Natural killer lytic-associated molecule plays a role in controlling tumor dissemination and metastasis

Frontiers in Immunology

Volumn 3, Issue DEC, 2012, Pages

  Hoover, Richard G ^a   Gullickson, Gail ^a   Kornbluth, Jacki ^a,b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cell mediated cytotoxicity; Natural killer cells; Natural killer lytic associated molecule; Ubiquitin ligase

Indexed keywords

EID: 84874302949     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00393     Document Type: Article

References (44)

1. Anandasabapathy, N., Ford, G. S., Bloom, D., Holness, C., Paragas, V., Seroogy, C., et al. (2003). GRAIL: An E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. Immunity 18, 535-547.
2. Ardley, H. C., and Robinson, P. A. (2005). E3 ubiquitin ligases. Essays Biochem. 41, 15-30.
3. Bezman, N. A., Kim, C. C., Sun, J. C., Min-Oo, G., Hendricks, D. W., Kamimura, Y., et al. (2012). Molecular definition of the identity and activation of natural killer cells. Nat. Immunol. 13, 1000-1009.
4. Cerwenka, A., Baron, J. L., and Lanier, L. L. (2001). Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc. Natl. Acad. Sci. U.S.A. 98, 11521-11526.
5. Chen, Z. J. (2005). Ubiquitin signalling in the NF-kappaB pathway. Nat. Cell Biol. 7, 758-765.
6. Chuang, T. H., and Ulevitch, R. J. (2004). Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat. Immunol. 5, 495-502.
7. Diefenbach, A., Jensen, E. R., Jamieson, A. M., and Raulet, D. H. (2001). Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413, 165-171.
8. Ewens, A., Luo, L., Berleth, E., Alderfer, J., Wollman, R., Hafeez, B. B., et al. (2006). Doxorubicin plus interleukin-2 chemoimmunother-apy against breast cancer in mice. Cancer Res. 66, 5419-5426.
9. Ewens, A., Mihich, E., and Ehrke, M. J. (2005). Distant metastasis from subcutaneously grown E0771 medullary breast adenocarcinoma. Anticancer Res. 25, 3905-3915.
10. Fang, S., Lorick, K. L., Jensen, J. P., and Weissman, A. M. (2003). RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer. Semin. Cancer Biol. 13, 5-14.
11. Fehniger, T. A., Cai, S. F., Cao, X., Bredemeyer, A. J., Presti, R. M., French, A. R., et al. (2007). Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. Immunity 26, 798-811.
12. Fortier, J. M., and Kornbluth, J. (2006). NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. J. Immunol. 176, 6454-6463.
13. Gu, J. W., Young, E., Busby, B., Covington, J., and Johnson, J. W. (2009). Oral administration of pyrrolidine dithiocarbamate (PDTC) inhibits VEGF expression, tumor angiogenesis, and growth of breast cancer in female mice. Cancer Biol. Ther. 8, 514-521.
14. Herberman, R. B., and Ortaldo, J. R. (1981). Natural killer cells: their roles in defenses against disease. Science 214, 24-30.
15. Heyder, C., Gloria-Maercker, E., Hatzmann, W., Niggemann, B., Zanker, K. S., and Dittmar, T. (2005). Role of the beta1-integrin subunit in the adhesion, extravasation and migration of T24 human bladder carcinoma cells. Clin. Exp. Metastasis 22, 99-106.
16. Hoover, R. G., Gullickson, G., and Kornbluth, J. (2009). Impaired NK cytolytic activity and enhanced tumor growth in NK lytic-associated molecule-deficient mice. J. Immunol. 183, 6913-6921.
17. Imai, K., Matsuyama, S., Miyake, S., Suga, K., and Nakachi, K. (2000). Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population. Lancet 356, 1795-1799.
18. Ishigami, S., Natsugoe, S., Tokuda, K., Nakajo, A., Che, X., Iwashige, H., et al. (2000). Prognostic value of intratumoral natural killer cells in gastric carcinoma. Cancer 88, 577-583.
19. Karre, K., Ljunggren, H. G., Piontek, G., and Kiessling, R. (1986). Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319, 675-678.
20. Kasahara, T., Djeu, J. Y., Dougherty, S. F., and Oppenheim, J. J. (1983). Capacity of human large granular lymphocytes (LGL) to produce multiple lymphokines: interleukin 2, interferon, and colony stimulating factor. J. Immunol. 131, 2379-2385.
21. Kim, S., Iizuka, K., Aguila, H. L., Weissman, I. L., and Yokoyama, W. M. (2000). In vivo natural killer cell activities revealed by natural killer cell-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 97, 2731-2736.
22. Kornbluth, J., and Hoover, R. G. (1988). Changes in gene expression associated with IFN-beta and IL-2-induced augmentation of human natural killer cell function. J. Immunol. 141, 3234-3240.
23. Kozlowski, M., Schorey, J., Portis, T., Grigoriev, V., and Kornbluth, J. (1999). NK lytic-associated molecule: a novel gene selectively expressed in cells with cytolytic function. J. Immunol. 163, 1775-1785.
24. Lanier, L. L. (1998). NK cell receptors. Annu. Rev. Immunol. 16, 359-393.
25. Liu, Y. C. (2004). Ubiquitin ligases and the immune response. Annu. Rev. Immunol. 22, 81-127.
26. McHowat, J., Gullickson, G., Hoover, R. G., Sharma, J., Turk, J., and Kornbluth, J. (2011). Platelet-activating factor and metastasis: calcium-independent phospholi-pase A2beta deficiency protects against breast cancer metastasis to the lung. Am. J. Physiol. Cell Physiol. 300, C825-C832.
27. Nurieva, R. I., Zheng, S., Jin, W., Chung, Y., Zhang, Y., Martinez, G. J., et al. (2010). The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity 32, 670-680.
28. Ortaldo, J. R., Phillips, W., Wasserman, K., and Herberman, R. B. (1980). Effects of metabolic inhibitors on spontaneous and interferon-boosted human natural killer cell activity. J. Immunol. 125, 1839-1844.
29. Pickart, C. M. (2001). Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503-533.
30. Portis, T., Anderson, J., Esposito, A., and Kornbluth, J. (2000). Gene structure of human and mouse NKLAM, a gene associated with cellular cytotoxicity. Immunogenetics 51, 546-555.
31. Rocca, A., Lamaze, C., Subtil, A., and Dautry-Varsat, A. (2001). Involvement of the ubiqui-tin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments. Mol. Biol. Cell 12, 1293-1301.
32. Russell, J. H., and Ley, T. J. (2002). Lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 20, 323-370.
33. Screpanti, V., Wallin, R. P., Ljunggren, H. G., and Grandien, A. (2001). A central role for death receptor-mediated apoptosis in the rejection of tumors by NK cells. J. Immunol. 167, 2068-2073.
34. Stagg, J., Divisekera, U., McLaughlin, N., Sharkey, J., Pommey, S., Denoyer, D., et al. (2010). Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc. Natl. Acad. Sci. U.S.A. 107, 1547-1552.
35. Stinchcombe, J. C., and Griffiths, G. M. (2007). Secretory mechanisms in cell-mediated cytotoxicity. Annu. Rev. Cell Dev. Biol. 23, 495-517.
36. Sugiura, K., and Stock, C. C. (1952). Studies in a tumor spectrum. II. The effect of 2, 4, 6-triethylenimino-s-triazine on the growth of a variety of mouse and rat tumors. Cancer 5, 979-991
37. Tkach, M., Coria, L., Rosemblit, C., Rivas, M. A., Proietti, C. J., Diaz Flaque, M. C., et al. (2012). Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells. J. Immunol. 189, 1162-1172.
38. Trinchieri, G. (1989). Biology of natural killer cells. Adv. Immunol. 47, 187-376.
39. Trinchieri, G., Matsumoto-Kobayashi, M., Clark, S. C., Seehra, J., London, L., and Perussia, B. (1984). Response of resting human peripheral blood natural killer cells to interleukin 2. J. Exp. Med. 160, 1147-1169.
40. Tsukerman, P., Stern-Ginossar, N., Gur, C., Glasner, A., Nachmani, D.Bauman, Y., et al. (2012). MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells. Cancer Res. 72, 5463-5472.
41. Villegas, F. R., Coca, S., Villarrubia, V. G., Jimenez, R., Chillon, M. J., Jareno, J., et al. (2002). Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer. Lung Cancer 35, 23-28.
42. Zhao, H., Li, C. C., Pardo, J., Chu, P. C., Liao, C. X., Huang, J., et al. (2005). A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation. J. Immunol. 174, 5288-5297.
43. Zhou, H., Luo, Y., Mizutani, M., Mizutani, N., Reisfeld, R. A., and Xiang, R. (2005). T cell-mediated suppression of angiogenesis results in tumor protective immunity. Blood 106, 2026-2032
44. Zompi, S., Hamerman, J. A., Ogasawara, K., Schweighoffer, E., Tybulewicz, V. L., Di Santo, J. P., et al. (2003). NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat. Immunol. 4, 565-572.