Radioprotective effect of melatonin on the cervical spinal cord in irradiated rats

Cell Journal

Volumn 14, Issue 4, 2013, Pages 246-253

  Haddadi, Gholamhassan ^b   Shirazi, Alireza ^b   Sepehrizadeh, Zargham ^c   Mahdavi, Seied Rabie ^a   Haddadi, Maryam ^b  

^a FASA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Melatonin; Spinal cord; VEGF

Indexed keywords

COBALT 60; MELATONIN; RADIOPROTECTIVE AGENT; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CERVICAL SPINAL CORD; COBALT TELETHERAPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GAMMA IRRADIATION; MALE; MICROSCOPY; NONHUMAN; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION PROTECTION; RADIATION SICKNESS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD DISEASE; SPINAL PARALYSIS; UPREGULATION;

EID: 84874396789     PISSN: 22285806     EISSN: 22285814     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Bijl HP, Van Luijk P, Coppes RP, Schippers JM, Konings AW, Van Der Kogel AJ. Unexpected changes of rat cervical spinal cord tolerance caused by inhomogeneous dose distributions. Int J Radiat Oncol Biol Phys. 2003;57(1):274-281. (Pubitemid 36959766)
2. Nieder C, Atman F, Price RE, Ang KK. Radiation myelopathy: New perspective on an old problem. Radiat Oncol Investig. 1999;7(4):193-203. (Pubitemid 29427196)
3. Shirazi A, Mahdavi SR, Trott KR. Radiation myelopathy. A radiobiological review. Rep Pract Oncol Radiother. 2004;9(4):119-127.
4. Wong CS, Van Der Kogel AJ. Mechanisms of radiation injury to the central nervous system: implications for neuroprotection. Mol Interv. 2004;4(5):273-284.
5. Siegal T, Pfeffer MR, Meltzer A, Shezen E, Nimrod A, Ezov N, et al. Cellular and secretory mechanisms related to delayed radiation-induced microvessel dysfunction in the spinal cord of rats. Int J Radiat Oncol Biol Phys. 1996;36(3):649-659. (Pubitemid 26404308)
6. Savas S, Savas C, Altuntas I, Adiloglu A. The correlation between nitric oxide and vascular endothelial growth factor in spinal cord injury. Spinal Cord. 2008;46(2):113-117. (Pubitemid 351220572)
7. Van Bruggen N, Thibodeaux H, Palmer JT, Lee WP, Fu L, Cairns B, et al. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. J Clin Invest. 1999;104(11):1613-1620. (Pubitemid 30002373)
8. Shirazi A, Ghobadi G, Ghazi-khansari M. A radiobiological review on melatonin: a novel radioprotector. J Radiat Res. 2007;48(4):263-272. (Pubitemid 47105598)
9. Cheung RT. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. J Pineal Res. 2003;34(3):153-160. (Pubitemid 36356840)
10. Reiter RJ, Tan DX, Leon J, Kilic U, Kilic E. When melatonin gets on your nerves: Its beneficial actions in experimental models of stroke. Exp Biol Med. 2005;230(2):104-117.
11. Dai M, Cui P, Yu M, Han J, Li H, Xiu R. Melatonin modulates the expression of VEGF and HIF-1 induced by CoCl2 in cultured cancer cells. J Pineal Res. 2008;44(2):121-126. (Pubitemid 351252913)
12. Chen TY, Lee MY, Chen HY, Kuo YL, Lin SC, Wu TS, et al. Melatonin attenuates the postischemic increase in bloodbrain barrier permeability and decreases hemorrhagic transformation of tissue-plasminogen activator therapy following ischemic stroke in mice. J Pineal Res 2006;40(3):242-250.
13. Shirazi A, Haddadi GH, Ghazikhansari M, Abolhassani F, Mahdavi SR, Eshraghyan MR. Evaluation of melatonin for prevention of radiation myelopathy in irradiated cervical spinal cord. Cell J. 2009;11(1):43-48.
14. Shirazi A, Haddadi GH, Minaee B, Sepehrizadeh Z, Mahdavi SR, Jaberi E, et al. Evaluation of melatonin for modulation of apoptosis-related genes in irradiated cervical spinal cord. Int J Low Radiation. 2010;7(6):436-445.
15. Serin M, Gulbas H, Gurses I, Erkal HS, Yucel N. The histopathological evaluation of the effectiveness of melatonin as a protectant against acute lung injury induced by radiation therapy in a rat model. Int J Radiat Biol. 2007;83(3):187-193.
16. Erol FS, Topsakal C, Ozveren MF, Kaplan M, Ilhan N, Ozercan IH, et al. Protective effects of melatonin and vitamin E in brain damage due to gamma radiation: an experimental study. Neurosurg Rev. 2004;27(1):65-69. (Pubitemid 38146176)
17. Atkinson SL, Li YQ, Wong CS. Apoptosis and proliferation of oligodendrocyte progenitor cells in the irradiated rodent spinal cord. Int J Radiat Oncol Biol Phys. 2005;62(2):535-544. (Pubitemid 40704473)
18. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta DeltaC (T)) method. Methods. 2001;25(4):402-408. (Pubitemid 34164012)
19. Boise LH, Gonzàlez-García M, Postema CE, Ding L, Lindsten T, Turka LA, et al. bcl-x, a bcl-2-related gene that functions as dominant regulator of apoptotic cell death. Cell. 1993;74(4):579-608.
20. Nordal RA, Nagy A, Pintillie M, Wong CS. Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor. Clin Cancer Res. 2004;10(10):3342-3353. (Pubitemid 38685439)
21. Chen HY, Chen TY, Lee MY, Chen ST, Hsu YS, Kuo YL, et al. Melatonin decreases neurovascular oxidative/nitrosative damage and protects against early increases in the blood-brain barrier permeability after transient focal cerebral ischemia in mice. J pineal Res. 2006;41(2):175-182.
22. Marti HJ, Bernaudin M, Bellail A, Schoch H, Euler M, Petit E, et al. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol. 2000;156(3):965-976. (Pubitemid 30626954)
23. Li YQ, Ballinger JR, Nordal RA, Su ZF, Wong CS. Hypoxia in radiation-induced blood-spinal cord barrier breakdown. Cancer Res. 2001;61(8):3348-3354. (Pubitemid 32695024)
24. Kaur C, Sivakumar V, Lu J, Ling EA. Increased vascular permeability and nitric oxide production in response to hypoxia in the pineal gland. J Pineal Res. 2007;42(4):338-349. (Pubitemid 46581657)
25. Blickenstaff RT, Brandstadter SM, Reddy S, Witt R. Potential radioprotective agents. 1. Homologs of melatonin. J Pharm Sci. 1994;83(2):216-218. (Pubitemid 24224180)
26. Vijayalaxmi, Meltz ML, Reiter RJ, Herman TS, Kumar KS. Melatonin and protection from whole-body irradiation: Survival studies in mice. Mutat Res. 1999;425(1):21-27. (Pubitemid 29122025)
27. Reiter RJ. Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol. 1998;56(3):359-384. (Pubitemid 28389724)