Optimal Nutrition in Hemodialysis Patients

Advances in Chronic Kidney Disease

Volumn 20, Issue 2, 2013, Pages 181-189

  Ikizler, T Alp ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anabolism; Inflammation; Metabolism; Parenteral nutrition; Protein energy wasting (PEW)

Indexed keywords

C REACTIVE PROTEIN; CHOLECYSTOKININ; CYPROHEPTADINE; DOCOSAHEXAENOIC ACID; DRONABINOL; GAMMA TOCOPHEROL; GESTAGEN; GHRELIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; MEGESTROL ACETATE; MELATONIN; NANDROLONE DECANOATE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OBESTATIN; PENTOXIFYLLINE; PEPTIDE YY; PHOSPHATIDYLINOSITOL 3 KINASE; PREALBUMIN; SERUM ALBUMIN; SOMATOMEDIN C; THALIDOMIDE; TUMOR NECROSIS FACTOR;

ALBUMIN BLOOD LEVEL; ALTERNATIVE MEDICINE; ANOREXIA; BODY MASS; CHRONIC INFLAMMATION; COST BENEFIT ANALYSIS; DIABETES MELLITUS; DIET SUPPLEMENTATION; DISEASE COURSE; ENERGY BALANCE; ENERGY METABOLISM; HEALTH STATUS; HEMODIALYSIS; HEMODIALYSIS PATIENT; HIGH RISK POPULATION; HUMAN; INSULIN RESISTANCE; INTRADIALYTIC PARENTERAL NUTRITION; KIDNEY DISEASE; KIDNEY FAILURE; LEAN BODY WEIGHT; MAINTENANCE THERAPY; MALNUTRITION; NUTRITION; NUTRITIONAL STATUS; PREVALENCE; PRIORITY JOURNAL; PROTEIN CALORIE MALNUTRITION; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW;

APPETITE STIMULANTS; DIETARY SUPPLEMENTS; EXERCISE THERAPY; GROWTH HORMONE; HUMANS; INFLAMMATION; INSULIN RESISTANCE; NUTRITIONAL STATUS; PARENTERAL NUTRITION; PROTEIN-ENERGY MALNUTRITION; RENAL DIALYSIS; RENAL INSUFFICIENCY, CHRONIC; WASTING SYNDROME;

EID: 84874264343     PISSN: 15485595     EISSN: 15485609     Source Type: Journal    
DOI: 10.1053/j.ackd.2012.12.002     Document Type: Review

References (71)

1. Fouque D., Kalantar-Zadeh K., Kopple J., et al. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 2008, 73:391-398.
2. Sardesai V.M. Fundamentals of Nutrition. Introduction to Clinical Nutrition 1998, 1-13. Sardesai V.M, New York, NY. M. Dekker (Ed.).
3. Ikizler T.A., Hakim R.M. Nutrition in end-stage renal disease. Kidney Int 1996, 50:343-357.
4. Jeejeebhoy K.N. Nutritional assessment. Nutrition 2000, 16:585-590.
5. Identifying patients at risk: ADA's definitions for nutrition screening and nutrition assessment. Council on Practice (COP) Quality Management Committee. J Am Diet Assoc 1994, 94:838-839.
6. Pupim L., Martin C.J., Ikizler T.A. Assessment of Protein-Energy Nutritional Status. Nutritional Management of Renal Disease 2004, 223-240. Lippincott Williams & Wilkins, Philadelphia, PA. 2nd ed. J.D. Kopple, S.G. Massry (Eds.).
7. Pifer T.B., McCullough K.P., Port F.K., et al. Mortality risk in hemodialysis patients and changes in nutritional indicators: DOPPS. Kidney Int 2002, 62:2238-2245.
8. Lopes A.A., Bragg-Gresham J.L., Elder S.J., et al. Independent and joint associations of nutritional status indicators with mortality risk among chronic hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). J Ren Nutr 2010, 20:224-234.
9. Cano N.J., Roth H., Aparicio M., et al. Malnutrition in hemodialysis diabetic patients: evaluation and prognostic influence. Kidney Int 2002, 62:593-601.
10. Anderson C.F., Wochos D.N. The utility of serum albumin values in the nutritional assessment of hospitalized patients. Mayo Clin Proc 1982, 57:181-184.
11. Reinhardt G.F., Myscofski J.W., Wilkens D.B., Dobrin P.B., Mangan J.E., Stannard R.T. Incidence and mortality of hypoalbuminemic patients in hospitalized veterans. JPEN J Parenter Enteral Nutr 1980, 4:357-359.
12. Apelgren K.N., Rombeau J.L., Twomey P.L., Miller R.A. Comparison of nutritional indices and outcome in critically ill patients. Crit Care Med 1982, 10:305-307.
13. Kaw M., Sekas G. Long-term follow-up of consequences of percutaneous endoscopic gastrostomy (PEG) tubes in nursing home patients. Dig Dis Sci 1994, 39:738-743.
14. Ikizler T.A. The use and misuse of serum albumin as a nutritional marker in kidney disease. Clin J Am Soc Nephrol 2012, 7:1375-1377.
15. Combe C., McCullough K.P., Asano Y., Ginsberg N., Maroni B.J., Pifer T.B. Kidney Disease Outcomes Quality Initiative (K/DOQI) and the Dialysis Outcomes and Practice Patterns Study (DOPPS): nutrition guidelines, indicators, and practices. Am J Kidney Dis 2004, 44:39-46.
16. Kalantar-Zadeh K., Cano N.J., Budde K., et al. Diets and enteral supplements for improving outcomes in chronic kidney disease. Nat Rev Nephrol 2011, 7:369-384.
17. Kalantar-Zadeh K., Kuwae N., Wu D.Y., et al. Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients. Am J Clin Nutr 2006, 83:202-210.
18. Mehrotra R., Duong U., Jiwakanon S., et al. Serum albumin as a predictor of mortality in peritoneal dialysis: comparisons with hemodialysis. Am J Kidney Dis 2011, 58:418-428.
19. Noori N., Kovesdy C.P., Dukkipati R., et al. Survival predictability of lean and fat mass in men and women undergoing maintenance hemodialysis. Am J Clin Nutr 2010, 92:1060-1070.
20. Cano N.J., Fouque D., Roth H., et al. Intradialytic parenteral nutrition does not improve survival in malnourished hemodialysis patients: a 2-year multicenter, prospective, randomized study. J Am Soc Nephrol 2007, 18:2583-2591.
21. Lacson E., Wang W., Zebrowski B., Wingard R., Hakim R.M. Outcomes associated with intradialytic oral nutritional supplements in patients undergoing maintenance hemodialysis: a quality improvement report. Am J Kidney Dis 2012, 60:591-600.
22. Cheu C., Pearson J., Dahlerus C., et al. Association between oral nutritional supplementation and clinical outcomes among patients with ESRD. Clin J Am Soc Nephrol 2012, 7:1897-1905.
23. Bossola M., Tazza L., Giungi S., Luciani G. Anorexia in hemodialysis patients: an update. Kidney Int 2006, 70:417-422.
24. Carrero J.J. Identification of patients with eating disorders: clinical and biochemical signs of appetite loss in dialysis patients. J Ren Nutr 2009, 19:10-15.
25. Carrero J.J. Mechanisms of altered regulation of food intake in chronic kidney disease. J Ren Nutr 2011, 21:7-11.
26. Chung S.H., Carrero J.J., Lindholm B. Causes of poor appetite in patients on peritoneal dialysis. J Ren Nutr 2011, 21:12-15.
27. Lim V.S., Kopple J.D. Protein metabolism in patients with chronic renal failure: role of uremia and dialysis. Kidney Int 2000, 58:1-10.
28. Raj D.S., Adeniyi O., Dominic E.A., et al. Amino acid repletion does not decrease muscle protein catabolism during hemodialysis. Am J Physiol Endocrinol Metab 2007, 292:E1534-E1542.
29. Ikizler T.A., Greene J.H., Wingard R.L., Hakim R.M. Nitrogen balance in hospitalized chronic hemodialysis patients. Kidney Int Suppl 1996, 57:S53-S56.
30. Ikizler T.A., Pupim R.B., Brouillette J.R., et al. Hemodialysis stimulates muscle and whole-body protein loss and alters substrate oxidation. Am J Physiol Endocrinol Metab 2002, 282:E107-E116.
31. Ikizler T.A. Nutrition, inflammation and chronic kidney disease. Curr Opin Nephrol Hypertens 2008, 17:162-167.
32. Nishimoto N., Kishimoto T. Interleukin 6: from bench to bedside. Nat Clin Pract Rheumatol 2006, 2:619-626.
33. Kalantar-Zadeh K., Block G., McAllister C.J., Humphreys M.H., Kopple J.D. Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr 2004, 80:299-307.
34. DeBoer M.D., Scarlett J.M., Levasseur P.R., Grant W.F., Marks D.L. Administration of IL-1β to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract. Peptides 2009, 30:210-218.
35. Lecker S.H., Goldberg A.L., Mitch W.E. Protein degradation by the ubiquitin-proteasome pathway in normal and disease States. J Am Soc Nephrol 2006, 17:1807-1819.
36. Deger S.M., Sundell M.B., Siew E.D., et al. Insulin resistance and protein metabolism in chronic hemodialysis patients. J Ren Nutr 2012 Nov 27, [Epub ahead of print].
37. Siew E.D., Ikizler T.A. Determinants of insulin resistance and its effects on protein metabolism in patients with advanced chronic kidney disease. Contrib Nephrol 2008, 161:138-144.
38. Flakoll P.J., Carlson M., Cherrington A.C. Physiological Action of Insulin. Diabetes Mellitus: A Fundamental and Clinical Text 2000, 148-161. Williams & Wilkins, Philadelphia, PA. 2nd ed. D.T.S. Leroith, J. Olefsky (Eds.).
39. Wang X., Hu Z., Hu J., Du J., Mitch W.E. Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology 2006, 147:4160-4168.
40. Pupim L.B., Flakoll P.J., Majchrzak K.M., Aftab Guy D.L., Stenvinkel P., Ikizler T.A. Increased muscle protein breakdown in chronic hemodialysis patients with type 2 diabetes mellitus. Kidney Int 2005, 68:1857-1865.
41. Pupim L.B., Heimburger O., Qureshi A.R., Ikizler T.A., Stenvinkel P. Accelerated lean body mass loss in incident chronic dialysis patients with diabetes mellitus. Kidney Int 2005, 68:2368-2374.
42. Siew E.D., Pupim L.B., Majchrzak K.M., Shintani A., Flakoll P.J., Ikizler T.A. Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients. Kidney Int 2007, 71:146-152.
43. Bailey J.L., Wang X., England B.K., Price S.R., Ding X., Mitch W.E. The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway. J Clin Invest 1996, 97:1447-1453.
44. Graham K.A., Reaich D., Channon S.M., Downie S., Goodship T.H.J. Correction of acidosis in hemodialysis decreases whole body protein degradation. J Am Soc Nephrol 1997, 8:632-637.
45. de Brito-Ashurst I., Varagunam M., Raftery M.J., Yaqoob M.M. Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol 2009, 20:2075-2084.
46. Wu D.Y., Shinaberger C.S., Regidor D.L., McAllister C.J., Kopple J.D., Kalantar-Zadeh K. Association between serum bicarbonate and death in hemodialysis patients: is it better to be acidotic or alkalotic?. Clin J Am Soc Nephrol 2006, 1:70-78.
47. Tonshoff B., Schaefer F., Mehls O. Disturbance of growth hormone-insulin-like growth factor axis in uraemia. Implications for recombinant human growth hormone treatment. Pediatr Nephrol 1990, 4:654-662.
48. Kopple J.D. National kidney foundation K/DOQI clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis 2001, 37:S66-S70.
49. Kovesdy C.P., Shinaberger C.S., Kalantar-Zadeh K. Epidemiology of dietary nutrient intake in ESRD. Semin Dial 2010, 23:353-358.
50. Shinaberger C.S., Greenland S., Kopple J.D., et al. Is controlling phosphorus by decreasing dietary protein intake beneficial or harmful in persons with chronic kidney disease?. Am J Clin Nutr 2008, 88:1511-1518.
51. Pupim L.B., Majchrzak K.M., Flakoll P.J., Ikizler T.A. Intradialytic oral nutrition improves protein homeostasis in chronic hemodialysis patients with deranged nutritional status. J Am Soc Nephrol 2006, 17:3149-3157.
52. Stratton R.J., Bircher G., Fouque D., et al. Multinutrient oral supplements and tube feeding in maintenance dialysis: a systematic review and meta-analysis. Am J Kidney Dis 2005, 46:387-405.
53. Caglar K., Fedje L., Dimmitt R., Hakim R.M., Shyr Y., Ikizler T.A. Therapeutic effects of oral nutritional supplementation during hemodialysis. Kidney Int 2002, 62:1054-1059.
54. Barakat M.M., Nawab Z.M., Yu A.W., Lau A.H., Ing T.S., Daugirdas J.T. Hemodynamic effects of intradialytic food ingestion and the effects of caffeine. J Am Soc Nephrol 1993, 3:1813-1818.
55. Pupim L.B., Flakoll P.J., Brouillette J.R., Levenhagen D.K., Hakim R.M., Ikizler T.A. Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients. J Clin Invest 2002, 110:483-492.
56. Ericsson F., Filho J.C., Lindgren B.F. Growth hormone treatment in hemodialysis patients-a randomized, double-blind, placebo-controlled study. Scand J Urol Nephrol 2004, 38:340-347.
57. Ikizler T.A., Wingard R.L., Breyer J.A., Schulman G., Parker R.A., Hakim R.M. Short-term effects of recombinant human growth hormone in CAPD patients. Kidney Int 1994, 46:1178-1183.
58. Johannsson G., Bengtsson B.A., Ahlmen J. Double-blind, placebo-controlled study of growth hormone treatment in elderly patients undergoing chronic hemodialysis: anabolic effect and functional improvement. Am J Kidney Dis 1999, 33:709-717.
59. Feldt-Rasmussen B., Lange M., Sulowicz W., et al. Growth hormone treatment during hemodialysis in a randomized trial improves nutrition, quality of life, and cardiovascular risk. J Am Soc Nephrol 2007, 18:2161-2171.
60. Kopple J.D., Cheung A.K., Christiansen J.S., et al. OPPORTUNITY™: a large-scale randomized clinical trial of growth hormone in hemodialysis patients. Nephrol Dial Transplant 2011, 26:4095-4103.
61. Yeh S., Wu S.Y., Levine D.M., et al. Quality of life and stimulation of weight gain after treatment with megestrol acetate: correlation between cytokine levels and nutritional status, appetite in geriatric patients with wasting syndrome. J Nutr Health Aging 2000, 4:246-251.
62. Johansen K.L., Painter P.L., Sakkas G.K., Gordon P., Doyle J., Shubert T. Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: a randomized, controlled trial. J Am Soc Nephrol 2006, 17:2307-2314.
63. Pupim L.B., Flakoll P.J., Levenhagen D.K., Ikizler T.A. Exercise augments the acute anabolic effects of intradialytic parenteral nutrition in chronic hemodialysis patients. Am J Physiol Endocrinol Metab 2004, 286:E589-E597.
64. Dong J., Sundell M.B., Pupim L.B., Wu P., Shintani A., Ikizler T.A. The effect of resistance exercise to augment long-term benefits of intradialytic oral nutritional supplementation in chronic hemodialysis patients. J Ren Nutr 2011, 21:149-159.
65. Kopple J.D., Wang H., Casaburi R., et al. Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscle. J Am Soc Nephrol 2007, 18:2975-2986.
66. Collins A.J., Foley R.N., Chavers B., et al. 'United States Renal Data System 2011 Annual Data Report: Atlas of chronic kidney disease & end-stage renal disease in the United States. Am J Kidney Dis 2012, 59:e1-e420.
67. Kalantar-Zadeh K., Abbott K.C., Salahudeen A.K., Kilpatrick R.D., Horwich T.B. Survival advantages of obesity in dialysis patients. Am J Clin Nutr 2005, 81:543-554.
68. Biolo G., Ciocchi B., Bosutti A., Situlin R., Toigo G., Guarnieri G. Pentoxifylline acutely reduces protein catabolism in chronically uremic patients. Am J Kidney Dis 2002, 40:1162-1172.
69. Himmelfarb J., Phinney S., Ikizler T.A., Kane J., McMonagle E., Miller G. Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients. J Ren Nutr 2007, 17:296-304.
70. Hung A.M., Ellis C.D., Shintani A., Booker C., Ikizler T.A. IL-1beta receptor antagonist reduces inflammation in hemodialysis patients. J Am Soc Nephrol 2011, 22:437-442.
71. Pupim L.B., Cuppari L., Ikizler T.A. Nutrition and metabolism in kidney disease. Semin Nephrol 2006, 26:134-157.