Diverse functions of secreted frizzled-related proteins in the osteoblastogenesis of human multipotent mesenchymal stromal cells

Biomaterials

Volumn 34, Issue 13, 2013, Pages 3270-3278

  Yamada, Azusa ^a,c   Iwata, Takanori ^b   Yamato, Masayuki ^b   Okano, Teruo ^b   Izumi, Yuichi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b Tokyo Women s Medical University Waseda University Joint Institution for Advanced Biomedical Sciences   (Japan)

^c JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

Author keywords

Cytotherapy; Human multipotent mesenchymal stromal cells; Osteoblastic differentiation; Osteogenesis; Pretreatment; WNT signalling

Indexed keywords

CYTOTHERAPY; MULTIPOTENT MESENCHYMAL STROMAL CELLS; OSTEOBLASTIC DIFFERENTIATION; OSTEOGENESIS; PRE-TREATMENT; WNT SIGNALLING;

CELLS; CYTOLOGY; ORGANIC ACIDS; PHOSPHATASES; PHOSPHOLIPIDS; PROTEINS;

CELL SIGNALING;

ALKALINE PHOSPHATASE; ASCORBIC ACID; DEXAMETHASONE; GLYCEROL 2 PHOSPHATE; SECRETED FRIZZLED RELATED PROTEIN 4; SECRETED FRIZZLED RELATED PROTEIN 5; WNT5A PROTEIN;

ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MESENCHYMAL STROMA CELL; MULTIPOTENT STEM CELL; OSTEOBLAST; PERIODONTAL LIGAMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WNT SIGNALING PATHWAY;

CELL DIFFERENTIATION; CELL MEMBRANE; CULTURE MEDIA; FLOW CYTOMETRY; FRIZZLED RECEPTORS; GENE EXPRESSION REGULATION; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MESENCHYMAL STROMAL CELLS; MODELS, BIOLOGICAL; OSTEOBLASTS; OSTEOGENESIS; POLYMERASE CHAIN REACTION; PROTEIN BINDING; RNA, SMALL INTERFERING; TRANSCRIPTOME; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84874251632     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.01.066     Document Type: Article

References (45)

1. Manolagas S.C., Jilka R.L. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 1995, 332(5):305-311.
2. Rodan G.A., Martin T.J. Therapeutic approaches to bone diseases. Science 2000, 289(5484):1508-1514.
3. Marx R.E., Sawatari Y., Fortin M., Broumand V. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 2005, 63(11):1567-1575.
4. Langer R., Vacanti J.P. Tissue engineering. Science 1993, 260(5110):920-926.
5. Mauney J.R., Kirker-Head C., Abrahamson L., Gronowicz G., Volloch V., Kaplan D.L. Matrix-mediated retention of in vitro osteogenic differentiation potential and in vivo bone-forming capacity by human adult bone marrow-derived mesenchymal stem cells during ex vivo expansion. J Biomed Mater Res A 2006, 79A(3):464-475.
6. Petite H., Viateau V., Bensaid W., Meunier A., de Pollak C., Bourguignon M., et al. Tissue-engineered bone regeneration. Nat Biotechnol 2000, 18(9):959-963.
7. Castano-Izquierdo H., Alvarez-Barreto J., van den Dolder J., Jansen J.A., Mikos A.G., Sikavitsas V.I. Pre-culture period of mesenchymal stem cells in osteogenic media influences their in vivo bone forming potential. J Biomed Mater Res A 2007, 82A(1):129-138.
8. Khaled E.G., Saleh M., Hindocha S., Griffin M., Khan W.S. Tissue engineering for bone production- stem cells, gene therapy and scaffolds. Open Orthop J 2011, 5(Suppl. 2):289-295.
9. Washio K., Iwata T., Mizutani M., Ando T., Yamato M., Okano T., et al. Assessment of cell sheets derived from human periodontal ligament cells: a pre-clinical study. Cell Tissue Res 2010, 341(3):397-404.
10. Urist M.R. Bone: formation by autoinduction. Science 1965, 150(3698):893-899.
11. Takuwa Y., Ohse C., Wang E.A., Wozney J.M., Yamashita K. Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1. Biochem Biophys Res Commun 1991, 174(1):96-101.
12. Katagiri T., Yamaguchi A., Komaki M., Abe E., Takahashi N., Ikeda T., et al. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 1994, 127(6 Pt 1):1755-1766.
13. Katagiri T., Yamaguchi A., Ikeda T., Yoshiki S., Wozney J.M., Rosen V., et al. The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun 1990, 172(1):295-299.
14. Yamaguchi A., Katagiri T., Ikeda T., Wozney J.M., Rosen V., Wang E.A., et al. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol 1991, 113(3):681-687.
15. Thies R.S., Bauduy M., Ashton B.A., Kurtzberg L., Wozney J.M., Rosen V. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology 1992, 130(3):1318-1324.
16. Yamaguchi A., Ishizuya T., Kintou N., Wada Y., Katagiri T., Wozney J.M., et al. Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem Biophys Res Commun 1996, 220(2):366-371.
17. Rifas L. The role of noggin in human mesenchymal stem cell differentiation. J Cell Biochem 2007, 100(4):824-834.
18. Jorgensen N.R., Henriksen Z., Sorensen O.H., Civitelli R. Dexamethasone, BMP-2, and 1,25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype: validation of an in vitro model for human bone marrow-derived primary osteoblasts. Steroids 2004, 69(4):219-226.
19. Taipale J., Beachy P.A. The Hedgehog and Wnt signaling pathways in cancer. Nature 2001, 411(6835):349-354.
20. Peifer M., Polakis P. Cancer-Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science 2000, 287(5458):1606-1609.
21. Huang H.C., Klein P.S. The Frizzled family: receptors for multiple signal transduction pathways. Genome Biol 2004, 5(7).
22. Logan C.Y., Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004, 20:781-810.
23. Gong Y.Q., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001, 107(4):513-523.
24. Boyden L.M., Mao J.H., Belsky J., Mitzner L., Farhi A., Mitnick M.A., et al. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 2002, 346(20):1513-1521.
25. Liu G.Z., Vijayakumar S., Grumolato L., Arroyave R., Qiao H.F., Akiri G., et al. Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. J Cell Biol 2009, 185(1):67-75.
26. de Boer J., Siddappa R., Gaspar C., van Apeldoorn A., Fodde R., van Blitterswijk C. Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 2004, 34(5):818-826.
27. Boland G.M., Perkins G., Hall D.J., Tuan R.S. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cell Biochem 2004, 93(6):1210-1230.
28. Iwata T., Yamato M., Zhang Z., Mukobata S., Washio K., Ando T., et al. Validation of human periodontal ligament-derived cells as a reliable source for cytotherapeutic use. J Clin Periodontol 2010, 37(12):1088-1099.
29. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method. Methods 2001, 25(4):402-408.
30. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F.C., Krause D.S., et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006, 8(4):315-317.
31. Huang S.M.A., Mishina Y.M., Liu S.M., Cheung A., Stegmeier F., Michaud G.A., et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 2009, 461(7264):614-620.
32. Harada S., Rodan G.A. Control of osteoblast function and regulation of bone mass. Nature 2003, 423(6937):349-355.
33. Serrano M., Hannon G.J., Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993, 366(6456):704-707.
34. Wang L., Li H., Chen Q., Zhu T., Zhu H., Zheng L. Wnt signaling stabilizes the DIXDC1 protein through decreased ubiquitin-dependent degradation. Cancer Sci 2010, 101(3):700-706.
35. Ono M., Inkson C.A., Kilts T.M., Young M.F. WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity. J Bone Miner Res 2011, 26(1):193-208.
36. Rawadi G., Vayssiere B., Dunn F., Baron R., Roman-Roman S. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 2003, 18(10):1842-1853.
37. Jones S.E., Jomary C. Secreted Frizzled-related proteins: searching for relationships and patterns. Bioessays 2002, 24(9):811-820.
38. Hoang B., Moos M., Vukicevic S., Luyten F.P. Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. J Biol Chem 1996, 271(42):26131-26137.
39. Loughlin J., Dowling B., Chapman K., Marcelline L., Mustafa Z., Southam L., et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A 2004, 101(26):9757-9762.
40. Lories R.J.U., Peeters J., Bakker A., Tylzanowski P., Derese I., Schrooten J., et al. Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum 2007, 56(12):4095-4103.
41. Nakanishi R., Akiyama H., Kimura H., Otsuki B., Shimizu M., Tsuboyama T., et al. Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass. J Bone Miner Res 2008, 23(2):271-277.
42. Maeda K., Kobayashi Y., Udagawa N., Uehara S., Ishihara A., Mizoguchi T., et al. Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med 2012, 18(3):405-412.
43. He X., Saint-Jeannet J.P., Wang Y., Nathans J., Dawid I., Varmus H. A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 1997, 275(5306):1652-1654.
44. Westendorf J.J., Kahler R.A., Schroeder T.M. Wnt signaling in osteoblasts and bone diseases. Gene 2004, 341:19-39.
45. Ling L., Nurcombe V., Cool S.M. Wnt signaling controls the fate of mesenchymal stem cells. Gene 2009, 433(1-2):1-7.