Hypoxia in radiation-induced blood-spinal cord barrier breakdown

Cancer Research

Volumn 61, Issue 8, 2001, Pages 3348-3354

  Li, Yu Qing ^a   Ballinger, James R ^a,c,d   Nordal, Robert A ^a   Su, Zi Fen ^c   Wong, C Shun ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; FEMALE; HUMAN; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IONIZING RADIATION; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION INJURY; RAT; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; WHITE MATTER;

ALBUMINS; ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CELL HYPOXIA; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; ETANIDAZOLE; FEMALE; HYDROCARBONS, FLUORINATED; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPHOKINES; NECROSIS; RADIATION-SENSITIZING AGENTS; RATS; RATS, INBRED F344; RNA, MESSENGER; SPINAL CORD; TECHNETIUM TC 99M PENTETATE; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035870259     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Radiation response of the central nervous system
2. Analysis of the histopathology of radiation myelopathy
3. Pathophysiological mechanisms leading to the development of late radiation-induced damage to the central nervous system
4. The cell biology of the blood-brain barrier
5. Oxygen sensing and molecular adaptation to hypoxia
6. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
7. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
8. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
9. VEGF mRNA induction correlates with changes in the vascular architecture upon spinal cord damage in the rat
10. Upregulation of vascular endothelial growth factor is associated with radiation-induced blood-spinal cord barrier breakdown
11. Central nervous system radiation injury in small animal models
12. Linear-quadratic model underestimates sparing effect of small doses per fraction in rat spinal cord
13. Effect of transient focal ischemia on blood-brain barrier permeability in the rat: Correlation to cell injury
14. Nonisotopic "sandwich" immunoassay of thyroglobulin in serum by the biotin-streptavidin technique: Evaluation and comparison with an immunoradiometric assay
15. VEGF and tPA co-expressed in malignant glioma
16. The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
17. Radioiodinated 1-(5-iodo-5-deoxy-β-D-arabinofuranosyl)-2-nitroimidazole (iodoazomycin arabinoside: IAZA): A novel marker of tissue hypoxia
18. A simple method for purification and preparation of I-123 azomycin arabinoside (IAZA) for patient use
19. Comparison of the biodistribution of gadolinium-153 DTPA and technetium-99m DTPA in rats
20. Blood-spinal cord barrier function and morphometry after single doses of x-rays in rat spinal cord
21. Technetium-99m HM-PAO stereoisomers: Differences in interaction with glutathione
22. 99mTc-ECD)
23. Radiation myelopathy with partial functional recovery: PET evidence of long-term increased metabolic activity of the spinal cord
24. Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2, 2, 3, 3, 3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors
25. 123I-iodoazomycin arabinoside: Preliminary report of a clinical study
26. Prediction of tumour hypoxia and radioresistance with nuclear medicine markers
27. Autoradiographic imaging of cerebral ischaemia using a combination of blood flow and hypoxic markers in an animal model
28. Late response of the cerebral circulation to X-irradiation of the brain in the rat
29. Late functional and circulatory changes in rats after local irradiation
30. Late changes in the architecture of blood vessels of the rat brain after irradiation
31. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
32. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
33. Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo
34. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
35. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms
36. The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas
37. Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro
38. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
39. VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly
40. Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct
41. Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats
42. Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat
43. Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain
44. Cellular and molecular mechanisms of glial scarring and progressive cavitation: In vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma
45. The radioresponse of the central nervous system: A dynamic process