Towards heat-stable oxytocin formulations: Analysis of degradation kinetics and identification of degradation products

Pharmaceutical Research

Volumn 26, Issue 7, 2009, Pages 1679-1688

  Hawe, Andrea ^a   Poole, Robert ^a   Romeijn, Stefan ^a   Kasper, Piotr ^a   Van Der Heijden, Rob ^a   Jiskoot, Wim ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Aggregation; Arrhenius kinetics; Degradation; Mass spectrometry; Oxytocin

Indexed keywords

DISULFIDE; GLYCINE; OXYTOCIN; TYROSINE;

ARTICLE; DEAMINATION; DRUG ELIMINATION; DRUG FORMULATION; ELECTROSPRAY MASS SPECTROMETRY; FLUORESCENCE SPECTROSCOPY; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TEMPERATURE SENSITIVITY; THERMOSTABILITY; ULTRAVIOLET SPECTROSCOPY;

CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HOT TEMPERATURE; HYDROGEN-ION CONCENTRATION; KINETICS; MASS SPECTROMETRY; OXYTOCIN; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 67349113825     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9878-2     Document Type: Article

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