Perfusion pressure and movement-induced hyperemia: Evidence of limited vascular function and vasodilatory reserve with age

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 304, Issue 4, 2013, Pages

  Jonathan Groot, H ^a,b   Trinity, Joel D ^a,c   Layec, Gwenael ^a,c   Rossman, Matthew J ^a,b   Ives, Stephen J ^a,c   Richardson, Russell S ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Blood flow; Passive movement; Posture

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; ARTERY CATHETER; ARTERY PERFUSION; ARTICLE; BODY POSTURE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; FEMORAL ARTERY; FEMORAL ARTERY FLOW; FEMORAL VEIN; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; HYPEREMIA; INTRAVENOUS CATHETER; LEG BLOOD FLOW; LEG MOVEMENT; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; PASSIVE MOVEMENT; PERFUSION PRESSURE; PHOTOELECTRIC PLETHYSMOGRAPHY; PRIORITY JOURNAL; SEAT; STANDING; SUPINE POSITION; VASODILATATION;

AGED; AGING; BLOOD FLOW VELOCITY; CARDIAC OUTPUT; CATHETERIZATION, PERIPHERAL; FEMORAL ARTERY; FEMORAL VEIN; FINGERS; HEART RATE; HUMANS; HYPEREMIA; LEG; MALE; MOVEMENT; PHOTOPLETHYSMOGRAPHY; POSTURE; ULTRASONOGRAPHY, DOPPLER; VASCULAR RESISTANCE; VASODILATION; YOUNG ADULT;

EID: 84874101735     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00656.2012     Document Type: Article

References (56)

1. Abel MG, Hannon JC, Sell K, Lillie T, Conlin G, Anderson D. Validation of the Kenz Lifecorder EX and ActiGraph GT1M accelerometers for walking and running in adults. Appl Physiol Nutr Metab 33: 1155-1164, 2008.
2. Black MA, Cable NT, Thijssen DH, Green DJ. Impact of age, sex, and exercise on brachial artery flow-mediated dilatation. Am J Physiol Heart Circ Physiol 297: H1109-H1116, 2009.
3. Caspersen CJ, Pereira MA, Curran KM. Changes in physical activity patterns in the United States, by sex and cross-sectional age. Med Sci Sports Exerc 32: 1601-1609, 2000.
4. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 24: 471-476, 1994.
5. Clifford PS, Kluess HA, Hamann JJ, Buckwalter JB, Jasperse JL. Mechanical compression elicits vasodilatation in rat skeletal muscle feed arteries. J Physiol 572: 561-567, 2006.
6. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H, Seals DR. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 102: 1351-1357, 2000.
7. Dinenno FA, Jones PP, Seals DR, Tanaka H. Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand. Circulation 100: 164-170, 1999.
8. Dinenno FA, Seals DR, DeSouza CA, Tanaka H. Age-related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects. J Physiol 531: 573-579, 2001.
9. Dinenno FA, Tanaka H, Stauffer BL, Seals DR. Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction. J Physiol 536: 977-983, 2001.
10. Donato AJ, Uberoi A, Bailey DM, Wray DW, Richardson RS. Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men. Am J Physiol Heart Circ Physiol 298: H671-H678, 2010.
11. Donato AJ, Uberoi A, Wray DW, Nishiyama S, Lawrenson L, Richardson RS. Differential effects of aging on limb blood flow in humans. Am J Physiol Heart Circ Physiol 290: H272-H278, 2006.
12. Egana M, Green S. Effect of body tilt on calf muscle performance and blood flow in humans. J Appl Physiol 98: 2249-2258, 2005.
13. Egashira K, Inou T, Hirooka Y, Kai H, Sugimachi M, Suzuki S, Kuga T, Urabe Y, Takeshita A. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation 88: 77-81, 1993.
14. Gonzalez-Alonso J, Mortensen SP, Jeppesen TD, Ali L, Barker H, Damsgaard R, Secher NH, Dawson EA, Dufour SP. Haemodynamic responses to exercise, ATP infusion and thigh compression in humans: insight into the role of muscle mechanisms on cardiovascular function. J Physiol 586: 2405-2417, 2008.
15. Groothuis JT, Thijssen DH, Kooijman M, Paulus R, Hopman MT. Attenuated peripheral vasoconstriction during an orthostatic challenge in older men. Age Ageing 37: 680-684, 2008.
16. Hagstromer M, Oja P, Sjostrom M. Physical activity and inactivity in an adult population assessed by accelerometry. Med Sci Sports Exerc 39: 1502-1508, 2007.
17. Harris RA, Nishiyama SK, Wray DW, Richardson RS. Ultrasound assessment of flow-mediated dilation. Hypertension 55: 1075-1085, 2010.
18. Hayman MA, Nativi JN, Stehlik J, McDaniel J, Fjeldstad AS, Ives SJ, Walter Wray D, Bader F, Gilbert EM, Richardson RS. Understanding exercise-induced hyperemia: central and peripheral hemodynamic responses to passive limb movement in heart transplant recipients. Am J Physiol Heart Circ Physiol 299: H1653-H1659, 2010.
19. Hellsten Y, Rufener N, Nielsen JJ, Hoier B, Krustrup P, Bangsbo J. Passive leg movement enhances interstitial VEGF protein, endothelial cell proliferation, and eNOS mRNA content in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol 294: R975-R982, 2008.
20. Hirai DM, Copp SW, Hageman KS, Poole DC, Musch TI. Aging alters the contribution of nitric oxide to regional muscle hemodynamic control at rest and during exercise in rats. J Appl Physiol 111: 989-998, 2011.
21. Hoier B, Rufener N, Bojsen-Moller J, Bangsbo J, Hellsten Y. The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle. J Physiol 588: 3833-3845, 2010.
22. Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, Luscher TF. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 91: 1314-1319, 1995.
23. Kirby BS, Carlson RE, Markwald RR, Voyles WF, Dinenno FA. Mechanical influences on skeletal muscle vascular tone in humans: insight into contraction-induced rapid vasodilatation. J Physiol 583: 861-874, 2007.
24. Laitinen T, Niskanen L, Geelen G, Lansimies E, Hartikainen J. Age dependency of cardiovascular autonomic responses to head-up tilt in healthy subjects. J Appl Physiol 96: 2333-2340, 2004.
25. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease. Circulation 107: 139-146, 2003.
26. Lawrenson L, Poole JG, Kim J, Brown C, Patel P, Richardson RS. Vascular and metabolic response to isolated small muscle mass exercise: effect of age. Am J Physiol Heart Circ Physiol 285: H1023-H1031, 2003.
27. Lind L, Lithell H. Decreased peripheral blood flow in the pathogenesis of the metabolic syndrome comprising hypertension, hyperlipidemia, and hyperinsulinemia. Am Heart J 125: 1494-1497, 1993.
28. McDaniel J, Hayman MA, Ives S, Fjeldstad AS, Trinity JD, Wray DW, Richardson RS. Attenuated exercise induced hyperaemia with age: mechanistic insight from passive limb movement. J Physiol 588: 4507-4517, 2010.
29. McDaniel J, Ives SJ, Richardson RS. Human muscle length-dependent changes in blood flow. J Appl Physiol 112: 560-565, 2012.
30. 2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol 298: H466-H476, 2010.
31. Musch TI, Eklund KE, Hageman KS, Poole DC. Altered regional blood flow responses to submaximal exercise in older rats. J Appl Physiol 96: 81-88, 2004.
32. Newcomer SC, Leuenberger UA, Hogeman CS, Proctor DN. Heterogeneous vasodilator responses of human limbs: influence of age and habitual endurance training. Am J Physiol Heart Circ Physiol 289: H308-H315, 2005.
33. Nishiyama SK, Wray DW, Richardson RS. Aging affects vascular structure and function in a limb-specific manner. J Appl Physiol 105: 1661-1670, 2008.
34. Nurhayati Y, Boutcher SH. Cardiovascular response to passive cycle exercise. Med Sci Sports Exerc 30: 234-238, 1998.
35. Parker BA, Smithmyer SL, Pelberg JA, Mishkin AD, Proctor DN. Sex-specific influence of aging on exercising leg blood flow. J Appl Physiol 104: 655-664, 2008.
36. Pohl U, Holtz J, Busse R, Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 8: 37-44, 1986.
37. Poole JG, Lawrenson L, Kim J, Brown C, Richardson RS. Vascular and metabolic response to cycle exercise in sedentary humans: effect of age. Am J Physiol Heart Circ Physiol 284: H1251-H1259, 2003.
38. Rowell LB. Human Cardiovascular Control. New York: Oxford Univ. Press, 1993.
39. Sanada H, Higashi Y, Goto C, Chayama K, Yoshizumi M, Sueda T. Vascular function in patients with lower extremity peripheral arterial disease: a comparison of functions in upper and lower extremities. Atherosclerosis 178: 179-185, 2005.
40. Schmidt MD, Cleland VJ, Shaw K, Dwyer T, Venn AJ. Cardiometabolic risk in younger and older adults across an index of ambulatory activity. Am J Prev Med 37: 278-284, 2009.
41. Seals DR, Walker AE, Pierce GL, Lesniewski LA. Habitual exercise and vascular ageing. J Physiol 587: 5541-5549, 2009.
42. Sisson SB, Camhi SM, Tudor-Locke C, Johnson WD, Katzmarzyk PT. Characteristics of step-defined physical activity categories in U.S. adults. Am J Health Promot 26: 152-159, 2012.
43. Sun D, Huang A, Recchia FA, Cui Y, Messina EJ, Koller A, Kaley G. Nitric oxide-mediated arteriolar dilation after endothelial deformation. Am J Physiol Heart Circ Physiol 280: H714-H721, 2001.
44. Thijssen DH, Rongen GA, van Dijk A, Smits P, Hopman MT. Enhanced endothelin-1-mediated leg vascular tone in healthy older subjects. J Appl Physiol 103: 852-857, 2007.
45. Trinity JD, Amann M, McDaniel J, Fjeldstad AS, Barrett-O'Keefe Z, Runnels S, Morgan DE, Wray DW, Richardson RS. Limb movementinduced hyperemia has a central hemodynamic component: evidence from a neural blockade study. Am J Physiol Heart Circ Physiol 299: H1693-H1700, 2010.
46. Trinity JD, Groot HJ, Layec G, Rossman MJ, Ives SJ, Runnels S, Gmelch B, Bledsoe A, Richardson RS. Nitric oxide and passive limb movement: a new approach to assess vascular function. J Physiol 590: 1413-1425, 2012.
47. Trinity JD, McDaniel J, Venturelli M, Fjeldstad AS, Ives SJ, Witman MA, Barrett-O'Keefe Z, Amann M, Wray DW, Richardson RS. Impact of body position on central and peripheral hemodynamic contributions to movement-induced hyperemia: implications for rehabilitative medicine. Am J Physiol Heart Circ Physiol 300: H1885-H1891, 2011.
48. Tsutsui Y, Sagawa S, Yamauchi K, Endo Y, Yamazaki F, Shiraki K. Cardiovascular responses to lower body negative pressure in the elderly: role of reduced leg compliance. Gerontology 48: 133-139, 2002.
49. Tudor-Locke C, Bassett DR Jr. How many steps/day are enough? Preliminary pedometer indices for public health. Sports Med 34: 1-8, 2004.
50. Venturelli M, Amann M, McDaniel J, Trinity JD, Fjeldstad AS, Richardson RS. Central and peripheral hemodynamic responses to passive limb movement: the role of arousal. Am J Physiol Heart Circ Physiol 302: H333-H339, 2012.
51. Walker AE, Eskurza I, Pierce GL, Gates PE, Seals DR. Modulation of vascular endothelial function by low-density lipoprotein cholesterol with aging: influence of habitual exercise. Am J Hypertens 22: 250-256, 2009.
52. Welk GJ, Blair SN, Wood K, Jones S, Thompson RW. A comparative evaluation of three accelerometry-based physical activity monitors. Med Sci Sports Exerc 32: S489-S497, 2000.
53. Westerterp KR, Meijer EP. Physical activity and parameters of aging: a physiological perspective. J Gerontol A Biol Sci Med Sci 56, Spec No 2: 7-12, 2001.
54. Wray DW, Donato AJ, Uberoi A, Merlone JP, Richardson RS. Onset exercise hyperaemia in humans: partitioning the contributors. J Physiol 565: 1053-1060, 2005.
55. Wray DW, Nishiyama SK, Donato AJ, Richardson RS. Human vascular aging: limb-specific lessons. Exerc Sport Sci Rev 38: 177-185, 2010.
56. Wray DW, Nishiyama SK, Richardson RS. Role of α1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age. Am J Physiol Heart Circ Physiol 296: H497-H504, 2009.