메뉴 건너뛰기




Volumn 2, Issue JUNE, 2011, Pages

Epigenetic memory in mammals

Author keywords

Epigenetic disease inheritance; Epigenetic inheritance; Epigenetic memory; Genomic imprinting; Germ line reprogramming

Indexed keywords

MAMMALIA;

EID: 84874338943     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2011.00028     Document Type: Review
Times cited : (75)

References (65)
  • 1
    • 3042794631 scopus 로고    scopus 로고
    • Building the centromere: from foundation proteins to 3D organization
    • Amor, D. J., Kalitsis, P., Sumer, H., and Choo, A. (2004). Building the centromere: from foundation proteins to 3D organization. Trends Cell Biol. 14,359-368.
    • (2004) Trends Cell Biol. , vol.14 , pp. 359-368
    • Amor, D.J.1    Kalitsis, P.2    Sumer, H.3    Choo, A.4
  • 2
    • 74249101368 scopus 로고    scopus 로고
    • Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
    • doi: 10.1371/journal.pgen.1000764, e10000764
    • Aravin, A. A., Van der Heijden, G. W., Castaneda, J., Vagin, V. V., Han-non, G. J., and Bortvin, A. (2009). Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet. 5, e10000764. doi: 10.1371/journal.pgen.1000764
    • (2009) PLoS Genet. , vol.5
    • Aravin, A.A.1    Van der Heijden, G.W.2    Castaneda, J.3    Vagin, V.V.4    Han-non, G.J.5    Bortvin, A.6
  • 3
    • 70349104647 scopus 로고    scopus 로고
    • Genomic imprinting: employing and avoiding epigenetic processes
    • Bartolomei, M. S. (2009). Genomic imprinting: employing and avoiding epigenetic processes. Genes Dev. 23, 2124-2133.
    • (2009) Genes Dev. , vol.23 , pp. 2124-2133
    • Bartolomei, M.S.1
  • 4
    • 70350397570 scopus 로고    scopus 로고
    • Epigenetic specification of centromeres by CENP-A
    • Bernad, R., Sanchez, P., and Losada, A. (2009). Epigenetic specification of centromeres by CENP-A. Exp. Cell Res. 315, 3233-3241.
    • (2009) Exp. Cell Res. , vol.315 , pp. 3233-3241
    • Bernad, R.1    Sanchez, P.2    Losada, A.3
  • 6
    • 78049402859 scopus 로고    scopus 로고
    • Molecular signals of epigenetic states
    • Bonasio, R., Tu, S., and Reinberg, D. (2010). Molecular signals of epigenetic states. Science 330, 612-616.
    • (2010) Science , vol.330 , pp. 612-616
    • Bonasio, R.1    Tu, S.2    Reinberg, D.3
  • 8
    • 0037371674 scopus 로고    scopus 로고
    • Epimutations in Prader-Willi and Angelman syndromes: a molecular study of 136 patients with an imprinting defect
    • Buiting, K., Grob, S., Lich, C., Gillessen-Kaesbach, El-Maarri, O., and Hors-themke, B. (2003). Epimutations in Prader-Willi and Angelman syndromes: a molecular study of 136 patients with an imprinting defect. Am. J. Hum. Genet. 72, 571-577.
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 571-577
    • Buiting, K.1    Grob, S.2    Lich, C.3    Kaesbach, G.4    El-Maarri, O.5    Hors-themke, B.6
  • 9
    • 77954899586 scopus 로고    scopus 로고
    • Epigenetic reprogramming: enforcer or enabler of developmental fate? Dev
    • Combes, A., and Whitelaw, E. (2010). Epigenetic reprogramming: enforcer or enabler of developmental fate? Dev. Growth Differ. 52, 483-491.
    • (2010) Growth Differ. , vol.52 , pp. 483-491
    • Combes, A.1    Whitelaw, E.2
  • 10
    • 40649111338 scopus 로고    scopus 로고
    • Non-coding RNAs, epigenetics and complexity
    • Costa, F. F. (2008). Non-coding RNAs, epigenetics and complexity. Gene 410,9-17.
    • (2008) Gene , vol.410 , pp. 9-17
    • Costa, F.F.1
  • 11
    • 77949391388 scopus 로고    scopus 로고
    • CpG methylation of a silent controlling element in the murine avy allele is incomplete and unresponsive to methyl donor supplementation
    • doi: 10.1371/journal.pone. 0009055, e9055
    • Cropley, J. E., Suter, C. M., Beck-man, K. B., and Martin, D. I. K. (2010). CpG methylation of a silent controlling element in the murine avy allele is incomplete and unresponsive to methyl donor supplementation. PLoS ONE 5,e9055. doi: 10.1371/journal.pone. 0009055
    • (2010) PLoS ONE , vol.5
    • Cropley, J.E.1    Suter, C.M.2    Beck-man, K.B.3    Martin, D.I.K.4
  • 12
    • 65249174549 scopus 로고    scopus 로고
    • Epigenetic specification of centromeres
    • Dala, Y. (2009). Epigenetic specification of centromeres. Biochem. Cell Biol. 87, 273-282.
    • (2009) Biochem. Cell Biol. , vol.87 , pp. 273-282
    • Dala, Y.1
  • 13
    • 70349844377 scopus 로고    scopus 로고
    • Sperm chromatin-induced ectopic polar body extrusion in mouse eggs after ICSI and delayed egg activation
    • doi: 10.1371/journal.pone.0007171, e7171
    • Deng, M., and Li, R. (2009). Sperm chromatin-induced ectopic polar body extrusion in mouse eggs after ICSI and delayed egg activation. PLoS ONE 4, e7171. doi: 10.1371/journal.pone.0007171
    • (2009) PLoS ONE , vol.4
    • Deng, M.1    Li, R.2
  • 14
    • 78649894788 scopus 로고    scopus 로고
    • Dynamics of a novel centromeric histone variant CenH3 reveals the evolutionary ancestral timing of centromere biogenesis
    • Dubin, M., Fuchs, J., Graf, R., Schubert, I., and Nellen, W. (2010). Dynamics of a novel centromeric histone variant CenH3 reveals the evolutionary ancestral timing of centromere biogenesis. Nucleic Acids Res. 1-12.
    • (2010) Nucleic Acids Res. , pp. 1-12
    • Dubin, M.1    Fuchs, J.2    Graf, R.3    Schubert, I.4    Nellen, W.5
  • 15
    • 34250160167 scopus 로고    scopus 로고
    • Mechanisms regulating imprinted genes in clusters
    • Edwards, C. A., and Ferguson-Smith, A. C. (2007). Mechanisms regulating imprinted genes in clusters. Curr. Opin. Cell Biol. 19,281-289.
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 281-289
    • Edwards, C.A.1    Ferguson-Smith, A.C.2
  • 16
    • 78049414227 scopus 로고    scopus 로고
    • Epigenetic reprogramming in plant and animal development
    • Feng, S., Jacobsen, S. E., and Reik, W. (2010). Epigenetic reprogramming in plant and animal development. Science 330, 622-627.
    • (2010) Science , vol.330 , pp. 622-627
    • Feng, S.1    Jacobsen, S.E.2    Reik, W.3
  • 17
    • 0031843173 scopus 로고    scopus 로고
    • Histone-and Protamine-DNA Association: conservation of different patterns within B-globin domain in human sperm
    • Gardiner-Garden, M., Ballesteros, M. G., and Tam, P. P. L. (1998). Histone-and Protamine-DNA Association: conservation of different patterns within B-globin domain in human sperm. Mol Cell. Biol. 18, 3350-3356.
    • (1998) Mol Cell. Biol. , vol.18 , pp. 3350-3356
    • Gardiner-Garden, M.1    Ballesteros, M.G.2    Tam, P.P.L.3
  • 18
  • 19
    • 49049100441 scopus 로고    scopus 로고
    • Epigenetics regulate centromere formation and kineto-chore function
    • Gieni, R. S., Chan, G. K. T., and Hen-zel, M. J. (2008). Epigenetics regulate centromere formation and kineto-chore function.J. Cell. Biochem. 104, 2027-2039
    • (2008) J. Cell. Biochem. , vol.104 , pp. 2027-2039
    • Gieni, R.S.1    Chan, G.K.T.2    Hen-zel, M.J.3
  • 20
    • 39949083375 scopus 로고    scopus 로고
    • Conserved themes in small-RNA-mediated transposon control
    • Girard, A., and Hannon, G. J. (2007). Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol. 18,136-148.
    • (2007) Trends Cell Biol. , vol.18 , pp. 136-148
    • Girard, A.1    Hannon, G.J.2
  • 21
    • 33847367675 scopus 로고    scopus 로고
    • Non-genomic transgen-erational inheritance of disease risk
    • Gluckman, P., Hanson, M., and Beedle, A. 2007). Non-genomic transgen-erational inheritance of disease risk. Bioessays 29, 145-154.
    • (2007) Bioessays , vol.29 , pp. 145-154
    • Gluckman, P.1    Hanson, M.2    Beedle, A.3
  • 22
    • 78649518098 scopus 로고    scopus 로고
    • Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population
    • Gu, A., Ji, G., Shi, X., Long, Y., Xia, Y., Song, L., Wang, S., and Wang, X. (2010). Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population. Hum. Reprod. 25, 2955-2961.
    • (2010) Hum. Reprod. , vol.25 , pp. 2955-2961
    • Gu, A.1    Ji, G.2    Shi, X.3    Long, Y.4    Xia, Y.5    Song, L.6    Wang, S.7    Wang, X.8
  • 23
    • 33748107733 scopus 로고    scopus 로고
    • Dynamics in the early mammalian embryo: implications of genome reprogramming defects for development
    • Haaf, T. (2006). Dynamics in the early mammalian embryo: implications of genome reprogramming defects for development. Curr. Top. Microbiol. Immunol. 310, 13-22.
    • (2006) Curr. Top. Microbiol. Immunol. , vol.310 , pp. 13-22
    • Haaf, T.1
  • 25
    • 67749114140 scopus 로고    scopus 로고
    • Distinctive chromatin in human sperm packages genes for embryo development
    • Hammoud, S. S., Nix, D. A., Zhang, H., Purwar, J., Carrell, D. T., and Cairns, B.R. (2009). Distinctive chromatin in human sperm packages genes for embryo development. Nature 460, 73-478
    • (2009) Nature , vol.460 , pp. 473-478
    • Hammoud, S.S.1    Nix, D.A.2    Zhang, H.3    Purwar, J.4    Carrell, D.T.5    Cairns, B.R.6
  • 26
    • 2942746179 scopus 로고    scopus 로고
    • Histone variants, nucle-osome assembly and epigenetic inheritance
    • Heinkoff, S., Furuyama, T., and Ahmad, K. (2004). Histone variants, nucle-osome assembly and epigenetic inheritance. Trends Genet. 20, 320-326.
    • (2004) Trends Genet. , vol.20 , pp. 320-326
    • Heinkoff, S.1    Furuyama, T.2    Ahmad, K.3
  • 27
    • 68049097008 scopus 로고    scopus 로고
    • Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal
    • Hemberger, M., Dean, W., and Reik, W. (2009). Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal. Nat. Rev. Mol. Cell Biol. 10, 526-537.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 526-537
    • Hemberger, M.1    Dean, W.2    Reik, W.3
  • 28
    • 77953664146 scopus 로고    scopus 로고
    • Epimutations and cancer predisposition: importance and mechanisms
    • Hesson, L., Hitchins, M., and Ward, R. (2010). Epimutations and cancer predisposition: importance and mechanisms. Curr. Opin. Genet. Dev. 20,290-298.
    • (2010) Curr. Opin. Genet. Dev. , vol.20 , pp. 290-298
    • Hesson, L.1    Hitchins, M.2    Ward, R.3
  • 29
    • 45349108598 scopus 로고    scopus 로고
    • Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development
    • Hirasawa, R., Chiba, H., Kaneda, M., Tajima, S., Li, E., Jaenisch, R., and Sasaki, H. (2008). Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev. 22,1607-1616.
    • (2008) Genes Dev. , vol.22 , pp. 1607-1616
    • Hirasawa, R.1    Chiba, H.2    Kaneda, M.3    Tajima, S.4    Li, E.5    Jaenisch, R.6    Sasaki, H.7
  • 33
    • 68049107038 scopus 로고    scopus 로고
    • Trans-generational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution
    • Jablonka, E., and Raz, G. (2009). Trans-generational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution. Q. Rev. Biol. 84, 131-176.
    • (2009) Q. Rev. Biol. , vol.84 , pp. 131-176
    • Jablonka, E.1    Raz, G.2
  • 34
    • 34548705374 scopus 로고    scopus 로고
    • Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse
    • Kato, Y., Masahiro, K., Hata, H., Kumaki, K., Hisano, M., Kohara, Y., Okano, M., Li, E., Nozaki, M., and Sasaki, H. (2007). Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum. Mol. Genet. 16, 2272-2280
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 2272-2280
    • Kato, Y.1    Masahiro, K.2    Hata, H.3    Kumaki, K.4    Hisano, M.5    Kohara, Y.6    Okano, M.7    Li, E.8    Nozaki, M.9    Sasaki, H.10
  • 35
    • 1542513556 scopus 로고    scopus 로고
    • Mobile elements: drivers of genome evolution
    • Kazazian, H. H. Jr. (2004). Mobile elements: drivers of genome evolution. Science 303, 1626-1636.
    • (2004) Science , vol.303 , pp. 1626-1636
    • Kazazian Jr, H.H.1
  • 36
    • 33746636025 scopus 로고    scopus 로고
    • Small RNAs just got bigger: piwi-interacting RNAs (piR-NAs) in mammalian testes
    • Kim, V. N. (2006). Small RNAs just got bigger: piwi-interacting RNAs (piR-NAs) in mammalian testes. Genes Dev. 20, 1993-1997.
    • (2006) Genes Dev. , vol.20 , pp. 1993-1997
    • Kim, V.N.1
  • 37
    • 38849167412 scopus 로고    scopus 로고
    • Biogenesis and germline functions of piRNAs
    • Klattenhoff, C. A., and Theurkauf, W. E. (2008). Biogenesis and germline functions of piRNAs. Development 135, 3-9.
    • (2008) Development , vol.135 , pp. 3-9
    • Klattenhoff, C.A.1    Theurkauf, W.E.2
  • 38
    • 77954821594 scopus 로고    scopus 로고
    • What an epigenome remembers
    • Lange, U. C., and Schneider, R. (2010). What an epigenome remembers. Bioessays 32, 659-668.
    • (2010) Bioessays , vol.32 , pp. 659-668
    • Lange, U.C.1    Schneider, R.2
  • 39
    • 0027378582 scopus 로고
    • Role for DNA methylation in genomic imprinting
    • Li, E., Beard, C., and Jaenisch, R. (1993). Role for DNA methylation in genomic imprinting. Nature 366, 362-365.
    • (1993) Nature , vol.366 , pp. 362-365
    • Li, E.1    Beard, C.2    Jaenisch, R.3
  • 43
    • 33947731008 scopus 로고    scopus 로고
    • Mighty piwis defend the germline against genome intruders
    • O'Donnell, K. A., and Boeke, J. D. (2007). Mighty piwis defend the germline against genome intruders. Cell 129, 37-44.
    • (2007) Cell , vol.129 , pp. 37-44
    • O'Donnell, K.A.1    Boeke, J.D.2
  • 44
    • 34250189494 scopus 로고    scopus 로고
    • Germline histone dynamics and epi-genetics
    • Ooi, S. L., and Henikoff, S. (2007). Germline histone dynamics and epi-genetics. Curr. Opin. Cell Biol. 19, 257-265.
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 257-265
    • Ooi, S.L.1    Henikoff, S.2
  • 45
    • 0025203527 scopus 로고
    • The centromere specific histone CENP-A is selectively retained in discrete loci in mammalian sperm nuclei
    • Palmer, D. K., O'Day, K., and Margolis, R. L. (1990). The centromere specific histone CENP-A is selectively retained in discrete loci in mammalian sperm nuclei. Chromosoma 100, 32-36.
    • (1990) Chromosoma , vol.100 , pp. 32-36
    • Palmer, D.K.1    O'Day, K.2    Margolis, R.L.3
  • 47
    • 77249148019 scopus 로고    scopus 로고
    • Genome-wide erasure of DNA methylation in mouse primordial germ cells isaffected by AID deficiency
    • Popp, C., Dean, W., Feng, S., Cokus, S. J., Andrews, S., Pellegrini, M., Jacobsen, S. E., and Reik, W. (2010). Genome-wide erasure of DNA methylation in mouse primordial germ cells isaffected by AID deficiency. Nature 463, 1101-1105.
    • (2010) Nature , vol.463 , pp. 1101-1105
    • Popp, C.1    Dean, W.2    Feng, S.3    Cokus, S.J.4    Andrews, S.5    Pellegrini, M.6    Jacobsen, S.E.7    Reik, W.8
  • 48
    • 77954664328 scopus 로고    scopus 로고
    • The paternal hidden agenda: epigenetic inheritance through sperm chromatin
    • Puri, D., Dhawan, J., and Mishra, R. K. (2010). The paternal hidden agenda: epigenetic inheritance through sperm chromatin. Epigenetics 5, 386-391.
    • (2010) Epigenetics , vol.5 , pp. 386-391
    • Puri, D.1    Dhawan, J.2    Mishra, R.K.3
  • 50
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • Reik, W. (2007). Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447,425-432.
    • (2007) Nature , vol.447 , pp. 425-432
    • Reik, W.1
  • 51
    • 35348992639 scopus 로고    scopus 로고
    • The genetics of hereditary colon cancer
    • Rustgi, A. K. (2007). The genetics of hereditary colon cancer. Genes Dev. 21,2525-2538.
    • (2007) Genes Dev , vol.21 , pp. 2525-2538
    • Rustgi, A.K.1
  • 52
    • 33845528560 scopus 로고    scopus 로고
    • Implication of abnormal epigenetic patterns for human diseases
    • Santos-Reboucas, C. B., and Pimentel, M. M. G. (2007). Implication of abnormal epigenetic patterns for human diseases. Eur. J. Hum. Genet. 15, 10-17.
    • (2007) Eur. J. Hum. Genet. , vol.15 , pp. 10-17
    • Santos-Reboucas, C.B.1    Pimentel, M.M.G.2
  • 53
    • 38349100549 scopus 로고    scopus 로고
    • Epigenetic events in mammalian germ-cell development: reprogramming and beyond
    • Sasaki, H., and Matsui, Y. (2008). Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat. Rev. Genet. 9, 129-140.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 129-140
    • Sasaki, H.1    Matsui, Y.2
  • 54
    • 0036275755 scopus 로고    scopus 로고
    • Allele-specific expression of imprinted genes in mouse migratory primordial germ cells
    • Szabo, P. E., Hubner, K., Scholer, H., and Mann, J. R. (2002). Allele-specific expression of imprinted genes in mouse migratory primordial germ cells. Mech. Dev. 115, 157-160.
    • (2002) Mech. Dev. , vol.115 , pp. 157-160
    • Szabo, P.E.1    Hubner, K.2    Scholer, H.3    Mann, J.R.4
  • 56
    • 0030802395 scopus 로고    scopus 로고
    • A 5' 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development
    • Tremblay, K. D., Duran, K. L., and Bartolomei, M. S. (1997). A 5' 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development. Mol. Cell. Biol. 17,4322-4329.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4322-4329
    • Tremblay, K.D.1    Duran, K.L.2    Bartolomei, M.S.3
  • 59
    • 77649211158 scopus 로고    scopus 로고
    • Function of sperm chromatin structural elements infertilization and development
    • Ward, W S. (2010). Function of sperm chromatin structural elements infertilization and development. Mol. Hum. Reprod. 16, 30-36.
    • (2010) Mol. Hum. Reprod. , vol.16 , pp. 30-36
    • Ward, W.S.1
  • 60
    • 8844260400 scopus 로고    scopus 로고
    • Expression of Dnmt3b in mouse hematopoietic progenitor cells and spermatogonia at specific stages
    • Watanabe, D., Suetake, I., Tajima, S., and Hanaoka, K. (2004). Expression of Dnmt3b in mouse hematopoietic progenitor cells and spermatogonia at specific stages. GeneExpr. Patterns 5,43-49.
    • (2004) GeneExpr. Patterns , vol.5 , pp. 43-49
    • Watanabe, D.1    Suetake, I.2    Tajima, S.3    Hanaoka, K.4
  • 61
    • 52949126723 scopus 로고    scopus 로고
    • Transgenerational epigenetic inheritance in health and disease
    • Whitelaw, N. C., and Whitelaw, E. (2008). Transgenerational epigenetic inheritance in health and disease. Curr. Opin. Genet. Dev. 18, 273-279.
    • (2008) Curr. Opin. Genet. Dev. , vol.18 , pp. 273-279
    • Whitelaw, N.C.1    Whitelaw, E.2
  • 62
    • 33751086773 scopus 로고    scopus 로고
    • DefiencyofRbbp1/Arid4b alters epigenetic modifications and suppresses an imprinting defect in the PWS/AS domain
    • Wu, M. Y., Tsai, T. F., and Beaudet, A. L. (2006).DefiencyofRbbp1/Arid4b alters epigenetic modifications and suppresses an imprinting defect in the PWS/AS domain. Genes Dev. 20, 2859-2870.
    • (2006) Genes Dev , vol.20 , pp. 2859-2870
    • Wu, M.Y.1    Tsai, T.F.2    Beaudet, A.L.3
  • 63
    • 0042031173 scopus 로고    scopus 로고
    • The structural organization of sperm chromatin
    • Wykes, S. M., and Krawetz, S. A. (2003). The structural organization of sperm chromatin. J. Biol. Chem. 278,29471-29477.
    • (2003) J. Biol. Chem. , vol.278 , pp. 29471-29477
    • Wykes, S.M.1    Krawetz, S.A.2
  • 64
    • 79251494766 scopus 로고    scopus 로고
    • Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs
    • Xu, F., Mao, C., Ding, Y., Rui, C., Wu, L., Shi, A., Zhang, H., Zhang, L., and Xu, Z. (2010). Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs. Curr. Med. Chem. 17,4052-4071.
    • (2010) Curr. Med. Chem. , vol.17 , pp. 4052-4071
    • Xu, F.1    Mao, C.2    Ding, Y.3    Rui, C.4    Wu, L.5    Shi, A.6    Zhang, H.7    Zhang, L.8    Xu, Z.9
  • 65
    • 0028231062 scopus 로고
    • Obesity, diabetes, and neoplasia in yellow A(vy)-mice: ectopic expression of the agouti gene
    • Yen, T. T., Gill, A. M., Frigeri, L. G., Barsh, G. S., and Wol, G. L. (1994). Obesity, diabetes, and neoplasia in yellow A(vy)-mice: ectopic expression of the agouti gene. FASEB J. 8, 479-488.
    • (1994) FASEB J. , vol.8 , pp. 479-488
    • Yen, T.T.1    Gill, A.M.2    Frigeri, L.G.3    Barsh, G.S.4    Wol, G.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.