Discovery of novel acetohydroxyacid synthase inhibitors as active agents against Mycobacterium tuberculosis by virtual screening and bioassay

Journal of Chemical Information and Modeling

Volumn 53, Issue 2, 2013, Pages 343-353

  Wang, Di ^a   Zhu, Xuelian ^b   Cui, Changjun ^c   Dong, Mei ^a   Jiang, Hualiang ^b   Li, Zhengming ^c   Liu, Zhen ^a   Zhu, Weiliang ^b   Wang, Jian Guo ^c  

^a 309TH HOSPITAL OF PLA   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c NANKAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOHYDROXYACID SYNTHASE; ACTIVE AGENTS; BRANCHED CHAIN AMINO ACIDS; DRUG TARGETS; MOLECULAR DOCKING; MYCOBACTERIUM TUBERCULOSIS; SIMILARITY SEARCH; VIRTUAL SCREENING;

BIOCHEMISTRY;

ACETOLACTATE SYNTHASE; TUBERCULOSTATIC AGENT;

ARTICLE; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; MACROPHAGE; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR DOCKING; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

ACETOLACTATE SYNTHASE; ANTITUBERCULAR AGENTS; CELL LINE; HUMANS; MACROPHAGES; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

EID: 84874402545     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci3004545     Document Type: Article

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