Determinants of insulin resistance and its effects on protein metabolism in patients with advanced chronic kidney disease

Contributions to Nephrology

Volumn 161, Issue , 2008, Pages 138-144

  Siew, E ^a   Ikizler, T ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN;

CHRONIC DISEASE; HUMAN; INSULIN RESISTANCE; KIDNEY DISEASE; METABOLISM; REVIEW;

CHRONIC DISEASE; HUMANS; INSULIN RESISTANCE; KIDNEY DISEASES; PROTEINS;

EID: 48049123542     PISSN: 03025144     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000130659     Document Type: Conference Paper

References (15)

1. US Renal Data System: Excerpts from the USRDS 2001 Annual Data Report. Am J Kidney Dis 2001;38:S1-S248.
2. Zubrod CG, Eversole SL, Dana GW: Amelioration of diabetes and striking rarity of acidosis in patients with Kimmelstiel-Wilson lesions. N Engl J Med 1951;245:518-528.
3. Rabkin R, Simon NM, Steiner S, Colwell JA: Effect of renal disease on renal uptake and excretion of insulin in man. N Engl J Med 1970;282:182-187.
4. DeFronzo RA, Smith D, Alvestrand A: Insulin action in uremia. Kidney Int Suppl 1983;16:S102-S114.
5. Price SR, Du JD, Bailey JL, Mitch WE: Molecular mechanisms regulating protein turnover in muscle. Am J Kidney Dis 2001;37:S112-S114.
6. Lee SW, Dai G, Hu Z, Wang X, et al: Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3-kinase. J Am Soc Nephrol 2004;15:1537-1545.
7. Bergstrom J, Lindholm B, Lacson E Jr, Owen W Jr, et al: What are the causes and consequences of the chronic inflammatory state in chronic dialysis patients? Semin Dial 2000;13:163-175.
8. 3 corrects insulin and lipid abnormalities in uremia. Kidney Int 1998;53:1353-1357.
9. 3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo. Endocrinology 1986;119:84-90.
10. Biolo G, Inchiostro S, Tiengo A, Tessari P: Regulation of postprandial whole-body proteolysis in insulin-deprived IDDM. Diabetes 1995;44:203-209.
11. Bohe J, Rennie MJ: Muscle protein metabolism during hemodialysis. J Ren Nutr 2006;16:3-16.
12. Lee SW, Dai G, Hu Z, Wang X, et al: Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3-kinase. J Am Soc Nephrol 2004;15:1537-1545.
13. Du J, Wang X, Miereles C, Bailey JL, et al: Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 2004;113:115-123.
14. Pupim LB, Flakoll PJ, Majchrzak KM, Aftab Guy DL, et al: Increased muscle protein breakdown in chronic hemodialysis patients with type 2 diabetes mellitus. Kidney Int 2005;68:1857-1865.
15. Pupim LB, Heimburger O, Qureshi AR, Ikizler TA, et al: Accelerated lean body mass loss in incident chronic dialysis patients with diabetes mellitus. Kidney Int 2005;68:2368-2374.