Synthesis and evaluation of novel monosubstituted sulfonylurea derivatives as antituberculosis agents

European Journal of Medicinal Chemistry

Volumn 50, Issue , 2012, Pages 18-26

  Pan, Li ^a   Jiang, Ying ^b   Liu, Zhen ^b   Liu, Xing Hai ^a   Liu, Zhuo ^a   Wang, Gang ^a   Li, Zheng Ming ^a   Wang, Di ^b  

^a NANKAI UNIVERSITY   (China)

^b 309TH HOSPITAL OF PLA   (China)

Author keywords

Antimycobacterial activity; C 5 Substituted benzene ring; Cytotoxicity; Mycobacterium tuberculosis; Sulfonylurea

Indexed keywords

2 (4 CHLORO 3 SULFAMOYLPHENYLAMINO) 2 OXOETHYL ACETATE; 2 CHLORO 5 NITROBENZENESULFONAMIDE; 2 CHLORO 5 NITROBENZENESULFONIC ACID; 2 CHLORO 5 NITROBENZENESULFONYL CHLORIDE; 2 CHLORO N (4 CHLORO 3 SULFAMOYLPHENYL)ACETAMIDE; 2 CHLORO N (4 CHLORO 3 SULFAMOYLPHENYL)PROPANAMIDE; 4 CHLORO 2 PYRIMIDINAMINE; 4 METHOXY 2 PYRIMIDINAMINE; 5 AMINO2 CHLOROBENZENESULFONAMIDE; ETHYL 2 (4 CHLORO 3 SULFAMOYLPHENYLAMINO) 2 OXOACETATE; N (4 CHLORO 3 SULFAMOYLPHENYL) 2,2,2 TRIFLUOROACETAMIDE; N (4 CHLORO 3 SULFAMOYLPHENYL) 2,2,3,3,4,4,4 HEPTAFLUOROBUTANAMIDE; N (4 CHLORO 3 SULFAMOYLPHENYL)ACETAMIDE; N (4 CHLORO 3 SULFAMOYLPHENYL)ACRYLAMIDE; N (4 CHLORO 3 SULFAMOYLPHENYL)BENZAMIDE; N (4 CHLORO 3 SULFAMOYLPHENYL)CYCLOPROPANECARBOXAMIDE; N (4 CHLORO 3 SULFAMOYLPHENYL)FORMAMIDE; N (4 CHLORO 3 SULFAMOYLPHENYL)ISOBUTYRAMIDE; N (4 CHLORO 3 SULFAMOYLPHENYL)PIVALAMIDE; N [4 CHLORO 3 [N (4 METHYLPYRIMIDIN 2 YLCARBAMOYL)SULFAMOYL]PHENYL]ACETAMIDE; N [4 CHLORO 3 [N [4 METHYLPYRIMIDIN 2 YLCARBAMOYL)SULFAMOYL]PHENYL]ISOBUTYRAMIDE; PHENYL 4 METHOXYPYRIMIDIN 2 YLCARBAMATE; PHENYL 4 METHYLPYRIMIDIN 2 YLCARBAMATE; SODIUM 2 CHLORO 5 NITROBENZENESULFONIC ACID; SULFONYLUREA DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTITUBERCULAR AGENTS; CELL PROLIFERATION; CELLS, CULTURED; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MONOCYTES; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONYLUREA COMPOUNDS; TUBERCULOSIS;

EID: 84862822242     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.011     Document Type: Article

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