-
1
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ (2001) Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 81, 741-766 (Pubitemid 32267077)
-
(2001)
Physiological Reviews
, vol.81
, Issue.2
, pp. 741-766
-
-
Selkoe, D.J.1
-
2
-
-
33749177143
-
A Hundred Years of Alzheimer's Disease Research
-
DOI 10.1016/j.neuron.2006.09.016, PII S0896627306007239
-
Hardy J (2006) A hundred years of Alzheimer's disease research. Neuron 52, 3-13 (Pubitemid 44472602)
-
(2006)
Neuron
, vol.52
, Issue.1
, pp. 3-13
-
-
Hardy, J.1
-
3
-
-
84864471159
-
Amutation in APP protects against Alzheimer's disease and age-related cognitive decline
-
Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jonsson EG, Palotie A, BehrensTW, MagnussonOT,Kong A, Thorsteinsdottir U,Watts RJ, StefanssonK(2012)Amutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 488, 96-99
-
(2012)
Nature
, vol.488
, pp. 96-99
-
-
Jonsson, T.1
Atwal, J.K.2
Steinberg, S.3
Snaedal, J.4
Jonsson, P.V.5
Bjornsson, S.6
Stefansson, H.7
Sulem, P.8
Gudbjartsson, D.9
Maloney, J.10
Hoyte, K.11
Gustafson, A.12
Liu, Y.13
Lu, Y.14
Bhangale, T.15
Graham, R.R.16
Huttenlocher, J.17
Bjornsdottir, G.18
Andreassen, O.A.19
Jonsson, E.G.20
Palotie, A.21
Behrens, T.W.22
Magnusson, O.T.23
Kong, A.24
Thorsteinsdottir, U.25
Watts, R.J.26
Stefansson, K.27
more..
-
4
-
-
0036049185
-
Presenilins and APP in neuritic and synaptic plasticity: Implications for the pathogenesis of Alzheimer's disease
-
DOI 10.1385/NMM:2:2:167
-
Chan SL, Furukawa K, Mattson MP (2002) Presenilins and APP in neuritic and synaptic plasticity: Implications for the pathogenesis of Alzheimer's disease. Neuromolecular Med 2, 167-196 (Pubitemid 37012503)
-
(2002)
NeuroMolecular Medicine
, vol.2
, Issue.2
, pp. 167-196
-
-
Chan, S.L.1
Furukawa, K.2
Mattson, M.P.3
-
5
-
-
47749095383
-
Linking Calcium to Aβ and Alzheimer's Disease
-
DOI 10.1016/j.neuron.2008.07.013, PII S0896627308005862
-
Green KN, LaFerla FM (2008) Linking calcium to Abeta and Alzheimer's disease. Neuron 59, 190-194 (Pubitemid 352033693)
-
(2008)
Neuron
, vol.59
, Issue.2
, pp. 190-194
-
-
Green, K.N.1
LaFerla, F.M.2
-
6
-
-
77949899089
-
Calcium hypothesis of Alzheimer's disease
-
Berridge MJ (2010) Calcium hypothesis of Alzheimer's disease. Pflugers Arch 459, 441-449
-
(2010)
Pflugers Arch
, vol.459
, pp. 441-449
-
-
Berridge, M.J.1
-
7
-
-
84859882828
-
Neuronal calcium signaling and Alzheimer's disease
-
Woods NK, Padmanabhan J (2012) Neuronal calcium signaling and Alzheimer's disease. Adv Exp Med Biol 740, 1193-1217
-
(2012)
Adv Exp Med Biol
, vol.740
, pp. 1193-1217
-
-
Woods, N.K.1
Padmanabhan, J.2
-
8
-
-
0032127927
-
Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families
-
DOI 10.1006/nbdi.1998.0176
-
Etcheberrigaray R, Hirashima N, Nee L, Prince J, Govoni S, Racchi M, Tanzi RE, Alkon DL (1998) Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families. Neurobiol Dis 5, 37-45 (Pubitemid 28361650)
-
(1998)
Neurobiology of Disease
, vol.5
, Issue.1
, pp. 37-45
-
-
Etcheberrigaray, R.1
Hirashima, N.2
Nee, L.3
Prince, J.4
Govoni, S.5
Racchi, M.6
Tanzi, R.E.7
Alkon, D.L.8
-
9
-
-
47749113650
-
Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks
-
DOI 10.1016/j.neuron.2008.06.008, PII S0896627308005011
-
Kuchibhotla KV, Goldman ST, Lattarulo CR,Wu HY, Hyman BT, Bacskai BJ (2008) Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron 59, 214-225 (Pubitemid 352033686)
-
(2008)
Neuron
, vol.59
, Issue.2
, pp. 214-225
-
-
Kuchibhotla, K.V.1
Goldman, S.T.2
Lattarulo, C.R.3
Wu, H.-Y.4
Hyman, B.T.5
Bacskai, B.J.6
-
10
-
-
61349096009
-
Synchronous hyperactivity and intercellular calciumwaves in astrocytes in Alzheimer mice
-
KuchibhotlaKV, Lattarulo CR, HymanBT, Bacskai BJ (2009) Synchronous hyperactivity and intercellular calciumwaves in astrocytes in Alzheimer mice. Science 323, 1211-1215
-
(2009)
Science
, vol.323
, pp. 1211-1215
-
-
Kuchibhotla, K.V.1
Lattarulo, C.R.2
Hyman, B.T.3
Bacskai, B.J.4
-
11
-
-
66249135657
-
Calcium dyshomeostasis and neurotoxicity of Alzheimer's betaamyloid protein
-
Kawahara M, Negishi-Kato M, Sadakane Y (2009) Calcium dyshomeostasis and neurotoxicity of Alzheimer's betaamyloid protein. Expert Rev Neurother 9, 681-693
-
(2009)
Expert Rev Neurother
, vol.9
, pp. 681-693
-
-
Kawahara, M.1
Negishi-Kato, M.2
Sadakane, Y.3
-
12
-
-
77951251848
-
Calcium signaling and amyloid toxicity in Alzheimer disease
-
Demuro A, Parker I, Stutzmann GE (2010) Calcium signaling and amyloid toxicity in Alzheimer disease. J Biol Chem 285, 12463-12468
-
(2010)
J Biol Chem
, vol.285
, pp. 12463-12468
-
-
Demuro, A.1
Parker, I.2
Stutzmann, G.E.3
-
13
-
-
34547479273
-
Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content
-
DOI 10.1111/j.1471-4159.2007.04627.x
-
Hamid R, Kilger E, Willem M, Vassallo N, Kostka M, Bornhovd C, Reichert AS, Kretzschmar HA, Haass C, Herms J (2007) Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content. J Neurochem 102, 1264-1275 (Pubitemid 47174237)
-
(2007)
Journal of Neurochemistry
, vol.102
, Issue.4
, pp. 1264-1275
-
-
Hamid, R.1
Kilger, E.2
Willem, M.3
Vassallo, N.4
Kostka, M.5
Bornhovd, C.6
Reichert, A.S.7
Kretzschmar, H.A.8
Haass, C.9
Herms, J.10
-
14
-
-
0037007140
-
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP
-
DOI 10.1073/pnas.072033799
-
Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Muller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM (2002) A physiologic signaling role for the gamma-secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A 99, 4697-4702 (Pubitemid 34286047)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.7
, pp. 4697-4702
-
-
Leissring, M.A.1
Murphy, M.P.2
Mead, T.R.3
Akbari, Y.4
Sugarman, M.C.5
Jannatipour, M.6
Anliker, B.7
Muller, U.8
Saftig, P.9
De Strooper, B.10
Wolfe, M.S.11
Golde, T.E.12
LaFerla, F.M.13
-
15
-
-
84864957971
-
Presenilins: Role in calcium homeostasis
-
Honarnejad K, Herms J (2012) Presenilins: Role in calcium homeostasis. Int J Biochem Cell Biol 44, 1983-1986
-
(2012)
Int J Biochem Cell Biol
, vol.44
, pp. 1983-1986
-
-
Honarnejad, K.1
Herms, J.2
-
16
-
-
0030987603
-
Caffeine stimulates amyloid β-peptide release from β-amyloid precursor protein-transfected HEK293 cells
-
QuerfurthHW, Jiang J, Geiger JD, Selkoe DJ (1997) Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells. J Neurochem 69, 1580-1591 (Pubitemid 27406959)
-
(1997)
Journal of Neurochemistry
, vol.69
, Issue.4
, pp. 1580-1591
-
-
Querfurth, H.W.1
Jiang, J.2
Geiger, J.D.3
Selkoe, D.J.4
-
17
-
-
0028207004
-
Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner
-
Buxbaum JD, Ruefli AA, Parker CA, Cypess AM, Greengard P (1994) Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc Natl Acad Sci U S A 91, 4489-4493 (Pubitemid 24143459)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.10
, pp. 4489-4493
-
-
Buxbaum, J.D.1
Ruefli, A.A.2
Parker, C.A.3
Cypess, A.M.4
Greengard, P.5
-
18
-
-
72449130946
-
Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic shortterm plasticity
-
Yang L, Wang Z, Wang B, Justice NJ, Zheng H (2009) Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic shortterm plasticity. J Neurosci 29, 15660-15668
-
(2009)
J Neurosci
, vol.29
, pp. 15660-15668
-
-
Yang, L.1
Wang, Z.2
Wang, B.3
Justice, N.J.4
Zheng, H.5
-
19
-
-
65549153713
-
Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations
-
Santos SF, Pierrot N, Morel N, Gailly P, Sindic C, Octave JN (2009) Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations. J Neurosci 29, 4708-4718
-
(2009)
J Neurosci
, vol.29
, pp. 4708-4718
-
-
Santos, S.F.1
Pierrot, N.2
Morel, N.3
Gailly, P.4
Sindic, C.5
Octave, J.N.6
-
20
-
-
43849103683
-
Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production
-
Parisiadou L, Bethani I, Michaki V, Krousti K, Rapti G, Efthimiopoulos S (2008) Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production. Neurobiol Dis 30, 353-364
-
(2008)
Neurobiol Dis
, vol.30
, pp. 353-364
-
-
Parisiadou, L.1
Bethani, I.2
Michaki, V.3
Krousti, K.4
Rapti, G.5
Efthimiopoulos, S.6
-
21
-
-
0021895138
-
2+ indicators with greatly improved fluorescence properties
-
Grynkiewicz G, Poenie M, Tsien RY (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260, 3440-3450 (Pubitemid 15114340)
-
(1985)
Journal of Biological Chemistry
, vol.260
, Issue.6
, pp. 3440-3450
-
-
Grynkiewicz, G.1
Poenie, M.2
Tsien, R.Y.3
-
22
-
-
0025919762
-
2+ accumulation, storage, and release
-
Fasolato C, Zottini M, Clementi E, Zacchetti D, Meldolesi J, Pozzan T (1991) Intracellular Ca2+ pools in PC12 cells. Three intracellular pools are distinguished by their turnover and mechanisms of Ca2+ accumulation, storage, and release. J Biol Chem 266, 20159-20167 (Pubitemid 21908440)
-
(1991)
Journal of Biological Chemistry
, vol.266
, Issue.30
, pp. 20159-20167
-
-
Fasolato, C.1
Zottini, M.2
Clementi, E.3
Zacchetti, D.4
Meldolesi, J.5
Pozzan, T.6
-
23
-
-
77549084517
-
The dysregulation of intracellular calcium in Alzheimer disease
-
Supnet C, Bezprozvanny I (2010) The dysregulation of intracellular calcium in Alzheimer disease. Cell Calcium 47, 183-189
-
(2010)
Cell Calcium
, vol.47
, pp. 183-189
-
-
Supnet, C.1
Bezprozvanny, I.2
-
24
-
-
79952409731
-
Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection
-
Zundorf G, ReiserG(2011) Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection. Antioxid Redox Signal 14, 1275-1288
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 1275-1288
-
-
Zundorf, G.1
Reiser, G.2
-
25
-
-
79952405292
-
Neuronal calcium homeostasis and dysregulation
-
Gleichmann M, Mattson MP (2011) Neuronal calcium homeostasis and dysregulation. Antioxid Redox Signal 14, 1261-1273
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 1261-1273
-
-
Gleichmann, M.1
Mattson, M.P.2
-
26
-
-
84862908515
-
Effects of amyloid-beta peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels
-
Kim S, Rhim H (2011) Effects of amyloid-beta peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels. Mol Cells 32, 289-294
-
(2011)
Mol Cells
, vol.32
, pp. 289-294
-
-
Kim, S.1
Rhim, H.2
-
27
-
-
0026570528
-
Beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
-
Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE (1992) beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12, 376-389
-
(1992)
J Neurosci
, vol.12
, pp. 376-389
-
-
Mattson, M.P.1
Cheng, B.2
Davis, D.3
Bryant, K.4
Lieberburg, I.5
Rydel, R.E.6
-
28
-
-
0028169905
-
Secreted forms of betaamyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury
-
Goodman Y, Mattson MP (1994) Secreted forms of betaamyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp Neurol 128, 1-12
-
(1994)
Exp Neurol
, vol.128
, pp. 1-12
-
-
Goodman, Y.1
Mattson, M.P.2
-
29
-
-
0029739316
-
Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease
-
Okamoto T, Takeda S, Giambarella U, MurayamaY, Matsui T, Katada T, Matsuura Y, Nishimoto I (1996) Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease. EMBO J 15, 3769-3777 (Pubitemid 26289786)
-
(1996)
EMBO Journal
, vol.15
, Issue.15
, pp. 3769-3777
-
-
Okamoto, T.1
Takeda, S.2
Giambarella, U.3
Murayama, Y.4
Matsui, T.5
Katada, T.6
Matsuura, Y.7
Nishimoto, I.8
-
30
-
-
0037462753
-
Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein
-
DOI 10.1074/jbc.M206769200
-
Herms J, Schneider I, Dewachter I, Caluwaerts N, Kretzschmar H, Van Leuven F (2003) Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. J Biol Chem 278, 2484-2489 (Pubitemid 36801325)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.4
, pp. 2484-2489
-
-
Herms, J.1
Schneider, I.2
Dewachter, I.3
Caluwaerts, N.4
Kretzschmar, H.5
Van Leuven, F.6
-
31
-
-
0036830947
-
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
-
LaFerlaFM(2002) Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci 3, 862-872
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 862-872
-
-
Laferla, F.M.1
-
33
-
-
4944259359
-
2+ entry in cortical neurons
-
DOI 10.1111/j.1460-9568.2004.03680.x
-
Bouron A, Mbebi C, Loeffler JP, De Waard M (2004) The beta-amyloid precursor protein controls a store-operated Ca2+ entry in cortical neurons. Eur J Neurosci 20, 2071-2078 (Pubitemid 39331127)
-
(2004)
European Journal of Neuroscience
, vol.20
, Issue.8
, pp. 2071-2078
-
-
Bouron, A.1
Mbebi, C.2
Loeffler, J.-P.3
De Waard, M.4
-
34
-
-
41149133293
-
2+] in adult Alzheimer's disease mice
-
DOI 10.1111/j.1471-4159.2007.05135.x
-
Lopez JR, Lyckman A, Oddo S, Laferla FM, Querfurth HW, Shtifman A (2008) Increased intraneuronal resting Ca2+] in adult Alzheimer's disease mice. J Neurochem 105, 262-271 (Pubitemid 351441642)
-
(2008)
Journal of Neurochemistry
, vol.105
, Issue.1
, pp. 262-271
-
-
Lopez, J.R.1
Lyckman, A.2
Oddo, S.3
LaFerla, F.M.4
Querfurth, H.W.5
Shtifman, A.6
-
35
-
-
77957790011
-
FAD mutations in amyloid precursor protein do not directly perturb intracellular calcium homeostasis
-
Stieren E, Werchan WP, El Ayadi A, Li F, Boehning D (2010) FAD mutations in amyloid precursor protein do not directly perturb intracellular calcium homeostasis. PLoS One 5, e11992
-
(2010)
PLoS One
, vol.5
-
-
Stieren, E.1
Werchan, W.P.2
El Ayadi, A.3
Li, F.4
Boehning, D.5
-
36
-
-
11444267601
-
Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases
-
DOI 10.1016/j.neurobiolaging.2004.09.018, PII S0197458004002945, Developmental Origins of Aging in the Brain and Blood Vessels
-
Nixon RA (2005) Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiol Aging 26, 373-382 (Pubitemid 40082721)
-
(2005)
Neurobiology of Aging
, vol.26
, Issue.3
, pp. 373-382
-
-
Nixon, R.A.1
-
37
-
-
1242316279
-
Niemann-Pick Type C Disease and Alzheimer's Disease: The APP-Endosome Connection Fattens Up
-
Nixon RA (2004) Niemann-Pick Type C disease and Alzheimer's disease: The APP-endosome connection fattens up. Am J Pathol 164, 757-761 (Pubitemid 38235457)
-
(2004)
American Journal of Pathology
, vol.164
, Issue.3
, pp. 757-761
-
-
Nixon, R.A.1
-
38
-
-
21844467425
-
2+ entry: Vesicle fusion or reversible trafficking and de novo conformational coupling?
-
DOI 10.1002/jcp.20399
-
Rosado JA, Redondo PC, Sage SO, Pariente JA, Salido GM (2005) Store-operated Ca2+ entry:Vesicle fusion or reversible trafficking and de novo conformational coupling? J Cell Physiol 205, 262-269 (Pubitemid 41428909)
-
(2005)
Journal of Cellular Physiology
, vol.205
, Issue.2
, pp. 262-269
-
-
Rosado, J.A.1
Redondo, P.C.2
Sage, S.O.3
Pariente, J.A.4
Salido, G.M.5
-
39
-
-
79953304059
-
STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human platelets
-
Zbidi H, Jardin I, Woodard GE, Lopez JJ, Berna-Erro A, Salido GM, Rosado JA (2011) STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human platelets. J Biol Chem 286, 12257-12270
-
(2011)
J Biol Chem
, vol.286
, pp. 12257-12270
-
-
Zbidi, H.1
Jardin, I.2
Woodard, G.E.3
Lopez, J.J.4
Berna-Erro, A.5
Salido, G.M.6
Rosado, J.A.7
|