Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 34, Issue 2, 2013, Pages 399-405

  Chong, Mei Sian ^a   Lim, Wee Shiong ^a   Chan, Mark ^a   Tay, Laura ^a   Chen, Gengbo ^b   Feng, Lei ^c   Ng, Tze Pin ^c   Tan, Chay Hoon ^d   Lee, Tih Shih ^b,e  

^a TAN TOCK SENG HOSPITAL   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; gene expression; progression; TOMM40

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; DISEASE COURSE; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION PROFILING; HUMAN; KIR2DL5A GENE; LEUKOCYTE; MALE; PLOD1 GENE; PRIORITY JOURNAL; SLC2A8 GENE; TOMM40 GENE; UPREGULATION;

EID: 84874288023     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-121621     Document Type: Article

References (28)

1. Chong MS, Lim WS, Sahadevan S (2006) Biomarkers in prediction of progression of preclinical Alzheimer's disease. Curr Opin Invest Drugs 7, 600-607 (Pubitemid 44018341)
2. Hebert SS, Horre K, Nicolai L, Papadopoulou AS, Mademakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B (2008) Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/- secretase expression. Proc Natl Acad Sci U S A 105, 6415-6420 (Pubitemid 351758360)
3. Espeseth AS, Huang Q, Gates A, Xu M, Yu Y, Simon AJ, Shi XP, Zhang X, Hodor P, Stone DJ, Burchard J, Cavet G, Bartz S, Linsley P, Ray WJ, Hazuda D (2006) A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels. Mol Cell Neurosci 33, 227-235 (Pubitemid 44692488)
4. Yokota T, Mishra M, Akatsu H, Tani U, Miyauchi T, Yamamoto T, Kosaka K, Nagai Y, Sawada T, Heese K (2006) Brain site-specific gene expression analysis in Alzheimer's disease patients. Eur J Clin Invest 36, 820-830 (Pubitemid 44569971)
5. Maes OC, Xu S, Yu B, Chertkow HM,Wang E, Schipper HM (2007) Transcriptional profiling of Alzheimer blood mononuclear cells by microarray. Neurobiol Aging 28, 1795-1809 (Pubitemid 47539691)
6. Fehlbaum-Beurdeley P, Jarrige AC, Pallares D, Carriere J, Guihal C, Soucaille C, Rouet F, Drouin D, Sol O, Jordan H, Wu D, Lei L, Einstein R, Schweighoffer F, Bracco L (2010) Toward an Alzheimer's disease diagnosis via high-resolution blood gene expression. Alzheimers Dement 6, 25-38
7. Grunblatt E, Bartl J, Zehetmayer S, Ringel TM, Bauer P, Riederer P, Jacob CP (2009) Gene expression as peripheral biomarkers for sporadic Alzheimer's disease. J Alzheimers Dis 16, 627-634
8. Booij BB, Lindahl T,Wetterberg P, SkaaneNV, Sæbø S, Feten G, Rye PD, Kristiansen LI, Hagen N, Jensen M, Bardsen K, Winblad B, Sharma P, L?onneborgA(2010)Agene expression pattern in blood for the early detection of Alzheimer's disease. J Alzheimers Dis 23, 1-11
9. Lee TS, Goh L, Chong MS, Chua SM, G, Feng L, Lim WS, Chan M, Ng TP, Krishnan KR (2012) TOMM40 gene expression is downregulated in Alzheimer disease patients' blood compared with controls. J Psychiatry Res 46, 828-830
10. Sahadevan S, Lim PP, Tan NJ, Chan SP (2010) Diagnostic performance of two mental status tests in the older Chinese: Influence of education and age on cut-off values. Int J Geriatr Psychiatry 15, 234-241
11. Sahadevan S, Lim JP, Tan NJ, Chan SP (2000) Psychometric identification of early Alzheimer disease in an elderly Chinese population with differing educational levels. Alzheimer Dis Assoc Disord 16, 65-72 (Pubitemid 34627673)
12. Schroeder A, Mueller O, Stocker S, Salowsky R, Leiber M, Gassmann M, Lightfoot S, Menzel W, Granzow M, Ragg T (2006) The RIN: An RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol 7, 3
13. Roses AD (2010) An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease. Arch Neurol 67, 536-541
14. Roses AD, Lutz MW, Amrine-Madsen, Saunders AM, Crenshaw DG, Sundseth SS, Huentelman MJ,Welsh-Bohmer KA, Reiman EM (2010) A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease. Pharmacogenomics J 10, 375-384
15. Abraham R, Moskvina V, Sims R, Hollingworth P, Morgan A, Georgieva L, Dowzell K, Cichon S, Hillmer AM, O'Donovan MC, Williams J, Owen MJ, Kirov G (2008) A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. BMC Med Genomic 1, 44
16. Feulner TM, Laws SM, Friedrich P,Wagenpfeil S,Wurst SH, Riehle C, Kuhn KA, Krawczak M, Schreiber S, Nikolaus S, F?orstl H, Kurz A, Riemenschneider M (2010) Examination of the current top candidate genes for AD in a genome-wide association study. Mol Psychiatry 15, 756-766
17. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K,Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schurmann B, van den Bussche H, Heuser I, Kornhuber J,Wiltfang J, Dichgans M, Fr?olich L, Hampel H, Hull M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van BroeckhovenC,Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Muhleisen TW, Nothen MM, Moebus S, Jockel KH, Klopp N,Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 41, 1088-1093
18. Heinzen EL, Need AC, Hayden KM, Chiba-Falek O, Roses AD, Strittmatter WJ, Burke JR, Hulette CM, Welsh-Bohmer KA, GoldsteinDB(2010) Genome-wide scan of copy number variation in late-onset Alzheimer's disease. J Alzheimers Dis 19, 69-77
19. Naj AC, Beecham GW, Martin ER, Gallins PJ, Powell EH, Konidari I, Whitehead PL, Cai G, Haroutunian V, Scott WK, Vance JM, Slifer MA, Gwirtsman HE, Gilbert JR, Haines JL, Buxbaum JD, Pericak-Vance MA (2010) Dementia revealed: Novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. PLoS Gene 23, 58
20. Shen L, Kim S, Risacher SL, Nho K, Swaminathan S, West JD, Foroud T, Pankratz N, Moore JH, Sloan CD, Huentelman MJ, Craig DW, Dechairo BM, Potkin SG, Jack CR Jr, Weiner MW, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative (2010) Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trail loci in MCI and AD: A study of the ADNI cohort. Neuroimage 53, 1051-1063
21. Cruchaga C, Nowotny P, Kauwe JSK, Ridge PG, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM; Alzheimer's Disease Neuroimaging Initiative (2011) Association and expression analysis with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease. Arch Neurol 68, 1013-1019
22. Dunckley T, Beach TG, Ramsey KE, Grover A, Mastroeni D, Walker DG, LaFleur BJ, Coon KD, Brown KM, Caselli R, Kukull W, Higdon R, McKeel D, Morris JC, Hulette C, Schmechel D, Reiman EM, Rogers J, Stephan DA (2006) Gene expression correlates of neurofibrillary tangles in Alzheimer's disease. Neurobiol Aging 27, 1359-1371 (Pubitemid 44279890)
23. Blalock EM, Geddes JW, Chen KC, Portner NM, Markesbery WR, Landfield PW (2004) Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci U S A 101, 2173-2178 (Pubitemid 38229034)
24. Mandrekar-Colucci S, Landreth GE (2010) Microglia and inflammation in Alzheimer's disease. CNS Neurol Disord Drug Targets 9, 156-167
25. McGeer PL, Schulzer M, McGeer EG (1996) Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies. Neurology 47, 425-432 (Pubitemid 26324038)
26. McEwen BS, Reagan LP (2004) Glucose transporter expression in the central nervous system: Relationship to synaptic function. Eur J Pharmacol 490, 13-24 (Pubitemid 38482158)
27. de la Monte SM (2012) Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease. Drugs 72, 49-66
28. Park CR (2001) Cognitive effects of insulin in the central nervous system. Neurosci Biobehav Rev 25, 311-323 (Pubitemid 32624374)