KE, Farmer PJ, Smith SM, et al. Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. J Clin Invest 2007; 117: 1627-36.
24. Majumdar MK, Askew R, Schelling S, Stedman N, Blanchet T, Hopkins B, et al. Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis. Arthritis Rheum 2007; 56: 3670-4.
25. Glasson SS, Askew R, Sheppard B, Carito BA, Blanchet T, Ma HL, et al. Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum 2004; 50: 2547-58.
26. Rogerson FM, Stanton H, East CJ, Golub SB, Tutolo L, Farmer PJ, et al. Evidence of a novel aggrecan-degrading activity in cartilage: studies of mice deficient in both ADAMTS-4 and ADAMTS-5. Arthritis Rheum 2008; 58: 1664-73.
27. Villena J, Berndt C, Granes F, Reina M, Vilaro S,. Syndecan-2 expression enhances adhesion and proliferation of stably transfected Swiss 3T3 cells. Cell Biol Int 2003; 27: 1005-10.
28. Kirsch T, Koyama E, Liu M, Golub EE, Pacifici M,. Syndecan-3 is a selective regulator of chondrocyte proliferation. J Biol Chem 2002; 277: 42171-7.
29. Ikesue M, Matsui Y, Ohta D, Danzaki K, Ito K, Kanayama M, et al. Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Arterioscler Thromb Vasc Biol 2011; 31: 1066-74.
30. Orend G, Huang W, Olayioye MA, Hynes NE, Chiquet-Ehrismann R,. Tenascin-C blocks cell-cycle progression of anchorage-dependent fibroblasts on fibronectin through inhibition of syndecan-4. Oncogene 2003; 22: 3917-26.
31. Rauch BH, Millette E, Kenagy RD, Daum G, Fischer JW, Clowes AW,. Syndecan-4 is required for thrombin-induced migration and proliferation in human vascular smooth muscle cells. J Biol Chem 2005; 280: 17507-11.
32. Song Y, McFarland DC, Velleman SG,. Role of syndecan-4 side chains in turkey satellite cell growth and development. Dev Growth Differ 2011; 53: 97-109.
33. Cevikbas F, Schaefer L, Uhlig P, Robenek H, Theilmeier G, Echtermeyer F, et al. Unilateral nephrectomy leads to up-regulation of syndecan-2- and TGF-β-mediated glomerulosclerosis in syndecan-4 deficient male mice. Matrix Biol 2008; 27: 42-52.
34. Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Matsuo S, Kusugami K, et al. Syndecan-4 deficiency increases susceptibility to κ-carrageenan- induced renal damage. Lab Invest 2001; 81: 509-16.
35. Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Iwase M, Yoshikai Y, et al. Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice. J Biol Chem 2001; 276: 47483-8.
36. Cornelison DD, Wilcox-Adelman SA, Goetinck PF, Rauvala H, Rapraeger AC, Olwin BB,. Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration. Genes Dev 2004; 18: 2231-6.
37. Cornelison DD, Filla MS, Stanley HM, Rapraeger AC, Olwin BB,. Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Dev Biol 2001; 239: 79-94.
38. Echtermeyer F, Harendza T, Hubrich S, Lorenz A, Herzog C, Mueller M, et al. Syndecan-4 signalling inhibits apoptosis and controls NFAT activity during myocardial damage and remodelling. Cardiovasc Res 2011; 92: 123-31.
39. Matsui Y, Ikesue M, Danzaki K, Morimoto J, Sato M, Tanaka S, et al. Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction. Circ Res 2011; 108: 1328-39.
40. Kojima T, Takagi A, Maeda M, Segawa T, Shimizu A, Yamamoto K, et al. Plasma levels of syndecan-4 (ryudocan) are elevated in patients with acute myocardial infarction. Thromb Haemost 2001; 85: 793-9.
41. Bohme K, Winterhalter KH, Bruckner P,. Terminal differentiation of chondrocytes in culture is a spontaneous process and is arrested by transforming growth factor-β2 and basic fibroblast growth factor in synergy. Exp Cell Res 1995; 216: 191-8.
42. Serra R, Karaplis A, Sohn P,. Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor β (TGF-β) on endochondral bone formation. J Cell Biol 1999; 145: 783-94.