-
1
-
-
0038554077
-
Biology of the p21-activated kinases
-
Bokoch GM (2003). Biology of the p21-activated kinases. Annu Rev Biochem 72, 743-781.
-
(2003)
Annu Rev Biochem
, vol.72
, pp. 743-781
-
-
Bokoch, G.M.1
-
4
-
-
0031443641
-
Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis
-
Lee N, MacDonald H, Reinhard C, Halenbeck R, Roulston A, Shi T, and Williams LT (1997). Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. Proc Natl Acad Sci USA 94, 13642-13647.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13642-13647
-
-
Lee, N.1
MacDonald, H.2
Reinhard, C.3
Halenbeck, R.4
Roulston, A.5
Shi, T.6
Williams, L.T.7
-
5
-
-
0030918572
-
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2
-
Rudel T and Bokoch GM (1997). Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 276,1571-1574.
-
(1997)
Science
, vol.276
, pp. 1571-1574
-
-
Rudel, T.1
Bokoch, G.M.2
-
6
-
-
0031907887
-
p21-Activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells
-
Rudel T, Zenke FX Chuang TH, and Bokoch GM (1998). p21-Activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells. J Immunol160, 7-11.
-
(1998)
J Immunol
, vol.160
, pp. 7-11
-
-
Rudel, T.1
Zenke, F.X.2
Chuang, T.H.3
Bokoch, G.M.4
-
7
-
-
0032582669
-
Cleavage and activation of p21-activated protein kinase γ-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity
-
Walter BN, Huang Z, Jakobi R, Tuazon PX, Alnemri ES, Litwack G, and Traugh JA (1998). Cleavage and activation of p21-activated protein kinase γ-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. J Biol Chem 273, 28733-28739.
-
(1998)
J Biol Chem
, vol.273
, pp. 28733-28739
-
-
Walter, B.N.1
Huang, Z.2
Jakobi, R.3
Tuazon, P.X.4
Alnemri, E.S.5
Litwack, G.6
Traugh, J.A.7
-
8
-
-
0035907371
-
-
Jakobi R, Moertl E, and Koeppel MA (2001). p21-Activated protein kinase 7-PAK suppresses programmed cell death of BALB3X3 fibroblasts. J Biol Chem0 276, 16624-16634.
-
Jakobi R, Moertl E, and Koeppel MA (2001). p21-Activated protein kinase 7-PAK suppresses programmed cell death of BALB3X3 fibroblasts. J Biol Chem0 276, 16624-16634.
-
-
-
-
9
-
-
0040056864
-
p21-Activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis
-
Schurmann A, Mooney AF, Sanders LC, Sells MA, Wang HG, Reed JC, and Bokoch GM (2000). p21-Activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol 20, 453-461.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 453-461
-
-
Schurmann, A.1
Mooney, A.F.2
Sanders, L.C.3
Sells, M.A.4
Wang, H.G.5
Reed, J.C.6
Bokoch, G.M.7
-
10
-
-
0034737807
-
The akt protooncogene links ras to pak and cell survival signals
-
Tang Y, Zhou H, Chen A, Pittman RN, and Field J (2000). The akt protooncogene links ras to pak and cell survival signals. JBiol Chem 275, 9106-9109.
-
(2000)
JBiol Chem
, vol.275
, pp. 9106-9109
-
-
Tang, Y.1
Zhou, H.2
Chen, A.3
Pittman, R.N.4
Field, J.5
-
11
-
-
0035957986
-
The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis
-
Gnesutta N, Qu J, and Minden A (2001). The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J Biol Chem 276, 14414-14419.
-
(2001)
J Biol Chem
, vol.276
, pp. 14414-14419
-
-
Gnesutta, N.1
Qu, J.2
Minden, A.3
-
12
-
-
0141532132
-
Caspaseactivated PAK-2 is regulated by subcellular targeting and proteasomal degradation
-
Jakobi R, McCarthy CC, Koeppel MA, and Stringer DK (2003). Caspaseactivated PAK-2 is regulated by subcellular targeting and proteasomal degradation. Biol Chem 278, 38675-38685.
-
(2003)
Biol Chem
, vol.278
, pp. 38675-38685
-
-
Jakobi, R.1
McCarthy, C.C.2
Koeppel, M.A.3
Stringer, D.K.4
-
13
-
-
11144244278
-
Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2
-
Koeppel MA, McCarthy CC, Moertl E, and Jakobi R (2004). Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. J Biol Chan279, 53653-53664.
-
(2004)
J Biol Chan
, vol.279
, pp. 53653-53664
-
-
Koeppel, M.A.1
McCarthy, C.C.2
Moertl, E.3
Jakobi, R.4
-
14
-
-
0034602690
-
Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21 -activated kinase-dependent pathway
-
Mita JP, Benard V, Groffen J, Sanders LC, and Knaus UG (2000). Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21 -activated kinase-dependent pathway. Proc Natl Acad Set USA 97, 185-189.
-
(2000)
Proc Natl Acad Set USA
, vol.97
, pp. 185-189
-
-
Mita, J.P.1
Benard, V.2
Groffen, J.3
Sanders, L.C.4
Knaus, U.G.5
-
15
-
-
2542451854
-
Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions
-
Stofega MR, Sandets LC, Gardiner EM, and Bokoch GM (2004). Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions. Mol Biol Cell 15, 2965-2977.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 2965-2977
-
-
Stofega, M.R.1
Sandets, L.C.2
Gardiner, E.M.3
Bokoch, G.M.4
-
16
-
-
0034680834
-
Regulatable exptession of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells
-
Vadlamudi RK, Adam L, Wang R-A, Mandal M, Nguyen D, Sahin A, Chernoff J, Hung M-C, and Kumat R (2000). Regulatable exptession of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem 275, 36238-36244.
-
(2000)
J Biol Chem
, vol.275
, pp. 36238-36244
-
-
Vadlamudi, R.K.1
Adam, L.2
Wang, R.-A.3
Mandal, M.4
Nguyen, D.5
Sahin, A.6
Chernoff, J.7
Hung, M.-C.8
Kumat, R.9
-
17
-
-
0034697303
-
Regulation of microfilament teorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1
-
Adam L, Vadlamudi R, Mandal M, Chernoff J, and Kumar R (2000). Regulation of microfilament teorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. J Biol Chem 275, 12041-12050.
-
(2000)
J Biol Chem
, vol.275
, pp. 12041-12050
-
-
Adam, L.1
Vadlamudi, R.2
Mandal, M.3
Chernoff, J.4
Kumar, R.5
-
18
-
-
33846425793
-
The prognostic role of a gene signature from tumotigenic breast-cancer cells
-
Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, Sherlock G, Lewicki J, Shedden K, and Clarke MF (2007). The prognostic role of a gene signature from tumotigenic breast-cancer cells. N Engl J Med 356, 217-226.
-
(2007)
N Engl J Med
, vol.356
, pp. 217-226
-
-
Liu, R.1
Wang, X.2
Chen, G.Y.3
Dalerba, P.4
Gurney, A.5
Hoey, T.6
Sherlock, G.7
Lewicki, J.8
Shedden, K.9
Clarke, M.F.10
-
19
-
-
0035089957
-
Vectors for the generation of FLAG- or EGFP-tagged cDNA constructs and EGFP-tagged antisense RNA constructs
-
Jakobi R, Moertl E, and Koeppel MA (2001). Vectors for the generation of FLAG- or EGFP-tagged cDNA constructs and EGFP-tagged antisense RNA constructs. Biotechniques 30, 476-482.
-
(2001)
Biotechniques
, vol.30
, pp. 476-482
-
-
Jakobi, R.1
Moertl, E.2
Koeppel, M.A.3
-
20
-
-
0029002136
-
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
-
Littlewood TD, Hancock DC, Danielian PS, Parker MG, and Evan GI (1995).A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res 23, 1686-1690.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 1686-1690
-
-
Littlewood, T.D.1
Hancock, D.C.2
Danielian, P.S.3
Parker, M.G.4
Evan, G.I.5
-
21
-
-
0024358172
-
A sensitive method for detection of ealmodulindependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamidegel
-
Kameshita I and Fujisawa H (1989). A sensitive method for detection of ealmodulindependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamidegel. Anal Biochem 183, 139-143.
-
(1989)
Anal Biochem
, vol.183
, pp. 139-143
-
-
Kameshita, I.1
Fujisawa, H.2
-
22
-
-
0040298568
-
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
-
Janicke RU, Sprengart ML, Wati MR, and Porter AG (1998). Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273, 9357-9360.
-
(1998)
J Biol Chem
, vol.273
, pp. 9357-9360
-
-
Janicke, R.U.1
Sprengart, M.L.2
Wati, M.R.3
Porter, A.G.4
-
23
-
-
30044435192
-
Unique and overlapping substrate specificities of caspase-8 and caspase-10
-
Fischer U, Stroh C, and Schulze-Osthoff K (2006). Unique and overlapping substrate specificities of caspase-8 and caspase-10. Oncogene 25, 152-159.
-
(2006)
Oncogene
, vol.25
, pp. 152-159
-
-
Fischer, U.1
Stroh, C.2
Schulze-Osthoff, K.3
-
24
-
-
0038293152
-
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase
-
Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P Mizzen CA, Beeser A, Etkin LD, Chernoff J, Earnshaw WC, et al. (2003). Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 113,507-517.
-
(2003)
Cell
, vol.113
, pp. 507-517
-
-
Cheung, W.L.1
Ajiro, K.2
Samejima, K.3
Kloc, M.4
Cheung, P.5
Mizzen, C.A.6
Beeser, A.7
Etkin, L.D.8
Chernoff, J.9
Earnshaw, W.C.10
-
25
-
-
0037439820
-
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer
-
Mueller T, Voigt W, Simon H, Fruehauf A, Bulankin A, Grothey A, and Schmoll H-J (2003). Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer. Cancer Res 63, 513-521.
-
(2003)
Cancer Res
, vol.63
, pp. 513-521
-
-
Mueller, T.1
Voigt, W.2
Simon, H.3
Fruehauf, A.4
Bulankin, A.5
Grothey, A.6
Schmoll, H.-J.7
-
26
-
-
34347209876
-
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis proteinj-mediated inhibition of caspase 9
-
Denault JB, Eckelman BP, Shin H, Pop C, and Salvesen GS (2007). Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis proteinj-mediated inhibition of caspase 9. Biochem J 405, 11-19.
-
(2007)
Biochem J
, vol.405
, pp. 11-19
-
-
Denault, J.B.1
Eckelman, B.P.2
Shin, H.3
Pop, C.4
Salvesen, G.S.5
-
27
-
-
0037016748
-
Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines
-
Callow MG, Clairvoyant F, Zhu S, Schryver B, Whyte DB, Bischoff JR, Jallal B, and Smeal T (2002). Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J Biol Chem 277, 550-558.
-
(2002)
J Biol Chem
, vol.277
, pp. 550-558
-
-
Callow, M.G.1
Clairvoyant, F.2
Zhu, S.3
Schryver, B.4
Whyte, D.B.5
Bischoff, J.R.6
Jallal, B.7
Smeal, T.8
-
28
-
-
0029829898
-
Cleavage arrest of early frog embryos by the G protein-activated protein kinase PAK I
-
Rooney RD, Tuazon PT, Meek WE, Carroll EJ, Hagen JJ, Gump EL, Monnig CA, Lugo T, and Traugh JA (1996). Cleavage arrest of early frog embryos by the G protein-activated protein kinase PAK I. J Biol Chem 271, 21498-21504.
-
(1996)
J Biol Chem
, vol.271
, pp. 21498-21504
-
-
Rooney, R.D.1
Tuazon, P.T.2
Meek, W.E.3
Carroll, E.J.4
Hagen, J.J.5
Gump, E.L.6
Monnig, C.A.7
Lugo, T.8
Traugh, J.A.9
-
30
-
-
51349139607
-
Executioner caspase-3 and caspase-7 are functionally distinct proteases
-
Walsh JG, Cullen SP, Sheridan C, Luthi AU, Gerner C, and Martin SJ (2008). Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci USA 105, 12815-12819.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 12815-12819
-
-
Walsh, J.G.1
Cullen, S.P.2
Sheridan, C.3
Luthi, A.U.4
Gerner, C.5
Martin, S.J.6
-
31
-
-
34447565905
-
Caspase-9 cleavage, do you need it? Biochem J
-
el-e2
-
Twiddy D and Cain K (2007). Caspase-9 cleavage, do you need it? Biochem J 405, el-e2.
-
(2007)
, vol.405
-
-
Twiddy, D.1
Cain, K.2
-
32
-
-
0034896098
-
Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death
-
Kagawa S, Gu J, Honda T, McDonnell TJ, Swisher SG, Roth JA, and Fang B (2001). Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. Clin Cancer Res 7, 1474-1480.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1474-1480
-
-
Kagawa, S.1
Gu, J.2
Honda, T.3
McDonnell, T.J.4
Swisher, S.G.5
Roth, J.A.6
Fang, B.7
-
33
-
-
33745297408
-
New signals from the invasive front
-
Christofori G (2006). New signals from the invasive front. Nature 441, 444-450.
-
(2006)
Nature
, vol.441
, pp. 444-450
-
-
Christofori, G.1
-
34
-
-
33751252276
-
Cancer metastasis; building a framework
-
Gupta GP and Massague J (2006). Cancer metastasis; building a framework. Cell 127, 679-695.
-
(2006)
Cell
, vol.127
, pp. 679-695
-
-
Gupta, G.P.1
Massague, J.2
-
35
-
-
33745684527
-
Metastasis: A question of life or death
-
Mehlen P and Puisieux A (2006). Metastasis: a question of life or death. Nat Rev Cancer 6, 449-458.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 449-458
-
-
Mehlen, P.1
Puisieux, A.2
-
36
-
-
4344627055
-
Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
-
Douma S, Van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E, and Peeper DS (2004). Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 430, 1034-1039.
-
(2004)
Nature
, vol.430
, pp. 1034-1039
-
-
Douma, S.1
Van Laar, T.2
Zevenhoven, J.3
Meuwissen, R.4
Van Garderen, E.5
Peeper, D.S.6
-
37
-
-
23844533212
-
The neurotrophic receptor TrkB in anoikis resistance and metastasis: A perspective
-
Geiger TR and Peeper DS (2005). The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective. Cancer Res 65, 7033-7036.
-
(2005)
Cancer Res
, vol.65
, pp. 7033-7036
-
-
Geiger, T.R.1
Peeper, D.S.2
-
38
-
-
4344687434
-
Anoikis: Cancer and the homeless cell
-
Liotta LA and Kohn E (2004). Anoikis: cancer and the homeless cell. Nature 430, 973-974.
-
(2004)
Nature
, vol.430
, pp. 973-974
-
-
Liotta, L.A.1
Kohn, E.2
-
39
-
-
34547197026
-
Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo
-
Derouet M, Wu X, May L, Hoon Yoo B, Sasazuki T, Shirasawa S, Rak J, and Rosen KV (2007). Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo. Neoplasia 9, 536-545.
-
(2007)
Neoplasia
, vol.9
, pp. 536-545
-
-
Derouet, M.1
Wu, X.2
May, L.3
Hoon Yoo, B.4
Sasazuki, T.5
Shirasawa, S.6
Rak, J.7
Rosen, K.V.8
-
40
-
-
0034595381
-
Adhesion to the extracellular matrix regulates the coupling of the small GTPase rac to its effector PAK
-
del Pozo MA, Price LS, Alderson NB, Ren XD, and Schwartz MA (2000). Adhesion to the extracellular matrix regulates the coupling of the small GTPase rac to its effector PAK. EMBO J 19, 2008-2014.
-
(2000)
EMBO J
, vol.19
, pp. 2008-2014
-
-
del Pozo, M.A.1
Price, L.S.2
Alderson, N.B.3
Ren, X.D.4
Schwartz, M.A.5
-
41
-
-
0031844821
-
Activation of Rac and Cdc42 by integrins mediates cell spreading
-
Price LS, Leng J, Schwartz MA, and Bokoch GM (1998). Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol Biol Cell 9, 1863-1871.
-
(1998)
Mol Biol Cell
, vol.9
, pp. 1863-1871
-
-
Price, L.S.1
Leng, J.2
Schwartz, M.A.3
Bokoch, G.M.4
-
42
-
-
23244467708
-
Active p21 -activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis
-
Menard RE, Jovanovski AP, and Mattingly RR (2005). Active p21 -activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis. Neoplasia 7, 638-645.
-
(2005)
Neoplasia
, vol.7
, pp. 638-645
-
-
Menard, R.E.1
Jovanovski, A.P.2
Mattingly, R.R.3
-
43
-
-
41649085584
-
p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer
-
Li Q, Mullins SR, Sloane BF, and Mattingly RR (2008). p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia 10, 314-329.
-
(2008)
Neoplasia
, vol.10
, pp. 314-329
-
-
Li, Q.1
Mullins, S.R.2
Sloane, B.F.3
Mattingly, R.R.4
-
45
-
-
0036009115
-
NF-kB at the crossroads of life and death
-
Karin M and Lin A (2002). NF-kB at the crossroads of life and death. Nat Immunol 3, 221-227.
-
(2002)
Nat Immunol
, vol.3
, pp. 221-227
-
-
Karin, M.1
Lin, A.2
-
46
-
-
17144377113
-
IAPs, RINGs and ubiquitylation
-
Vaux DL and Silke J (2005). IAPs, RINGs and ubiquitylation. Nat Rev Mol Cell Biol 6, 287-297.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 287-297
-
-
Vaux, D.L.1
Silke, J.2
|