Transferrin-tailored solid lipid nanoparticles as vectors for site-specific delivery of temozolomide to brain

Journal of Nanoparticle Research

Volumn 15, Issue 3, 2013, Pages

  Jain, Aviral ^a   Singhai, Priyanka ^a   Gurnany, Ekta ^a   Updhayay, Satish ^a   Mody, Nishi ^a  

^a ADINA Institute of Pharmaceutical Sciences   (India)

Author keywords

Blood brain barrier; Brain targeting; Solid lipid nanoparticles; Transferrin

Indexed keywords

BLOOD; CELL CULTURE; CONTROLLED DRUG DELIVERY; DISEASES; EFFICIENCY; MORPHOLOGY; NANOPARTICLES; PARTICLE SIZE; SURFACE MORPHOLOGY; TARGETED DRUG DELIVERY;

BLOOD-BRAIN BARRIER; BRAIN TARGETING; CARBODIIMIDE HYDROCHLORIDES; PHOSPHATE-BUFFERED SALINES; POLYDISPERSITY INDICES; SOLID LIPID NANOPARTICLE (SLN); SOYA PHOSPHATIDYLCHOLINE; TRANSFERRIN;

BRAIN;

1 (3 DIMETHYLAMINOPROPYL) 3 ETHYLCARBODIIMIDE; ALCOHOL; AMINE; CHOLESTEROL; DISTEAROYLPHOSPHATIDYLETHANOLAMINE; PHOSPHATE BUFFERED SALINE; PHOSPHATIDYLCHOLINE; SOLID LIPID NANOPARTICLE; TEMOZOLOMIDE; TRANSFERRIN; TRIOLEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY DEVICE; DRUG RELEASE; FLUORESCENCE; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MORPHOLOGY; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAT; ZETA POTENTIAL;

EID: 84874366288     PISSN: 13880764     EISSN: 1572896X     Source Type: Journal    
DOI: 10.1007/s11051-013-1518-4     Document Type: Article

References (30)

1. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness L (1996) Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-309 (Pubitemid 26124406)
2. Boltri L, Canal T, Esposito PA, Carli F (1993) Lipid nanoparticles: evaluation of some critical formulation parameters. Int Symp Control Rel Bioact Mater 20:346-347 (Pubitemid 23269633)
3. Bradford MA (1976) Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
4. Fishman JB, Rubin JB, Handrahen JV, Connor JR, Fine RE (1987) Receptor mediated transcytosis of transferrin across the blood brain barrier. J Neurosci Res 48:299-305 (Pubitemid 18016458)
5. Friedman HS, Kerby T, Calvert H (2000) Temozolamide and treatment of malignant glioma. Clin Cancer Res 6:2585-2597
6. Fry DW, White JC, Goldman ID (1978) Rapid separation of low molecular weight solutes from liposomes without dilution. J Anal Biochem 90:803-807
7. Gupta Y, Soni V, Chourasia MK, Jain A, Khare P (2005) Targeted drug delivery to the brain via transferrin coupled liposomes. Drug Deliv Tech 5:66-71
8. Gupta Y, Jain A, Jain SK (2007) Transferrin conjugated solid lipid nanoparticles for enhanced delivery of quinine dihydrochloride to the brain. J Pharm Pharmacol 59:935-940 (Pubitemid 47051073)
9. Hatakeyama H, Akita H, Maruyama K, Suhara T, Harashima H (2004) Factors governing the in vivo tissue uptake of transferrin coupled polyethylene glycol liposomes in vivo. Int J Pharm 281:25-33 (Pubitemid 39024260)
10. Jain A, Jain SK (2010) Transferrin coupled PEGylated nanoparticles bearing temozolomide for brain delivery and their assessment for fluorescence and confocal laser scanning microscopy. J Adv Micro Res 5:91-99
11. Jain A, Jain SK (2011) Drug targeting to the brain: a review. Curr Nanosci 7:21-36
12. Jain A, Chasoo G, Singh SK, Saxena AK, Jain SK (2011) Transferrin appended PEGylated nanoparticles for temozolomide delivery to brain: in vitro characterization. J Microencap 28:21-28
13. Khare P, Jain A, Gulbake A, Soni V, Jain NK, Jain SK (2009) Bioconjugates: harnessing potential for effective therapeutics. Crit Rev Ther Drug Carrier Syst 26:119-155
14. Mishra V, Mahor S, Rawat A, Gupta PN, Dubey P, Khatri K, Vyas SP (2006) Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles. J Drug Target 14(1):45-53
15. Muller RH, Mehnert W, Lucks JS, Schwarz C, Zur Muhlen A, Weyhers H, Freitas C, Ruhl D (1995) Solid lipid nanoparticles (SLN) an alternative colloidal carrier system for controlled drug delivery. Eur J Pharm Biopharm 41:62-69
16. Muller RH, Madder K, Gohla S (2000) Solid lipid nanoparticles (SLN) for controlled drug delivery: a review of the state of the art. Eur J Pharm Biopharm 50:161-177 (Pubitemid 30326695)
17. Pardridge WM (1995) Transport of small molecules through the blood brain barrier: biology and methodology. Adv Drug Del Rev 15:5-38
18. Pardridge WM, Eisinberg J, Yang J (1987) Human blood-brain barrier transferrin receptor. Metabolism 36:892-895 (Pubitemid 17135085)
19. Pardris WP (1992) Brain capillary endothelial transport of insulin. In: Simionescu N, Simionescu M (eds) Endothelial cell dysfunctions. Plenum Press, New York, pp 347-368
20. Qian ZM, Li H, Sun H, Ho K (2002) Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol Rev 54:561-587 (Pubitemid 35351196)
21. Roullin VG, Callewaert M, Molinari M, Delavoie F, Second A, Andry MC (2010) Optimised NSAIDS-loaded biocompatible nanoparticles. Nano-Micro Lett 2:247-255
22. Schwarz C, Mehnert W, Lucks JS, Muller RH (1994) Solid lipid nanoparticle (SLN) for controlled drug delivery: I production, characterization and sterilization. J Control Release 30:83-96 (Pubitemid 24173181)
23. Shokuhfar A, Ghaffari A, Ghasemi RH (2012) Cavity control of prefoldin nanoactuator (PNA) by temperature and pH. Nano-Micro Lett 4(2):110-117
24. Siekmann B, Westesen K (1992) Submicron-sized parental carrier system based on solid lipids. Pharm Pharmacol Lett 1:123-126
25. Sjostrom B, Bergenstahl B (1992) Preparation of submicron drug particles in lecithin-stabilized o/w emulsions I. Model studies of the precipitation of cholesteryl acetate. Int J Pharm 88:53-62 (Pubitemid 23000408)
26. Soni V, Kohli DV, Jain SK (2005) Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-fluorouracil. J Drug Target 13:245-250 (Pubitemid 41086289)
27. Soni V, Jian A, Khare P, Gulbake A, Jain SK (2010) Potential approaches for drug delivery to the brain: Past, Present, and Future. Crit Rev Ther Drug Carrier Syst 27:187-236
28. Stevens PJ, Sekido M, Lee RJ (2004) Synthesis and evaluation of a hematoporphyrin derivative in a folate-targeted solid-lipid nanoparticle formulation. Anticancer Res 24:161-166
29. Visser CC, Stevanovic S, Heleen Voorwinden L, Gaillard PJ, Crommelin DJ, Danhof M, De Boer AG (2004) Validation of the transferrin receptor for drug targeting to brain capillary endothelial cells in vitro. J Drug Target 12(3):145-150 (Pubitemid 38868161)
30. Wagner E, Cruel D, Cotton M (1994) Delivery of drug protein and genes into cells using transferrin as a ligand for receptor mediated endocytosis. Adv Drug Del Rev 14:113-135 (Pubitemid 24131676)