Significance and Suppression of Redundant IL17 Responses in Acute Allograft Rejection by Bioinformatics Based Drug Repositioning of Fenofibrate

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Roedder, Silke ^a   Kimura, Naoyuki ^b   Okamura, Homare ^b   Hsieh, Szu Chuan ^a   Gong, Yongquan ^b   Sarwal, Minnie M ^a  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; F6020; FENOFIBRATE; GAMMA INTERFERON; INTERLEUKIN 17; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOINFORMATICS; CARDIAC GRAFT REJECTION; CELL INFILTRATION; CELL STIMULATION; CHILD; DRUG APPROVAL; DRUG MECHANISM; DRUG REPOSITIONING; ENZYME INHIBITION; FOOD AND DRUG ADMINISTRATION; GENETIC ANALYSIS; GRAFT SURVIVAL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; KIDNEY BIOPSY; LEUKOCYTE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; SCHOOL CHILD; SIGNAL TRANSDUCTION; SPLEEN; TH1 CELL; TREATMENT INDICATION;

ADOLESCENT; ADULT; ANIMALS; CHILD; CHILD, PRESCHOOL; COMPUTATIONAL BIOLOGY; FEMALE; FENOFIBRATE; GENE EXPRESSION; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSION; INTERFERON-GAMMA; INTERLEUKIN-17; KIDNEY TRANSPLANTATION; LEUKOCYTES, MONONUCLEAR; MALE; MICE; TISSUE ARRAY ANALYSIS; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 84874283414     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056657     Document Type: Article

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