NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase

Journal of Immunology

Volumn 176, Issue 11, 2006, Pages 6454-6463

  Fortier, Julie M ^a   Kornbluth, Jacki ^a,b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; COMPLEMENTARY DNA; CYTOKINE; INTERLEUKIN 2; NKLAM PROTEIN; PROTEIN; RING FINGER PROTEIN; UBCH10 PROTEIN; UBCH7 PROTEIN; UBCH8 PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; URIDINE KINASE LINE 1 PROTEIN;

ARTICLE; CELL LYSATE; CELL STRAIN HEK293; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; EMBRYO; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; NATURAL KILLER T CELL; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE SUBPOPULATION; UBIQUITINATION; WESTERN BLOTTING;

EID: 33646879250     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.11.6454     Document Type: Article

References (35)

1. Russell, J., and T. Ley. 2002. Lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 20: 323-370.
2. Lehmann, C., M. Zeis, and L. Uharek. 2001. Activation of natural killer cells with interleukin 2 (IL-2) and IL-12 increases perforin binding and subsequent lysis of tumour cells. Br. J. Haematol. 114: 660-665.
3. Kozlowski, M., J. Schorey, T. Portis, V. Grigoriev, and J. Kornbluth. 1999. NK lytic associated molecule: a novel gene selectively expressed in cells with cytolytic function. J. Immunol. 163: 1775-1785.
4. Portis, T., J. Anderson, A. Esposito, and J. Kornbluth. 2000. Gene structure of human and mouse NKLAM, a gene associated with cellular cytotoxicity. Immunogenetics 51: 546-555.
5. Borden, K. 1998. RING fingers and B-boxes: zinc binding protein-protein interaction domains. Biochem. Cell Biol. 76: 351-358.
6. Saurin, A., K. Borden, M. Boddy, and P. Freemont. 1996. Does this have a familiar RING? Trends Biochem. Sci. 21: 208-214.
7. Martinez-Noel, G., U. Müller, and K. Harbers. 2001. Identification of molecular determinants required for interaction of ubiquitin-conjugating enzymes and RING finger proteins. Eur. J. Biochem. 268: 5912-5919.
8. Niwa, J., S. Ishigaki, M. Doyu, T. Suzuki, K. Tanka, and G. Sobue. 2001. A novel centrosomal RING-finger protein, Dorfin, mediates ubiquitin activity. Biochem. Biophys. Res. Commun. 281: 706-713.
9. Ita, T., J. Niwa, N. Hishikawa, S. Ishigaki, M. Doyu, and G. Sobue. 2003. Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1. J. Biol. Chem. 278: 29106-29114.
10. Hishikawa, N., J. Niwa, D. Manabu, T. Ito, S. Ishigaki, Y. Hashizume, and G. Sobue. 2003. Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. Am. J. Pathol. 163: 609-619.
11. Zang, Y., J. Gao, K. Chung, H. Huang, V. Dawson, and T. Dawson. 2000. Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc. Natl. Acad. Sci. USA 97: 13354-13359.
12. Shimura, H., M. Schlossmacher, N. Hattori, M. Frosch, A. Trockenbacher, R. Schneider, Y. Mizuno, K. Kosik, and D. Selkoe. 2001. Ubiquitination of a new form of α-synuclein by Parkin from human brain: implications for Parkinson's disease. Science 293: 263-269.
13. Joazeiro, C., and A. Weissman. 2000. RING finger proteins: mediators of ubiquitin ligase activity. Cell 102: 549-552.
14. Pickart, C. M. 2001. Mechanisms underlying Ubiquitination. Annu. Rev. Biochem. 70: 503-533.
15. Fallon, L., F. Moreau, B. Croft, N. Labib, W. Gu, and E. Fon. 2002. Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J. Biol. Chem. 277: 486-491.
16. Kitada, T., S. Asakawa, N. Hattori, H. Matsumine, Y. Yamamura, S. Minoshima, M. Yokochi, Y. Mizuno, and N. Shimizu. 1998. Mutations in the Parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392: 605-608.
17. Shimura, H., N. Hattori, S. Kubo, Y. Mizuno, S. Asakawa, S. Minoshima, N. Shimizu, K. Iwai, T. Chiba, K. Tanaka, and T. Suzuki. 2000. Familial Parkinson disease gene product, Parkin, is a ubiquitin-protein ligase. Nat. Genet. 25: 302-305.
18. Imai, Y., M. Soda, and R. Takahashi. 2000. Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J. Biol. Chem. 275: 35661-35664.
19. Liu, Y. C. 2004. Ubiquitin ligases and the immune response. Annu. Rev. Immunol. 22: 81-127.
20. Fang, D., H.-Y. Wang, N. Fang, Y. Altman, C. Elly, and Y. C. Liu. 2001. Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. J. Biol. Chem. 276: 4872-4878,
21. Fang, D., and Y. C. Liu. 2001. Proteolysis-independent regulation of phosphatidylinositol 3-kinase by Cbl-b-mediated ubiquitination in T cells. Nat. Immunol. 2: 870-875.
22. Panigada, M., S. Porcellini, E. Barbier, S. Hoeflinger, P. A. Cazenave, H. Gu, H. Band, H. von Boehmer, and F. Grassi. 2002. Constitutive endocytosis and degradation of the pre-T cell receptor. J. Exp. Med. 195: 1585-1597.
23. + T cells. Immunity 18: 535-547.
24. Zhao, H., C. C. Li, J. Pardo, P. C. Chu, C. X. Liao, J. Huang, J. G. Dong, X. Zhou, Q. Huang, B. Huang, et al. 2005. A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation. J. Immunol. 174: 5288-5297.
25. Chuang, T., and R. J. Ulevitch. 2004. Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat. Immunol. 5: 495-502.
26. Zhao, C., S. L. Beaudenon, M. L. Kelley, M. B. Waddell, W. Yuan, B. S. Schulman, J. M. Huilbregtse, and R. M. Krug. 2004. The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-αβ-induced ubiquitin-like protein. Proc. Natl. Acad. Sci. USA 101: 7578-7582.
27. Van Der Reijden, B. A., C. A. J. Erpelinck-Verschueren, B. Lowenberg, and J. H. Jansen. 1999. TRIADs: a new class of proteins with a novel cysteine-rich signature. Protein Sci. 8: 1557-1561.
28. Berg, J., and Y. Shi. 1996. The galvanization of biology: a growing appreciation of the roles of zinc. Science 271: 1081-1085.
29. Freemont, P. 1993. The RING finger, a novel protein sequence motif related to the zinc finger. Annu. NY Acad. Sci. 684: 174-192.
30. Kashuba, E., V. Kashuba, T. Sandalova, G. Klein, and L. Szekely. 2002. Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase. BMC Cell Biol. 3: 23.
31. Mitterbauer, R., T. Karl, and G. Adam. 2002. Saccharomyces cerevisiae URHI (encoding uridine-cytidine N-ribohydrolase): functional complementation by a nucleoside hydrolase from a protozoan parasite and by a mammalian uridine phosphorylase. Appl. Environ. Microbiol. 68: 1336-1343.
32. Van Rompay, A. R., A. Norda, K. Linden, M. Johansson, and A. Karlsson. 2001. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol. Pharmacol. 59: 1181-1186.
33. Moilanen, A., H. Poukka, U. Karvonen, M. Hakli, O. A. Janne, and J. J. Palvimo. 1998. Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Mol. Cell. Biol. 18: 5128-5139.
34. Asamitsu, K., T. Tetsuka, S. Kanazawa, and T. Okamoto. 2003. RING finger protein AO7 supports NF-κB-mediated transcription by interacting with transactivation domain of the p65 subunit. J. Biol. Chem. 278: 26879-26887.
35. Nie, J., M. A. McGill, M. Dermer, S. E. Dho, C. D. Wolting, and C. J. McGlade. 2002. LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J. 21: 93-102.