메뉴 건너뛰기




Volumn 30, Issue 3, 2013, Pages 260-266

RD Lawrence Lecture 2012 Assessing aetiology in diabetes: How C-peptide, CRP and fucosylation came to the party!

(1)  Owen, K R a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; C REACTIVE PROTEIN; GLICLAZIDE; GLUCOKINASE; HEMOGLOBIN A1C; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SODIUM GLUCOSE COTRANSPORTER 2; SULFONYLUREA;

EID: 84874136002     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/dme.12038     Document Type: Review
Times cited : (8)

References (38)
  • 1
    • 79953808430 scopus 로고    scopus 로고
    • Role of molecular genetics in transforming diagnosis of diabetes mellitus
    • Molven A, Njolstad PR. Role of molecular genetics in transforming diagnosis of diabetes mellitus. Expert Rev Mol Diagn 2011; 11: 313-320.
    • (2011) Expert Rev Mol Diagn , vol.11 , pp. 313-320
    • Molven, A.1    Njolstad, P.R.2
  • 4
    • 64249170094 scopus 로고    scopus 로고
    • A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patients
    • Shepherd M, Shields B, Ellard S, Rubio-Cabezas O, Hattersley AT. A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patients. Diabet Med 2009; 26: 437-441.
    • (2009) Diabet Med , vol.26 , pp. 437-441
    • Shepherd, M.1    Shields, B.2    Ellard, S.3    Rubio-Cabezas, O.4    Hattersley, A.T.5
  • 6
    • 34247500820 scopus 로고    scopus 로고
    • Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene
    • Pearson ER, Boj SF, Steele AM, Barrett T, Stals K, Shield JP et al. Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene. PLoS Med 2007; 4: e118.
    • (2007) PLoS Med , vol.4
    • Pearson, E.R.1    Boj, S.F.2    Steele, A.M.3    Barrett, T.4    Stals, K.5    Shield, J.P.6
  • 8
    • 0036210337 scopus 로고    scopus 로고
    • The genetic abnormality in the beta cell determines the response to an oral glucose load
    • Stride A, Vaxillaire M, Tuomi T, Barbetti F, Njolstad PR, Hansen T et al. The genetic abnormality in the beta cell determines the response to an oral glucose load. Diabetologia 2002; 45: 427-435.
    • (2002) Diabetologia , vol.45 , pp. 427-435
    • Stride, A.1    Vaxillaire, M.2    Tuomi, T.3    Barbetti, F.4    Njolstad, P.R.5    Hansen, T.6
  • 9
    • 80054844895 scopus 로고    scopus 로고
    • Microvascular complication risk in patients with 50 years of moderte hyperglycaemia: are target ranges for glycaemic control appropriate?
    • Steele A, Shields BM, Shepherd M, Ellard S, Colclough K, Hattersley AT. Microvascular complication risk in patients with 50 years of moderte hyperglycaemia: are target ranges for glycaemic control appropriate?. Diabet Med 2011; 28: 28.
    • (2011) Diabet Med , vol.28 , pp. 28
    • Steele, A.1    Shields, B.M.2    Shepherd, M.3    Ellard, S.4    Colclough, K.5    Hattersley, A.T.6
  • 11
    • 41749086664 scopus 로고    scopus 로고
    • Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation
    • Murphy R, Turnbull DM, Walker M, Hattersley AT. Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation. Diabet Med 2008; 25: 383-399.
    • (2008) Diabet Med , vol.25 , pp. 383-399
    • Murphy, R.1    Turnbull, D.M.2    Walker, M.3    Hattersley, A.T.4
  • 12
    • 81355151397 scopus 로고    scopus 로고
    • Mechanistic insights into insulin resistance in the genetic era
    • Parker VE, Savage DB, O'Rahilly S, Semple RK. Mechanistic insights into insulin resistance in the genetic era. Diabet Med 2011; 28: 1476-1486.
    • (2011) Diabet Med , vol.28 , pp. 1476-1486
    • Parker, V.E.1    Savage, D.B.2    O'Rahilly, S.3    Semple, R.K.4
  • 13
    • 0028948245 scopus 로고
    • Is maturity onset diabetes at young age (MODY) more common in Europe than previously assumed? [letter] [see comments]
    • Ledermann HM. Is maturity onset diabetes at young age (MODY) more common in Europe than previously assumed? [letter] [see comments]. Lancet 1995; 345: 648.
    • (1995) Lancet , vol.345 , pp. 648
    • Ledermann, H.M.1
  • 14
    • 79954628753 scopus 로고    scopus 로고
    • Prevalence of monogenic diabetes in young adults: a community-based, cross-sectional study in Oxfordshire, UK
    • Kropff J, Selwood MP, McCarthy MI, Farmer AJ, Owen KR. Prevalence of monogenic diabetes in young adults: a community-based, cross-sectional study in Oxfordshire, UK. Diabetologia 2011; 54: 1261-1263.
    • (2011) Diabetologia , vol.54 , pp. 1261-1263
    • Kropff, J.1    Selwood, M.P.2    McCarthy, M.I.3    Farmer, A.J.4    Owen, K.R.5
  • 15
  • 17
    • 0034628425 scopus 로고    scopus 로고
    • Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy.
    • The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group.
    • The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy.. N Engl J Med 2000; 342: 381-389.
    • (2000) N Engl J Med , vol.342 , pp. 381-389
  • 18
    • 0016641270 scopus 로고
    • A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people
    • Tattersall RB, SS Fajans. A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people. Diabetes 1975; 24: 44-53.
    • (1975) Diabetes , vol.24 , pp. 44-53
    • Tattersall, R.B.1    Fajans, S.S.2
  • 19
    • 79961222235 scopus 로고    scopus 로고
    • Clinical Characteristics and Diagnostic Criteria of Maturity-Onset Diabetes Of The Young (MODY) due to Molecular Anomalies of the HNF1A Gene
    • Bellanne-Chantelot C, Levy DJ, Carette C, Saint-Martin C, Riveline JP, Larger E et al. Clinical Characteristics and Diagnostic Criteria of Maturity-Onset Diabetes Of The Young (MODY) due to Molecular Anomalies of the HNF1A Gene. J Clin Endocrinol Metab 2011; 96: E1346-E1351.
    • (2011) J Clin Endocrinol Metab , vol.96
    • Bellanne-Chantelot, C.1    Levy, D.J.2    Carette, C.3    Saint-Martin, C.4    Riveline, J.P.5    Larger, E.6
  • 20
    • 84861333315 scopus 로고    scopus 로고
    • Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young
    • Thanabalasingham G, Pal A, Selwood MP, Dudley C, Fisher K, Bingley PJ et al. Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young. Diabetes Care 2012; 35: 1206-1212.
    • (2012) Diabetes Care , vol.35 , pp. 1206-1212
    • Thanabalasingham, G.1    Pal, A.2    Selwood, M.P.3    Dudley, C.4    Fisher, K.5    Bingley, P.J.6
  • 21
    • 84874131888 scopus 로고    scopus 로고
    • International Diabetes Federation Definition of the Metabolic Syndrome. Available at Last accessed 10 September 2012
    • International Diabetes Federation Definition of the Metabolic Syndrome 2006. Available at http://www.idf.org/metabolic-syndrome Last accessed 10 September 2012.
    • (2006)
  • 22
    • 0035458854 scopus 로고    scopus 로고
    • The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1alpha mutations is a feature of all patients with diabetes and is associated with glucosuria
    • Bingham C, Ellard S, Nicholls AJ, Pennock CA, Allen J, James AJ et al. The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1alpha mutations is a feature of all patients with diabetes and is associated with glucosuria. Diabetes 2001; 50: 2047-2052.
    • (2001) Diabetes , vol.50 , pp. 2047-2052
    • Bingham, C.1    Ellard, S.2    Nicholls, A.J.3    Pennock, C.A.4    Allen, J.5    James, A.J.6
  • 23
    • 84864487679 scopus 로고    scopus 로고
    • Metabolic Profiling in Maturity-Onset Diabetes of the Young (MODY) and Young Onset Type 2 Diabetes Fails to Detect Robust Urinary Biomarkers
    • Gloyn AL, Faber JH, Malmodin D, Thanabalasingham G, Lam F, Ueland PM et al. Metabolic Profiling in Maturity-Onset Diabetes of the Young (MODY) and Young Onset Type 2 Diabetes Fails to Detect Robust Urinary Biomarkers. PLoS One 2012; 7: e40962.
    • (2012) PLoS One , vol.7
    • Gloyn, A.L.1    Faber, J.H.2    Malmodin, D.3    Thanabalasingham, G.4    Lam, F.5    Ueland, P.M.6
  • 24
    • 75749155017 scopus 로고    scopus 로고
    • An investigation of serum concentration of apoM as a potential MODY3 marker using a novel ELISA
    • Cervin C, Axler O, Holmkvist J, Almgren P, Rantala E, Tuomi T et al. An investigation of serum concentration of apoM as a potential MODY3 marker using a novel ELISA. J Intern Med 2010; 267: 316-321.
    • (2010) J Intern Med , vol.267 , pp. 316-321
    • Cervin, C.1    Axler, O.2    Holmkvist, J.3    Almgren, P.4    Rantala, E.5    Tuomi, T.6
  • 25
    • 0344412888 scopus 로고    scopus 로고
    • Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels
    • Richter S, Shih DQ, Pearson ER, Wolfrum C, Fajans SS, Hattersley AT et al. Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels. Diabetes 2003; 52: 2989-2995.
    • (2003) Diabetes , vol.52 , pp. 2989-2995
    • Richter, S.1    Shih, D.Q.2    Pearson, E.R.3    Wolfrum, C.4    Fajans, S.S.5    Hattersley, A.T.6
  • 28
    • 42749083781 scopus 로고    scopus 로고
    • Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein
    • Reiner AP, Barber MJ, Guan Y, Ridker PM, Lange LA, Chasman DI et al. Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. Am J Hum Genet 2008; 82: 1193-1201.
    • (2008) Am J Hum Genet , vol.82 , pp. 1193-1201
    • Reiner, A.P.1    Barber, M.J.2    Guan, Y.3    Ridker, P.M.4    Lange, L.A.5    Chasman, D.I.6
  • 29
    • 42749092252 scopus 로고    scopus 로고
    • Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study
    • Ridker PM, Pare G, Parker A, Zee RY, Danik JS, Buring JE et al. Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am J Hum Genet 2008; 82: 1185-1192.
    • (2008) Am J Hum Genet , vol.82 , pp. 1185-1192
    • Ridker, P.M.1    Pare, G.2    Parker, A.3    Zee, R.Y.4    Danik, J.S.5    Buring, J.E.6
  • 31
    • 0025674251 scopus 로고
    • Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites
    • Toniatti C, Demartis A, Monaci P, Nicosia A, Ciliberto G. Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites. Embo J 1990; 9: 4467-4475.
    • (1990) Embo J , vol.9 , pp. 4467-4475
    • Toniatti, C.1    Demartis, A.2    Monaci, P.3    Nicosia, A.4    Ciliberto, G.5
  • 32
    • 0035072875 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
    • Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL, Suchy FJ et al. Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet 2001; 27: 375-382.
    • (2001) Nat Genet , vol.27 , pp. 375-382
    • Shih, D.Q.1    Bussen, M.2    Sehayek, E.3    Ananthanarayanan, M.4    Shneider, B.L.5    Suchy, F.J.6
  • 33
    • 78649810544 scopus 로고    scopus 로고
    • Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations
    • Owen KR, Thanabalasingham G, James TJ, Karpe F, Farmer AJ, McCarthy MI et al. Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations. Diabetes Care 2010; 33: 1919-1924.
    • (2010) Diabetes Care , vol.33 , pp. 1919-1924
    • Owen, K.R.1    Thanabalasingham, G.2    James, T.J.3    Karpe, F.4    Farmer, A.J.5    McCarthy, M.I.6
  • 35
    • 80054692207 scopus 로고    scopus 로고
    • A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes
    • Thanabalasingham G, Shah N, Vaxillaire M, Hansen T, Tuomi T, Gasperikova D et al. A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes. Diabetologia 2011; 54: 2801-2810.
    • (2011) Diabetologia , vol.54 , pp. 2801-2810
    • Thanabalasingham, G.1    Shah, N.2    Vaxillaire, M.3    Hansen, T.4    Tuomi, T.5    Gasperikova, D.6
  • 36
    • 84975742481 scopus 로고    scopus 로고
    • Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1alpha as a master regulator of plasma protein fucosylation
    • Lauc G, Essafi A, Huffman JE, Hayward C, Knezevic A, Kattla JJ et al. Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1alpha as a master regulator of plasma protein fucosylation. PLoS Genet 2010; 6: e1001256.
    • (2010) PLoS Genet , vol.6
    • Lauc, G.1    Essafi, A.2    Huffman, J.E.3    Hayward, C.4    Knezevic, A.5    Kattla, J.J.6
  • 38
    • 84862526033 scopus 로고    scopus 로고
    • The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes
    • Shields BM, McDonald TJ, Ellard S, Campbell MJ, Hyde C, Hattersley AT. The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes. Diabetologia 2012; 55: 1265-1272.
    • (2012) Diabetologia , vol.55 , pp. 1265-1272
    • Shields, B.M.1    McDonald, T.J.2    Ellard, S.3    Campbell, M.J.4    Hyde, C.5    Hattersley, A.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.