Fishing for targets: Novel approaches using small molecule baits

Drug Discovery Today: Technologies

Volumn 1, Issue 1, 2004, Pages 9-15

  Szardenings, Katrin ^a   Li, Bei ^a   Ma, Lifu ^a   Wu, Min ^a  

^a ACTIVX BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; CASPASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR; ESTERASE INHIBITOR; FR 182877; GELDANAMYCIN; GLYCOGEN SYNTHASE KINASE INHIBITOR; GWENPAULLONE; INDISULAM; MATRIX METALLOPROTEINASE INHIBITOR; NUCLEOTIDE BINDING PROTEIN; PAULLONE DERIVATIVE; PHOSPHOTRANSFERASE INHIBITOR; PROTEASOME INHIBITOR; PROTEIN INHIBITOR; PROTEIN KINASE INHIBITOR; PURVALANOL; QUINOLINE DERIVATIVE; TWS 119; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANALYTIC METHOD; ARTICLE; CELL ACTIVITY; CELL LABELING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; INTERMETHOD COMPARISON; MEDICAL TECHNOLOGY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PROTEIN ANALYSIS; PROTEOMICS;

EID: 13344275782     PISSN: 17406749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddtec.2004.08.009     Document Type: Review

References (21)

1. G. Manning The protein kinase complement of the human genome Science 298 2002 1912-1934
2. L. Meijer et al. Intracellular targets of paullones: Identification following affinity purification on immobilized inhibitor J. Biol. Chem. 277 2002 25493-25501
3. L. Meijer et al. Intracellular targets of cyclin-dependent kinase inhibitors: Identification by affinity chromatography using immobilized inhibitors Chem. Biol. 7 2000 411-422
4. M. Knockaert and L. Meijer Identifying in vivo targets of cyclin-dependent kinase inhibitors by affinity chromatography Biochem. Pharmacol. 7298 2002 1-7
5. R. Bischoff and J.R. Freije Activity-based enrichment of matrix metalloproteinases using reversible inhibitors as affinity ligands J. Chromatogr. A 1009 2003 155-169
6. P. Schultz et al. Synthetic small molecules that control stem cell fate Proc. Natl. Acad. Sci. 100 2003 7632-7637
7. Y. Oda et al. Quantitative chemical proteomics for identifying candidate drug targets Anal. Chem. 75 2003 2159-2165
8. P.R. Graves et al. Discovery of novel targets of quinoline drugs in the human purine binding proteome Mol. Pharmacol. 62 2002 1364-1372
9. D. Jeffery and M. Bogyo Chemical proteomics and its application to drug discovery Curr. Opin. Biotechnol. 14 2003 87-95
10. N. Jessani and B. Cravatt The development and application of methods for activity-based protein profiling Curr. Opin. Chem. Biol. 8 2003 54-59
11. J. Kozarich Activity-based proteomics: Enzyme chemistry redux Curr. Opin. Chem. Biol. 7 2003 78-83
12. D. Campbell and K. Szardenings Functional profiling of the proteome with affinity labels Curr. Opin. Chem. Biol. 7 2003 296-303
13. S. Yao et al. Design and synthesis of an affinity probe that targets caspases in proteomic experiments Tetrahedron Lett. 44 2003 1043-1046
14. S. Yao Activity-based fluorescent probes that target phosphatases Tetrahedron Lett. 44 2003 2669-2672
15. Z.-Y. Zhang Activity-based probes for protein tyrosine phosphatases Proc. Natl. Acad. Sci. 101 2004 7943-7948
16. B. Cravatt et al. (-)-FR182877 is a potent and selective inhibitor of carboxylesterase-1 Angew. Chem. Int. Ed. 42 2003 5480-5484
17. M. Patricelli and B. Cravatt Mapping enzyme active sites in complex proteomes J. Am. Chem. Soc. 126 2004 1363-1368
18. C. Bertozzi et al. Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation Proc. Natl. Acad. Sci. USA 99 2002 19-24
19. V. Fokin et al. A stepwise Huisgen cycloaddition process: copper(I)-catalyzed regioselective ligation of azides and terminal alkynes Angew. Chem. Int. Ed. 41 2002 2708-2711
20. S. Overkleeft et al. Chemistry in living cells: Detection of active poteasomes by a two-step labeling strategy Angew. Chem. Int. Ed. 42 2003 3626-3629
21. B. Cravatt and A. Speers Profiling enzyme activities in vivo using click chemistry methods Chem. Biol. 11 2004 535-546