A postmortem assessment of mammillary body volume, neuronal number and densities, and fornix volume in subjects with mood disorders

European Archives of Psychiatry and Clinical Neuroscience

Volumn 262, Issue 8, 2012, Pages 637-646

  Bernstein, Hans Gert ^a   Klix, Melanie ^a   Dobrowolny, Henrik ^a   Brisch, Ralf ^a   Steiner, Johann ^a   Bielau, Hendrik ^a   Gos, Tomasz ^b   Bogerts, Bernhard ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Bipolar disorder; Fornix; Major depression; Mammillary bodies; Morphometry

Indexed keywords

ADULT; AGED; ARTICLE; AUTOPSY; BIPOLAR I DISORDER; BRAIN FORNIX; BRAIN NERVE CELL; BRAIN SIZE; CAUSE OF DEATH; CELL DENSITY; CONTROLLED STUDY; FEMALE; HEART FAILURE; HUMAN; MAJOR DEPRESSION; MALE; MAMMILLARY BODY; MOOD DISORDER; PRIORITY JOURNAL; SUICIDAL BEHAVIOR;

ADULT; AGED; ANTIDEPRESSIVE AGENTS; CELL COUNT; DIAGNOSIS; FEMALE; FRONTAL LOBE; HUMANS; MALE; MAMILLARY BODIES; MIDDLE AGED; MOOD DISORDERS; NEURONS;

EID: 84874108740     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-012-0300-4     Document Type: Article

References (41)

1. Elliott R, Rubinsztein JS, Sahakian BJ, Dolan RJ (2002) The neural basis of mood-congruent processing biases in depression. Arch Gen Psychiatr 59:597-604
2. Shumake J, Gonzalez-Lima F (2003) Brain systems underlying susceptibility to helplessness and depression. Behav Cogn Neurosci Rev 2:198-221
3. Bielau H, Trubner K, Krell D, Agelink MW, Bernstein HG, Stauch R, Mawrin C, Danos P, Gerhard L, Bogerts B, Baumann B (2007) Volume deficits of subcortical nuclei in mood disorders a postmortem study. Eur Arch Psychiatr Clin Neurosci 255:401-412
4. Lee BT, Seong WC, Hyung HC, Lee SK, Choi IG, Lyoo IK, Ham BJ (2007) The neural substrates of affective processing toward positive and negative affective pictures in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatr 31:1487-1492
5. Nelson EE, Vinton DT, Berghorst L, Towbin KE, Hommer RE, Dickstein DP, Rich BA, Brotman MA, Pine DS, Leibenluft E (2007) Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI study. Bipolar Disord 9:810-819
6. Sahay A, Hen R (2007) Adult hippocampal neurogenesis in depression. Nat Neurosci 10:1110-1115
7. Brisch R, Bernstein HG, Stauch R, Dobrowolny H, Krell D, Trubner K, Meyer-Lotz G, Bielau H, Steiner J, Kropf S, Gos T, Danos P, Bogerts B (2008) The volumes of the fornix in schizophrenia and affective disorders: a post-mortem study. Psychiatry Res 164:265-273
8. Costafreda SG, Chu C, Ashburner J, Fu CH (2009) Prognostic and diagnostic potential of the structural neuroanatomy of depression. PLoS One 4:e6353
9. Koenigs M, Grafman J (2009) The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex. Behav Brain Res 201:239-243
10. Cheng YQ, Xu J, Chai P, Li HJ, Luo CR, Yang T, Li L, Shan BC, Xu XF, Xu L (2010) Brain volume alteration and the correlations with the clinical characteristics in drug-na?ve first-episode MDD patients: a voxel-based morphometry study. Neurosci Lett 480:30-34
11. Savitz J, Drevets WC (2009) Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide. Neurosci Biobehav Rev 33:699-771
12. Emsell L, McDonald CD (2009) The structural neuroimaging of bipolar disorder. Int Rev Psychiatr 21:297-313
13. Brisch R, Bernstein HG, Dobrowolny H, Krell D, Stauch R, Trubner K, Steiner J, Ghabriel MN, Bielau H, Wolf R, Winter J, Kropf S, Gos T, Bogerts B (2011) A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorder. Eur Arch Psychiatr Clin Neurosci 261:47-58
14. Vann SD, Aggleton JP (2004) The mammillary bodies: two memory systems in one? Nat Rev Neurosci 5:35-44
15. Bernstein HG, Krause S, Krell D, Dobrowolny H, Wolter M, Stauch R, Ranft K, Danos P, Jirikowski GF, Bogerts B (2007) Strongly reduced number of parvalbumin-immunoreactive projection neurons in the mammillary bodies in schizophrenia: further evidence for limbic neuropathology. Ann N Y Acad Sci 1096:120-127
16. Vann SD (2010) Re-evaluating the role of the mammillary bodies in memory. Neuropsychologia 48:2316-2327
17. Bernstein HG, Stanarius A, Baumann B, Henning H, Krell D, Danos P, Falkai P, Bogerts B (1998) Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience 83:867-875
18. Baumann B, Danos P, Krell D, Diekmann S, Leschinger A, Stauch R, Wurthmann C, Bernstein HG, Bogerts B (1999) Reduced volume of limbic system-affiliated basal ganglia in mood disorders: preliminary data from a postmortem study. J. Neuropsychiatr Clin Neurosci 11:71-78
19. Manaye KF, Lei DL, Tizabi Y, Davila-Garc?a MI, Mouton PR, Kelly PH (2005) Selective neuron loss in the paraventricular nucleus of hypothalamus in patients suffering from major depression and bipolar disorder. J Neuropathol Exp Neurol 64: 224-229
20. Ranft K, Dobrowolny H, Krell D, Bielau H, Bogerts B, Bernstein HG (2010) Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia. Psychol Med 40:557-567
21. Schindler S, Geyer S, Strauß M, Anwander A, Hegerl U, Turner R, Schonknecht P (2011) Structural studies of the hypothalamus and its nuclei in mood disorders. Psychiatr Res Neuroimag. doi: 10.106/j.psychresns.2011.06.06.005
22. Danos P, Baumann B, Kramer A, Bernstein HG, Stauch R, Krell D, Falkai P, Bogerts B (2003) Volumes of association thalamic nuclei in schizophrenia: a postmortem study. Schizophr Res 60: 141-155
23. Kumar R, Woo MA, Birrer BV, Macev PM, Fonarow GC, Hamilton MA, Harper RM (2009) Mammillary bodies and fornix fibers are injured in heart failure. Neurobiol Dis 33:236-242
24. Davila MD, Shear PK, Lane B, Sullivan EV, Pfefferbaum A (1994) Mammillary body and cerebellar shrinkage in chronic alcoholics: an MRI and neuropsychological study. Neuropsychology 8:433-444
25. Sullivan EV, Lane B, Deshmukh A, Rosenbloom MJ, Desmond JE, Lim KO, Pfefferbaum A (1999) In vivo mammillary body volume deficits in amnesic and nonamnesic alcoholics. Alcoholism Clin Exp Res 23:1629-1636
26. Kumar R, Birrer BV, Macey PM, Woo MA, Gupta RK, Yan-Go FL, Harper RM (2008) Reduced mammillary body volume in patients with obstructive sleep apnea. Neurosci Lett 438:330-334
27. Kumar Mandal P, Kumar Yadav S, Anand Saraswat V, Kumar Singh J, Upreti P, Singh R, Kshore Singh Rathore R, Kumar Gupta R (2009) Mammillary body atrophy in acute liver failureand acute-on chronic liver failure off non-alcoholic etiology. Metab Brain Dis 24:361-371
28. Woo MA, Macey PM, Fonarow GC, Hamilton MA, Harper RM (2003) Regional brain gray matter loss in heart failure. J Appl Physiol 95:677-684
29. Denby CE, Vann SD, Tsivilis D, Aggleton JP, Montaldi D, Roberts N, Mayes AR (2009) The frequency and extent of mammillary body atrophy associated with surgical removal of a colloid cyst. Am J Neuroradiol 30:736-743
30. Rajkowska G, Miguel-Hidalgo JJ (2007) Gliogenesis and glial pathology in depression. CNS Neurol Disord Drug Targets 6: 219-233
31. Schroeter ML, Abdul-Khaliq H, Krebs M, Diefenbacher A, Blasig IE (2008) Serum markers support disease-specific glial pathology in major depression. J Affect Disord 111:271-280
32. Alfonso J, Frasch AC, Flugge G (2005) Chronic stress, depression and antidepressants: effects on gene transcription in the hippocampus. Rev Neurosci 16:43-56
33. Barnea-Goraly N, Chang KD, Karchemskiy A, Howe ME, Reiss AL (2009) Limbic and corpus callosum aberrations in adolescents with bipolar disorder: a tract-based spatial statistics analysis. Biol Psychiatry 66:238-244
34. Vann SD (2009) Gudden's ventral tegmental nucleus is vital for memory: re-evaluating diencephalic inputs for amnesia. Brain 132:372-2384
35. Saunders RC, Vann SD, Aggleton JP (2011) Projections from gudden's tegmental nuclei to the mammillary body region in the cynomolgus monkey (Macaca fascicularis). J Comp Neurol. doi: 10.1002/cne.22740. [Epub ahead of print]
36. Dere E, Pause BN, Pietrowsky R (2009) Emotion and episodic memory in neuropsychiatric disorders. Behav Brain Res 215: 162-171
37. Bearden CE, Woogen M, Glahn DC (2010) Neurocognitive and neuroimaging predictors of clinical outcome in bipolar disorder. Curr Psychiatry Rep 12:499-504
38. Behnken A, Schoning RE, Gerss J, Konrad C, de Jong-Meyer R, Zwanziger P, Arolt V (2010) Persistent non-verbal memory impairment in remitted major depression-caused by encoding deficits? J Affect Disord 122:144-148
39. Mega MS, Cummings JL, Salloway S, Malloy P (1997) The limbic system: an anatomic, phylogenetic, and clinical perspective. J Neuropsychiatr Clin Neurosci 9:315-330
40. Beracochea D (2005) Interaction between emotion and memory: importance of mammillary bodies damage in a mouse model of the alcoholic Korsakoff syndrome. Neural Plast 12:275-280
41. Kim E, Ku J, Namkoong K, Lee W, Lee KS, Park JY, Lee SY, Kim JJ, Kim SI, Jung YC (2009) Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy. Brain 132:369-376