Inactivation of the ilvB1 gene in mycobacterium tuberculosis leads to branched-chain amino acid auxotrophy and attenuation of virulence in mice

Microbiology

Volumn 155, Issue 9, 2009, Pages 2978-2987

  Awasthy, Disha ^a   Gaonkar, Sheshagiri ^a   Shandil, R K ^a   Yadav, Reena ^a   Bharath, Sowmya ^a   Marcel, Nimi ^a,b   Subbulakshmi, Venkita ^a   Sharma, Umender ^a  

^a Astra Zeneca   (India)

^b TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOLACTATE SYNTHASE; ISOLEUCINE; LEUCINE; VALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUXOTROPHY; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL VIABILITY; BACTERIAL VIRULENCE; BACTERIUM CULTURE; CARBON SOURCE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE INACTIVATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS;

ACETOLACTATE SYNTHASE; AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; CELL CULTURE TECHNIQUES; GENE DELETION; GENES, BACTERIAL; MACROPHAGES; MICE; MICE, INBRED BALB C; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS VACCINES; TUBERCULOSIS, PULMONARY; VACCINES, ATTENUATED; VIRULENCE;

MUS; MYCOBACTERIUM TUBERCULOSIS;

EID: 69949184894     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.029884-0     Document Type: Article

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