DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis

Genes and Development

Volumn 27, Issue 4, 2013, Pages 372-377

  Georgia, Senta ^a,b   Kanji, Murtaza ^a   Bhushan, Anil ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

Differentiation; DNA methylation; DNMT1; P53; Pancreatic development

Indexed keywords

DNA METHYLTRANSFERASE 1; PROTEIN P53;

AGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; GENE DELETION; GENE LOCUS; HAPLOINSUFFICIENCY; MOUSE; NONHUMAN; ORGANOGENESIS; PANCREAS; PANCREAS DISEASE; PRIORITY JOURNAL; STEM CELL;

ANIMALS; APOPTOSIS; CELL SURVIVAL; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HAPLOINSUFFICIENCY; MICE; ORGANOGENESIS; PANCREAS; STEM CELLS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84874250442     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.207001.112     Document Type: Article

References (33)

1. Anderson RM., Bosch JA, Goll MG, Hesselson D, Dong PDS, Shin D, Chi NC, Shin CH, Schlegel A, Halpern M, et al. 2009. Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Dev Biol 334: 213-223.
2. Bhushan A., Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R. 2001. Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 128: 5109-5117.
3. Chen T., Hevi S, Gay F, Tsujimoto N, He T, Zhang B, Ueda Y, Li E. 2007. Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet 39: 391-396.
4. Clements EG., Mohammad HP, Leadem BR, Easwaran H, Cai Y, Van Neste L., Baylin SB. 2012. DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes. Nucleic Acids Res 40: 4334-4346.
5. Dahl JA., Collas P. 2008. A rapid micro chromatin immunoprecipitation assay (microChIP). Nat Protoc 3: 1032-1045.
6. Fan G., Beard C, Chen RZ, Csankovszki G, Sun Y, Siniaia M, Biniszkiewicz D, Bates B, Lee PP, Kuhn R, et al. 2001. DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci 21: 788-797.
7. Fan G., Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W., Shen Y, Wu H, et al. 2005. DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development 132: 3345-3356.
8. Georgia S., Soliz R, Li M, Zhang P, Bhushan A. 2006. p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol 298: 22-31.
9. Gittes GK. 2009. Developmental biology of the pancreas: A comprehensive review. Dev Biol 326: 4-35.
10. Gu G., Dubauskaite J, Melton DA. 2002. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129: 2447-2457.
11. Gu G., Brown JR, Melton DA. 2003. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev 120: 35-43.
12. Herrera PL. 2000. Adult insulin-and glucagon-producing cells differentiate from two independent cell lineages. Development 127: 2317-2322.
13. Hutnick LK., Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G. 2009. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet 18: 2875-2888.
14. Jacks T., Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA. 1994. Tumor spectrum analysis in p53-mutant mice. Curr Biol 4: 1-7.
15. Jackson-Grusby L, Beard C, Possemato R, Tudor M, Fambrough D, Csankovszki G., Dausman J, Lee P, Wilson C, Lander E, et al. 2001. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet 27: 31-39.
16. Jensen J. 2004. Gene regulatory factors in pancreatic development. Dev Dyn 229: 176-200.
17. Jensen J., Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G., Madsen OD, Serup P. 2000a. Independent development of pancreatic a-and b-cells from neurogenin3-expressing precursors: A role for the notch pathway in repression of premature differentiation. Diabetes 49: 163-176.
18. Jensen J., Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R., Guillemot F, Serup P, Madsen OD. 2000b. Control of endodermal endocrine development by Hes-1. Nat Genet 24: 36-44.
19. Jones SN., Roe AE, Donehower LA, Bradley A. 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206-208.
20. Lei H., Oh SP, Okano M, Juttermann R, Goss KA, Jaenisch R, Li E. 1996. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122: 3195-3205.
21. Li E., Bestor TH, Jaenisch R. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915-926.
22. Liu G., Terzian T, Xiong S, Van Pelt CS, Audiffred A, Box NF, Lozano G. 2007. The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development. J Pathol 213: 360-368.
23. Montes de Oca Luna R, Wagner DS, Lozano G. 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378: 203-206.
24. Panning B., Jaenisch R. 1996. DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev 10: 1991-2002.
25. Reik, W. 2007. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447: 425-432.
26. Schwitzgebel VM., Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS. 2000. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127: 3533-3542.
27. Sen GL., Reuter JA, Webster DE, Zhu L, Khavari PA. 2010. DNMT1 maintains progenitor function in self-renewing somatic tissue. Nature 463: 563-567.
28. Srinivas S., Watanabe T, Lin CS, William CM, Tanabe Y, Jessell TM, Costantini F. 2001. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 1: 4.
29. Su CH., Shann YJ, Hsu MT. 2009. p53 chromatin epigenetic domain organization and p53 transcription. Mol Cell Biol 29: 93-103.
30. Trowbridge JJ., Snow JW, Kim J, Orkin SH. 2009. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell 5: 442-449.
31. Tschen S-I, Dhawan S, Gurlo T, Bhushan A. 2009. Age-dependent decline in b-cell proliferation restricts the capacity of b-cell regeneration in mice. Diabetes 58: 1312-1320.
32. Valdez CD., Davis JN, Odeh HM, Layfield TL, Cousineau CS, Berton TR, Johnson DG, Wojno KJ, Day ML. 2011. Repression of androgen receptor transcription through the E2F1/DNMT1 axis. PLoS ONE 6: e25187.
33. Zhong L., Georgia S, Tschen SI, Nakayama K, Bhushan A. 2007. Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic b cells. J Clin Invest 117: 2869-2876.