Revisiting the putativetcr Cα dimerization model through structural analysis

Frontiers in Immunology

Volumn 4, Issue JAN, 2013, Pages

  Wang, Jia Huai ^a   Reinherz, Ellis L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Receptor dimerization; Signal transduction; Structural immunology; TCR

Indexed keywords

EID: 84874234249     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00016     Document Type: Article

References (34)

1. Acuto, O., Di Bartolo, V., and Michel, F. (2008). Tailoring T-cell receptor signals by proximal negative feedback mechanisms. Nat. Rev. Immunol. 8, 699-712.
2. Alam, S. M., Davies, G. M., Lin, C. M., Zal, T., Nasholds, W., Jameson, S. C., et al. (1999). Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. Immunity 10, 227-237.
3. Au-Yueng, B. B., Deindl, S., Hsu, L. Y., Palacios, E. H., Levin, S. E., Kuriyan, J., et al. (2009). The structure, regulation and functionof ZAP-70. Immunol. Rev. 228, 41-57.
4. Baker, B. M., and Wiley, D. C. (2001). αβ T cell receptor ligand-specific oligomerization revisited. Immunity 14, 681-692.
5. Ballinger, M. D., and Wells, J. A. (1998). Will any dimer do? Nat. Struct. Biol. 938-940.
6. Boniface, J. J., Rabinowitz, J. D., Wülfing, C., Hampl, J., Reich, Z., Altman, J. D., et al. (1998). Initiation of signal transduction through the T cell receptor requires the multivalent engagement of pep-tide/MHC ligands. Immunity 9, 459-466.
7. Cunningham, B. C., Ultsch, M., De Vos, A. M., Mulkerrin, M. G., Clauser, K. R., and Wells, J. A. (1991). Dimeriza-tion of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science 254, 821-825.
8. De Vos, A. M., Ultsch, M., and Kossiakoff, A. A. (1992). Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255, 306-312.
9. Fernandes, R. A., Shore, D. A., Vuong, M. T., Yu, C., Zhu, X., et al. (2012). T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements. J. Biol. Chem. 287, 13324- 13335.
10. Husson, J., Chemin, K., Bohineust, A., Hivroz, C., and Henry, N. (2011). Force generation upon T cell receptor engagement. PLoS ONE 6:e19680. doi: 10.1371/journal.pone. 0019680
11. Judokusumo, E., Tabdanov, E., Kumari, S., Dustin, M. L., and Kam, L. C. (2012). Mechanosensing in T lymphocyte activation. Biophys. J. 102, L5-L7.
12. Kasturi, L., Chen H., and Shakin-Eshleman S. H. (1997). Regulation of N-linked core glycosylation: use of a site-directed mutagenesis approach to identify Asn-Xaa-Ser/Thr sequons that are poor oligosac-charide acceptors. Biochem. J. 323, 415-419.
13. Kim, S. T., Shin, Y., Brazin, K., Mallis, R., Sun, J., Wagner, G., et al. (2012). TCR mechanobiology: torques and tunable structures linked to early T cell signaling. Front. Immunol. 3:76. doi: 10.3389/fimmu.2012. 00076
14. Kim, S. T., Takeuchi, K., Sun, Z. Y., Touma, M., Castro, C. E., Fahmy, A., et al. (2009). The alpha-beta T cell receptor is an anisotropic mechanosensor. J. Biol. Chem. 284, 31028-31037.
15. Krogsgaard, M., Li, Q. J., Sumen, C., Huppa, J. B., Huse, M., and Davis, M. M. (2005). Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature 434, 238-243.
16. Kuhns, M. S., and Davis, M. M. (2012). TCR signaling emerges from the sum of many parts. Front. Immunol. 3:159. doi: 10.3389/fimmu.2012.00159
17. Kuhns, M. S., Girvin, A. T., Klein, L. O., Chen, R., Jensen, K. D., Newell, E. W., et al. (2010). Evidence for a functional sidedness to the alphabetaTCR. Proc. Natl. Acad. Sci. U.S.A. 107, 5094-5099.
18. Letourneur, F., and Klausner, R. D. (1992). Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science 255, 79-82.
19. Li, Y. C., Chen, B. M., Wu, P. C., Cheng, T. L., Kao, L. S., Tao, M. H., et al. (2010). Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling. J. Immunol. 184, 5959- 5963.
20. Ma, Z., and Finkel, T. H. (2010). T cell receptor triggering by force. Trends Immunol. 31, 1-6.
21. Meuer, S. C., Hodgdon, J. C., Hussey, R. E., Protentis, J. P., Schlossman, S. F., and Reinherz, E. L. (1983). Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones. J. Exp. Med. 158, 988-993.
22. Meuer, S. C., Hussey, R. E., Cantrell, D. A., Hodgdon, J. C., Schlossman, S. F., Smith, K. A., et al. (1984). Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc. Natl. Acad. Sci. U.S.A. 81, 1509- 1513.
23. Rasmussen, S. G., Devree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., et al. (2011). Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature 477, 549-555.
24. Reich, Z., Boniface, J. J., Lyons, D. S., Borochov, N., Wachtel, E. J., and Davis, M. M. (1997). Ligand-specific oligomerization of T-cell receptor molecules. Nature 387, 617-620.
25. Reth, M. (1989). Antigen receptor tail clue. Nature 338, 383-384.
26. Rudd, P. M., Elliott, T., Cresswell, P., Wilson, I. A., and Dwek, R. A. (2001). Glycosylation and the immune system. Science 291, 2370-2376.
27. Rudolph, M. G., Stanfield, R. L., and Wilson, I. A. (2006). How TCRs bind MHCs, peptides, and coreceptors. Annu. Rev. Immunol. 24, 419-466.
28. Schlessinger, J. (2002). Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110, 669-672.
29. Smith-Garvin, J. E., Koretzky, G. A., and Jordan, M. S. (2009). T cell activation. Annu. Rev. Immunol. 27, 591-619.
30. van der Merwe, P. A., and Dushek, O. (2011). Mechanisms for T cell receptor triggering. Nat. Rev. Immunol. 11, 47-55.
31. Wang, J., Lim, K., Smolyar, A., Teng, M.-K., Liu, J.-H., Tse, A. G. T., et al. (1998). Atomic structure of an αβ T cell receptor (TCR) het-erodimer in complex with an anti-TCR Fab fragment derived from a mitogenic antibody. EMBO J. 17, 10-26.
32. Wang, J. H., and Reinherz, E. L. (2012). The structural basis of αβ T lineage immune recognition: TCR docking topologies, mechanotrans-duction and co-receptor function. Immunol. Rev. 250, 102-119.
33. Yin, Y., Wang, X. X., and Mariuzza, R. A. (2012). Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4. Proc. Natl. Acad. Sci. U.S.A. 109, 5405-5410.
34. Yokosuka, T., Kobayash, I. W., Sakata-Sogawa, K., Takamatsu, M., Hashimoto-Tane, A., Dustin, M. L., et al. (2008). Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity 29, 589-601.