A new strategy to stabilize oxytocin in aqueous solutions: I. the effects of divalent metal ions and citrate buffer

AAPS Journal

Volumn 13, Issue 2, 2011, Pages 284-290

  Avanti, Christina ^a   Amorij, Jean Pierre ^a   Setyaningsih, Dewi ^a   Hawe, Andrea ^b   Jiskoot, Wim ^b   Visser, Jan ^a   Kedrov, Alexej ^a   Driessen, Arnold J M ^a   Hinrichs, Wouter L J ^a   Frijlink, Henderik W ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

citrate buffer; divalent metal ions; improved stability; oxytocin

Indexed keywords

ACETIC ACID; BUFFER; CALCIUM CHLORIDE; CALCIUM ION; CITRIC ACID; MAGNESIUM CHLORIDE; MAGNESIUM ION; METAL ION; OXYTOCIN; POTASSIUM ION; SODIUM ION; ZINC CHLORIDE; ZINC ION;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; GEL PERMEATION CHROMATOGRAPHY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR INTERACTION; PH; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIZE EXCLUSION HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STORAGE TEMPERATURE;

BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRATES; DRUG STABILITY; DRUG STORAGE; METALS; OXYTOCICS; OXYTOCIN; PHARMACEUTICAL SOLUTIONS; TEMPERATURE;

EID: 79957529274     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-011-9268-7     Document Type: Article

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