A "Clickable" MTX Reagent as a Practical Tool for Profiling Small-Molecule-Intracellular Target Interactions via MASPIT

ChemMedChem

Volumn 8, Issue 3, 2013, Pages 521-526

  Risseeuw, Martijn D P ^a   DeClercq, Dries J H ^a   Lievens, Sam ^a,b   Hillaert, Ulrik ^a   Sinnaeve, Davy ^a   VandenBroeck, Freya ^a   Martins, José C ^a   Tavernier, Jan ^a,b   VanCalenbergh, Serge ^a  

^a GHENT UNIVERSITY   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Click chemistry; MASPIT; Methotrexate conjugates; Profiling; Target identification; Three hybrid

Indexed keywords

ACETYLENE; AZIDE; CELL PROTEIN; METHOTREXATE; REVERSINE; TACROLIMUS; TAMOXIFEN; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONJUGATION; CYTOSOL; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; LIGATION; MAMMALIAN SMALL MOLECULE PROTEIN INTERACTION TRAP; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; SCREENING TEST;

ANTIMETABOLITES, ANTINEOPLASTIC; CELL SURVIVAL; CLICK CHEMISTRY; CYCLOADDITION REACTION; HEK293 CELLS; HUMANS; METHOTREXATE; MORPHOLINES; PURINES; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STAT3 TRANSCRIPTION FACTOR; STEREOISOMERISM; TACROLIMUS; TAMOXIFEN; TETRAHYDROFOLATE DEHYDROGENASE; TISSUE ARRAY ANALYSIS;

EID: 84874315356     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200493     Document Type: Article

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