Aspartate buffer and divalent metal ions affect oxytocin in aqueous solution and protect it from degradation

International Journal of Pharmaceutics

Volumn 444, Issue 1-2, 2013, Pages 139-145

  Avanti, Christina ^a,b   Oktaviani, Nur Alia ^c   Hinrichs, Wouter L J ^a   Frijlink, Henderik W ^a   Mulder, Frans A A ^c,d  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF SURABAYA   (Indonesia)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

Aqueous solution; Aspartate buffer; Conformation; Divalent metal ions; NMR; Oxytocin

Indexed keywords

ASPARTIC ACID; CYSTEINE; MAGNESIUM ION; METAL ION; OXYTOCIN; ZINC ION;

AQUEOUS SOLUTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG CONFORMATION; DRUG DEGRADATION; DRUG STRUCTURE; HYPOTHESIS; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

ASPARTIC ACID; BUFFERS; DRUG STABILITY; MAGNESIUM; MAGNETIC RESONANCE SPECTROSCOPY; OXYTOCIN; PROTEIN CONFORMATION; ZINC;

EID: 84874328444     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.01.051     Document Type: Article

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