Full-length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells

FEBS Letters

Volumn 587, Issue 5, 2013, Pages 496-503

  Ng, Yuen Keng ^a,b   Lau, Wing Sze ^b   Lui, Vivian Wai Yan ^a   Cheng, Alfred Sze Lok ^c   Ng, Patrick Kwok Shing ^d   Tsui, Stephen Kwok Wing ^c   Cheung, Yue Sun ^b   Lai, Paul Bo San ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Prince of Wales Hospital   (Hong Kong)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Akt; Hep3B; Huh7; NORE1B; PLC PRF 5; Staurosporine; Stk4

Indexed keywords

TUMOR SUPPRESSOR MST1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOMA CELL; DOWN REGULATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HEPATOCYTE GROWTH FACTOR; HUMANS; LIVER NEOPLASMS; MOLECULAR WEIGHT; MONOMERIC GTP-BINDING PROTEINS; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; UP-REGULATION;

EID: 84874193499     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.01.018     Document Type: Article

References (20)

1. K. Steinmann, A. Sandner, U. Schagdarsurengin, and R.H. Dammann Frequent promoter hypermethylation of tumor-related genes in head and neck squamous cell carcinoma Oncol. Rep. 22 2009 1519 1526
2. P. Minoo, I. Zlobec, K. Baker, L. Tornillo, L. Terracciano, J.R. Jass, and A. Lugli Prognostic significance of mammalian sterile 20-like kinase 1 in colorectal cancer Mod. Pathol. 20 2007 331 338 (Pubitemid 46348330)
3. D. Zhou, C. Conrad, F. Xia, J.-S. Park, B. Payer, Y. Yin, G.Y. Lauwers, W. Thasler, J.T. Lee, and J. Avruch Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene Cancer Cell 16 2009 425 438
4. H. Song, K.K. Mak, L. Topol, K. Yun, J. Hu, L. Garrett, Y. Chen, O. Park, J. Chang, and R.M. Simpson Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression Proc. Natl. Acad. Sci. USA 107 2010 1431 1436
5. J.D. Graves, Y. Gotoh, K.E. Draves, D. Ambrose, D.K. Han, M. Wright, J. Chernoff, E.A. Clark, and E.G. Krebs Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1 EMBO J. 17 1998 2224 2234 (Pubitemid 28171908)
6. F.K. Collak, K. Yagiz, D.J. Luthringer, B. Erkaya, and B. Cinar Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1 J. Biol. Chem. 287 2012 23698 23709 M112.358713 [pii] http://dx.doi.org/10.1074/jbc.M112.358713
7. Z. Yuan, D. Kim, S. Shu, J. Wu, J. Guo, L. Xiao, S. Kaneko, D. Coppola, and J.Q. Cheng Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120 J. Biol. Chem. 285 2010 3815 3824 M109.059675 [pii] http://dx.doi.org/10.1074/jbc.M109.059675
8. M. Praskova, A. Khoklatchev, S. Ortiz-Vega, and J. Avruch Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras Biochem. J. 381 2004 453 462 (Pubitemid 38969690)
9. D. Macheiner, G. Heller, S. Kappel, C. Bichler, S. Stättner, B. Ziegler, D. Kandioler, F. Wrba, R. Schulte-Hermann, and S. Zöhbauer- Müller NORE1B: a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma J. Hepatol. 45 2006 81 89 (Pubitemid 43850612)
10. J.J. Brown, B. Parashar, H. Moshage, K.E. Tanaka, D. Engelhardt, E. Rabbani, N. Roy-Chowdhury, and J. Roy-Chowdhury A long-term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag-2-deficient mice Hepatology 31 2000 173 181 (Pubitemid 30033704)
11. X. Chen, S.T. Cheung, S. So, S.T. Fan, C. Barry, J. Higgins, K.M. Lai, J. Ji, S. Dudoit, and I.O. Ng Gene expression patterns in human liver cancers Mol. Biol. Cell 13 2002 1929 1939 (Pubitemid 34651483)
12. E. Wurmbach, Y.B. Chen, G. Khitrov, W. Zhang, S. Roayaie, M. Schwartz, I. Fiel, S. Thung, V. Mazzaferro, and J. Bruix Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma Hepatology 45 2007 938 947 (Pubitemid 46646500)
13. V.R. Mas, D.G. Maluf, K.J. Archer, K. Yanek, X. Kong, L. Kulik, C.E. Freise, K.M. Olthoff, R.M. Ghobrial, and P. McIver Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma Mol. Med. 15 2009 85 94
14. I.C. Hsu, T. Tokiwa, W. Bennett, R.A. Metcalf, J.A. Welsh, T. Sun, and C.C. Harris P53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines Carcinogenesis 14 1993 987 992 10.1093/carcin/14.5.987 (Pubitemid 23169159)
15. S.-W. Jang, S.-J. Yang, S. Srinivasan, and K. Ye Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation J. Biol. Chem. 282 2007 30836 30844 10.1074/jbc.M704542200 (Pubitemid 350035233)
16. B. Cinar, P.-K. Fang, M. Lutchman, D. Di Vizio, R.M. Adam, N. Pavlova, M.A. Rubin, P.C. Yelick, and M.R. Freeman The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1 EMBO J. 26 2007 4523 4534 (Pubitemid 350036629)
17. C. Seidel, U. Schagdarsurengin, K. Blümke, P. Würl, G.P. Pfeifer, S. Hauptmann, H. Taubert, and R. Dammann Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma Mol. Carcinog. 46 2007 865 871 (Pubitemid 47549772)
18. J.W. Marlin, A. Eaton, G.T. Montano, Y.W. Chang, and R. Jakobi Elevated p21-activated kinase 2 activity results in anchorage-independent growth and resistance to anticancer drug-induced cell death Neoplasia 11 2009 286 297
19. R. Jakobi, E. Moertl, and M.A. Koeppel P21-activated protein kinase γ-PAK suppresses programmed cell death of BALB3T3 fibroblasts J. Biol. Chem. 276 2001 16624 16634 10.1074/jbc.M007753200
20. J. Park, S.I. Kang, S.-Y. Lee, X.F. Zhang, M.S. Kim, L.F. Beers, D.-S. Lim, J. Avruch, H.-S. Kim, and S.B. Lee Tumor suppressor Ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis J. Biol. Chem. 285 2010 35029 35038 10.1074/jbc.M110.165506