Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice

Cardiovascular Research

Volumn 97, Issue 3, 2013, Pages 490-499

  Yang, Jian ^a   Mou, Yun ^a   Wu, Tao ^a   Ye, Yang ^b   Jiang, Jun Chang ^b   Zhao, Chen Ze ^a   Zhu, Huan Huan ^a   Du, Chang Qing ^a   Zhou, Liang ^c   Hu, Shen Jiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cardiac hypertrophy; Heart failure; Molecular biology; Signal transduction

Indexed keywords

FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; GERANYLTRANSFERASE; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ADENOVIRUS INFECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME SYNTHESIS; GENE EXPRESSION; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ADENOVIRIDAE; ANIMALS; CARDIOMEGALY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; GERANYLTRANSTRANSFERASE; HEART FAILURE; HEART VALVE DISEASES; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; MYOCARDIUM; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLYISOPRENYL PHOSPHATES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84874269796     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs347     Document Type: Article

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